Optimal Exercise Intensity for Enhancing Sperm Parameters: A Network Meta-Analysis of Rodent Studies.

Exercise training as a potential intervention to improve male reproductive health, its efficacy appears to be contingent on exercise intensity. However, the optimal training intensity remains poorly defined. Hence, this study aimed to identify the optimal exercise intensity for improving sperm parameters through network meta-analysis of rodent studies.

Chronic exposure to environmental concentrations of 6PPDQ induces neurotoxicity via perturbing multiple neurotransmission pathways in zebrafish.

Previous research has demonstrated acute toxicity of 6PPD-quinone (6PPDQ), the ozonation product of tire-manufacturing additive 6PPD; however, chronic effects on aquatic organisms under real-world conditions remain unclear. We exposed 2-month-old zebrafish to 6PPDQ at concentrations of 2, 20 and 200 µg/L for 30 days. Whole-body desorption electrospray ionization-mass spectrometry (DESI-MS) revealed accumulation mainly in the muscle, abdomen, and brain of zebrafish exposed to 200 µg/L 6PPDQ, which was verified by MS quantification of muscle and brain tissues.

Exposure to benzotriazole UV stabilizer-329 at environmental concentrations induces neurotoxicity by affecting neurotransmission in Caenorhabditis elegans.

Benzotriazole UV stabilizer-329 (UV-329), a novel stabilizer used in polymers, has been detected in various environmental matrices and organisms, where it exerts toxic effects. However, the neurotoxic effects and underlying mechanisms of UV-329 remain largely unexplored. In this study, Caenorhabditis elegans was used as a model organism to investigate the neurotoxicity of UV-329 at environmental concentrations (0.

Corrigendum: Case report: A novel PTCH1 frameshift mutation leading to nevoid basal cell carcinoma syndrome.

[This corrects the article DOI: 10.3389/fmed.2024.

Sex-specific reproductive toxicity of subacute exposure to glufosinate-ammonium in zebrafish (Danio rerio).

Glufosinate-ammonium (GLA) is a common agricultural herbicide used worldwide. It can be transported into water bodies and can persist for long periods, posing a risk to non-target aquatic organisms. In this study, adult zebrafish were exposed to GLA (0, 0.

Neurotoxicity of tetrabromobisphenol-A-bis(2,3-dibromopropyl ether) through the GABAergic and serotonergic neurotransmission in Caenorhabditis elegans.

Tetrabromobisphenol-A-bis(2,3-dibromopropyl ether) (TBBPA-BDBPE), a novel additive brominated flame retardant, is being developed for use in polyolefin and copolymers. Despite its emerging application, the neurotoxicity and mechanisms of action of TBBPA-BDBPE remain unexplored. Caenorhabditis elegans was utilized as the model organism to study the neurotoxic effects of TBBPA-BDBPE across environmental concentrations ranging from 0 to 100 μg/L.

Inventorization and ecological risk assessment of tetrabromobisphenol A and hexabromocyclododecane in sediments from Guangdong coastal area of South China Sea.

Brominated flame retardants (BFRs) exhibit excellent flame retardant properties and are widely used in various industries. Among the common BFRs, tetrabromobisphenol A (TBBPA) and hexabromocyclododecane (HBCDs) pose substantial ecological and human health risks due to their extensive application and long-range transport. This study established 131 sample collection sites along the coast of the South China Sea (SCS) in Guangdong Province to assess the concentration, distribution, inventory, and ecological risk of TBBPA and HBCDs in surface sediments.

Combined neurotoxicity of aged microplastics and thiamethoxam in the early developmental stages of zebrafish (Daniorerio).

Microplastics (MPs) pollution, together with its consequential effect on aquatic biota, represent a burgeoning environmental concern that has garnered significant scholarly attention. Thiamethoxam (TMX), a prevalently utilized neonicotinoid insecticide, is renowned for its neurotoxic impact and selective action against targeted pests. The aquatic environment serves as a receptacle for numerous pollutants, such as MPs and neonicotinoid insecticides.

Case report: A novel PTCH1 frameshift mutation leading to nevoid basal cell carcinoma syndrome.

A patient presenting with several basal cell carcinomas, pigmented nevi, and developmental defects was diagnosed with nevoid basal cell carcinoma syndrome. Gene panel sequencing and Sanger sequencing were used to identify a novel heterozygous frameshift mutation, c.1312dupA:p.

Photoaged polystyrene microplastics result in neurotoxicity associated with neurotransmission and neurodevelopment in zebrafish larvae (Danio rerio).

Microplastics (MPs) are emerging pollutants widely distributed in the environment, inducing toxic effects in various organisms. However, the neurotoxicity and underlying mechanisms of simulated sunlight-aged MPs have rarely been investigated. In this study, zebrafish (Danio rerio) were exposed to environmentally relevant concentrations (0, 0.

Bioaccumulation and biotransformation of 1,2-bis (2,4,6-tribromophenoxyethane) (BTBPE) and 1,2-dibromo-4-(1,2-dibromoethyl)-cyclohexane (TBECH) in zebrafish (Danio rerio).

Despite the increasing production, use, and ubiquitous occurrence of novel brominated flame retardants (NBFRs), little information is available regarding their fate in aquatic organisms. In this study, the bioaccumulation and biotransformation of two typical NBFRs, i.e.

Transcriptome-based approach to identify mechanisms underlying locomotor abnormality induced by decabromodiphenyl ethane in zebrafish larvae.

The brominated flame retardant decabromodiphenyl ethane (DBDPE) has been extensively used following restrictions on BDE-209 and thus, been frequently detected in aquatic environment. However, information on impact of DBDPE on fish development and the potential mechanisms remains scarce. In present study, developing zebrafish were employed as a study model.

Sub-acute toxicity of the herbicide glufosinate-ammonium exposure in adult red swamp crayfish (Procambarus clarkii).

Glufosinateammonium (GLA) is one of the most widely used agricultural herbicides. It is frequently detected in surface waters near farmland and may pose a risk to non-target aquatic species. This study aimed to explore the toxicity of subacute GLA exposure in crayfish.

Photoaged microplastics induce neurotoxicity associated with damage to serotonergic, glutamatergic, dopaminergic, and GABAergic neuronal systems in Caenorhabditis elegans.

Microplastics (MPs) are ubiquitous environmental contaminants that cause neurotoxicity in various organisms. MPs are typically affected by light irradiation and undergo photoaging. However, the neurotoxic effects of photoaged polystyrene (P-PS) and its underlying mechanisms remain unclear.

Case report: Post-streptococcal pustulosis after subcutaneous injection of secukinumab.

An acute diffuse pustular eruption occurred in a patient after secukinumab injection and then the clinical presentation has been related to streptococcus infection after it has been isolated from throat swabs. Pustulosisacuta generalisata was definitively diagnosed. Antibiotic treatment had a poor effect, but the response to glucocorticoids was better.

Tris(1,3-dichloro-2-propyl) phosphate causes female-biased growth inhibition in zebrafish: Linked with gut microbiota dysbiosis.

Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is ubiquitous in aquatic environment, but its effect on intestinal health of fish has yet not been investigated. In the present study, the AB strain zebrafish embryos were exposed to environmentally realistic concentrations (0, 30, 300, and 3000 ng·L) of TDCIPP for 90 days, after which the fish growth and physiological activities were evaluated, and the intestinal microbes were analyzed by 16S rRNA gene high-throughput sequencing. Our results manifested that the body length and body weight were significantly reduced in the female zebrafish but not in males.

Sorption in soils and bioaccumulation potential of 2,2'-DiBBPA.

2,2'-Dibromobisphenol A (2,2'-DiBBPA) is frequently detected in the environment. However, the mobility of 2,2'-DiBBPA in the soil environment is poorly understood. The present study examined the effects of soil components such as the NaClO-resistant fraction, dithionite-citrate-bicarbonate -demineralized fraction, humin fraction, black carbon, DOC-removed fraction, exogenous dissolved organic carbon and heavy metal cations on the adsorption of 2,2'-DiBBPA on several types of agricultural soils.

UV-aged microplastics induces neurotoxicity by affecting the neurotransmission in larval zebrafish.

Microplastics (MPs) are nearly ubiquitous in aquatic ecosystems and may affect aquatic organisms. In this study, virgin and aged polystyrene MPs (PS-MPs) of size 1 μm were selected to analyze their adverse effects on larvae zebrafish. Exposure to PS-MPs significantly reduced the average swimming speed of zebrafish, and the behavioral effects caused by aged PS-MPs on zebrafish were more pronounced.

Growth inhibition of offspring larvae caused by the maternal transfer effects of tetrabromobisphenol A in zebrafish.

Tetrabromobisphenol A (TBBPA) is an industrial chemical and the most widely used brominated flame retardant, and has raised environmental health concerns. However, the maternal transfer toxicity of TBBPA is less studied in fish despite its frequency in the water environment, and limited evidence exists to confirm the major contributing factors. In this study, we performed a 28-d experiment on female and male zebrafish exposed to TBBPA (0, 5, 50, and 500 μg/L), and shortened body length of offspring larvae was observed at the maximum exposure concentration.

Tissue-specific and stereoselective accumulation of Dechlorane Plus isomers in two predator fish in a laboratory feeding study.

The tissue-specific bioaccumulation of Dechlorane Plus (DP) isomers was investigated in two predator fish species (redtail catfish, RF; and oscar fish, OF) that were feeding on tiger barb (TB), which was exposed to syn-DP and anti-DP isomers. The biotransformation potential of DP isomers was examined by in vitro metabolism using fish liver microsomes. No difference in accumulation behaviors of DP isomers was observed between RF and OF, and the accumulation of both syn- and anti-DP isomers exhibiting a linear increase trend with the exposure time in all fish tissues.

Carboxyl-modified polystyrene microplastics induces neurotoxicity by affecting dopamine, glutamate, serotonin, and GABA neurotransmission in Caenorhabditis elegans.

Microplastics (MPs) are ubiquitous in various environmental media and have potential toxicity. However, the neurotoxicity of carboxyl-modified polystyrene microplastics (PS-COOH) and their mechanisms remain unclear. In this study, Caenorhabditis elegans was used as a model to examine the neurotoxicity of polystyrene microplastic (PS) and PS-COOH concentrations ranging from 0.

Biochar aerogel enhanced remediation performances for heavy oil-contaminated soil through biostimulation strategy.

Petroleum leakages can seriously damage the soil environment and cause a persistent harm to human health, due to the release of heavy oil pollutants with a high viscosity and high molecular weight. In this paper, biochar aerogel materials were successfully prepared under 600, 700 and 800 ℃ (accordingly labeled as 600-aerogel, 700-aerogel and 800-aerogel) with green, sustainable and abundant sisal leaves as raw materials for the remediation of heavy oil-contaminated soil. The remediation performances of biochar aerogel supplement for heavy oil-contaminated soil were investigated, while microbial abundance and community structure were characterized.

Promotion effect on liver tumor progression of microcystin-LR at environmentally relevant levels in female krasV12 transgenic zebrafish.

Microcystin-LR (MC-LR) is a kind of natural toxin which exists widely in aquatic environments and has been reported to be hepatotoxic and carcinogenic. At present, the promoting mechanism of MC-LR on hepatocellular carcinoma (HCC) remains largely unexplored. In this study, the hepatocellular promoting effect of MC-LR was described in Kras transgenic zebrafish, a doxycycline (DOX) inducible HCC model.