Foam dust suppressant based on synergistic coordination between oxidized starch-gelatin Schiff base reaction and multiple crosslinking.

Aiming at the problems such as large dust in each production process of open-pit mines, insufficient water resistance of the curing layer of dust control materials, and poor mechanical strength, this research applied the network generated by Schiff base reaction between oxidized starch (OS) and gelatin (GEL) as the basis, and combined with polyvinyl alcohol (PVA) and calcium chloride (CaCl). This material improves the problem of poor dust suppression effect caused by the environment of open-pit coal mines. It was found that the large number of amino groups contained in GEL attack the carbon atoms in the carbonyl group of OS to form carbon-nitrogen double bonds, generating Schiff bases as the crosslinking network, which enhanced the water resistance of the polymers.

Immunological profiling in type 2 diabetes mellitus and type 2 diabetic kidney disease: insights from single-cell LacNAc sequencing.

Background: Diabetic kidney disease (DKD), a major complication of type 2 diabetes mellitus (T2DM), is the leading cause of end-stage renal disease (ESRD). Recently, the innate immune system, particularly neutrophils and the process of NET formation, has garnered significant attention for its role in the progression of T2DKD in patients with T2DM. However, the underlying mechanism remains unclear.

Bioinformatics and Experimental Validation of Diagnostic Marker Genes for Myocardial Infarction and Analysis of Their Immune Cell Infiltration.

This study aimed to identify diagnostic marker genes for myocardial infarction (MI) and analyzed the key genes pertaining to immune cell infiltration. The MI expression microarrays GSE48060 and GSE66360 were retrieved and downloaded from the GEO database. The merged expression data were subjected to Weighted Gene Co-expression Network Analysis (WGCNA).

2″-O-rhamnosyl icariside Ⅱ from Epimedium sagittatum maxim ameliorates pulmonary fibrosis by modulating the E-cadherin-mediated oxidative-epithelial mesenchymal transition axis.

Ethnopharmacological Relevance: Epimedium sagittatum Maxim (EPI) is a prominent herb in Traditional Chinese Medicine (TCM) with a millennia-long history of therapeutic applications. In TCM theory, its actions are linked to improving blood circulation, reducing phlegm, and restoring lung qi regulation-functions that align with modern understandings of anti-fibrotic and anti-inflammatory mechanisms. 2″-O-rhamnosyl icariside Ⅱ (Ica Ⅱ), a compound isolated from EPI, has been shown to significantly reduce TGF-β1-induced injury in BEAS-2B cells.

Prediction of early biochemical and symptomatic hypocalcemia in thyroid cancer patients after total thyroidectomy.

Purpose: Hypocalcemia is a common complication after total thyroidectomy (TT). Several studies have identified risk factors for early biochemical hypocalcemia, nevertheless, the noteworthy symptomatic hypocalcemia has not been considered. This study aims to construct an intuitive predictive model for biochemical and symptomatic hypocalcemia to assist individualized management.

Global trends in thermal burn burden, 1990-2021: a comprehensive analysis for the global burden of disease study 2021.

Background: The purpose of this study is to explore the global burden of thermal burns from 1990 to 2021 and to predict the trends in thermal burn burden up to 2040.

Methods: We utilized data from the Global Burden of Disease Study 2021 to assess the incidence, prevalence, and years lived with disability (YLDs) of thermal burns at the global, regional, and national levels. Decomposition analysis was performed to quantify the relative contributions of epidemiological changes, age structure shifts, and population growth to the thermal burn burden.

Prediction models after hepatectomy for hepatocellular carcinoma-based ultrasonic radiomics: an observational study.

Background: This study aims to develop and validate predictive models for postoperative complications and early recurrence in hepatocellular carcinoma (HCC) patients.

Methods: In a 7:3 ratio, 633 post-hepatectomy HCC patients were modeled and validated. Using 1561 radiomic features from two-dimensional shear wave elastography (2D-SWE), predictive models for the Comprehensive Complication Index (CCI) and recurrence were constructed, refined by LASSO regression, and integrated with clinical and pathologic data.

Discovery of potent and selective STAT3 inhibitors against triple-negative breast cancer.

The development of effective targeted therapies for triple-negative breast cancer (TNBC) remains challenging due to its diverse molecular subtypes and intrinsically aggressive tumor biology. Constitutive STAT3 activation drives TNBC pathogenesis and confers treatment resistance, establishing it as a promising precision oncology target. In this study, LZJ66 (previously designated as compound 40) was used as the lead compound for further optimization.

Potential use of repetitive transcranial magnetic stimulation in treating pediatric avoidant/restrictive food intake disorder: a case report.

Background: Avoidant/Restrictive Food Intake Disorder (ARFID) is a heterogeneous eating disorder that typically manifests during adolescence, potentially leading to various health issues, such as malnutrition, developmental delays, and psychological disturbances. Currently, the management of ARFID is multidisciplinary, involving dietary modifications, pharmacological treatments, and psychotherapy, but no standardized treatment protocol exists. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, has shown promise in treating various psychiatric disorders.

Regulating the Constituents of 1D Metal Oxalate Chains for Enhanced Electrocatalytic OER Performance.

As a new generation of crystalline materials, coordination polymers (CPs) with modular structures have been widely investigated as precatalysts for the oxygen evolution reaction (OER). However, controlling the structural transformation of CPs to form metal oxyhydroxide phases with high catalytic activity remains a challenge. Herein, two similar anionic metal oxalate chains, {[(DEAPA][Co(CO)]} () (DEAPA = ,-diethylpropane-1,3-diaminium) and {[CyNH][Co(CO)]·HO} () (CyNH = cyclopentylaminium), with different organic ammonium cations, are synthesized.

The association between widowhood duration and depressive symptoms among Chinese older adults: mediation role of sleeping duration and dietary diversity.

Widowhood represents a major life transition that can profoundly impact the mental health of older adults. However, limited research has explored how the duration of widowhood relates to depressive symptoms. This study examines the mediating roles of sleep duration and dietary diversity in the association between widowhood duration and depressive symptoms.

Design, synthesis and biological evaluation of novel platelet-derived growth factor receptor-α (PDGFR-α) inhibitors based on 4-anilinoquinoline and 4-anilinoquinazoline scaffolds.

Novel 4-anilinoquinoline and 4-anilinoquinazoline hybrids were designed and synthesized as PDGFR-α inhibitors based on lenvatinib, ripretinib and sorafenib. The target compounds were screened in vitro for their anti-PDGFR-α activity. Most of the compounds had shown promising activity in the PDGFR-α kinase assay.

Hypopharyngeal Squamous Cell Carcinoma in Elderly Patients Aged ≥70 Years: Surgery and Postoperative Radiotherapy Improves Outcomes in Selected Patients.

Objective: To summarize the efficacy of surgery plus postoperative radiotherapy as initial treatment in elderly patients aged ≥70 years with advanced hypopharyngeal cancer and to analyze prognostic factors.

Methods: Retrospective analysis of 77 elderly patients aged ≥70 years with stage III-IV hypopharyngeal squamous cell carcinoma who underwent surgery as initial treatment at Shandong Provincial ENT Hospital between 2006-2020. Treatment completion rate and prognostic factors were summarized and analyzed, with comparisons made to non-surgical treatments in published literature.

Clinical features and management of head and neck castleman disease: a single-center retrospective analysis.

Background: Castleman disease, a rare lymphoproliferative disorder with diverse features, is often misdiagnosed due to rarity and similarity to malignancies.

Aims: The study analyzed the clinicopathological characteristics, diagnostic challenges, and outcomes of head and neck Castleman disease (HNCD) to improve diagnostic accuracy and optimize management strategies.

Material And Methods: Retrospective study of 21 HNCD patients treated at Beijing Tongren Hospital (2007-2024).

Performance of fluorine removal using flow electrode capacitive deionization (FCDI): validation and optimization.

This study demonstrates the efficacy of a symmetrically designed flow-electrode capacitive deionization (FCDI) system for the electrochemical defluorination of photovoltaic (PV) wastewater, with a systematic investigation conducted to optimize operational parameters and analyze key factors influencing system performance, offering valuable insights into enhancing FCDI efficiency. The results revealed that an optimal applied voltage of 1.2 V yielded a fluoride removal efficiency of 92.

Multi-Omics Exploration of Obesity Biomarkers in Sedentary and Weight Loss Cohorts.

Unlabelled: Sedentary behavior for two years during the coronavirus disease 2019 (COVID-19) pandemic contributes to weight gain. Gut microbiota and blood metabolome are related to body mass index (BMI) and indicate individual metabolic changes. Surgery and exercise are effective weight-loss methods.

Two-stage optimization based on heterogeneous branch fusion for knowledge distillation.

Knowledge distillation transfers knowledge from the teacher model to the student model, effectively improving the performance of the student model. However, relying solely on the fixed knowledge of the teacher model for guidance lacks the supplementation and expansion of knowledge, which limits the generalization ability of the student model. Therefore, this paper proposes two-stage optimization based on heterogeneous branch fusion for knowledge distillation (THFKD), which provides appropriate knowledge to the student model in different stages through a two-stage optimization strategy.

Exerkines: Potential regulators of diabetic cardiomyopathy.

Diabetic cardiomyopathy (DCM) is a significant contributor to diabetes-related mortality, manifesting through progressive diastolic dysfunction, cardiomyocyte apoptosis, and pathological fibrotic remodeling. While exercise is advocated as a therapeutic intervention for DCM, the molecular basis of its cardioprotective effects remains incompletely understood, particularly regarding systemic interorgan communication mediated by exercise-induced signaling factors. Emerging evidence highlights exerkines, a class of peptides and nucleic acids secreted by skeletal muscle (myokines), adipose tissue (adipokines), bone (osteokines), liver (hepatokines), and other organs in response to physical exercise-as key regulators of DCM pathogenesis.

Absolute Configuration and Chiroptical Properties of Flexible Drug Avapritinib.

: Avapritinib is an orally bioavailable tyrosine kinase inhibitor and was approved by the FDA in 2020 for gastrointestinal stromal tumor treatments. Although avapritinib is known to be chiral, its stereochemistry was initially established randomly. This study aims to develop a definitive method for determining avapritinib's absolute configuration and propose a universal methodology for stereochemical characterization of flexible chiral drugs.

[Advances in the function and mechanisms of stearoyl-CoA desaturase 1 in metabolic diseases].

Metabolic diseases characterized by an imbalance in energy homeostasis represent a significant global health challenge. Individuals with metabolic diseases often suffer from complications related to disorders in lipid metabolism, such as obesity and non-alcoholic fatty liver disease (NAFLD). Understanding core genes involved in lipid metabolism can advance strategies for the prevention and treatment of these conditions.

Proton-Sensing G Protein-Coupled Receptors and Their Potential Role in Exercise Regulation of Arterial Function.

During periods of exercise, the primary cause of metabolic acidosis is the accumulation of lactate from anaerobic metabolism, whereas a transient increase in CO triggers a mild respiratory acidosis through the production of carbonic acid (HCO). The combined effects of these reactions result in a slight acidifying shift in arterial blood pH. Proton-sensing G protein-coupled receptors (including GPR68, GPR4, GPR132, and GPR65) represent the primary receptors within the body for detecting alterations in extracellular proton concentrations.

Trinitarian Stabilization of Electrolyte/Interphase/Cathode for 5.0-5.4 V Dual-Ion Batteries Realized by a Gel-Polymer Electrolyte Capable of HF Elimination.

Dual-ion batteries (DIBs) that are composed of graphite cathodes and low-potential anodes such as Li possess the unique advantages of high working voltage (≈5.0 V) and high power density, but suffer from the serious oxidative decomposition of electrolyte and cointercalation of solvent/anions into graphite cathode, leading to unsatisfactory cycling stability. From the perspectives of blocking the generation of corrosive HF in electrolyte and reinforcing the stability of cathode/electrolyte interphase (CEI), a gel-polymer electrolyte incorporating zeolite molecular sieve into the polymer matrix of polyvinylidene fluoride and polyacrylonitrile is prepared and utilized in DIBs.

A reassessment of existing systematic reviews evaluating the effectiveness of cryotherapy in patients following total knee arthroplasty.

Objective: This study reassessed systematic reviews on cryotherapy efficacy following total knee arthroplasty (TKA).

Methods: Ten databases were searched from January 1, 2018 to September 15, 2023 for relevant systematic reviews. Two researchers independently screened articles and extracted data.