Optimizing extended ablation margins in papillary thyroid carcinoma using digital pathology.

Background: To reduce the risk of local recurrence of papillary thyroid carcinoma (PTC) after thermal ablation, in clinical practice, the ablation area is typically extended 2-3 mm beyond the original tumor margin. However, there is no definitive evidence to support the validity of this extended margin.

Objective: The objective of this study was to measure the distance from the edge of a PTC to the farthest point of tumor infiltration using digital pathology and to analyze the associated risk factors.

A Pathology-Based Risk Stratification Model for Predicting Occult Lesions in Papillary Thyroid Carcinoma Patients: Validation Using 5-Year Thermal Ablation Outcome Data.

Background: Thermal ablation (TA) is a minimally invasive alternative for patients with papillary thyroid carcinoma (PTC). However, sonographically occult lesions may lead to new tumor development during follow-up monitoring. This study involved developing and validating a prediction model for identifying patients at high risk of new tumors after receiving TA.

Propensity-matched comparison of microwave ablation and surgical resection for preoperative T1N0M0 papillary thyroid carcinoma: 5-year follow-up.

Background: Microwave ablation (MWA) has demonstrated short-term efficacy comparable to surgical resection (SR) for papillary thyroid carcinoma (PTC), but long-term data are limited.

Objective: To compare the long-term efficacy and safety of MWA versus SR in preoperative T1N0M0 PTC.

Materials And Methods: This single-center retrospective study included 792 patients with preoperative T1N0M0 PTC treated with MWA or SR from January 2016 to June 2019.

Clinical study on the relationship between the incidence of complications and tumour size after thermal ablation of benign thyroid nodules.

Objective: The present study aimed to analyze the relationship between the incidence of complications and tumor size following thermal ablation of benign thyroid nodules (BTNs).

Methods: In this retrospective study, 1198 patients who underwent thermal ablation for unifocal BTN were enrolled. Receiver Operating Characteristic analysis was performed to select the cutoff values of the maximum diameter (MD) for dividing patients into different groups or subgroups.

Clinical outcomes of microwave ablation for solitary T1N0M0 papillary thyroid carcinoma: a more than 5-year follow-up study.

Objectives: This study aimed to evaluate the long-term efficacy and safety of microwave ablation (MWA) for solitary T1N0M0 papillary thyroid carcinoma (PTC) and compare them between T1a and T1b disease.

Materials And Methods: This retrospective study included 136 patients with solitary T1N0M0 PTC who were treated with MWA and followed up for more than 5 years. Outcomes were compared between patients with T1a and T1b disease.