Role of eIF4E in mediating cytotoxic effect of HHT and ATO on AML cells in bone marrow microenvironment.

Background: The bone marrow (BM) microenvironment in acute myeloid leukemia (AML) shields leukemic cells from chemotherapy, fostering disease recurrence and progression.

Objectives: This study investigated the impact of eukaryotic initiation factor 4E (eIF4E) in AML progression and chemosensitivity, highlighting stroma-dependent chemoprotection mechanisms to develop potential microenvironment-directed therapies.

Methods: The GEO dataset was analyzed for the relationship between eIF4E mRNA expression and clinical characteristics in AML patients.