Publications by authors named "Chiara Di Censo"
: Spinopelvic alignment may affect the outcomes of total hip arthroplasty (THA), with pelvic version influencing the risk of mechanical complications occurring after surgery. On the other hand, THA surgery itself may contribute to the modification of pelvis version. The sacro-femoro-pubic (SFP) angle is measured on anteroposterior (AP) radiographs of the pelvis in a supine position, and is used to estimate pelvic tilt (PT), representative of pelvic version, which requires lateral views of the sacrum for its calculation; however, these X rays are not routinely performed in the preoperative setting of hip surgery.
View Article and Find Full Text PDFThe antimetastatic activity of NK cells is well established in several cancer types, but the mechanisms underlying NK cell metastasis infiltration and acquisition of antitumor characteristics remain unclear. Herein, we investigated the cellular and molecular factors required to facilitate the generation of an ILC1-like CD49a+ NK cell population within the liver metastasis (LM) environment of colorectal cancer (CRC). We show that CD49a+ NK cells had the highest cytotoxic capacity among metastasis-infiltrating NK cells in the MC38 mouse model.
View Article and Find Full Text PDFThis article explores the historical significance and lasting impact of Vittorio Putti's "Decalogue of Fractures" in the field of orthopedic trauma. Putti served as director of the Rizzoli Orthopedic Institute in Bologna from 1915 until his death in 1940 and was one of the founding members of the "Société Internationale de Chirurgie Orthopédique et de Traumatologie" (SICOT). He also played a key role in organizing the third SICOT World Congress, held in Bologna in 1936.
View Article and Find Full Text PDFSport and sexual recovery after total hip arthroplasty in young adults: a retrospective cohort study.
Arch Orthop Trauma Surg
September 2024
Introduction: Total Hip Arthroplasty (THA) is the main treatment for end-stage degenerative hip arthrosis in the elderly, while became increasingly performed as treatment of secondary arthrosis in younger patients, a population at high functional requests in terms of resumption of physical activity and resumption of sexual activity. This study evaluates the physical, sports recovery and the sexual quality of life in young patients undergoing primary THA.
Materials And Methods: Patients undergoing primary THA aged between 18 and 45, operated in a 10 year timeframe, were selected.
Article Synopsis
- * The study found that the transferrin receptor CD71 is increased in Tregs in liver cancer, and its deficiency caused severe health issues in mice due to impaired Treg expansion during early life.
- * CD71 deficiency led to iron overload in the liver, changes in gut microbiota, and suggests that Tregs may contribute to nutritional balance by competing for iron during early bacterial colonization.
Article Synopsis
- Chemotherapy is the primary treatment for triple-negative breast cancer (TNBC), and there's growing interest in targeting CD73 to enhance immunotherapy effectiveness, as it suppresses anti-cancer immunity.
- CD73 carries a dual role in promoting tumor survival by both inhibiting immune response and enabling the growth of cancer stem cells (CSCs), which may lead to tumor relapse after treatment.
- Researchers conducted in silico screening of compounds and found that quercetin and luteolin, when combined with the chemotherapy drug paclitaxel, effectively downregulated pathways associated with CD73 and CSCs, indicating a potential strategy for improved TNBC treatment outcomes.*
Divergent roles for STAT4 in shaping differentiation of cytotoxic ILC1 and NK cells during gut inflammation.
Proc Natl Acad Sci U S A
October 2023
Article Synopsis
- Natural killer (NK) cells and type 1 innate lymphoid cells (ILC1) need the protein STAT4 to respond quickly to pathogens and help with immune defense.
- Research using genetic and transcriptomic methods revealed that STAT4 has different roles in the development of NK cells and ILC1, affecting their ability to fight infections.
- STAT4 helps control inflammation in the gut by modulating immune responses, especially by limiting the production of harmful molecules from certain T cells during intestinal inflammation.
Colorectal cancer (CRC) is one of the most common malignancies and leading causes of cancer-related deaths worldwide. Despite its complex pathogenesis and progression, CRC represents a well-fitting example of how the immune contexture can dictate the disease outcome. The presence of cytotoxic lymphocytes, both CD8 T cells and natural killer (NK) cells, represents a relevant prognostic factor in CRC and is associated with a better overall survival.
View Article and Find Full Text PDFGranzyme A and CD160 expression delineates ILC1 with graded functions in the mouse liver.
Eur J Immunol
November 2021
Article Synopsis
- Type 1 innate lymphoid cells (ILC1) play a crucial role in defending against infections and exhibit different states of functionality in various conditions.
- Research shows that ILC1 in the liver are diverse, particularly in their expression of effector molecules like granzyme A (GzmA) and surface receptors like CD160, with those expressing high GzmA being more prevalent as mice age.
- The study also finds that ILC1 are distinct from natural killer (NK) cells and that their diversity may arise from the ability of ILC3 cells to transform into ILC1, contributing to various functions such as cytotoxicity and IFN-γ production.
Assessing Phosphorylation of STAT Transcription Factors in Mouse Innate Lymphoid Cells.
Methods Mol Biol
February 2021
Article Synopsis
- * Activation of Janus kinases (JAKs) and STAT family proteins leads to specific cellular responses and transcriptional changes that enhance immune functions.
- * The text presents an optimized protocol for studying STAT phosphorylation in murine NK and ILC subsets from various tissues, building on previous work with IL-23 and IL-12 signaling.
Article Synopsis
- NK cell differentiation begins in the bone marrow and continues in other body areas, influenced by specific organ trajectories.
- Various soluble factors and cytokines play crucial roles in regulating the stages and functions of NK cells, particularly through the Janus kinases (JAKs) and STAT pathway.
- Recent advancements in next generation sequencing (NGS) have revealed new molecular details on how STATs control gene regulation, enhancing our understanding of NK cell development and functionality.