PRKN/PINK1 Mutations in a Chinese Patient With Early-Onset Parkinson's Disease.

Background: PRKN and PINK1 gene mutations have been associated with Parkinson's disease (PD), particularly early-onset PD (EOPD).

Objectives: To describe the clinical and molecular features of a Chinese patient with EOPD who had uncommon PRKN and PINK1 mutations.

Methods: The patient's clinical history was reviewed, and whole-exome sequencing was performed to identify genetic mutations.

Targeting miR-337 mitigates disuse-induced bone loss.

Disuse-induced bone loss occurs in long-term bed-ridden patients and in astronauts during spaceflight. The underlying mechanisms are poorly understood. In a rodent model of disuse-induced bone loss (called hindlimb unloading (HU)), we observed that decreased numbers of leptin receptor (LepR) positive mesenchymal stem cells (MSCs) in adult bone marrow, contribute to bone loss.

Metabolic Mechanism of Qizhi Capsule for Treating Hyperlipoidemia Based on Chinmedomics Strategy.

To elucidate the active ingredients, and mechanism of action of Qizhi Capsules (QZC), a traditional Chinese patent medicine for the treatment of hyperlipidemia (HP). A high-fat diet-induced HP rat model was used to evaluate the therapeutic effect of QZC. Then, we integrated metabolomics, serum pharmacochemistry, network pharmacology, and molecular docking strategies for investigation.

Nuclear Magnetic Resonance Based Metabolomics-A Rising Star in Traditional Chinese Medicine Research.

Metabolomics, a promising field in the realm of omics, focuses on the investigation of alterations and patterns in the composition and abundance of metabolites generated by organisms under perturbation, directly linking measurable chemical reactions with biological events. Its research philosophy aligns harmoniously with the holistic perspective and syndrome differentiation and treatment principles of traditional Chinese medicine (TCM). Consequently, metabolomics has garnered unparalleled attention and has been widely applied in various fields of TCM research such as disease diagnosis, effective constituents and mechanism related with efficacy.

Telitacicept Inhibits the Maturation and Differentiation of B Lymphocytes in NMOSD.

Telitacicept, a novel recombinant fusion protein comprising the ligand-binding domain of the TACI receptor and the Fc component of human IgG, has rarely been studied for the treatment of neuromyelitis optica spectrum disorders (NMOSD). This study aimed to explore the effects of telitacicept in NMOSD mice. An NMOSD mouse model was constructed.

NDUFB9 ameliorates CUMS-induced depression-like behavior by promoting mitophagy.

Major depressive disorder (MDD) is characterized by persistent low mood and anhedonia. Mitochondrial dysfunction is linked to MDD, but the mechanisms are unclear. In this study, transcriptomic analysis of MDD patients' peripheral blood found three key genes: TFAM, SURF1, and NDUFB9.

miR-210-3p Ameliorates Metabolic Dysfunction-Associated Steatohepatitis-Related Fibrosis by Targeting ISCU and Induces Ferroptosis.

Background And Aims: Metabolic dysfunction-associated steatohepatitis (MASH)-related fibrosis plays an important role in MASH prognosis; however, the underlying mechanism remains unknown. Here, we explored the involvement of miR-210-3p in MASH-associated fibrosis.

Methods: We examined miR-210-3p expression in patients with MASH, with or without fibrosis using microarray analysis.

Heterogeneity of the adult mammalian forebrain neurogenic ependyma: a comprehensive cellular map.

The presence or absence of adult neural stem cells in the mammalian forebrain ependyma has been debated for two decades. In this study, we performed single-cell RNA sequencing to investigate the cellular composition of the ependymal surface of the adult mouse forebrain using whole mounts of lateral walls of lateral ventricles. We identified 12 different cell subtypes in the ependymal surface.

Phylogenomic incongruence in Castanopsis (Fagaceae) is primarily caused by gene flow rather than incomplete lineage sorting.

Reticulate evolution complicates phylogenetic reconstruction and obscures species delimitation. Investigating gene flow and its evolutionary consequences across the phylogenetic breadth of the genus provides critical insights into the mechanisms causing diversification within this lineage. By utilizing RAD-seq data from 39 Castanopsis species, we reconstructed phylogenetic relationships through both concatenation- and coalescent-based methods.

From bench to bedside: nanomedicine development for intracerebral hemorrhage - exploring microenvironment, innovation, and translation.

Intracerebral hemorrhage (ICH) carries a substantial global disease burden, and although it occurs less frequently than ischemic stroke, it results in a greater loss of disability-adjusted life years worldwide and is associated with one of the poorest prognoses among stroke patients. Due to the mechanisms of secondary injury following ICH, angiogenesis, inflammation, and oxidative stress (OS) levels in brain tissue are regulated by complex molecular pathways, leading to significant changes in the brain microenvironment (BME). While traditional treatments for ICH improve survival rates, they have notable drawbacks and limitations.

Genetic Loss of RORα Impairs Visual Function With Rod Bipolar Cell Degeneration In Mice.

Purpose: Retinoic acid receptor-related orphan receptor alpha (RORα) is a ligand-dependent nuclear receptor involved in eye development and diseases. Genetic variations of RORα have been linked with the development of age-related macular degeneration, yet whether RORα regulates visual function is unknown. In this study we investigated the role of RORα in regulating visual function in mice with genetic deficiency of RORα.

Clinical effects, mechanisms and spread of erector spinae plane block and paravertebral block in thoracic surgery: a narrative review.

Resolving the controversies surrounding the anatomical spread, clinical effectiveness and safety of erector spinae plane block (ESPB) versus paravertebral block (PVB) is crucial for optimizing postoperative pain management in thoracic and breast surgery. This review systematically examines evidence published between 1 January 2014, and 1 January 2025, regarding the clinical efficacy, anatomical mechanisms, and complication profiles of ESPB and PVB, with a specific focus on their application in video-assisted thoracoscopic and breast surgery. Both ESPB and PVB significantly reduce postoperative pain and opioid consumption compared to controls (p<0.

TREM2-Mediated Myeloid Cells Protect Against Pathological Choroidal Neovascularization.

Choroidal neovascularization (CNV) is a hallmark of neovascular age-related macular degeneration, a leading cause of irreversible vision loss in the elderly. While immune dysregulation and myeloid cell activation have been implicated in CNV pathogenesis, the molecular mechanisms by which myeloid subsets influence NV remain incompletely understood. Triggering receptor expressed on myeloid cells 2 (TREM2) is an immunomodulatory receptor enriched in microglia and tissue macrophages, known to play protective roles in retinal and neurodegenerative diseases.

Flexible, nonfused sulfone functionalized polymer with enhanced active site access for photocatalytic sacrificial hydrogen evolution.

The fused sulfone unit has been a key building block for hydrogen evolution photocatalysts for 9 years but still faces the challenge of a poor water/polymer interface due to its rigid structure. This work introduces nonfused, flexible sulfur segments (SSs) into the polymer's backbone to enhance hydrophilicity and active site access. Unlike rigid, fused sulfone moieties, our flexible SS improves interfacial water contact and charge transport.

Malleable, Self-Healing, and Highly Thermally Conductive Interface Material Enabled by Interfacial Networks for Thermal Management.

Heat dissipation has become a critical issue for the development of the microelectronic industry. Thermal interface materials (TIMs) play an important role in the thermal management of electronic devices, facilitating efficient heat transfer between components and heat sinks. However, the contradiction between high thermal conductivity, electrical insulation, and self-healing function is a bottleneck that restricts multifunctional applications of elastic TIMs.

GeneticPrism: Multifaceted Visualization of Citation-Based Scholarly Research Evolution.

Understanding the evolution of scholarly research is essential for many real-life decision-making processes in academia, such as research planning, frontier exploration, and award selection. Popular platforms like Google Scholar and Web of Science rely on numerical indicators that are too abstract to convey the context and content of scientific research, while most existing visualization approaches on mapping science do not consider the presentation of individual scholars' research evolution using curated self-citation data. This paper builds on our previous work and proposes an integrated pipeline to visualize a scholar's research evolution from multiple topic facets.

Ferulic Acid as an Anti-Inflammatory Agent: Insights into Molecular Mechanisms, Pharmacokinetics and Applications.

Ferulic acid (FA), a hydroxycinnamic acid derivative, is a key bioactive component in traditional medicinal plants including and . Accumulating evidence supports its therapeutic efficacy in inflammatory disorders, such as rheumatoid arthritis (RA) and ulcerative colitis (UC). FA exerts anti-inflammatory effects through (1) the regulation of inflammatory cytokine levels; (2) modulation of signaling pathways such as nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and janus kinase/signal transducer and activator of transcription (JAK/STAT); (3) amelioration of oxidative stress; and (4) regulation of immune cell homeostasis.

Impact of the COVID-19 Pandemic on Healthcare Utilization Rates and Obesity in Urban Minority Children With High Asthma Disease Burden: A Retrospective Cohort Study.

Background: The COVID-19 pandemic caused dramatic changes in daily routines, healthcare access, and utilization in children with asthma, particularly urban minority children with poorly controlled asthma.

Objectives: In this study, we aimed to elucidate changes in healthcare utilization, lung function, and weight as a result of the COVID-19 "shutdown" in patients followed at the Pediatric Asthma Center at the Children's Hospital at Montefiore.

Study Design: We conducted a retrospective cohort study including children aged 2-21 with physician-diagnosed persistent asthma.

Assessment of S100A8/A9 and resistin as predictive biomarkers for mortality in critically ill patients with sepsis.

Introduction: Sepsis is associated with high mortality. Early intervention is crucial to reducing sepsis-related mortality. This study aims to assess the clinical potential of S100A8/A9 and resistin as novel biomarkers for predicting mortality risk in sepsis patients.

Biodegradable Mg-Cu alloy inhibits HBV replication and hepatocellular carcinoma progression.

This study explores the biocompatibility and inhibitory effects of magnesium (Mg) and its alloy, specifically the Mg-Cu alloy, on hepatocellular carcinoma (HCC) cells. The importance of this research stems from the potential use of magnesium alloys as biomaterials in bone repair and tissue engineering, while their effects on cancer cells have not been thoroughly investigated. Existing literature shows that although the degradation properties and biocompatibility of magnesium alloys have been examined, their anticancer properties remain a topic of debate.

Cell-specific ferroptosis targeting tumors while sparing immune cells.

Ferroptosis serves as a pivotal mechanism in diverse clinical chemotherapeutics and physiological processes, profoundly impacting tumor metabolism and the tumor microenvironment. Recently, the immunosuppression induced by ferroptosis has raised major concerns regarding tumor recurrence upon ferroptosis-based antitumor therapies. However, due to the lack of cell specificity, the antitumor and immunosuppressive effects in ferroptosis are inherently intertwined.

Resilience of science after austerity.

In 2009, many governments implemented austerity measures. This often resulted in restrictions on science funding, increasing competition for funds. Here, we study the allocation of funding across universities by using a competitiveness measure from complexity science based on the bipartite network of universities and scientific subjects.

Harnessing natural products for myocardial infarction therapy: Mechanistic insights and translational opportunities.

Myocardial infarction (MI) continues to pose significant challenges in clinical treatment despite medical advancements. Natural products (NPs) derived from botanical and biological sources demonstrate considerable therapeutic potential through their ability to simultaneously address multiple pathological features of MI. This comprehensive review examines the past decade of research investigating the therapeutic effects of various classes of NPs, notably terpenoids, flavonoids, alkaloids, phenolic acids, and phenylpropanoids in MI treatment.