Dual-Network Cross-Learning for Metabolite-Disease Association Prediction.

In recent years, increasing evidence has demonstrated a close association between metabolites and various complex human diseases, providing valuable insights for disease diagnosis, treatment, and prevention. Although deep learning-based approaches have achieved certain success in predicting metabolic disease associations, challenges remain in enriching graph information and effectively integrating metabolic and disease features. To address these issues, this paper proposes a model named DCMDA, which extracts deep features of both metabolites and diseases using Dual-network Cross-learning for Metabolite-Disease Association prediction.

Using artifact suppression OCT based on polarization multiplexing for tomographic imaging of LCD screens.

Defect detection in the inner layers of liquid crystal display (LCD) panels is crucial for the quality control of displays. Optical coherence tomography (OCT), a nondestructive, high-resolution tomographic imaging technique, has been applied in the inspection of display panels. However, the artifacts that arise in imaging multilayer samples remain a challenge.

PitVis-2023 challenge: Workflow recognition in videos of endoscopic pituitary surgery.

The field of computer vision applied to videos of minimally invasive surgery is ever-growing. Workflow recognition pertains to the automated recognition of various aspects of a surgery, including: which surgical steps are performed; and which surgical instruments are used. This information can later be used to assist clinicians when learning the surgery or during live surgery.

Associations Among Obstructive Sleep Apnea, Thyroid Function and Morphology Changes.

Purpose: This study unveils the complex interplay among obstructive sleep apnea (OSA), thyroid function, and morphological changes.

Methods: Data from 1,102 patients were collected retrospectively from the Department of Otorhinolaryngology-Head and Neck Surgery of the Second Affiliated Hospital of Xi'an Jiaotong University from 2012 to 2023. The patients were divided into severe and non-severe OSA groups according to their polysomnography results.

Ideal topological flat bands in chiral symmetric moiré systems from non-holomorphic functions.

Recent studies on topological flat bands and their fractional states have revealed increasing similarities between moiré flat bands and Landau levels (LLs). For instance, like the lowest LL, topological exact flat bands with ideal quantum geometry can be constructed using the same holomorphic function structure, , where f(z) is a holomorphic function. This holomorphic structure has been the foundation of existing knowledge on constructing ideal topological flat bands.

Irrigation of with Saline Wastewater and Microalgae: Improving Saline-Alkali Soil and Revealing the Composition and Function of Rhizosphere Bacteria.

Limited research has been conducted on the potential and mechanisms of irrigating with wastewater and microalgae to improve saline-alkali land. This study used three irrigation treatments (freshwater, saline wastewater, and saline wastewater with microalgae) to irrigate , and microalgae promoted the growth of and increased soil nutrient content, increasing available nitrogen (4.85%), available phosphorus (44.

circRNA_BMPR2 affects the progression of polycystic ovary syndrome by regulating the expression of Rab43.

Polycystic Ovary Syndrome (PCOS) is a common reproductive and metabolic disorder causing infertility in women of childbearing age.Circular RNAs are known to be involved in PCOS development, but their regulatory mechanisms remain unclear. This study explored the role of circ_BMPR2 in PCOS to advance early diagnosis and treatment.

Identification and validation of an explainable early-stage chronic kidney disease prediction model: a multicenter retrospective study.

Background: Chronic Kidney Disease (CKD) has become a significant global public health issue, affecting approximately 10% of adults. Due to the lack of obvious symptoms in the early stages, CKD is often difficult to diagnose in a timely manner, leading to the gradual progression of the disease, which can eventually develop into End-Stage Renal Disease (ESRD). This study applied machine learning (ML) methods to integrate patient clinical data and developed an early CKD prediction model applicable to individuals .

A modified TOPSIS algorithm for the assessment of sports quality in higher education using circular pythagorean fuzzy information.

Higher education institutions experience difficulties in sports quality assessment because multiple qualitative and quantitative factors, including sports facilities and coaching abilities, combine with student participation and institutional backing. Standard assessment systems encounter challenges when measuring subjective phenomena found in quality assessment evaluations. This research introduces an improved version of the technique for order of preference by similarity to ideal solution (TOPSIS) based multi-criteria decision-making (MCDM) model that utilizes circular Pythagorean fuzzy sets (CPyFS) to effectively process imprecise expert judgments.

Differential Methylation Analysis of Hypermelanosis in Chinese Tongue Sole (Cynoglossus semilaevis).

Hypermelanosis on the blind side is a major concern in tongue sole (Cynoglossus semilaevis) aquaculture in China and causes great economic loss for farmers. To investigate the relationship between DNA methylation and hypermelanosis, different skin tissues on both the ocular and blind sides of both normal and hypermelanotic fish were used in this study, and set analysis was utilized to narrow and filter the possible, potential, and direct differentially methylated regions (DMRs). A total of 2278, 1015, and 6740 DMRs were discovered, which belonged to 1786, 908, and 4210 genes, for possible, potential, and direct methylation types, respectively.

A novel one-tube RPA/CRISPR melting curve detection sensing system based on unique 3'-toehold nucleic acid aptamer for Bacillus anthracis detection.

Developing effective detection methods for Bacillus anthracis is essential for our public health system to accurately detect hidden anthrax outbreaks. Herein, we introduce a unique 3'-toehold nucleic acid aptamer (probes) into Cas12a biosensor, combined with RPA, to establish a rapid (1h), specific, and sensitive (1copy/μL) detection method for B. anthracis.

Correction: Health disparities in cervical cancer: Estimating geographic variations of disease burden and association with key socioeconomic and demographic factors in the US.

[This corrects the article DOI: 10.1371/journal.pone.

Bifunctional S-doping-mediated interfacial gradient electric field for in-situ amplified photoelectrochemical immunoassay.

Ultrasensitive chemical reactions at the photoanode interface provide new ideas for the development of novel photoelectrochemical (PEC) immunoassays. Herein, we reported an in situ-promoted all-inorganic semiconductor reaction realizing an ultrasensitive PEC analysis of carcinoembryonic antigen (CEA). Uniform InO nanocubes were synthesized through one-step in situ growth, and composite InOS was obtained by one-step post-modification sulfurization, achieving ultra-high light-to-dark current switching ratios (169 times).

Exposure to deltamethrin leads to gill liver damage, oxidative stress, inflammation, and metabolic disorders of Japanese flounder ().

Introduction: Deltamethrin is a pyrethroid insecticide commonly used to kill animal parasites in aquaculture. However, increasing evidence suggests that deltamethrin affects the health of aquatic animals by causing tissue damage and even death.

Methods: In this study, the damage caused by deltamethrin to the gill and liver tissues, as well as its effects on oxidative stress and immune metabolism, were studied in .

Unraveling the Role of Programmed Cell Death Gene Signature and THBS1 in Gastric Cancer Progression and Therapy Response.

Background: Programmed cell death (PCD) genes play crucial roles in cancer progression and response to therapies, yet their impact on gastric cancer remains inadequately elucidated. This study aimed to create a prognostic cell death signature (PCDs) for gastric cancer, providing insights into potential therapeutic targets and survival predictors.

Methods: We utilized TCGA-STAD and five GEO datasets, representing thousands of gastric cancer samples, for a comprehensive analysis of PCD genes.

Diammonium phosphate supplementation in low-protein diets enhances growth performance in growing pigs without compromising carcass traits and meat quality.

Optimizing low-protein (LP) diets in swine nutrition is critical for reducing nitrogen excretion and resource waste while reducing meat quality. However, LP diets may disrupt amino acid (AA) balance, affecting growth and health. Supplementing with nonprotein nitrogen sources such as diammonium phosphate (DP) can enhance nitrogen utilization and support protein synthesis efficiently.

Function of Gene Response to Infection and LPS Stimulation in the Half-Smooth Tongue Sole ().

Lysosome-associated membrane glycoproteins (LAMPs), including lysosomal membrane protein 1 (Lamp1) and lysosomal membrane protein 2 (Lamp2), are involved in phagocytosis, chaperone-mediated autophagy (CMA), and other pathways that interact with lysosomal activity. However, the role of Lamp2 in teleosts has not been clarified. In this study, we investigated the functions of genes during infection.

Chemoresistance and immune evasion in hepatocellular carcinoma: the role of miRNA-425-5p.

Hepatocellular carcinoma (HCC) represents a significant global health challenge, with chemoresistance severely limiting treatment efficacy. This study investigates the role of miRNA-425-5p in exosomes in modulating the tumor microenvironment (TME) and contributing to chemoresistance and immune evasion in HCC. Differentially expressed miRNAs were identified using TaqMan low-density array technology in serum samples from XELOX-resistant and -sensitive HCC patients.

Dietary Iron Alleviates Dextran Sodium Sulfate-Induced Intestinal Injury by Regulating Regeneration of Intestinal Stem Cells in Weaned Mice.

Iron deficiency is the most common comorbidity of inflammatory bowel disease (IBD), but the effect of iron supplementation on the repair processes of intestinal injury in weaned mice is unknown. This study aimed to evaluate the potential mechanism of dietary iron on intestinal injury and intestinal regeneration in the dextran sodium sulfate (DSS)-induced colitis of the weaned mouse model. The mice were fed either a control diet containing (45.

Isolation, identification and the pathogenicity characterization of Pseudomonas putida 1C3 and its activation on immune responses in Japanese flounder (Paralichthys olivaceus).

The outbreak of mass mortality of Japanese flounder occurred in an aquaculture farm in Hebei province of China. This study isolated and identified Pseudomonas putida as the dominant bacterium from diseased Japanese flounder (Paralichthys olivaceus) based on morphological, physiological, biochemical characteristics, 16S rRNA gene sequencing, and whole-genome sequencing. Pathogenicity assessment, histopathological analysis, and host immune response were investigated.

Interaction between Hydrogen and Magnesium Films: From Hydrogenochromism to Applications.

Hydrogen, as a promising clean energy carrier, underscores the critical need for reliable detection technologies to ensure its safe and efficient use. Magnesium (Mg) thin films, with their hydrogenochromic properties, are particularly well-suited for hydrogen sensing applications due to their dramatic optical transitions. However, practical implementation faces challenges in achieving both rapid response and durability under cyclic conditions.

Deep Learning for Obstructive Sleep Apnea Detection and Severity Assessment: A Multimodal Signals Fusion Multiscale Transformer Model.

Purpose: To develop a deep learning (DL) model for obstructive sleep apnea (OSA) detection and severity assessment and provide a new approach for convenient, economical, and accurate disease detection.

Methods: Considering medical reliability and acquisition simplicity, we used electrocardiogram (ECG) and oxygen saturation (SpO) signals to develop a multimodal signal fusion multiscale Transformer model for OSA detection and severity assessment. The proposed model comprises signal preprocessing, feature extraction, cross-modal interaction, and classification modules.

Rapid and Visual Detection of Urinary Pathogens by Employing Bifunctional Deoxyribonucleic Acid Sensors and Aggregation of Gold Nanoparticles.

A simple, rapid, and visual approach is developed to perform diagnosis of urinary tract infection (UTI) and antimicrobial susceptibility testing (AST) by employing smart bifunctional DNA (bfDNA) sensors, exonuclease III, concatermers of CuO nanoparticles (CuONPs), and gold NPs (AuNPs) aggregation [AuNPs agglutination (AA)], namely, the bfDEC-AA method. The bfDNA sensors serve as probes for identifying 16S rRNA genes of bacterium or 18S rRNA of fungus and as mediators connecting the concatermers of CuONPs. The AA as a signal source is triggered by Cu(I)-catalyzed azide-alkyne cycloaddition click chemistry.

Craniofacial Development Characteristics in Children with Obstructive Sleep Apnea for Establishment and External Validation of the Prediction Model.

Purpose: Aimed to analyze the developmental characteristics of craniofacial structures and soft tissues in children with obstructive sleep apnea (OSA) and to establish and evaluate prediction model.

Methods: It's a retrospective study comprising 747 children aged 2-12 years (337 patients and 410 controls) visited the Department of Otolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Xi'an Jiaotong University (July 2017 to March 2024). Lateral head radiographs were obtained to compare the cephalometric measurements.