Facet-dependent Heterogeneous Fenton Reaction Mechanisms on Hematite Nanoparticles for (Photo)catalytic Degradation of Organic Dyes.

Although heterogeneous photo-Fenton reactions on nanoparticulate iron oxides effectively degrade organic pollutants, the underlying surface mechanisms remain debated. Here, we demonstrate how these pathways are modulated by specific hematite crystal facets. To investigate the influence of particle surface structure, methylene blue (MB) adsorption and photodegradation kinetics are examined using facet-engineered hematite nanoparticles with distinct exposed facets.

Correlation between the immune response to COVID-19 vaccines and the constitutions of traditional Chinese medicine.

Traditional Chinese Medicine (TCM) classifies individuals into constitution types that may influence physiological responses. SARS-CoV-2 vaccines induce spike-specific antibodies and activate B and T cells, including memory subsets. This study investigates whether TCM constitution types are associated with immune responses and adverse events following COVID-19 vaccination.

"Four-in-One" Strategy to Functionalize a Multiple Resonance Skeleton for Narrowband Ultrapure Green Emitters with Circularly Polarized Luminescence.

Novel chiral emitters are constructed using a "four-in-one" strategy through attachment of an octahydro-binaphthol unit onto a boron/nitrogen multiple resonance skeleton. They manifest ultrapure green emission peaking at 511 nm, a full width at half maximum of 22 nm, a Commission Internationale de l'Eclairage coordinate of 0.73, a small Δ of 0.

Deinagkistrodon acutus Venom Promotes Apoptosis of Vascular Tissue Cells Through PAR1, Leading To Mesenteric Vascular Damage.

The Deinagkistrodon acutus is the most widely distributed venomous snake in China, and its clinical manifestations are primarily characterized by hemorrhage and coagulation disorders. Previous studies have suggested that mesenteric vascular injury induced by Deinagkistrodon acutus venom may be the primary cause of hemorrhage in envenomation. Protease-activated receptor 1 (PAR1) is highly expressed in vascular tissues and plays an important role in regulating the structure and function of blood vessels.

Single cell-RNA sequencing reveal TOP2A as a key driver of hepatocellular carcinoma progression.

To investigate the biological functions of TOP2A in HCC using bioinformatics and single-cell RNA sequencing (scRNA-seq) methods, and to explore the functional consequences of TOP2A in HepG2 and Huh-7 cells with TOP2A knockdown. This study aims to provide new theoretical insights and potential therapeutic targets for the early diagnosis and targeted treatment of HCC. Through the analysis of single-cell RNA sequencing data, the immunological significance of TOP2A and its relationship with the diagnosis and prognosis of HCC were studied.

A hybrid supercapacitor containing NiO microflowers as cathode material with enhanced energy storage performance.

The NiO microflowers electrode material was synthesized through a simple and low-cost hydrothermal method using hexamethylenetetramine (HMTA) to provide hydroxide ions for the formation of corresponding precursors. On this basis, the effect of HMTA dosage on the morphology and electrochemical performance of nickel oxide was investigated. Two kinds of NiO powdered materials with distinct morphologies were successfully prepared.

High-performance color-tunable organic light-emitting diodes based on an exciplex-forming co-host.

Color-tunable organic light-emitting diodes (OLEDs) have great potential for use in information security, smart lighting, and wearable healthcare. However, the performance of color-tunable OLEDs is currently far from meeting practical requirements. Here we present high-performance color-tunable OLEDs based on a novel, to the best of our knowledge, exciplex-forming co-host.

Characterization of blaOXA-542-mediated carbapenem resistance in Acinetobacter baumannii.

Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) causes multiple anatomical site infections, representing a significant public health threat.

Aim: This study reports the isolation and characterization of a carbapenem-resistant A. baumannii harbouring blaOXA-542, followed by a comprehensive investigation of its antimicrobial resistance mechanisms and genomic characteristics.

Risk Factors for Recurrent Stroke and the Impact of Targeted Health Management.

Objective: This study aimed to identify the characteristics and risk factors associated with stroke recurrence in a Chinese patient population and to assess the effectiveness of targeted interventions addressing common stroke risk factors to inform stroke health management strategies.

Methods: A total of 1072 stroke patients who were hospitalized in Huai'an First People's Hospital from January 2018 to November 2020 were included in this study. Patients with recurrent stroke were assigned to the observation group (815 cases), while those experiencing a first-ever stroke were assigned to the control group (257 cases).

Blending coffee white tea with flower flavor rooibos to mask the burnt flavor.

Consumer preferences for rich flavor drive rapid growth in the new-style tea beverage market ($4.74 billion by 2030). Coffee-tea, a newly emerging product that integrates both coffee and tea flavor by blending process.

A multilevel genomic approach to uncover causal connections between CPFE and lung cancer subtypes: A two-sample Mendelian randomization study.

Combined pulmonary fibrosis and emphysema (CPFE) and lung cancer cast intertwined shadows, yet the molecular nexus binding them remains largely obscured. By integrating high-resolution transcriptomic landscapes, extensive genome-wide association resources, and a stratified Mendelian randomization (MR) framework, we distilled 809 differentially expressed genes and, in successive steps, confirmed their causal ties to squamous cell carcinoma, adenocarcinoma, and small cell lung cancer. The credibility of these associations was bolstered through 3 sequential validation tiers - eQTL-anchored MR, eQTL-anchored SMR, and pQTL-anchored MR analyses - each reinforcing the robustness of the signals.

meningitis in an immunocompetent patient diagnosed by metagenomic next-generation sequencing: a case report.

Cerebral nocardiosis caused by represents a rare and diagnostically challenging infectious disease, predominantly affecting immunocompromised patients. This opportunistic infection may also pose life-threatening risks to immunocompetent individuals. The diagnostic process is frequently complicated by the absence of distinctive clinical manifestations and technical limitations inherent to conventional microbiological detection methods, which collectively impede the acquisition of definitive pathogenic evidence, thereby resulting in diagnostic delays.

GLP-1-Mediated Pregnancy and Neonatal Complications in Mice.

Glucagon-like peptide 1 (GLP-1), a hormone derived from the proglucagon gene, regulates various physiological processes; however, its impact on pregnancy outcomes remains poorly understood. Assessing the effects of GLP-1 on neonates is vital as GLP-1 is increasingly administered during pregnancy. This study evaluates the effect of GLP-1 exposure on maternal complications and neonatal defects in mice.

Indole-3-acetic acid-mediated root exudates as potential inhibitors of antibiotic resistance genes in the rhizosphere microbiome: Mechanistic insights into microbial community assembly and resistome dissemination.

Although the threat of antibiotic resistance genes (ARGs) in agriculture to human health has raised concerns, there is still a lack of effective and environmentally friendly measures to mitigate antibiotic resistance. Indole-3-acetic acid (IAA) and root exudates are environmentally friendly natural substances. However, the development of technologies harnessing their potential to suppress agricultural ARGs remains unexplored.

Case Report: combined surgical and pharmacological management of basal ganglia cryptococcal meningoencephalitis.

Introduction: Cryptococcal meningoencephalitis involving the basal ganglia is exceedingly rare and poses diagnostic and therapeutic challenges due to its tumor-mimicking presentation. This case underscores the necessity of a multidisciplinary approach integrating surgical intervention and targeted antifungal therapy.

Case Presentation: A 47-years-old immunocompetent female presented with progressive headache and left-sided hemiparesis.

Role of eIF4E in mediating cytotoxic effect of HHT and ATO on AML cells in bone marrow microenvironment.

Background: The bone marrow (BM) microenvironment in acute myeloid leukemia (AML) shields leukemic cells from chemotherapy, fostering disease recurrence and progression.

Objectives: This study investigated the impact of eukaryotic initiation factor 4E (eIF4E) in AML progression and chemosensitivity, highlighting stroma-dependent chemoprotection mechanisms to develop potential microenvironment-directed therapies.

Methods: The GEO dataset was analyzed for the relationship between eIF4E mRNA expression and clinical characteristics in AML patients.

Natural killer cell granule protein 7 contributes to CD8 T cell-mediated platelet apoptosis in immune thrombocytopenia.

Background: CD8 T cells participate in the pathogenesis of primary immune thrombocytopenia (ITP). Natural killer cell granule protein 7 (NKG7) is essential for natural killer cell and CD8 T cell cytotoxicity. The function of NKG7 in CD8 T cells in ITP remains unclear.

Induced somatic mutation accumulation during skeletal muscle regeneration reduces muscle strength.

Aging is associated with a progressive decline in tissue function and regenerative capacity, partly due to genomic instability, one of the hallmarks of aging. Genomic instability encompasses DNA damage and the accumulation of somatic mutations in post-zygotic cells, yet the specific impact of these mutations on age-related tissue dysfunction remains poorly understood. To address this, we developed a mouse model in which genomic instability was induced specifically in muscle progenitor cells through targeted deletion of the Msh2 (ref.

Trastuzumab deruxtecan in patients from China with previously treated human epidermal growth factor receptor 2-positive locally advanced/metastatic gastric or gastroesophageal junction adenocarcinoma (DESTINY-Gastric06): results from a single-arm, multicenter, phase 2 trial.

Background: Trastuzumab deruxtecan (T-DXd; 6·4 mg/kg) is approved for metastatic human epidermal growth factor receptor 2 (HER2)-positive (HER2+) gastric or gastroesophageal junction (GEJ) adenocarcinoma after a trastuzumab-based regimen. We report the final analysis of DESTINY-Gastric06, evaluating T-DXd in pretreated patients from China with advanced HER2+ gastric cancers (GC).

Methods: The single-arm, multicenter, phase 2 DESTINY-Gastric06 trial (NCT04989816) enrolled patients from China with HER2+ (immunohistochemistry [IHC] 3+ or IHC 2+; locally documented) advanced gastric or GEJ adenocarcinoma with two or more prior treatments.

VUV photoelectron ionization source for molecular beam mass spectrometer and its application for SF discharge product detection.

This study developed a photoelectron ionization source (PEI) utilizing a compact vacuum ultraviolet (VUV) lamp for molecular beam mass spectrometer. Unlike conventional hot filament EI sources, the PEI source operates effectively at a pressure exceeding 0.1 Pa.

Orthodontic treatment in patients with chronic periodontitis significantly improves periodontal health.

Objective: To investigate alterations in inflammatory biomarkers and systemic homeostasis in patients with chronic periodontitis following orthodontic intervention.

Methods: Clinical data of 80 chronic periodontitis patients, treated between April 2019 and April 2024, were retrospectively analyzed. Patients were stratified into two groups: a control group (n=32) receiving standard periodontal therapy and a research group (n=48) undergoing additional orthodontic treatment.

Efficacy of thoracic paravertebral block with liposomal bupivacaine for postoperative analgesia in patients undergoing liver resection: A randomized controlled trial.

Patients often suffer from moderate to severe acute postoperative pain after liver resection, and the use of liposomal bupivacaine (LB) for pain management is widespread. However, no studies have demonstrated the effect of postoperative analgesia with LB administered via a thoracic paravertebral block (TPVB). The aim of this study was to evaluate the effects of TPVB-administered LB and standard bupivacaine (SB) on opioid sparing and postoperative recovery following liver resection METHODS: In this randomized, prospective, single-blind study, 96 patients were randomly (1:1) assigned to two groups.