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http://dx.doi.org/10.1007/s11427-025-3000-5 | DOI Listing |
Phytomedicine
August 2025
Cardiology Department, Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, China. Electronic address:
Background: Atherosclerosis (AS) is a leading risk factor for cardiovascular diseases globally, characterised by the accumulation of lipids and cholesterol in arterial walls, causing vascular narrowing and sclerosis along with chronic inflammation; this leads to increased risk of heart disease and stroke, significantly impacting patients' health. Danxia Tiaoban Decoction (DXTB), a traditional Chinese medicine (TCM) formula, has demonstrated positive clinical effects in treating AS; however, its mechanisms of action remain unclear.
Objective: To explore the potential mechanisms of action of DXTB in treating AS through multi-omics integration and experimental validation.
Cell
August 2025
Department of Systems Biology, UT MD Anderson Cancer Center, Houston, TX 77030, USA; MD Anderson UTHealth Graduate School of Biomedical Sciences, Houston, TX 77030, USA; Department of Bioinformatics, UT MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address:
Understanding epithelial lineages of breast cancer and genotype-phenotype relationships requires direct measurements of the genome and transcriptome of the same single cells at scale. To achieve this, we developed wellDR-seq, a high-genomic-resolution, high-throughput method to simultaneously profile the genome and transcriptome of thousands of single cells. We profiled 33,646 single cells from 12 estrogen-receptor-positive breast cancers and identified ancestral subclones in multiple patients that showed a luminal hormone-responsive lineage, indicating a potential cell of origin.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou 471003, China. Electronic address:
Background: Osteosarcoma (OS) progression is linked to kinase allostery dysregulation, but PRKX's allosteric role remains unknown. We aimed to decode PRKX's activation mechanism and assess its clinical potential as a biomarker and therapeutic target.
Methods: Differential expression analysis confirmed PRKX's oncogenic role.
Front Oncol
August 2025
International Cancer Center, Shenzhen University Medical School, Shenzhen, Guangdong, China.
Tumor draining lymph nodes (TDLNs), as secondary lymphoid organs, are pivotal in initiating and regulating adaptive immune responses. Historically, TDLNs were recognized primarily as metastasis gateways in cancer, promoting radical dissection to prevent recurrence. However, emerging preclinical studies reveals their critical role in orchestrating systemic anti-tumor immune responses during cancer therapy, highlighting the dilemma of balancing lymph nodes (LNs) preservation with metastasis control.
View Article and Find Full Text PDFNeural Regen Res
September 2025
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan Province, China.
Monocytes play a crucial role in post-stroke immune infiltration, yet the intricate immune regulatory networks they orchestrate in ischemic stroke remain poorly understood. This knowledge gap has hindered the development of targeted monocyte-based therapies for stroke. Here, we used a multi-omics approach combining single-cell and bulk transcriptomics.
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