Medical Hemorrhoid Gel Ameliorates Croton Oil-Induced Hemorrhoids by Suppressing the NLRP3 Inflammasome Activation via NF-κB Signaling Pathway.

Background: Hemorrhoidal disease (HD) is characterized by the pathological dilation of anal vascular cushions, causing pain, itching and bleeding. Recent evidence links HD onset and progression to rectal inflammation. Medical Hemorrhoid Gel (MHG), a multi-component botanical preparation, has gained empirical validation for HD management.

Virtual reality-based rehabilitation experience of stroke survivors: a meta-synthesis of qualitative studies.

Aim: To examine and synthesize qualitative data regarding the experiences of stroke survivors who underwent rehabilitation using virtual reality (VR).

Methods: We critically appraised the included study using the Joanna Briggs Institute Critical Assessment Checklist for Qualitative Research. Relevant qualitative studies were searched in PubMed, EMBASE, CINAHL, Web of Science, Cochrane Library, China National Knowledge Infrastructure, Wan Fang Database, China Science and Technology Journal Database, and China Biomedical Literature Database from inception to December 2024.

Effects of selenium supplementation on ornithine carbamoyl-transferase activity, the metabolisms of associated amino acids and fermentation flavors of Levilactobacillusbrevis.

Effects of Se supplementation on ornithine carbamoyl-transferase (OCT) activity and fermentation characteristics of Lactic acid bacteria are rarely reported. This work aimed to investigate the influences of Se supplementation on the OCT activity of Se-enriched L. brevis CICC 6239 with the metabolism of amino acids and flavor compounds of wolfberry wine.

The impact of teachers' caring behavior on EFL learners' academic engagement: the chain mediating role of self-efficacy and peer support.

Background: The significance of academic engagement for English as a Foreign Language (EFL) learners has gained increasing attention in recent research. While studies have shown that teachers' caring behavior positively influences academic engagement, the underlying roles of self-efficacy and peer support remain unexplored. This study examines the impact of teachers' caring behavior on academic engagement and investigates the chain-mediating effects of self-efficacy and peer support.

ER-induced PERK/TFEB cascade sequentially modulates mitochondrial dynamics during cranial suture expansion.

The effectiveness of cranial suture expansion therapy hinges on the timely and adequate regeneration of bone tissue in response to mechanical stimuli. To optimize clinical outcomes and prevent post-expansion relapse, we delved into the underlying mechanisms governing bone remodeling during the processes of suture expansion and relapse. Our findings revealed that in vitro stretching bolstered mesenchymal stem cells' antioxidative and osteogenic capacity by orchestrating mitochondrial activities, which governed by force-induced endoplasmic reticulum (ER) stress.

Unlocking the power of swine gut bacteria: newly isolated Blautia strain and its metabolites inhibit the replication of Salmonella Typhimurium in macrophages and alleviate DSS-induced colitis in mice.

Background: Inflammatory bowel disease is a significant health concern for both humans and large-scale farm animals. In the quest for effective alternatives to antibiotics, next-generation probiotics (NGPs) have emerged as a promising option. The genus Blautia presents a rich source of potential NGP strains.

Improving metabolic engineering design with enzyme-thermo optimization.

Metabolic target and strategy design play a critical role in enhancing the DBTL (Design-Build-Test-Learn) cycle in metabolic engineering. Classical stoichiometric algorithms such as OptForce and FSEOF narrow the experimental search space but fail to account for thermodynamic feasibility and enzyme-usage costs, leaving a space for their predictive performance. In this study, we introduce ET-OptME, a framework integrating two algorithms that systematically incorporate enzyme efficiency and thermodynamic feasibility constraints into genome-scale metabolic models.

Dietary supplementation with hydroxy-methionine manganese improves meat quality, antioxidant capacity, and lipid metabolism in Cherry Valley ducks ().

Hydroxymethionine manganese (MnHMet), as a novel organic trace element additive, has demonstrated significant effects on improving meat quality, enhancing antioxidant capacity, and lipid metabolism. However, its specific effects on Cherry Valley ducks remain unclear. This study explored the effects of dietary MnHMet on meat quality, antioxidant capacity, and lipid metabolism in meat ducks.

Experimental Study on the Mechanical Properties and Microstructural Mechanisms of Coal Gangue-Based Cementitious Materials Synergistically Activated by Desulfurization Gypsum and Lime.

Coal gangue and flue gas desulfurization gypsum (DG) are industrial by-products whose utilization is critical for sustainable development. This study explores the synergistic activation of coal gangue using DG and lime to develop eco-friendly cementitious materials. Three systems-CF (coal gangue-DG), CL (coal gangue-lime), and CFL (coal gangue-DG-lime)-were designed to investigate the effects of DG and lime on coal gangue reactivity.

Exploring the relationship between social media dependence and internet addiction among college students from a bibliometric perspective.

Background: Social media use among college students often leads to psychological dependence, resulting in a rising number of internet addictions. The link between social media dependence and addiction is garnering increasing attention.

Objective: The aim of this study was to analyze and discuss the research trends and hotspots on social media dependence and internet disorder among college students by bibliometric methods.

Microbiome-metabolomics analysis insight into the effects of dietary chromium picolinate on abdominal fat deposition and lipid metabolism of ducks.

This research endeavored to explore the impact of Cr-Pic on the abdominal fat deposition and lipid metabolism of ducks, as well as to uncover the mechanisms at play and identify the optimal dietary supplementation level of Cr-Pic. The results showed that adding 0.6 mg/kg Cr-Pic observably increased the body weight and serum levels of adiponectin and leptin, and decreased serum levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol in ducks at 14 days (P < 0.

Composition, Influencing Factors, and Effects on Host Nutrient Metabolism of Fungi in Gastrointestinal Tract of Monogastric Animals.

Intestinal fungi, collectively referred to as mycobiota, constitute a small (0.01-2%) but crucial component of the overall intestinal microbiota. While fungi are far less abundant than bacteria in the gut, the volume of an average fungal cell is roughly 100-fold greater than that of an average bacterial cell.

Predicting Microvascular Invasion and Early Recurrence in Hepatocellular Carcinoma Using DeepLab V3+ Segmentation of Multiregional MR Habitat Images.

Rationale And Objectives: Accurate identification of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) is crucial for treatment and prognosis. Single-modality and feature fusion models using manual segmentation fail to provide insights into MVI. This study aims to develop a DeepLab V3+ model for automated segmentation of HCC magnetic resonance (MR) images and a decision fusion model to predict MVI and early recurrence (ER).

Mild drought conditions at the tillering stage promote dry matter accumulation and increase grain weight in drip-irrigated spring wheat ( L.).

Introduction: In order to elucidate the physiological mechanism of post-flowering assimilate transport regulating the formation of yields in arid regions and to provide technological support for further water-saving and high yields in the wheat region in Xinjiang, we conducted a study on the effects of different fertility periods and different degrees of drought and re-watering on the post-flowering dry matter accumulation and transport of spring wheat and the characteristics of grain filling.

Methods: In two spring wheat growing seasons in 2023 and 2024, a split-zone design was used, with the drought-sensitive variety Xinchun 22 (XC22) and drought-tolerant variety Xinchun 6 (XC6) as the main zones and a fully irrigated control during the reproductive period [CK, 75%~80% field capacity (FC)], with mild drought at the tillering stage (T1, 60%~65% FC), moderate drought at the tillering stage (T2, 45%~50% FC), mild drought at the jointing stage (J1, 60%~65% FC), and mild drought at the jointing stage (J2, 45%~50% FC) as the sub-zones.

Results: The dry matter accumulation of the aboveground parts of wheat (stem sheaths, leaves, and spikes), the transfer rate and contribution rate of nutrient organs, the maximum filling rate (V), and the mean filling rate (V) increased significantly after re-watering in the T1 treatment, and decreased with the deepening of the degree of water stress.

Diabetes exacerbates periodontitis by disrupting IL-33-mediated interaction between periodontal ligament fibroblasts and macrophages.

Tissue-resident fibroblasts with immunomodulatory properties have recently been identified as key players in inflammation. However, their roles within the periodontal niche in diabetes-associated periodontitis remain unclear. Interleukin (IL)-33, known as an "alarmin" in inflammatory responses, has recently emerged as a potential contributor to periodontitis.

Mechanism of medical hemorrhoid gel in relieving pruritus ani via inhibiting the activation of JAK2/STAT3 pathway.

Background: Pruritus ani (PA), a neurofunctional dermatosis, is one of the most common complications of hemorrhoids, which seriously affects the quality of life of patients. Medical hemorrhoid gel (MHG), a product mainly composed of herbal medicine, is widely used for treatment of PA clinically. This study aim to assess the alleviating effect and mechanism of MHG on PA based on rectal epidermis-spinal cord-brain axis using animal models.

Threonine attenuates lipopolysaccharide-induced intestinal inflammatory responses in rabbits.

Purpose: Threonine (Thr) can be involved in the synthesis of immunoglobulins, which play the role of immune regulation, Thr also has to improve intestinal morphology, adjust the sticky protein synthesis, maintain the intestinal barrier function, etc. The experiment aimed to investigate the effects of diets supplemented with different levels of Thr on growth performance and intestinal health of rabbits under lipopolysaccharide (LPS) stress conditions.

Methods: A total of 180 healthy 35-day-old weaned New Zealand White rabbits were randomly assigned in a 2 × 3 factorial design to receive an intraperitoneal injection of 100 µg/kg BW LPS or saline and three diets with different levels of digestible threonine (0.

[Characteristics and Influencing Factors of Soil and Crops Selenium Content in Eastern Sanjiang Plain].

Too identify seleniut（Se） content characteristics and influencing factors in soil and crops of Shengli Farm in eastern Sanjiang Plain, statistical analysis and correlation analysis were comprehensively used to analyze the test results of 83 groups of surface soil samples and 34 groups of crop seed samples. The results showed that the Se content in the study area ranged from 0.12 to 0.

The microbiota and metabolome dynamics and their interactions modulate solid-state fermentation process and enhance clean recycling of brewers' spent grain.

The massive yield of brewers' spent grain (BSG) waste inevitably threaten environmental health. Here, solid-state fermentation (SSF) technology featuring multi-strain (MS) inoculation and high-throughput sequencing technology were employed to facilitate the sustainable and clean recycling of BSG waste while revealing the associated underlying microbiological and metabolic mechanisms. MS inoculation displayed a lower pH value (3.

Effectiveness of integrated care models for stroke patients: A systematic review and meta-analysis.

Introduction: Given that stroke is a leading cause of disability and mortality worldwide, there is an urgent need for a coordinated healthcare approach to mitigate its effects. The objectives of this study were to perform a systematic review and meta-analysis of stroke integrated care models and develop recommendations for a representative model.

Design: A systematic review and meta-analysis.

Artificial parasin I protein (API) supplementation improves growth performance and intestinal health in weaned piglets challenged with enterotoxigenic .

Diarrheas are common risks faced by piglets during the weaning period. This study investigated the alleviating effects of artificial parasin I protein (API) on growth performance and intestinal health of weaned pigs upon enterotoxigenic (ETEC) challenge. Sixty piglets were randomly divided into five groups and fed a basal diet (CON) or basal diet supplemented with API at 0, 750, and 1500 mg/kg or antibiotics for 5 weeks.