Gut Microbiota-Associated Metabolites Affected the Susceptibility to Heart Health Abnormality in Young Migrants at High-Altitude: Gut Microbiota and Associated Metabolites Impart Heart Health in Plateau.

Young migrants, particularly those at high altitudes, are predisposed to heart health abnormalities, including high-altitude heart disease. Despite the profound impact of hypobaric hypoxia on the gut microbial community, the understanding of the roles played by gut microbiota and gut microbiota-associated serum metabolites in high-altitude heart diseases remains limited. Therefore, we conducted a comprehensive multi-omics analysis involving 230 graduates from the same university, with 163 Tibetan Plateau migrants and 67 Chengdu Plain residents, and identified 206 differential metabolites (82 in serum and 124 in feces) and 369 species that differed between migrants and residents.

Varied responses of inland waters to compound heatwave-drought events in the Yangtze River Basin.

Extreme heatwaves and droughts are coinciding more frequently worldwide, exerting far reaching and adverse effects on ecosystems and economic development. Nevertheless, our knowledge of compound heatwave drought events (CHDEs) and their negative impacts on inland waters remains relatively scarce. Our findings indicate that the average annual duration of heatwaves varies: 3-107 days in river segments, 4-69 days in directly connected lakes, and 2-71 days in controlled lakes in the Yangtze River Basin (YRB), China's largest basin from 1980 to 2022.

Myricetin Potentiates Antibiotics Against Resistant by Disrupting Biofilm Formation and Inhibiting Motility Through FimX-Mediated c-di-GMP Signaling Interference.

biofilm formation is critical to antibiotic resistance and persistence. Targeting cyclic di-GMP (c-di-GMP) signaling, a master biofilm formation and virulence regulator, presents a promising strategy to combat resistant bacterial infections. Myricetin, a natural polyphenolic flavonoid with documented antimicrobial and anti-biofilm activities, may enhance antibiotic efficacy against .

Episodic flooding causes sudden deoxygenation shocks in human-dominated rivers.

Dissolved oxygen (DO) sustains river ecosystems, but the effects of hydrological extremes remain poorly understood. While high river discharge (Q) enhances aeration, floods also deliver oxygen-consuming pollutants, making net impacts uncertain. Here, we analyze daily DO and its percent saturation (DO), and Q in 1156 Chinese rivers over three years.

An automatic patient-specific quality assurance with a novel DVH scoring algorithm for volumetric modulated arc therapy of cervical cancer.

Purpose: To develop a novel DVH scoring algorithm to predict and classify patient-specific quality assurance (PSQA) results by different DVH metrics automatically and efficiently.

Methods: A total of 200 cervical cancer patients who treated by Infinity (109 cases) and Synergy (91 cases) linear accelerators underwent volumetric modulated arc therapy (VMAT) from 2019 to 2022 were enrolled and used as technical testing (TT) and technical validation (TV) datasets, respectively, which was then randomly divided into training, validation and testing set at a ratio of 7:1:2. PSQA dose distributions were predicted using U-shape-like network with skip-connection modules (called T-Net) with the input of CT and plan dose distributions.

High-Altitude Impacts on Gut Microbiota: Accelerated Aging and the Urgency for Targeted Health Interventions.

The human gut microbiota is integral to the aging process, and its composition is notably influenced by the unique environmental pressures of high-altitude plateaus, characterized by hypobaric and hypoxic conditions. This study explores the correlation between physiological aging and gut microbiota among high-altitude plateau inhabitants, an essential aspect of health preservation in such regions. We conducted a metagenomic analysis of fecal samples from 105 individuals who migrated to high-altitude areas before the age of 20.

Tauroursodeoxycholic Acid Induces Liver Regeneration and Alleviates Fibrosis Through GATA3 Activation.

: Liver regeneration is a critical measure of liver health and plays an essential role in inhibiting the progression of fibrotic lesions and preventing liver failure after hepatocellular carcinoma surgery. However, there are no approved drugs to address this clinical challenge. : The effects of TUDCA on liver regeneration and fibrosis were studied using BRL-3A cells, a partial hepatectomy (PH) rat liver regeneration model, and a carbon tetrachloride (CCl)-induced liver fibrosis model.

Succession of Particle-Attached and Free-Living Microbial Communities in Response to the Degradation of Algal Organic Matter in Lake Taihu, China.

Decomposition of Cyanobacterial blooms frequently occurs in Lake Taihu, releasing various fractions of algal organic matter into the water through cell lysis. These fractions influence the production and consumption of dissolved organic matter, nutrient dynamics, and bacterial succession in the lake. However, the interactions between free-living and particle-attached bacterial communities with different algal organic matter fractions remain poorly understood.

Plasma Proteomic Profiling Reveals ITGA2B as A Key Regulator of Heart Health in High-altitude Settlers.

Myocardial injury is a common disease in the plateau, especially in the lowlanders who have migrated to the plateau, in which the pathogenesis is not well understood. Here, we established a cohort of lowlanders comprising individuals from both low-altitude and high-altitude areas and conducted plasma proteome profiling. Proteomic data showed that there was a significant shift in energy metabolism and inflammatory response in individuals with myocardial abnormalities at high altitude.

Deubiquitinase JOSD2 alleviates colitis by inhibiting inflammation deubiquitination of IMPDH2 in macrophages.

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, which increases the incidence of colorectal cancer (CRC). In the pathophysiology of IBD, ubiquitination/deubiquitination plays a critical regulatory function. Josephin domain containing 2 (JOSD2), a deubiquitinating enzyme, controls cell proliferation and carcinogenesis.

[ exacerbates periodontal inflammation and impairs cognitive function in mice].

Objectives: To investigate the effects of periodontitis induced by (Pn) combined with ligation on cognitive functions in mice.

Methods: Twenty-four C57BL/6J mice were randomly divided into control group, ligation group, and ligation + Pn treatment (P+Pn) group. Experimental periodontitis was induced by silk ligation of the first molars followed by topical application of Pn for 6 weeks.

Terrestrial Organic Matter Inputs Modulate Methane Emissions from a Mega-Reservoir.

Reservoirs are hotspots for methane (CH) emissions. However, to date, the effects of terrestrial organic matter (OM) input and degradation on CH emissions from large reservoirs remain largely unknown. From May 2020 to April 2021, we conducted monthly sampling campaigns at 100 sites in Lake Qiandao (580 km), a mega-reservoir in China, and made monthly vertical profile observations from March to September 2023.

Microbial Metabolic Limitations and Their Relationships with Sediment Organic Carbon Across Lake Salinity Gradient in Tibetan Plateau.

Inland lakes, contributing substantially to the global storage of sediment organic carbon (SOC), are subject to marked changes in salinity due to climate warming. The imbalance in the supply of resources, such as carbon, nitrogen, and phosphorus, in sediments leads to microbial metabolic limitations (MMLs). This, in turn, triggers the secretion of extracellular enzymes by microorganisms to mine for deficient resources by decomposing complex organic carbon.

Rainstorm-induced organic matter pulses: A key driver of carbon emissions from inland waters.

Numerous rivers and lakes in the monsoon climate zone are heavily influenced by frequent rainstorms that mobilize dissolved organic matter (DOM) from pristine or urbanized environments into downstream lakes. Of particular concern is the mobilization of DOM from anthropogenic effluents, which are commonly enriched in aliphatic compounds that can be easily degraded by microorganisms. Rapid degradation of highly biodegradable DOM, in turn, may cause significant depletion of dissolved oxygen in the water, which, by creating anoxic conditions at the bottom water-sediment interface, promotes microbial production of CO and CH.

Quantitative Analysis of the Gait Variability and Asymmetry Using Inertial Measurement Unit During Dual-task Gait.

Well-established connections exist between increased gait variability and greater fall likelihood in human movement. Therefore, the assessment of gait symmetry can facilitate clinicians' decision-making in the treatment and evaluation of the progression of several diseases. This study proposed a workflow that used two self-developed inertial sensing measurement units (IMU) to collect the lower limb gait data of five subjects and then extracted the gait characteristic parameters to quantify the running process during a single-task condition and a dual-task condition, which requires additional cognitive loads (counting numbers backward).

KAT7-acetylated YBX1 promotes hepatocellular carcinoma proliferation by reprogramming nucleotide metabolism.

Background: Lysine acetylation is a critical post-translational modification regulating tumor initiation and progression. Lysine acetyltransferase 7 (KAT7)-mediated lysine acetylation is frequently dysregulated in cancer. However, the role of KAT7-mediated lysine acetylation in hepatocellular carcinoma (HCC) progression remains unclear.

A novel multi-level 3D pose estimation framework for gait detection of Parkinson's disease using monocular video.

Introduction: Parkinson's disease (PD) is characterized by muscle stiffness, bradykinesia, and balance disorders, significantly impairing the quality of life for affected patients. While motion pose estimation and gait analysis can aid in early diagnosis and timely intervention, clinical practice currently lacks objective and accurate tools for gait analysis.

Methods: This study proposes a multi-level 3D pose estimation framework for PD patients, integrating monocular video with Transformer and Graph Convolutional Network (GCN) techniques.

Inflow-modulated inputs of dissolved organic matter fuel carbon dioxide emissions from a large hyper-eutrophic lake.

Terrestrial dissolved organic matter (DOM) is potentially reactive and, upon entering lake ecosystems, can be readily degraded to low-molecular-weight organic matter and dissolved CO. However, to date, there has been limited research on the links between long-term variation in the composition of DOM and CO emissions from lakes. Lake Taihu is a large, shallow, and hyper-eutrophic lake where DOM composition is strongly influenced by inputs from the rivers draining cultivated and urbanized landscapes.

Gut microbiota's role in high-altitude cognitive impairment: the therapeutic potential of Clostridium sp. supplementation.

Prolonged exposure to high-altitude environments may increase the risk of cognitive decline in young migrants. Recent studies suggest that hypobaric hypoxia-induced alterations in gut microbial composition could partly contribute to this risk. However, the absence of direct evidence from cohort studies and an unclear mechanism hinder intervention development based on this hypothesis.

Synergistic Effects of Caffeoylquinic Acid Compounds with Levofloxacin Against Uropathogenic : Insights from Molecular Dynamics Simulations, Antibiofilm, and Antimicrobial Assessments.

Urinary tract infections (UTIs), primarily caused by uropathogenic (UPEC), have high morbidity and recurrence rates. Resistance to levofloxacin hydrochloride (LEV), a commonly used treatment for UTIs, is increasingly problematic, exacerbated by biofilm formation mediated by interactions between cyclic di-GMP (c-di-GMP or CDG) and YcgR. In this study, we identified three caffeoylquinic acid compounds from -chlorogenic acid (CGA), sibiricose A5 (Si-A5), and 3--caffeoylquinic acid methyl ester (CAM)-that target YcgR through molecular docking.

Growth Promoted by Lychee Major Flavonoid through Metabolism.

() possesses health-promoting properties. Nevertheless, enrichment remains a challenging endeavor. Quercetin-3--rutinose-7--α-l-rhamnoside (QRR), a flavonoid found in lychee pulp, has a unique double-substituted glycosylated structure, requiring a specific intestinal microbiota for effective metabolism.