EdgeVidCap: A Channel-Spatial Dual-Branch Lightweight Video Captioning Model for IoT Edge Cameras.

With the deep integration of edge computing and Internet of Things (IoT) technologies, the computational capabilities of intelligent edge cameras continue to advance, providing new opportunities for the local deployment of video understanding algorithms. However, existing video captioning models suffer from high computational complexity and large parameter counts, making them challenging to meet the real-time processing requirements of resource-constrained IoT edge devices. In this work, we propose EdgeVidCap, a lightweight video captioning model specifically designed for IoT edge cameras.

Trastuzumab deruxtecan in patients from China with previously treated human epidermal growth factor receptor 2-positive locally advanced/metastatic gastric or gastroesophageal junction adenocarcinoma (DESTINY-Gastric06): results from a single-arm, multicenter, phase 2 trial.

Background: Trastuzumab deruxtecan (T-DXd; 6·4 mg/kg) is approved for metastatic human epidermal growth factor receptor 2 (HER2)-positive (HER2+) gastric or gastroesophageal junction (GEJ) adenocarcinoma after a trastuzumab-based regimen. We report the final analysis of DESTINY-Gastric06, evaluating T-DXd in pretreated patients from China with advanced HER2+ gastric cancers (GC).

Methods: The single-arm, multicenter, phase 2 DESTINY-Gastric06 trial (NCT04989816) enrolled patients from China with HER2+ (immunohistochemistry [IHC] 3+ or IHC 2+; locally documented) advanced gastric or GEJ adenocarcinoma with two or more prior treatments.

Oncogenic roles of young human de novo genes and their potential as neoantigens in cancer immunotherapy.

Young human de novo genes, recently emerging from non-coding regions, are expected to contribute to human-specific traits and diseases. However, systematic explorations of this connection have been lacking. Here, we report 37 recently originated de novo genes in humans, with their evolution and characteristics defined within an updated genomic context.

A bispecific antibody-drug conjugate targeting EGFR and HER3 in metastatic esophageal squamous cell carcinoma: a phase 1b trial.

Research on patients with advanced esophageal squamous cell carcinoma (ESCC) who have progressed on immunotherapy remains limited. BL-B01D1 is a first-in-class antibody-drug conjugate consisting of an EGFR-HER3 bispecific antibody bound to a topoisomerase I inhibitor (Ed-04) payload via a cleavable linker. Here, we present safety and efficacy data from a phase 1 study of BL-B01D1, in 82 patients previously treated for ESCC.

An Innovative Artificial Intelligence Classification Model for Non-Ischemic Cardiomyopathy Utilizing Cardiac Biomechanics Derived from Magnetic Resonance Imaging.

Significant challenges persist in diagnosing non-ischemic cardiomyopathies (NICMs) owing to early morphological overlap and subtle functional changes. While cardiac magnetic resonance (CMR) offers gold-standard structural assessment, current morphology-based AI models frequently overlook key biomechanical dysfunctions like diastolic/systolic abnormalities. To address this, we propose a dual-path hybrid deep learning framework based on CNN-LSTM and MLP, integrating anatomical features from cine CMR with biomechanical markers derived from intraventricular pressure gradients (IVPGs), significantly enhancing NICM subtype classification by capturing subtle biomechanical dysfunctions overlooked by traditional morphological models.

Baseline profile peripheral Tfh cells predict immune-related adverse events in immune checkpoint inhibitor therapy of gastrointestinal cancer.

Background: Immune checkpoint inhibitors (ICIs) have transformed cancer therapy but are limited by immune-related adverse events (irAEs). This study aimed to assess peripheral T cell profiles to identify irAEs biomarkers and construct predictive models.

Methods: In our study, we enrolled and followed 51 gastrointestinal cancer patients receiving anti-PD-1/PD-L1 therapies, with 22 developed irAEs (AE) and 29 didn't (NAE).

Claudin-18 isoform 2-specific CAR T-cell therapy (satri-cel) versus treatment of physician's choice for previously treated advanced gastric or gastro-oesophageal junction cancer (CT041-ST-01): a randomised, open-label, phase 2 trial.

Background: Claudin-18 isoform 2 (CLDN18.2) has emerged as a promising therapeutic target in gastric or gastro-oesophageal junction cancer. Satricabtagene autoleucel (satri-cel; also known as CT041), an autologous CLDN18.

A comprehensive pan-cancer analysis of LRFN4: its potential as a prognostic biomarker and therapeutic target for immunotherapy.

Background: LRFN4, characterized by leucine-rich repeats and fibronectin type III domains, has been implicated in various human diseases. However, its role in immune regulation and cancer prognosis remains unclear.

Methods: We performed a comprehensive analysis using datasets from The Cancer Genome Atlas (TCGA), Cancer Cell Line Encyclopedia (CCLE), Genotype-Tissue Expression Project (GTE x), UALCAN, Star Base, and Comparative Toxicogenomics Database (CTD), and observed significant dysregulation of LRFN4 in multiple cancers compared to normal tissues.

Comparison of immune checkpoint inhibitors in combination with chemotherapy versus chemotherapy alone in the first-line treatment of advanced gastric cancer patients with low PD-L1 expression: a systematic review and meta-analysis.

Background: Immune checkpoint inhibitors (ICIs) + chemotherapy became standard her2-GC first line treatment.

Objectives: The aim of this study is to investigate whether ICIs + chemo provides benefit for patients with low programmed death-ligand 1 (PD-L1) expression.

Design: This study is a systematic review and meta-analysis.

Inhibition of SFRP1 by microRNA‑206‑3p may be the underlying cause of osteosarcopenia.

Osteosarcopenia is characterized by a simultaneous decrease in bone mass and muscle quality. Thus, determining the common pathogenesis between osteoporosis and sarcopenia may aid in identifying a solution. Secreted frizzled-related protein 1 (SFRP1), a Wnt/β-catenin pathway inhibitor, reportedly decreases during the osteogenesis process and is increased in osteoporosis and sarcopenia mice models.

Research on the effects of different sugar substitutes-Mogroside V, Stevioside, Sucralose, and Erythritol-On glucose, lipid, and protein metabolism in type 2 diabetic mice.

Sugar substitutes that maintain the homeostasis of glucose, lipid, and protein metabolism are important for nutritional intervention in type 2 diabetes mellitus (T2DM). However, the specific metabolic effects remain unclear. The aim of this study was to systematically compare the effects of four common sugar substitutes on a high-fat diet (HFD) combined with a streptozotocin (STZ)-induced T2DM mouse model from the perspective of hepatic glucose, lipid, and protein metabolism.

Atezolizumab and Trastuzumab Plus Chemotherapy for ERBB2-Positive Locally Advanced Resectable Gastric Cancer: A Randomized Clinical Trial.

Importance: Effective treatment of locally advanced gastric cancer (GC) or gastroesophageal junction (GEJ) cancer remains a challenge.

Objective: To compare the efficacy and safety of atezolizumab plus trastuzumab plus capecitabine and oxaliplatin chemotherapy (XELOX) vs trastuzumab plus XELOX in Chinese patients with locally advanced human epidermal growth factor receptor 2 (ERBB2; formerly HER2)-positive GC or adenocarcinoma of the GEJ.

Design, Setting, And Participants: This was an open-label phase 2 randomized clinical trial conducted at 8 study sites in China.

Lignin-polybutylene adipate-co-terephthalate(PBAT)-starch@urea bilayer nanohybrid biocomposite enable superior controlled slow-released fertilizer with good water-retention.

Slow-release fertilizers (SRFs) have revolutionized agricultural practices by enhancing nutrient utilization efficiency and minimizing environmental contamination. However, conventional SRFs face significant limitations, including unpredictable release patterns, dependence on non-biodegradable synthetic coatings, and inadequate performance in arid soil conditions. To address these challenges, we have developed an innovative approach to transform agricultural waste biomass into a multifunctional lignin-based SRF with superior water retention properties.

A Neural Network Model for Intelligent Classification of Distal Radius Fractures Using Statistical Shape Model Extraction Features.

Objective: Distal radius fractures account for 12%-17% of all fractures, with accurate classification being crucial for proper treatment planning. Studies have shown that in emergency settings, the misdiagnosis rate of hand/wrist fractures can reach up to 29%, particularly among non-specialist physicians due to a high workload and limited experience. While existing AI methods can detect fractures, they typically require large training datasets and are limited to fracture detection without type classification.

GCBRGCN: Integration of ceRNA and RGCN to Identify Gastric Cancer Biomarkers.

Gastric cancer (GC) is a prevalent malignancy, and the discovery of biomarkers plays a crucial role in the diagnosis and prognosis of GC. However, current strategies for identifying GC biomarkers often focus on a single ribonucleic acid (RNA) class, neglecting the potential for multiple RNA types to collectively serve as biomarkers with improved predictive capabilities. To bridge this gap, our study introduces the GC biomarker relation graph convolution neural network (GCBRGCN) model which integrates the competing endogenous RNA (ceRNA) network with GC clinical informations and whole transcriptomics data, leveraging the relational graph convolutional network (RGCN) to predict GC biomarkers.

Efficacy and safety of KN026, a bispecific anti-HER2 antibody, in combination with KN046, an anti-CTLA4/PD-L1 antibody, in patients with advanced HER2-positive nonbreast cancer: a combined analysis of a phase Ib and a phase II study.

To evaluate the efficacy and safety of KN026, a novel bispecific HER2 (ECD2 and ECD4) antibody, plus KN046, a PD-L1, and CTLA4 bispecific antibody, in patients with advanced HER2-positive solid tumors. We conducted two sequentially designed phase Ib and II studies with similar target populations and evaluation schedules. The primary endpoints included safety, maximum tolerated dose (MTD), the recommended phase II dose (RP2D) for the phase Ib study, and the objective response rate (ORR) and duration of response (DoR) for the phase II study.

PD-1 antibody camrelizumab plus apatinib and SOX as first-line treatment in patients with AFP-producing gastric or gastro-esophageal junction adenocarcinoma (CAP 06): a multi-center, single-arm, phase 2 trial.

Alpha-fetoprotein-producing gastric or gastro-esophageal junction (AFP-G/GEJ) cancer, a rare gastric cancer subtype, exhibits increased angiogenesis and more immunosuppression than non-AFP-G/GEJ cancer. The potential benefits of anti-angiogenic agents and immunotherapy for this specific subtype remain unknown. This multi-center, single-arm, phase 2 trial (ClinicalTrials.

Effects of organic material addition on carbon cycling and soil fertility in paddy soil.

Soil organic carbon (SOC) plays a crucial role in plant nutrient supply and soil physical, chemical, and biological function regulation. Factors such as climate change, human activities, and farm management practices can adversely affect SOC. Here, paddy soil in the double-cropping rice area of Hunan Province of China was cultured with eight kinds of organic materials, and the effects of organic fertilization on SOC content, humus content, and soil carbon sequestration efficiency were analyzed.

Risk factors and prediction model of metabolic disorders in adult patients with pituitary stalk interruption syndrome.

Pituitary stalk interruption syndrome (PSIS) is an infrequently occurring congenital condition, and there exists a dearth of systematic investigative work focusing on the clinical features and long-term outcomes in adult patients. Individuals who have reached adulthood with PSIS are at an increased risk of developing metabolic disorders, including metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) or metabolic dysfunction associated fatty liver disease (MAFLD), which are also one of the main factors for the poor prognosis of these patients. An analysis was conducted on the clinical data of adult PSIS patients who visited the endocrinology department of the First Medical Center of the People's Liberation Army General Hospital from January 2005 to August 2023.

Comparative effects of different sugar substitutes: Mogroside V, stevioside, sucralose, and erythritol on intestinal health in a type 2 diabetes mellitus mouse.

Intestinal health disorders significantly contribute to the development of type 2 diabetes mellitus (T2DM). Sugar substitutes such as mogroside V (MOG), stevioside (ST), sucralose (TGS), and erythritol (ERT), are increasingly used in T2DM management as alternatives to sucrose (SUC). However, their effects on intestinal health in T2DM have not been fully compared.

Integration of network pharmacology, bioinformatics and experimental verification strategy to discover the pharmacological mechanisms of mogroside acts against pharyngitis.

Ethnopharmacological Relevance: Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu & Zhang, a popular herb in traditional Chinese materials, has been broadly employed in food and medicine homology. According to TCM, S.

Causal Relationship Between Mitochondrial DNA Copy Number and Intervertebral Disc Degeneration: A Bidirectional 2-Sample Mendelian Randomization Study.

Objective: The causal relationship between mitochondrial DNA copy number (mtDNA-CN) and intervertebral disc degeneration (IVDD) remains unclear. The study aimed to investigate the causal relationship between mtDNA-CN and IVDD using Mendelian randomization (MR) analyses.

Methods: The causal relationship between mtDNA-CN and IVDD was estimated using a bidirectional 2-sample MR method.

Cross-Domain Generalization for LiDAR-Based 3D Object Detection in Infrastructure and Vehicle Environments.

In the intelligent transportation field, the Internet of Things (IoT) is commonly applied using 3D object detection as a crucial part of Vehicle-to-Everything (V2X) cooperative perception. However, challenges arise from discrepancies in sensor configurations between vehicles and infrastructure, leading to variations in the scale and heterogeneity of point clouds. To address the performance differences caused by the generalization problem of 3D object detection models with heterogeneous LiDAR point clouds, we propose the Dual-Channel Generalization Neural Network (DCGNN), which incorporates a novel data-level downsampling and calibration module along with a cross-perspective Squeeze-and-Excitation attention mechanism for improved feature fusion.

Exploring the therapeutic efficacy difference in claudin18.2-targeted cell therapy revealed by single-cell sequencing.

Chimeric antigen receptor T cell (CAR T) therapy has been successfully used to treat hematological malignancies. Nonetheless, its application to solid tumors remains challenging. Our previous analysis of the ongoing clinical trial (NCT03874897) demonstrated promising results in patients with advanced CLDN18.