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Objectives: To investigate the relationships among diabetes stress, expectations regarding aging, and self-management behaviors in older adults with type 2 diabetes mellitus.
Methods: In this cross-sectional study, we surveyed 257 older patients aged ≥60 years with type 2 diabetes mellitus using the Diabetes Distress Scale, the 21-item Expectations Regarding Aging Scale, and the Diabetes Self-Care Behavior Scale. We conducted correlation and mediation analyses using SPSS 26.0 and PROCESS software.
Results: Diabetes distress was negatively associated with diabetes self-management and expectations regarding aging. Expectations regarding aging were positively associated with diabetes self-management. Expectations regarding aging partially mediated the relationship between diabetes distress and self-management.
Conclusions: The self-management behavior of older patients with type 2 diabetes mellitus can be improved by reducing diabetes-related distress and increasing expectations regarding aging. Therefore, healthcare professionals should emphasize the mental health of older patients with type 2 diabetes mellitus and provide timely education on healthy aging.
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http://dx.doi.org/10.1016/j.gerinurse.2025.03.033 | DOI Listing |
Clin Epigenetics
September 2025
Department of Psychiatry and Psychotherapy, Philipps University Marburg, Marburg, Germany.
Background: Work-related stress is a well-established contributor to mental health decline, particularly in the context of burnout, a state of prolonged exhaustion. Epigenetic clocks, which estimate biological age based on DNA methylation (DNAm) patterns, have been proposed as potential biomarkers of chronic stress and its impact on biological aging and health. However, their role in mediating the relationship between work-related stress, physiological stress markers, and burnout remains unclear.
View Article and Find Full Text PDFAdv Mater
September 2025
School of Medical Sciences, University of Sydney, Sydney, NSW, 2006, Australia.
The disparity between the global increase in life expectancy and the steady decline in health outcomes with age has been a major driver for developing new ways to research aging. Although this current tools for studying aging outside of the human body-such as animal models and cells in a dish-have improved this fundamental understanding of the markers and key mechanisms underlying this process, several limitations remain. Animal models are poor biological representations of humans and have a weak track record of translating pre-clinical results into successful clinical applications.
View Article and Find Full Text PDFMusculoskelet Surg
September 2025
1st Orthopedic Department, IRCCS - Istituto Ortopedico Rizzoli, Bologna, Italy.
Introduction: Sarcopenia is a pathologic condition frequent in aged population, leading to functional and cognitive impairment. Given the ageing of the population worldwide, the topic has generated interest in the last decades and is expected to be more relevant in the near future. This paper aims to present the mechanism of sarcopenia, the current state of knowledge regarding diagnosis and treatment and the role of sarcopenia in orthopaedic and traumatological settings.
View Article and Find Full Text PDFMol Psychiatry
September 2025
Memory Center, Hospital Moinhos de Vento, Porto Alegre, RS, Brazil.
Blood-based biomarkers (BBMs) have emerged as promising tools to enhance Alzheimer's disease (AD) diagnosis. Despite two-thirds of dementia cases occurring in the Global South, research on BBMs has predominantly focused on populations from the Global North. This geographical disparity hinders our understanding of BBM performance in diverse populations.
View Article and Find Full Text PDFSemin Vasc Surg
September 2025
Division of Vascular and Endovascular Surgery, MaineHealth, Portland, ME. Electronic address:
As life expectancy increases, the prevalence of ruptured abdominal aortic aneurysms (rAAA) poses a significant challenge for our healthcare system. Aging induces biochemical changes, including degradation of the extracellular matrix and loss of vascular smooth muscle cells, which increase the propensity for the development of aneurysms and subsequent rupture due to compromised integrity of the aortic wall. The mortality rate for elderly patients presenting with rAAA is high, ranging from 80 to 90%.
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