Analysis of CME Participation and Credit Compliance Among Healthcare Professionals: A Five-Year Study (2019-2023) From a Hospital in Guangdong, China.

Objective: Continuing Medical Education (CME) is vital for maintaining and improving the competencies of healthcare professionals. Despite the recognized importance of CME, disparities in CME engagement across professional roles remain underexplored in China. This study aims to addresses this gap by analyzing the participation and credit compliance of healthcare professionals in CME programs at a hospital in Guangdong Province over a five-year period (2019-2023) and to explore the differences across different professional titles and specializations.

A single-base mutation on the 5' UTR of BrATG5 confers the premature leaf senescence phenotype in Chinese cabbage.

BrATG5 encoding autophagy protein was fine-mapped through MutMap and KASP analysis, and its function in regulating leaf senescence was verified using virus-induced gene silencing and functional complementation assays in Chinese cabbage. Leaf senescence is the final stage of leaf development, and is accompanied by the breakdown of organelle and catabolism of chlorophyll and macromolecules. The generated nutrients are supplied to developing seeds or other growing organs.

EAAT2 dysfunction mediates acrylamide-induced excitotoxicity and neuronal damage in a SH-SY5Y/U251 co-culture model.

Acrylamide (ACR) is a pervasive environmental and workplace contaminant with established neurotoxic effects but unclear pathogenic mechanisms. In this study, we screened for potential ACR binding targets associated with neurotoxicity and identified the astrocytic glutamate transporter EAAT2. Molecular docking and dynamics simulations revealed that ACR interacts stably with the glutamate-binding pocket of EAAT2, potentially impairing transport function.

A Detection Approach for Wheat Spike Recognition and Counting Based on UAV Images and Improved Faster R-CNN.

This study presents an innovative unmanned aerial vehicle (UAV)-based intelligent detection method utilizing an improved Faster Region-based Convolutional Neural Network (Faster R-CNN) architecture to address the inefficiency and inaccuracy inherent in manual wheat spike counting. We systematically collected a high-resolution image dataset (2000 images, 4096 × 3072 pixels) covering key growth stages (heading, grain filling, and maturity) of winter wheat ( L.) during 2022-2023 using a DJI M300 RTK equipped with multispectral sensors.

A multilevel genomic approach to uncover causal connections between CPFE and lung cancer subtypes: A two-sample Mendelian randomization study.

Combined pulmonary fibrosis and emphysema (CPFE) and lung cancer cast intertwined shadows, yet the molecular nexus binding them remains largely obscured. By integrating high-resolution transcriptomic landscapes, extensive genome-wide association resources, and a stratified Mendelian randomization (MR) framework, we distilled 809 differentially expressed genes and, in successive steps, confirmed their causal ties to squamous cell carcinoma, adenocarcinoma, and small cell lung cancer. The credibility of these associations was bolstered through 3 sequential validation tiers - eQTL-anchored MR, eQTL-anchored SMR, and pQTL-anchored MR analyses - each reinforcing the robustness of the signals.

A potential strategy to rebuild the tumor immune microenvironment: PANoptosis.

The convergence and interplay of pyroptosis, apoptosis, and necroptosis have led to the conceptualization of PANoptosis, an innovative paradigm of inflammatory programmed cell death. Characterized by the hierarchical assembly and activation of the PANoptosome, PANoptosis operates through tightly orchestrated signaling hubs and is intricately linked to organelle functionality. Accumulating evidence underscores its pivotal role in diverse oncogenic processes, positioning PANoptosis as a compelling frontier for antitumor therapeutic exploration.

Associations of perceived stress with depression in medical students: the mediating role of rumination and the moderating role of emotional intelligence.

Background: Medical students have become a group with a high prevalence of depression and are particularly vulnerable to it. Recognizing the factors affecting depression among medical students is crucial. This study was aimed at exploring the effects of perceived stress on medical students' depression under the mediating role of the rumination and the moderating role of the emotional intelligence.

Giant Electrostriction via Nanodomain Engineering in Relaxor Ferroelectric Polymers.

Relaxor ferroelectric (RFE) polymers hold great promise for artificial muscles due to their high actuation strain, high loading stress, and fast response. However, the structural origin underlying their large electrostrictive deformation remains elusive. In this study, we investigate poly(vinylidene fluoride--trifluoroethylene) [P(VDF-TrFE)]-based RFE terpolymers, incorporating 1,1-chlorofluoroethylene (CFE) or chlorotrifluoroethylene (CTFE) (the terpolymers are denoted as terP-CFE and terP-CTFE, respectively) as termonomers.

High-dimensional functional boundaries search for deviation-robust testing of autonomous driving system.

Testing and evaluation are essential for verifying the safety of the intended function (SOTIF) of autonomous driving systems (ADS), which focuses on estimating the system's functional boundaries through a limited set of tests to assess its safe operational range. To achieve this, a series of valuable safety-margin scenarios must be designed as test cases. However, scenario testing faces the dilemma of the curse of dimensionality and the requirements for test coverage.

Analysis of the use of prophylactic ureteral stents in preventing iatrogenic ureteral injury during radical hysterectomy for cervical Cancer.

Objective: To assess the use of prophylactic ureteral stent for preventing ureteral injury in patients with cervical cancer undergoing radical hysterectomy.

Methods: This retrospective study included 304 patients with cervical cancer who underwent abdominal radical hysterectomy at Qilu Hospital of Shandong University (Qingdao) from June 2018 to June 2023. Patients were divided into the ureteral stent group (129 cases) and the control group (175 cases).

Mutation of a magnesium chelatase BrCHLD affects the chlorophyll content and magnesium chelatase activity in Chinese cabbage.

Magnesium chelatase (MgCh) catalyzes the insertion of Mg into protoporphyrin IX, which is essential for chlorophyll (Chl) biosynthesis. MgCh consists of three subunits, CHLI, CHLD, and CHLH subunits. However, previous studies have cloned only BrCHLI and BrCHLH genes in Chinese cabbage, and the mechanism by which BrCHLD regulates chlorophyll synthesis in Chinese cabbage has not been identified.

The role of Nrf2 signaling pathway in diabetic cardiomyopathy: from pathogenesis to traditional Chinese medicine interventions.

Diabetic cardiomyopathy (DCM), a common diabetic complication independent of hypertension, coronary heart disease and heart valve disease is a major cause of cardiovascular mortality. The pathogenesis of DCM is complex. The Nrf2-related signaling pathway which regulates oxidative stress, energy metabolism and mitochondrial physiology may play important role in the pathogenesis of DCM.

Temporomandibular joint disc position affects condylar bone modeling-A randomized controlled clinical trial.

Backgrounds: The primary controversy surrounding the treatment of anterior disc displacement (ADD) of temporomandibular joints (TMJ) stems from the unclear relationship between disc position and condylar adaptation. The long-term impact of varying disc position on condylar bone remodeling remains poorly understood.

Methods: A randomized controlled clinical trial was conducted to evaluate the effects of different disc positions on condylar bone modeling/remodeling at baseline (T0) and after an 18-month-follow-up (T1).

Effect of Galls on the Metabolism of Chrysanthemum Species Based on Metabolomic Profiling.

Introduction: Galls, which are abnormal or protruding tissues, form when insects bite plant cells and serve as evidence for understanding plant-insect interactions.

Objectives: This study is aimed at understanding the interactions between Chrysanthemum species and insects at the metabolomic level and to reveal the metabolic changes induced by insect galls.

Methodology: This study employed liquid chromatography-mass spectrometry (LC-MS) and gas chromatography-mass spectrometry (GC-MS), along with multivariate statistics and pathway enrichment, for metabolomic profiling of Chrysanthemum glabriusculum, including gall-infected and gall-free leaves, and reported the gall phenomenon in Chrysanthemum species for the first time.

New Strategies for the Treatment of Diabetic Foot Ulcers Using Nanoenzymes: Frontline Advances in Anti-Infection, Immune Regulation, and Microenvironment Improvement.

Diabetic foot ulcers are one of the most serious consequences of diabetes, arising from vascular impairment of the skin and disturbances in the microenvironment. This condition involves pathological changes such as wound infection, hyperglycemia, hypoxia, oxidative stress, and cellular dysfunction, necessitating multifaceted interventions. Traditional treatments often target only the wound itself, resulting in limited effectiveness.

Effect of temporomandibular joint anterior disc displacement on condylar height in different age groups.

Background: Temporomandibular joint ADD is highly prevalent and harmful, and some patients have no obvious clinical symptoms, but it can cause facial asymmetry, mandibular retrusion and other dental and maxillofacial deformities. Nevertheless, the impact of ADD on condylar height in individuals of varying age groups remains uncertain particularly with regard to condylar heights at different stages of development. The aim of this retrospective case-control study was to investigate the association between condylar height and temporomandibular joint anterior disc displacement (ADD) in different age groups.

Gut microbiota has the potential to improve health of menopausal women by regulating estrogen.

Menopause is an age-related loss of ovarian function. As a woman enters menopause, the estrogen produced by her ovaries decreases, which will adversely affect women's health. The symptoms related to menopause are related to the imbalance of gut microbiota.

Carbonyls Mediated Dual-Function Enables High-Performance Carbon Anodes in Ester-based Electrolyte.

Constructing an "ether solid electrolyte interphase (SEI)"-like layer in ester electrolyte is highly attractive to realize excellent capacity and cycling stability for hard carbon anode, but has barely been mentioned yet. Herein, the hard carbon grafted by caffeic acid is developed via a surface reconstruction strategy, in which rich C═O moieties are introduced. Varied characterizations reveal that the existing C═O exhibits stronger adsorption energy on salt (PF ) than solvent (e.

Dual-Functional High-Entropy Polymer Exhibiting Giant Cross-Energy Couplings at Low Fields.

A key component of cooling devices is the transfer of entropy from the cold load to heat sink. An electrocaloric (EC) polymer capable of generating both large electrocaloric effect (ECE) and substantial electroactuation can enable EC cooling devices to pump heat without external mechanisms, resulting in compact designs and enhanced efficiency. However, achieving both high ECE and significant electroactuation remains challenging.

Facile One-Step Fabrication of 1T-Phase-Rich Bimetallic CoFe Co-Doped MoS Nanoflower: Synergistic Engineering for Bi-Functional Water Splitting Electrocatalysis.

MoS has emerged as a highly promising catalyst for the hydrogen evolution reaction (HER) owing to its exceptional catalytic properties. However, there is a pressing need to further enhance its reactivity and integrate oxygen evolution reaction (OER) capabilities to facilitate its industrial implementation. In this context, a dual-metal doping approach presents a straightforward and effective strategy to achieve superior catalytic performance.

Optimizing Nitrogen Fertilization and Irrigation Practices for Enhanced Winter Wheat Productivity in the North China Plain: A Meta-Analysis.

This study aimed to systematically evaluate the effects of different nitrogen application rates and irrigation practices on water-saving and yield enhancement in winter wheat production in the North China Plain (NCP) using a meta-analysis. By quantifying the impacts on crop yield, nitrogen use efficiency (NUE), and water use efficiency (WUE), the research provides a scientific basis for optimizing management practices in winter wheat production in this region. A comprehensive literature search was conducted across multiple databases, resulting in the inclusion of 94 eligible studies from 2018 to 2023.

Serum growth differentiation factor 15 associates with extra-glandular manifestations and disease activity of primary Sjögren's syndrome.

Recent interest in growth differentiation factor 15 (GDF15) has been further heightened by its association with rheumatic diseases. GDF15 has been extensively studied as a potential diagnostic and prognostic biomarker. However, no direct evidence currently links GDF15 to primary Sjögren's syndrome (pSS).

Unsupervised learning-based quantitative analysis of CT intratumoral subregions predicts risk stratification of bladder cancer patients.

Background: Preoperative diagnosis of muscle invasion and American Joint Committee on Cancer (AJCC) stage plays a crucial role in guiding treatment strategies for bladder cancer (BCa). Utilizing quantitative analysis of tumor subregions via CT imaging holds promise in identifying high-risk populations. Developing and evaluating the performance of an unsupervised clustering algorithm-based intratumoral subregion radiomics model for distinguishing between bladder muscle invasion and AJCC stage.

Synergistic Adsorption and Fluorescence in Porous Aromatic Frameworks for Highly Sensitive Detection of Radioactive Uranium.

Uranium plays an important role in the modern nuclear industry. However, such a radioactive element can also cause severe damage to the environment once leaked or discharged into water or air, having a huge impact on the safety of the biosphere. In this work, we pioneered the use of fluorescent monomers as imprinted units, which promoted fluorescence emission of the material.

Advances and challenges in lipid droplet isolation from animal tissues and cells.

Lipid droplets (LDs) are essential intracellular organelles involved in lipid storage and metabolism, playing critical roles in various cellular processes and diseases. Researchers require efficiently isolate and analyze LDs to understand lipid metabolism and related pathologies. This review summarizes recent advances in LD isolation methods, including traditional techniques such as centrifugation and density gradient centrifugation, as well as emerging technologies like automated and high-throughput approaches.