Impact of telomere length on autoimmune thyroid disease in Europeans: insights from Mendelian randomization.

Objective: This study aimed to investigate the causal relationship between Telomere Length (TL) and Autoimmune Thyroid Disease (AITD) in Europeans using Mendelian Randomization (MR).

Methods: Single nucleotide polymorphisms associated with TL and AITD were obtained from genome-wide association studies. MR analysis was conducted using inverse variance weighted as the primary method.

Dual-Functional Microneedles for In Situ Diagnosis and Biofilm-Targeted Therapy of Diabetic Periodontitis via Biomarker-Responsive Probes and Photothermal NO Nanomotors.

Chronic periodontitis, a frequent complication of diabetes, is exacerbated by bacterial biofilms that drive progressive periodontal tissue destruction and systemic inflammation. Conventional treatments, utilizing mechanical debridement and systemic antibiotics, often fail to eradicate bacterial biofilms, promote antibiotic resistance, and lack real-time monitoring, leading to suboptimal therapeutic outcomes. Herein, we report a separable bilayer microneedle (MN) patch that enables localized, antibiotic-free, biofilm-targeted therapy and in situ biomarker-based monitoring for the integrated management of chronic periodontitis.

Identification of a novel variant (c.778A>G) associated with CHOPS syndrome.

CHOPS (cognitive impairment, coarse facies, heart defects, obesity, pulmonary involvement, short stature, and skeletal dysplasia) syndrome is an extremely rare disorder with multiple congenital anomalies caused by missense variants in the ALF transcription elongation factor 4 gene (). This study aimed to identify causative variants in a Chinese family with CHOPS syndrome. A Chinese girl with short stature, obesity, and developmental delay underwent comprehensive clinical and genetic evaluations, including karyotyping analysis, multiple ligation-dependent probe amplification, detection of aberrant methylation, whole exome sequencing, Sanger sequencing, and copy number variation analysis, followed by analyses.

Forest canopy closure estimation in mountainous southwest China using multi-source remote sensing data.

Forest canopy closure (FCC) is an important biological parameter to evaluate forest resources and biodiversity, and the use of multi-source remote sensing synergy to achieve high-accuracy estimate regional FCC at low cost is a current research hotspot. In this study, Shangri-La City, a mountainous area in southwest China, was considered as the research area. The satellite-borne LiDAR ICESat-2/ATLAS data were used as the main information source.

Experiences and Perspectives of Chronic Heart Failure Patients and Caregivers in Advance Care Planning-A Meta-Synthesis.

Background: Chronic heart failure (CHF) is a progressive life-limiting condition that necessitates early implementation of advance care planning (ACP). However, patients and caregivers encounter emotional, informational, and cultural barriers to effective ACP engagement. This meta-synthesis consolidates qualitative evidence to deepen our understanding of ACP practices in CHF care.

Predicting the Efficacy of Neoadjuvant Chemotherapy Combined with Immunotherapy for Esophageal Squamous Cell Carcinoma via Enhanced CT Radiomics Combined with Clinical Features.

IntroductionTo evaluate the predictive efficacy of enhanced Computed Tomograph(CT) radiomics combined with clinical features for assessing treatment response to neoadjuvant chemotherapy plus immunotherapy in esophageal squamous cell carcinoma (ESCC) patients.MethodsWe retrospectively analyzed 189 pathologically confirmed esophageal squamous cell carcinoma patients (treated between January 2020 and October 2024) who underwent neoadjuvant chemoimmunotherapy. Patients were stratified into remission and non-remission groups based on pathological response and randomly divided into training (n = 114) and testing (n = 75) sets (6:4 ratio).

0.01% atropine combined with carteolol hydrochloride can inhibit the scleral remodeling in guinea pigs with form-deprivation myopia.

Myopia is the most widespread refractive error caused by an increase in the axial length (AL) of the eyeball, and is also a major risk factor for other blinding eye diseases, seriously endangering human health and quality of life. Investigating practical methods to control the progression of myopia is therefore crucial. The only medication that has been shown to effectively delay the progression of myopia over an extended period of time is atropine.

Deciphering Mitochondria: Unveiling Their Roles in Mechanosensing and Mechanotransduction.

Mitochondria are highly dynamic organelles that are responsible for essential cellular functions such as calcium regulation, reactive oxygen species (ROS) production, metabolism, and apoptosis initiation. Mitochondrial dysfunctions are associated with a variety of pathologies, and the onset and progression of disease are accompanied by alterations in extracellular biochemical and mechanical signals. Recent studies have demonstrated that physicochemical cues, especially mechanical cues, exert pivotal roles in the organization of mitochondrial network and their metabolic functions.

Clinical effects, mechanisms and spread of erector spinae plane block and paravertebral block in thoracic surgery: a narrative review.

Resolving the controversies surrounding the anatomical spread, clinical effectiveness and safety of erector spinae plane block (ESPB) versus paravertebral block (PVB) is crucial for optimizing postoperative pain management in thoracic and breast surgery. This review systematically examines evidence published between 1 January 2014, and 1 January 2025, regarding the clinical efficacy, anatomical mechanisms, and complication profiles of ESPB and PVB, with a specific focus on their application in video-assisted thoracoscopic and breast surgery. Both ESPB and PVB significantly reduce postoperative pain and opioid consumption compared to controls (p<0.

The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative Catalyst.

This perspective critically examines the paradigm-shifting findings regarding cellular senescence's dual role in tissue biology, particularly focusing on its unexpected regenerative potential in hair growth. While cellular senescence has traditionally been viewed as a detrimental process associated with aging and tissue dysfunction, research has revealed its surprising beneficial effects on tissue regeneration. We analyze the groundbreaking discovery that senescent melanocytes can stimulate hair follicle stem cells through the osteopontin-CD44 signaling pathway, challenging the conventional understanding of senescence.

Genetic analysis of TMEM230 variants in Han Chinese patients with Parkinson's disease.

Parkinson's disease (PD) is a common neurodegenerative disorder characterized by bradykinesia, rigidity, tremor, and gait disturbance. The transmembrane protein 230 gene (TMEM230) was initially identified as a disease-causing gene in autosomal dominant PD while the role of TMEM230 in PD remains controversial. This study investigated the genetic role of TMEM230 variants in PD.

Spatiotemporal Land Use Change Detection Through Automated Sampling and Multi-Feature Composite Analysis: A Case Study of the Ebinur Lake Basin.

Land use change plays a pivotal role in understanding surface processes and environmental dynamics, exerting considerable influence on regional ecosystem management. Traditional monitoring approaches, which often rely on manual sampling and single spectral features, exhibit limitations in efficiency and accuracy. This study proposes an innovative technical framework that integrates automated sample generation, multi-feature optimization, and classification model refinement to enhance the accuracy of land use classification and enable detailed spatiotemporal analysis in the Ebinur Lake Basin.

Chinese herbal foot baths as a new strategy for diabetic foot with Wagner grade of 0 or 1: a meta-analysis and data mining.

Objective: The benefit of Chinese herbal foot-baths in treating diabetic foot remains unclear. This study aims to assess the efficacy of Chinese herbal foot-baths for diabetic foot with Wagner grade of 0 or 1 and identify key candidate herbs.

Methods: A comprehensive search of eight databases was conducted for studies published up to 24 May 2025.

Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets.

Extracellular matrix (ECM) is a dynamic, three-dimensional network that provides structural support and regulates key biological processes, including cell adhesion, migration, differentiation, and signal transduction. Its mechanical properties, such as stiffness, topology, and viscoelasticity, are crucial in normal and pathological conditions, influencing cell behavior through mechanotransduction pathways. Dysregulation of ECM is linked to various diseases, making a thorough understanding of its composition and properties essential.

Talquetamab improves patient-reported symptoms and health-related quality of life in relapsed or refractory multiple myeloma: Results from the phase 1/2 MonumenTAL-1 study.

Background: Talquetamab is the first approved G protein-coupled receptor family C group 5 member D-targeting bispecific antibody for the treatment of triple-class exposed relapsed/refractory multiple myeloma (RRMM) on the basis of results from the phase 1/2 MonumenTAL-1 study (ClinicalTrials.gov identifiers NCT03399799 and NCT04634552). This study describes patient-reported outcomes (PROs) among patients who received talquetamab in MonumenTAL-1.

Complete genomic characterization of global pathogens respiratory syntical virus and human norovirus using probe based capture enrichment.

Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract infections in children worldwide, while human noroviruses (HuNoV) are a leading cause of epidemic and sporadic acute gastroenteritis. Generating full-length genome sequences for these viruses is crucial for understanding viral diversity and tracking emerging variants. However, obtaining high-quality sequencing data is often challenging due to viral strain variability, quality, and low titers.

The effect of Zuogui-Jiangtang-Yishen decoction on the intestinal flora's response to L-α-phosphatidylcholine and L-tyrosine in patients with diabetic kidney disease: an study.

Background: Animal and cell studies have demonstrated that Zuogui-Jiangtang-Yishen decoction (ZGJTYS) has a favorable effect on the treatment of diabetic kidney disease (DKD). Our previous clinical research also showed that ZGJTYS prevents DKD in a manner similar to that of benazepril. Nevertheless, the interactions between ZGJTYS and the human gut microbiota require further investigation, particularly its interference in the intestinal flora response to food ingredients that may increase DKD risk, such as L-α-phosphatidylcholine and L-tyrosine.

Angoroside C: A potent AMPK activator in the aqueous extract of Scrophularia ningpoensis, alleviates metabolic syndrome in db/db mice.

Background: Scrophularia ningpoensis Hemsl. (SN) is a traditional herbal medicine used for treating diabetes mellitus (DM). Previous studies indicated that the aqueous extract of SN (AESN) improves type 2 DM (T2DM) by activating AMP-activated protein kinase (AMPK), but the active components were unclear.

Efficacy and optimal acupoints of auricular acupressure for treating prediabetes: a meta-analysis and data mining.

Background And Purpose: Auricular acupressure has potential in treating prediabetes; however, its effectiveness remains unclear. We aimed to evaluate the effect of auricular acupressure on blood glucose levels in patients with prediabetes and to identify optimal acupoints.

Methods: We searched nine public databases for randomized controlled trials published before March 1, 2025, according to pre-established inclusion and exclusion criteria.

mTOR-mediated nutrient sensing and oxidative stress pathways regulate autophagy: a key mechanism for traditional Chinese medicine to improve diabetic kidney disease.

Context: Autophagy plays a pivotal role in the pathogenesis of DKD, and the mechanistic target of rapamycin (mTOR) pathway, which regulates nutrient sensing and oxidative stress responses, is a key regulator of autophagy. Traditional Chinese Medicine (TCM) has garnered attention for its potential to treat DKD by modulating the mTOR signaling pathway, reducing oxidative stress, and restoring autophagic function.

Objective: The objective of this study is to examine how mTOR-mediated regulation of nutrient sensing and oxidative stress impacts autophagy in DKD, and to explore how TCM modulates these pathways to improve the condition.

From glacier forelands to human settlements: Patterns, environmental drivers, and risks of antibiotic resistance genes.

Antibiotic resistance genes (ARGs) are biological pollutants widely present in glaciers, such as ice, snow, and melt water. However, it remains unclear whether ARGs in glaciers influence their distribution in human settlements within the glacier basins. Therefore, we investigated the distribution pattern and driving factors of ARGs in the Laohugou glacier basins on the Tibetan Plateau.

[Metabolic Characteristics of F-FDG in Different Types of Myeloid Leukemia Cells and Tumor-Bearing Nude Mice].

Objective: To investigate the metabolic characteristics of F-fluorodeoxyglucose (F-FDG) in myeloid leukemia by in vitro culture of myeloid leukemia cells and construction of tumor-bearing nude mouse model.

Methods: U937, THP-1, HL60 and K562 cells were cultured . The cells in logarithmic growth phase (l×10 cells/well) were added with F-FDG, and the uptake rate of F-FDG was measured at 15, 30, 60 and 120 min after addation, respectively.

Natural small molecules regulating the mitophagy pathway counteract the pathogenesis of diabetes and chronic complications.

Diabetes mellitus (DM) is a chronic metabolic disorder marked by sustained hyperglycemia. These disturbances contribute to extensive damage across various tissues and organs, giving rise to severe complications such as vision loss, kidney failure, amputations, and higher morbidity and mortality rates. Furthermore, DM imposes a substantial economic and emotional burden on patients, families, and healthcare systems.

Role of short-chain fatty acids in non-alcoholic fatty liver disease and potential therapeutic targets.

Non-alcoholic fatty liver disease (NAFLD) is increasing worldwide and has become the greatest potential risk for cirrhosis and hepatocellular carcinoma. The metabolites produced by the gut microbiota act as signal molecules that mediate the interaction between microorganisms and the host and have biphasic effects on human health. The gut microbiota and its metabolites, short-chain fatty acids (SCFAs), have been discovered to ameliorate many prevalent liver diseases, including NAFLD.

Characterization of Key Aroma Compounds in Dongpo Pork Dish and Their Dynamic Changes During Storage.

The objective of this study was to identify the key aroma compounds of Dongpo pork dish (DPD) and to explore the changes in key aroma compounds of DPD during the storage period. Quantitative descriptive analysis (QDA) combined with two-dimensional gas chromatography-mass spectrometry (GC×GC-MS) was employed to investigate the aroma characteristics and the volatile profiles of DPD. Further, a sensomic approach was used to decipher its key aroma compounds.