VUV photoelectron ionization source for molecular beam mass spectrometer and its application for SF discharge product detection.

This study developed a photoelectron ionization source (PEI) utilizing a compact vacuum ultraviolet (VUV) lamp for molecular beam mass spectrometer. Unlike conventional hot filament EI sources, the PEI source operates effectively at a pressure exceeding 0.1 Pa.

Overexpression of STOML1 is associated with good prognosis in nasopharyngeal carcinoma.

Nasopharyngeal carcinoma (NPC) is a prevalent head and neck malignancy characterized by high recurrence rate, adversely affecting patient prognosis. The present study aimed to identify key genes and mechanisms affecting NPC prognosis using DNA microarray, bioinformatics analysis and clinical data integration. The gene expression profile of patients with NPC with favorable (n=12) and unfavorable (n=8) prognoses was assessed using cDNA profiling.

Pollen food allergy syndrome in China：current knowledge and future research needs.

Background: Pollen-food allergy syndrome (PFAS) is a distinct form of IgE mediated food allergy that occurs in individuals sensitized to pollen. The characteristics of PFAS vary across regions and exhibit significant heterogeneity due to differing pollen sensitization profiles.

Summary: Research on PFAS in China has primarily focused on Northern regions, where weed and tree pollen allergy, particularly to Artemisia, are prevalent.

Clinical Characteristics and Molecular Aetiology of Cytochrome P450 Oxidoreductase Deficiency Diagnosed in 46,XX Patients.

P450 oxidoreductase deficiency (PORD) affects cytochrome enzyme activities, causing various symptoms, such as adrenal insufficiency, disorders of sex development and skeletal malformations. This study aims to elucidate the clinical manifestations, genotype characteristics, diagnosis and management of 46,XX karyotype patients with PORD in China. A retrospective study included twelve 46,XX PORD patients in a Chinese tertiary medical center from 2004 to 2024.

Associations between urinary and blood heavy metal exposure and heart failure in elderly adults: Insights from an interpretable machine learning model based on NHANES (2003-2020).

Background: The relationship between heavy metal exposure and heart failure is complex and poorly understood. This study employs machine learning techniques to model these associations in a population aged 50 years and older from the National Health and Nutrition Examination Survey (NHANES). Our findings emphasize the need for continued investigation into the mechanisms of these associations and highlight the importance of monitoring and regulatory measures to mitigate heavy metal exposure in populations at risk.

Associations Between Physical Capability Markers and Risk of Coronary Artery Disease: A Prospective Study of 439,295 UK Biobank Participants.

: The relationship between sarcopenia and the incidence of coronary artery disease (CAD) is not well understood. This study aimed to investigate this relationship and the modifying effect of potential risk factors. : We conducted a prospective study including 439,295 individuals from the UK Biobank.

Developing a polygenic risk score for pelvic organ prolapse: a combined risk assessment approach in Chinese women.

Pelvic organ prolapse (POP), whose etiology is influenced by genetic and clinical risk factors, considerably impacts women's quality of life. However, the genetic underpinnings in non-European populations and comprehensive risk models integrating genetic and clinical factors remain underexplored. This study constructed the first polygenic risk score (PRS) for POP in the Chinese population by utilizing 20 disease-associated variants from the largest existing genome-wide association study.

Association of calcium supplement with risk of incident arrhythmia.

Background And Aims: Calcium plays a crucial role in cardiac electrophysiology, but the association between calcium supplement and the risk of incident arrhythmia remains unclear.

Objective: To investigate the relationship between habitual calcium supplement and incident risk of cardiac arrhythmia.

Methods: We conducted a prospective study of 480,972 participants from the UK Biobank.

Associations between blood selenium and serum neurofilament light chain: results of a nationwide survey.

Background: Selenium (Se) is essential for many nervous system functions including memory, cognition and coordination, which has also been linked to a variety of neurological disorders, such as epilepsy, Alzheimer's disease (AD) and Parkinson's disease (PD). Serum neurofilament light chain (sNfL) is a biomarker of neurologic diseases. Studies on the relationship between blood Se and sNfL are limited.

The clinical diversity and molecular etiology in 46, XY disorders of sex development patients without uterus.

Background: Disorders of sexual development (DSDs) are a group of rare conditions with a discordance of chromosomal, gonadal, or phenotypic features of the internal and/or external genitalia, which accounts for 0.5% of the population. The precise diagnosis of 46, XY DSDs without uterus is often obscure because of the similar clinical manifestations.

Systemic thrombosis with prothrombin Belgrade mutation in a Chinese patient: A case report.

Background: Thrombophilia contributes to a significant increased risk of venous thromboembolism and can be either inherited or acquired. Hereditary thrombophilia may arise from various gene mutations, some of which have not even been adequately reported or poorly understood. Previous studies reported a rare and novel missense mutation in the prothrombin gene (p.

Gut Microbiota and Bile Acid Metabolism in the Mechanism of Ginsenoside Re Against Nonalcoholic Fatty Liver Disease.

Gut microbiota and bile acid metabolism play crucial roles in the progression of nonalcoholic fatty liver disease (NAFLD). Early evidence demonstrates that Ginsenoside Re (Re) possesses pharmacological effects on NAFLD, but its mechanisms of action are not well understood. This study aimed to investigate the hepatic protective effects of Re in NAFLD and elucidate relevant mechanisms.

Miniature Thermoelectric Cooler for Long-Term Stable Dehydration for On-Site Breath Analysis by Direct Inlet Photoionization Ion Mobility Spectrometry and Mass Spectrometry.

Rapid and highly frequent measurements of exhaled breath hold significant value for disease diagnosis and exposure assessments. Direct inlet mass spectrometry and ion mobility spectrometry demonstrate great potential for on-site breath analysis, but their accuracy and sensitivity are notably affected by the high humidity in the breath samples. A miniature and continuous dehydration device based on dual-switching thermoelectric cold traps has been developed to efficiently reduce the humidity of breath gas from saturation to relative humidity of 4.

Risk Prediction Models for Frailty in Adult Maintenance Haemodialysis Patients: A Systematic Review and Methodological Appraisal.

Background: Frailty affects over 35% of maintenance haemodialysis (MHD) patients globally-2-3 times higher than the general elderly-and is strongly linked to higher mortality, hospitalisation, and functional decline. Despite its clinical impact, frailty is often underdiagnosed in dialysis settings due to inconsistent assessments and limited resources. Existing prediction models vary widely in predictors and methods, requiring systematic review to guide clinical use and improve risk-stratified care.

Multi-omics reveal the effects and regulatory mechanism of dietary echinocystic acid supplementation on abdominal fat and liver steatosis in broiler chickens.

The accumulation of abdominal fat and the metabolic dysfunction-associated fatty liver disease (MAFLD) are prevalent problems in the poultry industry, and seriously compromise broiler health and reduce economic benefits. Echinocystic acid (EA), a natural product with anti-inflammatory and antioxidant effects, has been demonstrated to reduce abdominal fat deposition and improve intestinal inflammation in mice. However, it has not been reported in poultry research.

Associations between systemic immune-inflammatory index and visceral adipose tissue area: results of a national survey.

Background: Global health issues related to obesity are growing. Visceral adipose tissue (VAT) significantly contributes to complications associated with obesity. Reducing adipose tissue accumulation can improves inflammation.

Ginsenoside Rd protects against acute liver injury by regulating the autophagy NLRP3 inflammasome pathway.

Ginsenoside Rd (Rd) is a bioactive compound predominantly found in Panax ginseng C.A. Meyer and Panax notoginseng (Burkill) F.

SQYC formula improves the efficacy of PD-1 monoclonal antibodies in MSS colorectal cancer by regulating dendritic cell mitophagy via the PINK1-Parkin pathway.

Background: Microsatellite stable (MSS) colorectal carcinomas (CRCs) exhibit poor responsiveness to immunotherapy such as immune checkpoint inhibitors (ICIs). In the realm of clinical cancer treatment, traditional Chinese medicines (TCMs) are extensively utilized for their immunomodulatory properties. Shen Qi Yi Chang (SQYC), a clinical prescription for CRC treatment, improve the life quality of CRC patients and enhance their immune function.

Mendelian randomization analysis reveals causal relationship between depression, antidepressants and benign paroxysmal vertigo.

Benign paroxysmal vertigo (BPV) is a common cause of dizziness, and some patients are comorbid with psychiatric disorders such as depression, requiring intervention with antidepressants. However, the causal association between BPV, depression and antidepressants has not been clearly established. We used two-sample bidirectional Mendelian randomization (MR) to analyze the causal association between BPV, depression, and antidepressants.

Identification of novel variants and candidate genes in women with 46,XX complete gonadal dysgenesis.

Background: 46,XX complete gonadal dysgenesis (46,XX-CGD) is a rare disorder of sexual development (DSD) characterized by primary amenorrhea and a lack of spontaneous pubertal development in individuals with a 46,XX karyotype despite the presence of female internal and external genitalia due to failure of bilateral ovarian development. The condition is genetically heterogeneous, and in most cases, its etiology is unknown. Determining the genetic cause would provide insights into potential targets for genetic diagnosis and counseling.

Shengqiyichang decoction regulates antitumor immunity in colorectal cancer by downregulating lymphocyte antigen 6 family member G6D via the protein kinase B/p38 mitogen-activated protein kinase signaling pathway.

The traditional Chinese medicine (TCM) formulation Shengqiyichang Decoction (SQYCD) has been reported to stimulate host immunity, and it has been administered for the treatment of colorectal cancer (CRC). Here, we applied network and bioinformatics analyses to elucidate the mechanisms by which SQYCD ameliorates CRC and validated its modes of action via and experiments. We identified 46 active compounds in SQYCD and selected 237 proteins as potential therapeutic targets in CRC, most notably p38 mitogen-activated protein kinase (p38⍺).