Sex Hormone Androgen Elevates Blood Pressure Through Gut Microbiota-TMAO Pathway.

Background: Hypertension is a leading risk factor for all-cause mortality worldwide, affecting ≈1.3 billion people. Imbalanced gut microbiota contributes to blood pressure elevation.

Diversity, antibacterial and antioxidant activities of fungi associated with .

Insect-associated fungi are a treasure trove of natural active compounds. Nevertheless, the diversity and biological activities of fungi associated with have not been studied in depth. Here, we investigated fungal diversity in the gut and honeycomb using a combination of culture-dependent and -independent methods.

A density functional theory study on transition metals loaded on antimonene as effective electrocatalysts for oxygen reduction reaction and oxygen evolution reaction.

Developing high-efficiency bifunctional electrocatalysts for both oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) is an essential prerequisite for energy conversion and storage technologies. This work systematically investigates the potential of a series of transition metals (TM = Mn, Fe, Co, Ni, Cu, Ru, Rh, Pd, Ag, Re, Os, Ir, Pt, Au) loaded on two different sites of antimonene (I/II-TM-Sb) as ORR/OER bifunctional electrocatalysts by density functional theory (DFT) methods. For ORR, the calculation results show that I-Ag-Sb, II-Pt-Sb and II-Pd-Sb have the best ORR activity, and their overpotential values are 0.

Exploring Expectations Regarding Aging and Related Influencing Factors in Older People with Type 2 Diabetes Mellitus: A Cross-Sectional Study.

Purpose: Improving the health behaviors of older type 2 diabetes mellitus (T2DM) patients is crucial for promoting healthy aging worldwide. Given the significant role of expectations regarding aging (ERA) in fostering healthy behaviors and improving disease outcomes, understanding its status and influencing factors in this population is essential.

Patients And Methods: The cross-sectional study was conducted from December 2023 to February 2024 at a tertiary hospital in China, where 289 elderly T2DM patients were surveyed.

[Tracing origin of "Qinggong Maidong" production area based on analysis of literature and historical materials and identification of characteristics of Qinggong medicinal materials and cultural relics].

Maidong products are categorized into "Hang Maidong" and "Chuan Maidong". Since the Ming and Qing Dynasties, "Hang Maidong" has been regarded as having superior quality, but currently, it remains in name only in the market. This article reviewed historical materia medica and local chronicles from the Ming and Qing Dynasties and analyzed the historical evolution of Maidong production areas.

[Identification of characteristics, supply channels, and imperial court processing of Arecae Semen in the Qing court].

Qing court records show that Arecae Semen was extensively applied. The royal medical records of the Qing Dynasty document nine types of Arecae Semen, with the Palace Museum preserving seven kinds, totaling twelve cultural relics. Historical documents and physical artifacts corroborate each other, providing evidence for the study of the supply channels and court processing of Arecae Semen in the Qing court.

Combined lung compliance and oxygenation dynamics predict high-flow nasal cannula failure in acute respiratory distress syndrome: a retrospective cohort study.

Objectives: To evaluate the combined predictive value of lung compliance and dynamic oxygenation parameters for high-flow nasal cannula (HFNC) outcomes.

Methods: In this single-center retrospective cohort study, 154 patients with acute respiratory distress syndrome (ARDS) treated with HFNC (flow ≥50 L/min, fraction of inspired oxygen [FiO] ≥0.5) between 2019 and 2022 were analyzed.

Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study.

Background: Facial laser procedures may result in compromised skin barrier function and associated discomfort. It is essential to address these issues to facilitate a swift recovery and enhance patient satisfaction.

Objective: To evaluate the efficacy and safety of a panthenol-enriched mask, incorporating centella asiatica extract (madecassoside) and bisabolol, in repairing the skin barrier after 1550 and 1927 nm dual-wavelength non-ablative fractional laser therapy.

Propionate alleviated colitis by modulating iron homeostasis to inhibit ferroptosis and macrophage polarization.

Ulcerative colitis (UC) is a relapsing inflammatory bowel disease with limited effective treatment options. Ferroptosis, characterized by lipid peroxidation-induced cellular death, is involved in UC pathogenesis. Propionic acid, a short-chain fatty acid, has demonstrated therapeutic potential in alleviating numerous conditions; however, its role and underlying mechanisms in UC remain unclear.

Multi-Omics Exploration of Obesity Biomarkers in Sedentary and Weight Loss Cohorts.

Unlabelled: Sedentary behavior for two years during the coronavirus disease 2019 (COVID-19) pandemic contributes to weight gain. Gut microbiota and blood metabolome are related to body mass index (BMI) and indicate individual metabolic changes. Surgery and exercise are effective weight-loss methods.

Clinical nursing effect of comprehensive nursing in department of respiratory medicine.

Objective: To probe the clinical effect of comprehensive nursing in department of respiratory medicine.

Methods: A total of 176 patients who were diagnosed and treated in the department of respiratory medicine from January 2020 to June 2022 were chosen. Based on the random lottery method, there were 90 cases in the observation group (OG) and 86 cases in the control group (CG).

Copper-Carbon Bond Metal-Organic Frameworks for Highly Efficient and Stable CO Electrochemical Methanation.

Cu-based metal-organic frameworks (Cu-MOFs) integrate the high tunability of molecular systems with the high activity of metal sites, making them promising electrocatalysts for the electrocatalytic reduction of carbon dioxide (CORR). To date, the primary challenge in the application of Cu-MOFs in electrocatalytic CORR is their poor stability during the reduction process. Herein, we pursue experimental and theoretical insights into Cu-C MOFs for the CORR for the first time.

Engineering exosomes for mRNA delivery: a review.

Messenger RNA (mRNA) has emerged as a highly promising therapeutic approach with successful applications across various diseases. Developing safe and efficient carriers to preserve mRNA integrity during in vivo delivery is critical for ensuring the therapeutic efficacy of mRNA-based treatments. Exosomes, natural nanovesicles secreted by cells, possess several favorable properties, including excellent biocompatibility, low immunogenicity, the unique ability to traverse physiological barriers and to target specific cell types, which make them attractive candidates for mRNA delivery.

PVA/HA@BT hydrogel with antioxidant and antibacterial abilities for accelerating diabetic wound healing.

Diabetic wound healing is severely hindered by prolonged oxidative stress and susceptibility to bacterial infections. To address this challenge, a dual-network hydrogel (PVA/HA@BT) was developed by integrating baicalein (BCE), a natural antioxidant, and tannic acid-stabilized silver nanoparticles (TA-AgNPs) into a polyvinyl alcohol/hyaluronic acid (PVA/HA) matrix. The hydrogel enables sustained BCE release to neutralize reactive oxygen species and alleviate oxidative damage, while synergistically enhancing antibacterial efficacy through the combined action of BCE and TA-AgNPs.

Interactive Conversational Head Generation.

We introduce a new conversation head generation benchmark for synthesizing behaviors of a single interlocutor in a face-to-face conversation. The capability to automatically synthesize interlocutors which can participate in long and multi-turn conversations is vital and offer benefits for various applications, including digital humans, virtual agents, and social robots. While existing research primarily focuses on talking head generation (one-way interaction), hindering the ability to create a digital human for conversation (two-way) interaction due to the absence of listening and interaction parts.

A "Janus" structured nanoclay microgel system for targeted probiotic therapy in diarrhea-predominant irritable bowel syndrome.

Probiotic therapy holds potential for preventing and treating various gastrointestinal diseases, including diarrhea-predominant irritable bowel syndrome (IBS-D). Previous studies have suggested that it can help restore intestinal mucosal immunity and gut microbiota dysbiosis in IBS-D patients. Probiotics regulate host microbial metabolism and immune homeostasis, thereby improving host health.

The mediating role of expectations regarding aging between diabetes distress and self-management behaviors in older adults with type 2 diabetes mellitus.

Objectives: To investigate the relationships among diabetes stress, expectations regarding aging, and self-management behaviors in older adults with type 2 diabetes mellitus.

Methods: In this cross-sectional study, we surveyed 257 older patients aged ≥60 years with type 2 diabetes mellitus using the Diabetes Distress Scale, the 21-item Expectations Regarding Aging Scale, and the Diabetes Self-Care Behavior Scale. We conducted correlation and mediation analyses using SPSS 26.

Fungal community composition and function in different Chinese post-fermented teas.

Chinese post-fermented teas are produced through special fermentation by microorganisms, with fungi significantly contributing to their flavor and sensory characteristics. Here, the fungal community structure and function were investigated using Illumina HiSeq sequencing of the fungal ITS rDNA region across different post-fermented teas, including Fuzhuan, Qingzhuan, Tianjian black, Liupao, and raw and ripened Pu-erh. Additionally, the headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC-MS) technology was used to compare the volatile components of tea samples, and moisture content, pH, total nitrogen, carbon-nitrogen ratio, and total sulfur were measured.

Sphingosinicella rhizophila sp. nov., Isolated from Oat (Avena sativa L.) Rhizosphere Soil.

A Gram-stain-negative, aerobic, rod-shaped, and yellow-colored bacterium, designated strain GR2756, was isolated from a rhizosphere soil sample of oat (Avena sativa L.). The strain GR2756 was able to grow at 15-35 °C, pH 6.

Microstructure, Mechanical Properties, and Corrosion Behavior in Al-5.6Zn-2.5Mg-1.6Cu-0.2Cr Alloy with Minor Yttrium Addition.

This study systematically investigated the effects of the addition of the rare earth element yttrium (Y) on the microstructural evolution, mechanical properties, and corrosion behavior of as-extruded Al-5.6Zn-2.5Mg-1.

ALDH2 Overexpression Improves the Blood-brain Barrier and Represses Mitochondrial Dysfunction in Chronic Cerebral Hypoperfusion Through the SIRT1/ROS Axis.

The study investigated the mechanism of ALDH2 in mitochondrial dysfunction and blood-brain barrier (BBB) damage arising from chronic cerebral hypoperfusion (CCH). A rat model of bilateral common carotid artery occlusion (BCCAO) was established and treated with AAV-ALDH2. ALDH2 expression, cognitive function, and levels of inflammation- and oxidative stress-related factors, were examined, followed by observing changes in BBB and mitochondrial functions.

Magnolin ameliorates acetaminophen-induced liver injury in mice via modulating the MAPK pathway and lipid metabolism.

Acetaminophen (APAP)-induced liver injury (AILI) represents a common yet potentially severe type of drug-induced liver injury with limited available effective therapeutic methods. Magnolin possesses excellent anti-inflammatory and antioxidant properties for treating various diseases. However, its effects against AILI and the fundamental mechanisms still lack comprehensive exploration.

Microbiota-derived succinate promotes enterohaemorrhagic Escherichia coli virulence via lysine succinylation.

Succinate upregulates enterohaemorrhagic Escherichia coli (EHEC) virulence. Lysine succinylation, a post-translational modification, regulates cellular function in eukaryotes but is less characterized in bacteria. We hypothesized that lysine succinylation regulates EHEC virulence.

Relationship between secondary metabolites and ecological suitability zones for Eucommia ulmoides.

The quality of Chinese medicinal materials is closely related to the types and contents of their secondary metabolites, while ecological adaptability influences the production of secondary metabolites. Therefore, identifying the relationship between ecological adaptability and secondary metabolites is important for enhancing the quality of Chinese medicinal materials. In this study, we collected 10-year-old Cortex Eucommiae (Eucommia ulmoides, EU) samples from 21 plots in eight provinces which are the primary production areas of EU in central China.