Foam dust suppressant based on synergistic coordination between oxidized starch-gelatin Schiff base reaction and multiple crosslinking.

Aiming at the problems such as large dust in each production process of open-pit mines, insufficient water resistance of the curing layer of dust control materials, and poor mechanical strength, this research applied the network generated by Schiff base reaction between oxidized starch (OS) and gelatin (GEL) as the basis, and combined with polyvinyl alcohol (PVA) and calcium chloride (CaCl). This material improves the problem of poor dust suppression effect caused by the environment of open-pit coal mines. It was found that the large number of amino groups contained in GEL attack the carbon atoms in the carbonyl group of OS to form carbon-nitrogen double bonds, generating Schiff bases as the crosslinking network, which enhanced the water resistance of the polymers.

MRDagent: Iterative and Adaptive Parameter Optimisation for stable ctDNA-Based MRD Detection in Heterogeneous Samples.

Motivation: Minimal residual disease (MRD) as critical biomarker for cancer prognosis and management, plays a crucial role in improving patient outcomes. However, detecting minimal residual disease (MRD) via next-generation sequencing (NGS)-based circulating tumor DNA (ctDNA) variant calling remains unstable due to the extremely low variant allele frequency (VAF) and significant inter- and intra-sample heterogeneity. Although parameter optimization can theoretically enhance variants detection performance, achieving stable MRD detection remains challenging due to three key factors: (i) the necessity for individualized parameter tuning across numerous heterogeneous genomic intervals within each sample, (ii) the tightly interdependent parameter requirements across different stages of variant detection workflows, and (iii) the limitations of current automated parameter optimization methods.

Covert or connected: Motivations for online and interpersonal reassurance-seeking in OCD.

Interpersonal reassurance-seeking is a common anxiety-management strategy used by individuals with a range of disorders, but can be particularly repetitive and exacting among individuals with obsessive-compulsive disorder (OCD). Although this strategy yields short-term relief, it also comes at a cost, creating frustration and straining relationships. Non-interpersonal sources of reassurance-such as the internet-have been less thoroughly studied, but may offer unique advantages.

Synthesis of Semi-Saturated Heterocycles via Photocatalytic Intramolecular [2 + 2] Cycloaddition/Dearomatization.

Intramolecular [2 + 2] cycloaddition/dearomatization could be an ideal pathway to construct semi-saturated polycycles in a "one-pot" manner. However, such a reaction is considered as thermodynamically infeasible due to the instability of the cyclobutane-fused rings and the higher triplet-excited-energy barrier of substrates. Herein, we successfully achieved an array of semi-saturated alkaloid analogues─cyclobutane-fused indolizidines─in up to 98% yield for 33 examples through intramolecular [2 + 2] cycloaddition of indoles via high-energy diradical intermediates.

The Impact of Different Concentrations of Raspberry Extract on the Ethyl Carbamate Content in Chinese Rice Wine.

This study explores the regulatory effects of raspberry extract (RBE) as a natural inhibitor on the ethyl carbamate (EC) formation during the fermentation of Chinese rice wine (CRW) and assesses its impact on the wine's quality. We incorporated varying concentrations of RBE (250, 500, and 1000 mg·L) into both the fermentation mash of CRW and a simulated fermentation system. Systematic monitoring included the EC content, levels of precursors (urea, arginine, citrulline), activities of key enzymes (ADIase, OTCase, arginase, urease), and the impact of RBE on relevant genes' transcriptional levels.

.

Over the past decades, the incidence and modality of invasive fungal infections have been significantly underestimated. And the limited availability of clinically effective antifungals further underscores the need for novel therapeutic agents. In this study, a series of novel 8-hydroxyquinolin-5-ylidene thiosemicarbazone derivatives (-) were designed and synthesized via a condensation reaction between 5-formyl-8-hydroxyquinoline and substituted hydrazinecarbothioamides.

The Path to Global Equity in Surgical Care: Clinical and Technical Results of Cross-Border, Ultra-Long-Distance, Asia to Middle East Human Telesurgery.

Purpose: To demonstrate the feasibility and reproducibility of Ultra-long-distance, Asia to Middle East human telesurgery using low latency connectivity on multiple patients and different procedures.

Methods: Five human telesurgeries were performed over six months using a multiport robotic platform with fiber-optic and 5G connection. Remote surgeon (SA) was in Shanghai, China, and patients were in Kuwait City, Kuwait 7,000 kilometers (Km) apart.

Machine learning models predict risk of lower extremity deep vein thrombosis in hospitalized patients with spontaneous intracerebral hemorrhage.

Lower extremity deep vein thrombosis is one of the important complications of spontaneous intracerebral hemorrhage. We aimed to develop a risk assessment model to predict the risk of lower extremity DVT during hospitalization in patients with spontaneous cerebral hemorrhage. The retrospective study began by randomly dividing the data into a training set and a test set in a 7:3 ratio.

Data-Driven Mining of a Thermostable Lipase with Molecular Insights into Mechanisms of Its Substrate Specificity.

The discovery of novel heat-resistant lipases has the potential to broaden their applications in the food industry and other fields. This study identified a novel heat-resistant lipase PFHL from HK44 based on data-driven mining, which was subsequently expressed in for its molecular insights into substrate specificity. The purified PFHL demonstrated optimal activity at 60 °C and pH 7.

Associations between per- and polyfluoroalkyl substances exposure and renal function as well as poor prognosis in chronic kidney disease patients.

Objectives: The objectives of this study were to investigate the associations of single and mixed exposure to the environmental pollutants per- and polyfluoroalkyl substances (PFAS) with renal function and mortality in non-dialysis chronic kidney disease (CKD) patients.

Methods: Non-dialysis CKD1-4 stage patients in the 2003-2018 US National Health and Nutrition Examination Survey (NHANES) who were ≥20 years old were included. Five PFAS were measured and all patients were followed up till 31 December 2019.

Glucose-potassium ratio: a prognostic biomarker enhancing outcome prediction in mild-to-moderate traumatic brain injury.

Background: To determine the prognostic value of the serum glucose-to-potassium ratio (GPR) in patients with mild-to-moderate traumatic brain injury (MM-TBI).

Methods: Clinical data from patients admitted to the Second Affiliated Hospital of Fujian Medical University with MM-TBI between January 1, 2018 and December 31, 2022 were analyzed. Univariate logistic regression was performed to identify potential risk factors for poor prognosis, followed by multivariate logistic regression to evaluate the Rotterdam score and GPR as independent prognostic factors.

Multifaceted Engineering of Xylanase Guided by Structural Insights to Enhance Thermal Stability and Catalytic Functionality.

β-1,4-Xylanase is crucial for lignocellulosic biomass bioprocessing by degrading xylan, the major hemicellulose component. However, industrial applications are hindered by its inherent thermostability limitations. To overcome this challenge, we developed a comprehensive C-S-E strategy combining computational design, structural analysis, and experimental verification to first identify a novel thermotolerant xylanase (XynT) from .

CT-Derived spleen volume accurately diagnoses severe portal hypertension at HVPG thresholds of 16 mmhg.

To investigate the diagnostic utility of a noninvasive method based on spleen volume for the accurate diagnosis of severe portal hypertension (PH). We enrolled 260 patients undergoing hepatic venous pressure gradient (HVPG) assessment and enhanced CT at Tianjin Third Central Hospital (December 2019-July 2023), with clinical data collected. Patients were stratified by HVPG levels: ≥16 mmHg (severe PH group) and < 16 mmHg (non-severe PH group).

Construction of C-S and C-Se Bonds via Photocatalytic Aromatization-Driven Deconstructive Diversification of Spiro-Dihydroquinazolinones Derived from Unstrained Ketones.

A novel and robust deconstructive functionalization reaction of spiro-dihydroquinazolinones with sulfenylating reagents in the presence of base has been realized under visible light irradiation. This reaction enabled the direct ring-opening of unstrained cyclic ring systems, producing skeletally diverse functionalized quinazolinones with moderate to good yields. A range variety of sulfenylating reagents including diaryl disulfide, thiosulfonate, dithiosulfonate and 1-[(trifluoromethyl)thio]-2,5-pyrrolidinedione were compatible for this transformation.

Susceptibility from the immunological perspective of COVID-19-associated pulmonary aspergillosis: A literature review.

The incidence rate of COVID-19-associated pulmonary aspergillosis (CAPA) is rising. However, the pathogenesis of CAPA remains unclear. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection disrupts pathways related to type I interferon and Toll-like receptors, key components in innate immunity, thereby elevating the incidence of CAPA.

Hydrogen-Bonding-Driven Site-Selective Activation of α-C(sp)─H in Alcohols: A Straightforward Dual-Catalysis Strategy for Efficient Acceptorless Dehydrogenation.

The transformation of alcohols into corresponding carbonyl derivatives is of paramount importance for the construction of complex molecules. Current strategies for catalytic acceptorless dehydrogenation of alcohols were predominantly confined to reactive alcohols, such as benzyl or allyl alcohols, due to the relatively high α-C(sp)─H bond dissociation energy of the conventional unreactive alcohols. Notably, weak bond catalysis, particularly hydrogen bonding, can selectively activate C─H bonds by modulating the distribution of electron density.

Glucose-to-potassium ratio as a predictor for early post-traumatic epilepsy: a retrospective cohort study.

Background: Post-traumatic epilepsy (PTE) is a common complication following traumatic brain injury (TBI). Early PTE refers to the appearance of seizure symptoms within 7 days of the injury. The glucose-to-potassium ratio (GPR) has emerged as a potential biomarker for predicting Early PTE risk.

Intramuscular Reactivity of the Modified Graphene Oxides and Their Bio-Reactivity in Aging Muscle.

To enhance the biocompatibility and drug delivery efficiency of graphene oxide (GO), poly(ethylene glycol) (PEG), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), or its triblock copolymer PEG-PHBV-PEG (PPP) were used to chemically modify GO. However, it is still unknown whether non-toxic polymer-modified GO mediates muscle toxicity or triggers intramuscular inflammation. This study aims to investigate the biological reactivity and inflammation/immune response induced by PEG, PHBV, or PPP modified GO when injected into the tibialis anterior (TA) muscle of mice prior to drug loading.

Multifunctional polydopamine-carboxymethyl cellulose composite gels with Ag/AgCl/ZnO heterojunction to enhance sunlight-responsive photocatalytic activity.

Carboxymethyl cellulose (CMC) gel is an ideal substrate for supporting sunlight responsive photocatalysts, but the photocatalytic disinfection activity decreased due to the light-shielding effect of the gel. In order to enhance the formation of active oxygen species, polydopamine (PDA) was introduced in CMC gels to function as an intermediate to connect two semiconductors inside the gels via its quinhydrone charge-transfer complexation. CMC/PDA gel with a double-network was formed via chemical crosslinking and reversible hydrogen bonding between prepolymerized PDA and CMC, then Ag/AgCl, ZnO and Ag/AgCl/ZnO photocatalysts were formed in situ in CMC/PDA gel, respectively.

EMcnv: enhancing CNV detection performance through ensemble strategies with heterogeneous meta-graph neural networks.

Copy number variation (CNV) is a crucial biomarker for many complex traits and diseases. Although numerous CNV detection tools are available, no single method consistently achieves optimal performance across diverse sequencing samples, as each tool has distinct advantages and limitations. Therefore, integrating the strengths of these tools to improve CNV detection accuracy is both a promising strategy and a significant challenge.

Harnessing nitroarenes: photo-driven synergistic construction of phosphinic amides hydrogen transfer and oxygen migration.

A photo-mediated cascade rearrangement of nitroarenes in an electron donor-acceptor (EDA) complex generates phosphinic amides without metal or oxidants. Utilizing oxygen atoms from nitro groups, the reaction facilitates P(III) to P(V) conversion. The method shows broad substrate scope and compatibility with late-stage functionalization, offering potential for pharmaceutical synthesis.

Elevated basophils in peripheral blood predict lower extremity deep venous thrombosis in non-surgical patients with spontaneous intracerebral hemorrhage.

Leukocytes are associated with lower extremity deep venous thrombosis (LEDVT) in patients with spontaneous intracerebral hemorrhage (sICH). Nonetheless, the correlation between differential leukocyte subtype counts in peripheral blood and LEDVT is poorly understood. This study explored the relationship between admission basophils in leukocytes and 14-day LEDVT in non-surgical patients with sICH.

Association between cardiometabolic index and depression in a stroke population: a cross-sectional study of NHANES.

Background: Stroke is a prevalent neurological disorder globally, often resulting in post-stroke depression (PSD). The cardiometabolic index (CMI) is a novel marker for assessing cardiovascular and metabolic health, but its association with PSD has not been adequately investigated. This study aims to explore the relationship between CMI and PSD, providing a basis for clinical prevention and treatment.