Effects of different vitamins on individuals with septic shock: a Bayesian NMA of RCTs.

Objective: To compare the effects of different vitamins on patients with septic shock (SS) through Bayesian network meta-analysis.

Methods: Randomized controlled trials (RCTs) on vitamins for septic shock patients were retrieved from PubMed, Embase, Cochrane Library, Web of Science, etc. The retrieval time was set from the establishment of the database to May 20, 2024.

Electrochemical Alkyne Semi-Hydrogenation via Proton-Coupled Electron Transfer on Cu(111) Surface.

Electrocatalytic alkyne semi-hydrogenation (EASH) powered by renewable electricity using water as a hydrogen donor provides a sustainable alternative to conventional thermocatalysis. However, the current EASH systems predominantly follow hydrogen atom transfer (HAT) pathways, which are prone to over-hydrogenation and at the same time compete with the hydrogen evolution reaction. In this work, we report a proton-coupled electron transfer (PCET) mechanism enabled on Cu(111) surface for highly efficient and selective EASH.

Mechanistic insights into the evolution of microscopic molecular structures of bituminous coal and lignite during carbonization: a ReaxFF molecular dynamics study.

Context: The development of the carbon network in coal during carbonization significantly affects the quality of the resulting coke. A detailed understanding of the atomic-scale mechanisms governing coal carbonization is crucial for optimizing the coking process. This research employed ReaxFF molecular dynamics simulations to examine the carbonization processes of two coal types: bituminous coal and lignite.

Correction: Deep learning-based text generation for plant phenotyping and precision agriculture.

[This corrects the article DOI: 10.3389/fpls.2025.

Reevaluating antiviral thresholds in HBV DNA-negative inactive HBsAg carriers: a multicenter histopathological analysis.

Background: The definition of inactive HBsAg carriers (IHC) varies globally, particularly regarding HBV DNA thresholds. Whether HBV DNA negativity reliably predicts histological quiescence remains uncertain.

Aims: This study evaluated liver pathology in IHC patients to reassess antiviral therapy thresholds.

: C.4delG: A Novel Frameshift Mutation Causing α-Thalassemia Found in a Chinese Family.

We report a novel α-thalassemia (α-thal) point mutation identified in a Chinese man with mild hypochromia and microcytosis during premarital thalassemia screening. Sanger sequencing identified a frameshift variant (:c.4delG) at codon 1 (deletion of G) in the first exon of the α2-globin gene.

Deep learning-based text generation for plant phenotyping and precision agriculture.

Introduction: Plant phenotyping is a critical area in agricultural research that focuses on assessing plant traits quantitatively to enhance productivity and sustainability. While traditional methods remain important, they are constrained by the complexity of plant structures, variability in environmental conditions, and the need for high-throughput analysis. Recent advances in imaging technologies and machine learning offer new possibilities, but current methods still face challenges such as noise, occlusion, and limited interpretability.

Misdiagnosis of α-Thalassemia Heterozygotes as Homozygotes Due to Base Mutations in the Primer Binding Region.

Misdiagnosis of α-thalassemia genotypes due to primer site mutations presents diagnostic challenges in Chinese populations where -α deletion and :c.427T>C (Hb Constant Spring) heterozygotes are prevalent. We describe two cases where conventional diagnostic approaches erroneously identified heterozygous carriers as homozygotes.

Ertugliflozin induces vasodilation by inhibiting AMPK-mediated mitochondrial fission in vascular smooth muscle cells.

Hypertension is a primary risk factor for cardiovascular disease. Recently, Ertugliflozin (Ertu), a new sodium-glucose cotransporter-2 (SGLT2) inhibitor, though primarily approved by the FDA as an antidiabetic agent, has been reported to lower blood pressure. However, whether Ertu directly regulates the contractility of arteries remains unknown.

Inhibition of CAV1 attenuates diabetic cardiomyopathy through reducing ferroptosis via activating NRF2/GCLC signaling pathway.

: Diabetic cardiomyopathy (DCM), a prevalent complication of diabetes, is a major cause of heart failure and death among patients with diabetes. However, the pathological mechanisms underlying the development of DCM remain unclear. This study aims to investigate the role and underlying mechanisms of caveolin-1 (CAV1) in DCM.

Structural diversity and biological activities of terpenoids derived from Hook. f.

Terpenoids, a heterogeneous group of natural products, have garnered considerable attention in the field of drug discovery. This is attributed to their vast diversity, intricate structural features, and extensive biological activities. Hook.

A greater frequency of circulating CCR7loPD-1hi follicular helper T cells indicates a durable clinical cure after Peg IFN-α therapy in chronic hepatitis B patients.

Background: Emerging evidence indicates that the treatment duration of pegylated interferon-α and HBsAb may predict relapse in chronic hepatitis B (CHB) patients who achieved clinical cure. However, the host immunological mechanisms contributing to clinical relapse remain poorly characterized.

Objectives: This study aimed to identify the immunological factors associated with relapse in chronic hepatitis B (CHB) patients who achieved clinical cure based on pegylated interferon-alpha treatment.

Development of Fluorophilic Magnetic Adsorbents with Ultrahigh Adsorption Capacity from Red Mud: Defluorination Behavior and Mechanisms.

To address the low fluoride (F) adsorption capacity of red mud (RM)-based adsorbents, a novel Mn-coated RM adsorbent (Mn-RM) was prepared by Mn loading from red mud. Mn-RM features a 3D heteropolyhedral structure, which provides abundant functional groups for F adsorption. The maximum equilibrium adsorption capacity ( ) of Mn-RM for F is 141.

[Survey on the current situation of human resources and basic configuration of the intensive care medicine in Xinjiang Production and Construction Corps from 2019 to 2021].

Objective: To comprehensively understand the basic situation of critical care medicine in Xinjiang Production and Construction Corps in order to promote the standardization, specialization, and systematization of quality control in critical care medicine.

Methods: A survey was conducted from January 1, 2019, to December 31, 2021, using a questionnaire to investigate the human resources and basic allocation of comprehensive intensive care medicine departments in Xinjiang Production and Construction Corps division level hospitals and surrounding second-class hospitals. The survey content includes: basic situation of medical units, intensive care unit (ICU) basic information, ICU personnel situation, ICU equipment configuration situation, ICU performance situation, etc.

Activated CdS/ sulfur doped g-CN photocatalyst for dye and antibiotic degradation: Experimental and DFT verification of S-scheme heterojunction.

To alleviate situation caused by azo dyestuff and antibiotics, a series of CdS/sulfur doped carbon nitride (GCNS) S-scheme heterojunction photocatalysts have been successfully fabricated by a pretty facile solid-state diffusion (SSD) method,. Under visible light, the optimal sample called CdS/GCNS-1:2 presented the best photodegradation rate of nearly 100% over methyl orange (MO), of which the reaction constant k was about 9.67 and 5.

The synergistic protective effects of paeoniflorin and β-ecdysterone against cardiac hypertrophy through suppressing oxidative stress and ferroptosis.

Exploring feasible drugs for the treatment of pathological cardiac hypertrophy has always been a focus of cardiovascular disease research. Paeoniflorin (PF) and β-Ecdysterone (β-Ecd) are the main active components of Paeonia lactiflora and Achyranthes bidentata, which can be used for the treatment of cardiovascular diseases, but their mechanism of action remains unclear. This study focused on oxidative stress and ferroptosis to investigate the protective effects of PF and β-Ecd on cardiac hypertrophy in primary cardiomyocytes and C57BL/6 mice, utilizing the integration of CCK8 assays, ROS detection, molecular docking, real-time quantitative PCR, western blot, immunofluorescence, etc.

Exploring synergistic effects of Blume and Pall. on hypertension with liver yang hyperactivity using the multidisciplinary integrative strategy.

Traditional Chinese Medicine (TCM) formulations serve as a multi-component pharmacological combination therapy with various potential targets and have collected extensive knowledge regarding the in vivo efficacy of treating cardiovascular disorders in clinical practice for thousands of years. However, the obscurity of the chemicals and the molecular mechanisms are impediments to their continued growth and globalization. Therefore, new modern medications based on the combination of beneficial TCM components with precise clinical efficacy are required.

Regulating surface terminals and interlayer structure of TiCT for superior NH sensing.

MXene materials have exhibited potential in electrochemistry, particularly in gas sensing, due to their excellent conductivity, large specific surface area of layered materials, and unique functional groups. However, the gas sensing performance of intrinsic 2D MXene materials is often limited by their fluorine-containing terminals and interfacial structure. In this study, based on intrinsic TiCT, we employed alkali treatment and annealing to prepare oxygen-rich TiC(OH)/TiCO with expanded interlayer spacing, achieving enhanced gas sensing performance for NH.

Boosted 1,2-Dichloroethane Deep Destruction over CoRu/AlO Bifunctional Catalysts Surface Oxygen and Water Molecule Synergistic Activation.

Developing efficacious catalysts with superior Cl resistance and polychlorinated byproduct inhibition capability is crucial for realizing the environmentally friendly purification of chlorinated volatile organic compounds (CVOCs). Activating CVOC molecules and desorbing Cl species by modulating the metal-oxygen property is a promising strategy to fulfill these. Herein, a bifunctional CoRu/AlO catalyst with synergistic Co and Ru interactions (Ru-O-Co species) was rationally fabricated, which possesses abundant surface Co and Ru sites and collaboratively facilitates the activation of lattice oxygen (O) and molecular oxygen (O → O → O), accelerating 1,2-dichloroethane (1,2-DCE) decomposition the reaction route of enolic species → aldehydes → carboxylate/carbonate.

Novel Antioxidant Peptides from Fermented Whey Protein by B2-1: Separation and Identification by and Approaches.

Whey is a byproduct of the dairy industry and is rich in protein. To enhance the significance of such byproducts and find efficacious antioxidants for combating oxidative stress, this study reported on the preparation, purification, and identification of novel peptides with antioxidant activities from whey protein metabolites following fermentation by B2-1. The isolation and identification processes involved macroporous adsorption resin column chromatography, gel filtration column chromatography, and liquid chromatography-tandem mass spectrometry.

Bimetallic MOFs-Derived Metal Oxides CoO/SnO Microspheres for Ultrahigh Response -Butanol Gas Sensors.

The construction of p-n heterojunctions is expected to be one of the effective means to improve gas sensitivity. In this research, p-n heterojunctions are successfully constructed by metal oxides derived from metal-organic frameworks (MOFs). MOFs-derived bimetallic CoO/SnO microspheres are prepared by precipitation.

Comparative efficacy and safety of tenofovir amibufenamide vs tenofovir alafenamide in the initial 48-week treatment of high viral load chronic hepatitis B: A single-centre retrospective study.

Background/aim: Tenofovir amibufenamide (TMF) employs innovative ProTide technology and a methylation strategy to enhance the lipid solubility and plasma stability of the amide bond, providing advantages over tenofovir alafenamide (TAF). Despite promising Phase III clinical trial results demonstrating its antiviral efficacy, real-world data on TMF remains scarce. This study evaluates the antiviral efficacy and safety of TMF compared to TAF as the initial treatment in patients with high viral loads of chronic hepatitis B (CHB).

Selective CO Electroreduction to Multi-Carbon Products on Organic-Functionalized CuO Nanoparticles by Local Micro-Environment Modulation.

Surface functionalization of Cu-based catalysts has demonstrated promising potential for enhancing the electrochemical CO reduction reaction (CORR) toward multi-carbon (C) products, primarily by suppressing the parasitic hydrogen evolution reaction and facilitating a localized CO/CO concentration at the electrode. Building upon this approach, we developed surface-functionalized catalysts with exceptional activity and selectivity for electrocatalytic CORR to C in a neutral electrolyte. Employing CuO nanoparticles coated with hexaethynylbenzene organic molecules (HEB-CuO NPs), a remarkable C Faradaic efficiency of nearly 90% was achieved at an unprecedented current density of 300 mA cm, and a high FE (> 80%) was maintained at a wide range of current densities (100-600 mA cm) in neutral environments using a flow cell.

Unveiling the Promoting Mechanism of H Activation on CuFeO Catalyst for Low-Temperature CO Oxidation.

The effect of H activation on the performance of CuFeO catalyst for low-temperature CO oxidation was investigated. The characterizations of XRD, XPS, H-TPR, O-TPD, and in situ DRIFTS were employed to establish the relationship between physicochemical property and catalytic activity. The results showed that the CuFeO catalyst activated with H at 100 °C displayed higher performance, which achieved 99.