Oral colon-targeted paeonol emulsion for ameliorating ulcerative colitis based on charge adsorption.

Ulcerative colitis (UC), an inflammatory bowel disease, poses a severe threat to human health. Paeonol has demonstrated potential for the treatment of UC, particularly because of its remarkable anti-inflammatory properties. However, the high volatility and low oral bioavailability of paeonol hinder its application in the treatment of UC.

Spatial variability of soil geochemical elements using a novel ecological factor-incorporated interpretable machine learning model in China's coastal saline-alkali farmlands.

Rapid monitoring of soil geochemical elements (SGEs) in farmlands is crucial for the sustainable development of coastal agriculture. Traditional environmental factors are relatively uniform on a regional scale, leading to low sensitivity and accuracy for detecting geochemical variations. We developed novel ecological factors (ecological quality and soil erosion) combined with a tree-structured Parzen estimator extreme gradient boosting (TPE-XGBoost) model to predict the spatial variability of SGEs (i.

Intermuscular Septum Delivery of High-Mechanical Injectable Magnetic Hydrogels to Improve Muscle Atrophy.

Injectable hydrogels often lack sufficient mechanical robustness for long-term function under physiological loading, limiting their application in musculoskeletal repair. Inspired by natural soft matter, we developed a hierarchical reinforcement strategy that combines sliding-ring structures with rigid magnetic nanocomposite microdomains. Through self-assembly driven by chelation and hydrogen bonding, hydrophobic drugs and magnetic nanoparticles formed microphase units within the hydrogel network, resulting in an injectable magneto-responsive platform (0.

[Study on the underlying mechanisms of "" acupuncture for cerebral ischemia-reperfusion injury based on AMPK/mTOR/ULK1 signaling pathway].

Objectives: To observe the effect of "" (regaining consciousness and opening orifice) acupuncture on cerebral ischemia/reperfusion injury(CI/RI), autophagy and adenosine 5'-monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR)/UNC-51-like autophagy-activated kinase 1 (ULK1) signaling pathway, so as to explore its underlying mechanisms in improving CI/RI.

Methods: Male Sprague Dowley (SD) rats were randomly divided into sham-operation group, CI/RI model group, and acupuncture group, with 10 rats in each group. The CI/RI model was replicated by occlusion of the middle cerebral artery with intraluminal filament embolization.

Role of thromboelastography in predicting stroke risk after endovascular treatment for symptomatic intracranial atherosclerotic stenosis.

Background: Endovascular treatment (EVT) is among the first line therapies for symptomatic intracranial atherosclerotic stenosis (sICAS) patients, while post-EVT stroke hinders its efficacy. Thromboelastography (TEG), shows promise in predicting stroke events, yet research gaps exist regarding the role of TEG in post-EVT sICAS patients. This study adopts a retrospective case-control research method to explore the effectiveness of TEG in predicting stroke events after EVT.

Impact of antenatal corticosteroid therapy on neonatal outcomes in twin pregnancies.

Background: Corticosteroids are widely used in obstetric clinical practice for cases with signs of preterm labor to promote fetal lung maturity and reduce neonatal morbidity and mortality. Although short-term use is considered safe, there is ongoing debate regarding the dosage, therapeutic window, neonatal benefits, and maternal-fetal side effects, especially in high-risk pregnancies such as twins, where the impact remains unclear.

Methods: This retrospective study included 1,997 twin pregnancies, divided into two groups: those who received antenatal corticosteroid therapy (ACS) and those who did not.

Nonlinear Chiral-like State Transfer realized with a minimal set of parameters.

Chiral state transfers (CSTs) associated with exceptional points are always under the scrutiny of theoretical and experimental science, owing to its exotic physics and fascinating potential applications. In conventional wisdom, CSTs require adiabatically steering the non-Hermitian Hamiltonian in the parameter space, which inevitably leads to ultra-complex experimental setups and long evolution times, thereby exhibiting a bottleneck in integrating them into compact devices. Here, through both theoretical analysis and circuit-based experiments, we demonstrate nonlinear-exceptional-point-associated chiral-like state transfer, wherein the final state depends on the direction of parameter steering.

Characterization of blood and urine microbiome temporal variability in patients with acute myeloid leukemia.

Background: Investigating the microbiota of blood and urine from acute myeloid leukemia (AML) patients is essential to unravel the complex role of microbiota in systemic host-microbe interactions and implications.

Methods: We conducted a longitudinal observational study to characterize the temporal dynamics of blood and urine microbiota in 27 AML patients, utilizing metagenomic analysis pipeline for microbial identification to identify disease-associated microbial signatures.

Results: The composition of blood and urine microbiota of AML was dominated by Proteobacteria phylum in blood, Firmicutes phylum in urine.

Computed tomography features of gastric cancer with deficient mismatch repair: Radiologic-pathologic correlation.

Objectives: Our study aimed to identify CT features of locally advanced gastric cancer (LAGC) associated with deficient mismatch repair (dMMR), explore the underlying pathological basis, and develop a morphology-based model for dMMR prediction.

Methods: This multicenter, retrospective analysis included 397 patients with LAGC treated at three institutions between January 2016 and January 2022. Mismatch repair (MMR) status was determined by immunohistochemical analysis of postoperative specimens.

Four-step formula for the Siewert classification of adenocarcinomas of the esophagogastric junction: a computed tomography-based quantitative model.

Objective: This study aimed to develop a novel quantitative methodology to classify the Siewert type on multiplanar reconstructed (MPR) computed tomography (CT) and subsequently guide the diagnosis of adenocarcinoma of the esophagogastric junction.

Methods: Patients in the retrospective development and prospective validation cohort 1 were recruited from Peking University Cancer Hospital. Patients in prospective validation cohort 2 were recruited from Changzhi People's Hospital.

The global burden of polycystic ovary syndrome, endometriosis, uterine fibroids, cervical cancer, uterine cancer, and ovarian cancer from 1990 to 2021.

Background: Globally, common gynecological disorders such as Polycystic Ovary Syndrome (PCOS), endometriosis, uterine fibroids (non-malignant gynecological diseases), as well as cervical cancer, uterine cancer, and ovarian cancer (gynecological cancers), profoundly impact women's physical and mental health. The burden of these diseases exhibits significant geographical disparities across different countries and regions, making a comprehensive and precise assessment of the global burden of gynecological diseases particularly crucial. Such an assessment will facilitate the development of region-specific prevention and treatment strategies, contributing to a more effective response to these health challenges.

Gene Therapy with Enterovirus 3 C Protease: A Promising Strategy for Various Solid Tumors.

Current cancer gene therapies rely primarily on antitumor immunity, but the exploration of alternative mRNA cargoes for direct antitumor effects is crucial to expand cancer gene therapies. Here we show that lipid nanoparticles (LNPs) carrying mRNA encoding a viral 3 C protease can efficiently suppress tumors by selectively inducing tumor cell apoptosis. In various solid tumor models, intracranial injection of LNPs carrying mRNA encoding the 3 C protease (3C-LNPs) significantly inhibits tumor growth and prolongs survival in glioblastoma models.

Ligand-controlled divergent asymmetric C(sp)-H and C(sp)-O insertion via vinyl cations.

The insertion of either C-H bond or C-O bond via bond cleavage has proven to be a very attractive strategy for the construction of C-C and C-O bonds in organic synthesis. However, such divergent catalytic asymmetric reactions for the selective formation of C(sp)-H insertion and formal C(sp)-O insertion products from the same precursors are rarely explored. Herein, we report a ligand-controlled divergent asymmetric C(sp)-H insertion and formal C(sp)-O insertion reaction via vinyl cations by a non-diazo approach, leading to the practical and atom-economical assembly of a range of chiral spiro and fused polycyclic pyrroles in generally moderate to excellent yields with generally excellent chemo- and enantioselectivities.

UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia.

The prognosis for adult B-cell acute lymphoblastic leukemia remains unfavorable, especially in the context of relapsed and refractory disease. Exploring the molecular mechanisms underlying disease progression holds significant promise for improving clinical outcomes. In this investigation, utilizing single-cell transcriptome sequencing technology, we discerned a correlation between Ubiquitin-like containing PHD and RING finger domain 1 (UHRF1) and the progression of B-cell acute lymphoblastic leukemia.

Exploring the causal link between childhood maltreatment and asthma: a Mendelian randomization study.

Prior research indicates a potential connection between childhood maltreatment and asthma. In response, we designed a Mendelian Randomization (MR) study to further investigate this association. Utilizing the MR approach, we leveraged Genome-Wide Association Studies (GWAS) data from the UK Biobank (UKB).

Estimated pulse wave velocity is associated with all-cause and cardiovascular mortality in individuals with stroke: A national-based prospective cohort study.

Extensive evidence underscores the potential of estimated pulse wave velocity (ePWV) as a robust tool for predicting disease prevalence and mortality. However, its comparative effectiveness in forecasting all-cause and cardiovascular disease (CVD) mortality, particularly among stroke populations, remains inadequately characterized in relation to the traditional Framingham Risk Score (FRS) model. This prospective study included 1202 individuals with stroke from the National Health and Nutrition Examination Survey conducted between 1999 and 2014, with comprehensive follow-up data.

Left atrioventricular accessory pathway with Mahaim fiber characteristics: a rare case report.

Antidromic atrioventricular re-entrant tachycardia (AVRT) is a rare clinically wide-QRS tachycardia that can often be misdiagnosed as ventricular tachycardia (VT). If the accessory pathway (AP) is slower than the normal atrioventricular (AV) junction, evidence of preexcitation will not appear on the surface electrocardiogram (ECG), which increases the difficulty of diagnosis. This report describes a 13-year-old male patient who was diagnosed with VT at a local hospital at the time of onset of palpitation.

CT radiomics-based intratumoral and intertumoral heterogeneity indicators for prognosis prediction in gastric cancer patients receiving neoadjuvant chemotherapy.

Objectives: CT-based intratumoral and intertumoral heterogeneity indicators were integrated to develop a prognostic model for locally advanced gastric cancer (LAGC) patients undergoing neoadjuvant chemotherapy (NACT).

Methods: This retrospective study included 568 LAGC patients treated with NACT from two hospitals. The intratumor heterogeneity score (ITHscore) was developed to quantify the intratumoral heterogeneity of LAGCs on CT; intertumoral heterogeneity was characterized by combining the primary tumor (PT) and lymph node (LN) sizes on CT.

Plasma tsRNA Signatures Serve as a Novel Biomarker for Bladder Cancer.

Bladder cancer (BLCA) is one of the most common tumors of the urinary tract. The diagnosis of BLCA is mostly by invasive tests, which are damaging and unsuitable for early screening. Current non-invasive diagnostic modalities are insufficient in sensitivity and specificity.

Treatment of Acute Ulcerative Colitis with Zinc Hyaluronate in Mice.

Ulcerative colitis (UC) is a type of inflammatory bowel disease arising from numerous factors, while UC patients face insufficient treatment options and a high incidence of adverse reactions to the current therapies. As a functional food additive, hyaluronic acid plays a certain role in intestinal repair. In this study, we constructed a mouse model of dextran sulfate sodium (DSS)-induced UC to examine the effects and underlying mechanisms of action of zinc hyaluronate (ZnHA) on the pathogenesis of UC.

Regulating surface terminals and interlayer structure of TiCT for superior NH sensing.

MXene materials have exhibited potential in electrochemistry, particularly in gas sensing, due to their excellent conductivity, large specific surface area of layered materials, and unique functional groups. However, the gas sensing performance of intrinsic 2D MXene materials is often limited by their fluorine-containing terminals and interfacial structure. In this study, based on intrinsic TiCT, we employed alkali treatment and annealing to prepare oxygen-rich TiC(OH)/TiCO with expanded interlayer spacing, achieving enhanced gas sensing performance for NH.