Case Report: The integration of chemoradiotherapy and immunotherapy in a patient with advanced-stage renal squamous cell carcinoma and pulmonary metastases.

Renal squamous cell carcinoma (RSCC) is an uncommon malignancy, representing less than 1% of all renal cancers, and is associated with a notably poor prognosis. Surgical intervention is the primary treatment modality for early and intermediate-stage cases; however, the efficacy of combined chemoradiotherapy and immunotherapy in advanced-stage patients remains unclear. In this report, we present a case of RSCC with pulmonary metastases, wherein the patient attained disease remission following a treatment regimen comprising combined chemo-radiotherapy and immunotherapy.

Zexie Tang Polysaccharides (ZXTPs) alleviate high-fat diet-induced NAFL in mice through improving intestinal microbiota imbalance and liver metabolic dysfunction.

Zexie Tang (Alisma Decoction, ZXT), derived from "Jin-Guiyaolue" (Synopsis of Prescriptions from the Golden Chamber), is composed of two kinds of herbs, namely Zexie (Atractylodes macrocephala) and Baizhu (Atractylodes macrocephala). And Baizhu (Atractylodes macrocephala), and its extractions have demonstrated hepatoprotective properties. We hypothesize that the polysaccharides in Zexie Tang might have therapeutic effects on Non-Alcoholic Fatty Liver Disease (NAFLD).

Investigation of an Injectable Concentrated Growth Factor Gel for Pulp Tissue Regeneration.

Cell homing and stem cell transplantation offers promising approaches for pulp regeneration. This study investigated the efficacy of an injectable concentrated growth factor gel for dental pulp regeneration in beagles. Six groups of beagle teeth were studied: Blank control group, CGF group, Collagen sponge group, CGF + Collagen sponge group, Dental pulp stem cells group, CGF + Dental pulp stem cells group.

Ultrasound-assisted non-starch polysaccharide extraction from bulbils of Dioscorea opposita maxim and its bioactivity on ulcerative colitis via improving the intestinal barrier and modifying the gut microbiota.

Dioscorea opposite (D. opposita) has been extensively used in both medical and culinary applications for over 2000 centuries. Here, a response surface methodology (RSM) approach was employed in an effort to optimize the ultrasound-mediated extraction of polysaccharides from the bulbils of this species in order to facilitate the effective utilization of D.

Analysis of risk factors associated with Lymph Node Metastasis and Recurrence Post Thyroid Carcinoma Surgery.

Objective: To investigate the risk factors associated with postoperative lymph node metastasis and recurrence in patients with thyroid carcinoma.

Methods: Retrospective analysis of clinical data of one hundred patients with thyroid carcinoma who underwent first surgery at the Yellow River Sanmenxia Hospital from June 2019 to July 2023. Record postoperative lymph node metastasis, recurrence, and disease-free survival time.

Unveiling the Multifunctional Potential of MXenes in Rechargeable Batteries beyond Electrode Active Materials.

MXene materials have emerged as prominent candidates for revolutionizing energy storage technologies due to their unique properties and versatile applications. This review highlights the multifaceted roles of MXenes (beyond electrode active materials) in improving various components of rechargeable batteries. MXenes exhibit exceptional electrical conductivity, tunable surface functionalities, and a 2D structure, rendering them suitable for enhancing electrode or electrolyte materials, current collectors, binders, and separators.

VPA Enhances Pulp Regeneration by Regulating LPS-Induced Human Dental Pulp Stem Cells Odontogenic Differentiation.

Aim: This study aimed to investigate the effect of valproic acid (VPA) exposure on pulp inflammation and regeneration.

Methods: The effects of VPA on pulp regeneration and reparative dentin formation were examined using cone-beam computed tomography (CBCT) and histological staining in vivo after 3 months of endodontic regenerative procedures (ERPs). In vitro, the effect of VPA on the odontogenic differentiation of human dental pulp stem cells (hDPSCs) was assessed using mineralization assays following lipopolysaccharide (LPS) exposure.

Extraction of polysaccharides from Polygonum cuspidatum with activity against Type 2 Diabetes via alterations in gut microbiota.

The exact etiology and pathogenesis of diabetes are still unclear, and there is a lack of effective targeted clinical treatments. A polysaccharide (PCPs-I) with a good activity on T2D was isolated from Polygonum cuspidatum. Its average molecular weight (Mw) was 68.

Chromosome-scale genome assembly of three-spotted seahorse (Hippocampus trimaculatus) with a unique karyotype.

Three-spotted seahorse (Hippocampi trimaculata) is a unique fish with important economic and medicinal values, and its total chromosome number is potentially quite different from other seahorse species. Herein, we constructed a chromosome-level genome assembly for this special seahorse by integration of MGI short-read, PacBio HiFi long-read and Hi-C sequencing techniques. A 416.

Two-Dimensional MXenes: Innovative Materials for Efficient Thermal Management and Safety Solutions.

MXenes, a class of 2-dimensional transition metal carbides and nitrides, have garnered important attention due to their remarkable electrical and thermal conductivity, high photothermal conversion efficiency, and multifunctionality. This review explores the potential of MXene materials in various thermal applications, including thermal energy storage, heat dissipation in electronic devices, and the mitigation of electromagnetic interference in wearable technologies. Recent advancements in MXene composites, such as MXene/bacterial cellulose aerogel films and MXene/polymer composites, have demonstrated enhanced performance in phase change thermal storage and electromagnetic interference shielding, underscoring their versatility and effectiveness.

Insulin-like growth factor binding protein 7 identified in aged dental pulp by single-cell RNA sequencing.

Introduction: Aging influences the regenerative and reparative functions of dental pulp, and an in-depth and complete understanding of aged dental pulp is highly important.

Objective: This study aimed to explore the heterogeneity of young and aged dental pulp tissue via single-cell RNA sequencing (scRNA-seq), search novel markers of aged dental pulp, and further explore their mechanism.

Methods: ScRNA-seq was employed to analyze the heterogeneity of young and aged dental pulp tissue, and immunohistochemical staining was used to detect new marker Insulin-like Growth Factor Binding Protein 7 (IGFBP7) in aged dental pulp.

Clinical effects of debulking surgery combined with neoadjuvant chemotherapy in treating ovarian cancer and its influence on tumor markers and immune function.

Objective: Exploring the clinical efficacy of tumor cell reduction combined with neoadjuvant chemotherapy in treatment of ovarian cancer.

Methods: Retrospective analysis was conducted of one hundred patients with advanced ovarian cancer at Yellow River Sanmenxia Hospital from January 2017 to December 2022. They were divided into control group and observation group based on treatment methods, with 50 cases in each group.

Triptolide suppresses melanoma cell growth and through the Src-ERK signaling pathway.

Melanoma is a highly aggressive form of skin cancer with a rapidly increasing incidence. New strategies are urgently needed for treating advanced melanoma which is closely linked to metastasis and often results in death. The Src-ERK signaling axis contributes significantly to both cell growth and metastasis.

Hypoxia-induced NLRP3 inflammasome activation via the HIF-1α/NF-κB signaling pathway in human dental pulp fibroblasts.

Background: Previous studies have reported the link between hypoxic conditions and NLRP3 inflammasome-mediated pulpal inflammation in the progression of pulpitis. However, the underlying mechanism has not been fully elucidated. This study aimed to investigate the role of HIF-1α in the regulation of NLRP3 inflammasome pathway via NF-κB signaling under hypoxic conditions with or without LPS in human dental pulp fibroblasts (HDPFs) during the progression of pulpitis.

Advances and challenges in MXene-based electrocatalysts: unlocking the potential for sustainable energy conversion.

MXenes, a novel class of two-dimensional materials, have garnered significant attention for their promising electrocatalytic properties in various energy conversion applications such as water splitting, fuel cells, metal-air batteries, and nitrogen reduction reactions. Their excellent electrical conductivity, high specific surface area, and versatile surface chemistry enable exceptional catalytic performance. This review highlights recent advancements in the design and application strategies of MXenes as electrocatalysts, focusing on key reactions including hydrogen evolution reaction (HER), oxygen evolution reaction (OER), oxygen reduction reaction (ORR), and nitrogen reduction reaction (NRR).

Golm1 facilitates the CaO2-DOPC-DSPE200-PEI -CsPbBr3 QDs -induced apoptotic death of hepatocytes through the stimulation of mitochondrial autophagy and mitochondrial reactive oxygen species production through interactions with P53/Beclin-1/Bcl-2.

Mitophagy is a distinct physiological process that can have beneficial or deleterious effects in particular tissues. Prior research suggests that mitophagic activity can be triggered by CaO2-PM-CsPbBr3 QDs, yet the specific role that mitophagy plays in hepatic injury induced by CaO2-PM-CsPbBr3 QDs has yet to be established. Accordingly, in this study a series of mouse model- and cell-based experiments were performed that revealed the ability of CaO2-PM-CsPbBr3 QDs to activate mitophagic activity.

Th17/Treg balance: the bloom and wane in the pathophysiology of sepsis.

Sepsis is a multi-organ dysfunction characterized by an unregulated host response to infection. It is associated with high morbidity, rapid disease progression, and high mortality. Current therapies mainly focus on symptomatic treatment, such as blood volume supplementation and antibiotic use, but their effectiveness is limited.

A Novel pH-Responsive Iron Oxide Core-Shell Magnetic Mesoporous Silica Nanoparticle (M-MSN) System Encapsulating Doxorubicin (DOX) and Glucose Oxidase (Gox) for Pancreatic Cancer Treatment.

Introduction: This study developed a pancreatic cancer targeted drug delivery system that responds to changes in acidity. The system was based on iron oxide core-shell magnetic mesoporous silica nanoparticles (M-MSNs) to treat pancreatic cancer through combined chemotherapy and starvation therapy.

Methods: Glucose oxidase (Gox) was coupled to the cancer cell surface to reduce glucose availability for cancer cells, exacerbating the heterogeneity of the tumor microenvironment.

PINK1-PTEN axis promotes metastasis and chemoresistance in ovarian cancer via non-canonical pathway.

Background: Ovarian cancer is commonly associated with a poor prognosis due to metastasis and chemoresistance. PINK1 (PTEN-induced kinase 1) is a serine/threonine kinase that plays a crucial part in regulating various physiological and pathophysiological processes in cancer cells.

Methods: The ATdb database and "CuratedOvarianData" were used to evaluate the effect of kinases on ovarian cancer survival.

cRGD-Conjugated GdIO Nanoclusters for the Theranostics of Pancreatic Cancer through the Combination of T-T Dual-Modal MRI and DTX Delivery.

Clinically, magnetic resonance imaging (MRI) often uses contrast agents (CAs) to improve image contrast, but single-signal MRI CAs are often susceptible to calcification, hemorrhage, and magnetic sensitivity. Herein, iron acetylacetone and gadolinium acetylacetone were used as raw materials to synthesize a T-T dual-mode imaging gadolinium-doped iron oxide (GdIO) nanocluster. Moreover, to endow the nanoclusters with targeting properties and achieve antitumor effects, the cyclic Arg-Gly-Asp (cRGD) peptide and docetaxel (DTX) were attached to the nanocluster surface, and the efficacy of the decorated nanoclusters against pancreatic cancer was evaluated.

Nutritional Profile Changes in an Insect-Fungus Complex of Pupa Infected by .

Historically, some edible insects have been processed into a complex of insect and fungus, such as and . Until now, the dynamics of the nutritional changes due to this infection were unclear. This study reveals the dynamic changes in nutritional components of pupa after infection with at post-infection time points of 0 d, 10 d, 20 d, and 30 d.

Functionalized europium-doped hollow mesoporous silica nanospheres as a cell imaging and drug delivery agents.

In an effort to enhance the antitumor efficacy of breast cancer treatment, the chemotherapeutic agent Paclitaxel (PTX) was encapsulated within hyaluronic acid (HA) modified hollow mesoporous silica (HMSNs). In vitro drug release assays showed that the resulting formulation, Eu-HMSNs-HA-PTX, exhibited enzyme-responsive drug release. In addition, cell cytotoxicity and hemolysis assays demonstrated the favorable biocompatibility of both Eu-HMSNs and Eu-HMSNs-HA.