The predictive value of tongue pressure for dysphagia in community-dwelling older adults: A cross-sectional study.

Objectives: The purpose of this study was to evaluate the predictive value of tongue pressure in the identification of dysphagia among the community-dwelling older people.

Methods: A survey was conducted involving 3229 older adults aged 65 years and above in a community located in Yiwu, Zhejiang, China, from March to June 2023. The presence of dysphagia was determined using the Water Swallowing Test (WST) and the Eating Assessment Tool-10 (EAT-10) questionnaire.

Dual-Network Cross-Learning for Metabolite-Disease Association Prediction.

In recent years, increasing evidence has demonstrated a close association between metabolites and various complex human diseases, providing valuable insights for disease diagnosis, treatment, and prevention. Although deep learning-based approaches have achieved certain success in predicting metabolic disease associations, challenges remain in enriching graph information and effectively integrating metabolic and disease features. To address these issues, this paper proposes a model named DCMDA, which extracts deep features of both metabolites and diseases using Dual-network Cross-learning for Metabolite-Disease Association prediction.

EEG neural indicator of temporal integration in the human auditory brain with clinical implications.

Temporal integration, the process by which the auditory system combines sound information over a certain period to form a coherent auditory experience, is essential for auditory perception, yet its neural mechanisms remain underexplored. We use a "transitional click train" paradigm, which concatenates two click trains with slightly differing inter-click intervals (ICIs), to investigate temporal integration in the human brain. Using a 64-channel electroencephalogram (EEG), we recorded responses from healthy participants exposed to regular and irregular transitional click trains and conducted change detection tasks.

Unveiling the Multifunctional Potential of MXenes in Rechargeable Batteries beyond Electrode Active Materials.

MXene materials have emerged as prominent candidates for revolutionizing energy storage technologies due to their unique properties and versatile applications. This review highlights the multifaceted roles of MXenes (beyond electrode active materials) in improving various components of rechargeable batteries. MXenes exhibit exceptional electrical conductivity, tunable surface functionalities, and a 2D structure, rendering them suitable for enhancing electrode or electrolyte materials, current collectors, binders, and separators.

Enhanced Thermal Stability and Oxygen Activation of Electrostatically Assembled Single-Layer MnO for Thermocatalysis and Single-Atom Catalysis.

2D materials-supported single-atom catalysts are of considerable interest in heterogeneous catalysis due to their unique geometric and electronic structures. However, most of the reported catalytic reactions over these catalysts are hitherto limited to electrocatalysis, photocatalysis, and other reactions operated under modest conditions. The compromised thermal stabilities of 2D materials and single atoms, in comparison to their 3D bulk counterparts, limit a proper evaluation of their catalytic capabilities in thermocatalysis.

Characterization of blood and urine microbiome temporal variability in patients with acute myeloid leukemia.

Background: Investigating the microbiota of blood and urine from acute myeloid leukemia (AML) patients is essential to unravel the complex role of microbiota in systemic host-microbe interactions and implications.

Methods: We conducted a longitudinal observational study to characterize the temporal dynamics of blood and urine microbiota in 27 AML patients, utilizing metagenomic analysis pipeline for microbial identification to identify disease-associated microbial signatures.

Results: The composition of blood and urine microbiota of AML was dominated by Proteobacteria phylum in blood, Firmicutes phylum in urine.

Prognostic impact of methylation-related gene mutations in elderly acute myeloid leukemia: a real-world retrospective analysis.

Objective: This study aimed to evaluate the prognostic impact of methylation-related gene mutations in older patients with acute myeloid leukemia (AML).

Methods: We conducted a retrospective analysis of clinical characteristics in 645 patients aged ≥ 60 years diagnosed with AML at Fujian Medical University Union Hospital between July 2016 and December 2024.

Results: Methylation-related gene mutations-specifically , , , and -were identified in 24.

Revisiting the dissolution-recrystallization mechanism of rutile growth from protonated titanate nanotubes.

Rutile, as the most stable natural phase of TiO, is an important industrial chemical. The hydrothermal phase transition from protonated titanate towards rutile is a promising method for the low-temperature synthesis of rutile not only owing to the modest reaction conditions but also the possibility to achieve rutile with a high surface-area. Previous studies have proposed a dissolution-recrystallization growth mechanism to explain such phase transitions, based on indirect evidence.

Ethanolic Extrusion of Indica Rice Flour for Rice Noodle Production.

Due to the absence of gluten, rice noodles require complex processing to achieve a desirable texture. This study developed ethanolic-extruded indica rice flour (EERF) as a novel gluten substitute to simplify rice noodle production. EERF exhibited a distinct V-type crystalline structure (7.

UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia.

The prognosis for adult B-cell acute lymphoblastic leukemia remains unfavorable, especially in the context of relapsed and refractory disease. Exploring the molecular mechanisms underlying disease progression holds significant promise for improving clinical outcomes. In this investigation, utilizing single-cell transcriptome sequencing technology, we discerned a correlation between Ubiquitin-like containing PHD and RING finger domain 1 (UHRF1) and the progression of B-cell acute lymphoblastic leukemia.

Limitations of human t-lymphotropic virus type 1 antibody testing in hospitals of endemic regions in China.

Purpose: This study aims to evaluate the sensitivity and specificity of human T-lymphotropic virus type 1 (HTLV-1) antibody testing within hospitals located in HTLV-1 endemic areas of China.

Method: We performed a retrospective analysis of the clinical records and laboratory results for 1,147 patients who underwent HTLV-1 antibody testing using the Wantai HTLV-1 antibody detection kit and Polymerase Chain Reaction (PCR) testing for HTLV-1 nucleic acids, at Fujian Medical University Union Hospital between 2017 and 2023.

Result: The study population comprised 674 males (58.

The Opioid-Sparing Effects of Intraoperative Esketamine Combined with Dexmedetomidine During Laparoscopic Major Abdominal Surgery: A Randomized Controlled Double-Blind Trial.

Background: Recently, opioid-sparing (OS) interventions have been proposed to facilitate rapid postoperative recovery for patients. However, the advantages of OS anesthesia strategy in laparoscopic abdominal major surgery are still unknown.

Methods: 157 patients undergoing laparoscopic major abdominal surgery were randomly assigned to two groups: Remi (77, remifentanil) and OS (80, esketamine combined with dexmedetomidine), the drugs were administered at 0.

Mediation of macrophage M1 polarization dynamics change by ubiquitin-autophagy-pathway regulated NLRP3 inflammasomes in PD-1 inhibitor-related myocardial inflammatory injury.

Objective And Design: Immune checkpoint inhibitors (ICIs)-induced cardiac injury is a life-threatening immune-related adverse events (irAEs). However, the current understanding of its pathogenesis and therapeutic options is relatively limited. We aimed to provide a comprehensive overview of the myocardial inflammatory injury process and underlying mechanisms associated with ICIs.

Association between oral dryness and dysphagia in community-dwelling older population.

Objective: There remains inconsistent recognition of the relationship between oral dryness and dysphagia. This study aimed to investigate whether the degree of oral dryness was related to the prevalence of dysphagia in community-dwelling older adults.

Design: A cross-sectional study.

Dual efficacy of tocilizumab in managing PD-1 inhibitors-induced myocardial inflammatory injury and suppressing tumor growth with PD-1 inhibitors: a preclinical study.

The combined use of tocilizumab (TCZ) and immune checkpoint inhibitors (ICIs) in cancer treatment is gaining attention, but preclinical studies are lacking. Our study aims to investigate the synergistic anti-tumor effect of TCZ combined with ICIs and its role in treating immune-related adverse events (irAEs). The clinical significance of high interleukin-6 (IL-6) expression in tumor patients was analyzed from the Cancer Genome Atlas (TCGA) database.

Two-Dimensional MXenes: Innovative Materials for Efficient Thermal Management and Safety Solutions.

MXenes, a class of 2-dimensional transition metal carbides and nitrides, have garnered important attention due to their remarkable electrical and thermal conductivity, high photothermal conversion efficiency, and multifunctionality. This review explores the potential of MXene materials in various thermal applications, including thermal energy storage, heat dissipation in electronic devices, and the mitigation of electromagnetic interference in wearable technologies. Recent advancements in MXene composites, such as MXene/bacterial cellulose aerogel films and MXene/polymer composites, have demonstrated enhanced performance in phase change thermal storage and electromagnetic interference shielding, underscoring their versatility and effectiveness.

Development of a Copro-RPA-CRISPR/Cas12a assay to detect Echinococcus granulosus nucleic acids isolated from canine feces using NaOH-based DNA extraction method.

Background: Cystic echinococcosis (CE), caused by Echinococcus granulosus sensu lato (E. granulosus s.l.

One-pot preparation of V-type porous starch by thermal-stable amylase hydrolysis of normal maize starch in hot aqueous ethanol solution.

The V-type porous starch (VPS) displays remarkable adsorption capability, and has potential for encapsulating guest compounds within its unique single helical cavity. In this investigation, VPS was produced via a "one-pot method" utilizing thermostable α-amylase in a hot ethanol solution. The study demonstrates that the activity of thermostable α-amylase remains high, reaching up to 86 % when employing a 40-50 % ethanol concentration, and up to 74 % with ≤70 % ethanol concentration.

EnNet: Enhanced Interactive Information Network with Zero-Order Optimization.

Interactive image segmentation extremely accelerates the generation of high-quality annotation image datasets, which are the pillars of the applications of deep learning. However, these methods suffer from the insignificance of interaction information and excessively high optimization costs, resulting in unexpected segmentation outcomes and increased computational burden. To address these issues, this paper focuses on interactive information mining from the network architecture and optimization procedure.

E3 ubiquitin ligase BTBD3 inhibits tumorigenesis of colorectal cancer by regulating the TYRO3/Wnt/β-catenin signaling axis.

Clinical trials and studies have implicated that E3 ubiquitin ligase BTBD3 (BTB Domain Containing 3) is a cancer-associated gene. However, the role and underlying mechanism of BTBD3 in colorectal cancer (CRC) is not fully understood yet. Herein, our study demonstrated that the mRNA and protein levels of BTBD3 were decreased in CRC tissues and associated with TYPO3 and Wnt/β-catenin pathway.

Degradation of Amyloid-β Species by Multi-Copper Oxidases.

Background: Reduction of the production of amyloid-β (Aβ) species has been intensively investigated as potential therapeutic approaches for Alzheimer's disease (AD). However, the degradation of Aβ species, another potential beneficial approach, has been far less explored.

Objective: To investigate the potential of multi-copper oxidases (MCOs) in degrading Aβ peptides and their potential benefits for AD treatment.