A Comprehensive Analysis and Forecast of Rabies Epidemic and Elimination Challenges - China, 2005-2023.

Introduction: The 2030 global target for eliminating dog-mediated human rabies, jointly proposed by the World Health Organization (WHO) and other international organizations, presents significant challenges for China. This study analyzes epidemiological trends (2005-2023), forecasts future case numbers, and compares China's progress with elimination strategies from the United States, Japan, and Brazil to optimize national rabies prevention and control approaches.

Methods: Descriptive statistics were used to analyze the spatiotemporal distribution of human rabies cases across China.

Bismuth sulfide-titania heterostructure used for photothermal amplified sonodynamic therapy against hypoxic tumor.

Hypoxia and electron-hole recombination are two obstacles limiting sonodynamic therapeutic efficacy against cancer. Herein, bismuth sulfide (BiS)-titania (TiO) heterostructure is designed based on the excellent photothermal property of BiS, which could improve intratumor oxygen content through increasing blood flow with the help of near infrared light. BiS-TiO heterostructure nanoparticles (NPs) present similar photothermal performance to BiS NPs, while BiS-TiO NPs show higher reactive oxygen species (ROS) generating ability than BiS NPs under ultrasonic irradiation.

Prognostic Factors and Survival Outcomes in Thyroid Cancer Patients With Bone Metastasis: Insights From a Population-Based Cohort Study.

Objectives: Thyroid cancer (TC) is the most common endocrine malignancy, and bone metastasis (BM) is the second most common type of metastasis after lung. BM is associated with a poor prognosis; however, relevant research remains limited. This study aims to evaluate the prognostic factors and survival outcomes in patients with thyroid cancer with bone metastasis (TCBM).

Surgical Outcomes of Video-Assisted Thoracic Surgery Combined With Computed Tomography-Guided Microwave Ablation for Lung Cancer Presenting as Multiple Ground-Glass Opacities: A 5-Year Retrospective Cohort Study.

Background: Multiple ground glass opacities (mGGOs) are frequently observed in patients with early-stage lung adenocarcinoma. The most appropriate and effective treatment for these mGGOs remains controversial. The purpose of this study was to retrospectively review the usefulness and safety of performing video-assisted thoracic surgery (VATS) combined with computed tomography (CT)-guided microwave ablation (MWA) in patients with synchronous multiple primary lung cancer (sMPLC) and to demonstrate the long-term surgical outcomes at our institute.

Reversible Thermochromic Phase Change Material Microcapsules With High Latent Heat via Cellulose Nanocrystal Stabilized Pickering Emulsion for Smart Coatings.

Thermochromic (TC) smart coatings are promising for temperature indicator and anti-counterfeiting. However, it is still a big challenge to fabricate multifunctional TC coatings with sustainable materials by facile approaches. Herein, reversible TC phase change material (PCM) microcapsules with high latent heat, stability, rapid color-response, and tunable color-changing temperature are facile prepared via cellulose nanocrystal (CNC) stabilized Pickering emulsion.

Development and validation of CT-based fusion model for preoperative prediction of invasion and lymph node metastasis in adenocarcinoma of esophagogastric junction.

Purpose: In the context of precision medicine, radiomics has become a key technology in solving medical problems. For adenocarcinoma of esophagogastric junction (AEG), developing a preoperative CT-based prediction model for AEG invasion and lymph node metastasis is crucial.

Methods: We retrospectively collected 256 patients with AEG from two centres.

Multifunctional PHC Bandage for Accelerated Wound Healing in Movable Parts.

Wound healing in movable parts poses challenges owing to frequent activities, leading to delayed recovery and heightened susceptibility to bacterial infections and inflammation. Although hydrogel-based dressings have been explored, their therapeutic effectiveness is limited by poor resistance to stimuli and low mechanical strength. Here, we present a novel multifunctional PHC bandage that prevents bacterial infection and capitalizes on the inherent mobility of the affected area to expedite the wound-healing process.

Enhanced prevention on postoperative atrial fibrillation by using anti-inflammatory biodegradable drug patch.

Postoperative atrial fibrillation (POAF) is the most prevalent form of secondary atrial fibrillation and increases the risk of adverse cardiovascular outcomes, such as stroke, heart failure and increased mortality. Herein, we designed an andrographolide (Andr)-loaded degradable polymer patch to deliver the drug directly to the atrial tissue for prevention of POAF. The sterile pericarditis (SP) rat model was adopted for highly relationship to clinical practice.

Development and validity of type II sulcus vocalis in excised canine larynx.

Objectives: This study aims to develop a sulcus vocalis model in the excised canine larynx and to investigate the validity of the model.

Methods: Type II sulcus vocalis was created by continuous intradermal suture in six excised canine larynges. We investigated the validity of the model based on phonatory (aerodynamic and acoustic) measures, laryngeal videostroboscopy (LVS), and histological examination.

Neurodevelopmental hijacking of oligodendrocyte lineage programs drives glioblastoma infiltration.

Glioblastoma (GBM) is an aggressive brain tumor with a highly invasive nature. Despite the clinical relevance of this behavior, the molecular underpinnings of infiltrating GBM cells in the peritumoral zone remain underexplored in patients. Here, we show that peritumoral progenitor-like GBM cells activate transcriptional programs associated with increased invasivity, synaptic activity, and NOTCH signaling.

Waterborne Polyurethane-Stabilized Hydrogel Coating with Lubrication and Antibacterial Properties on Medical Catheters.

Medical catheters require lubrication and antimicrobial properties to reduce complications, such as tissue trauma and bacterial infections. Coating hydrogel on the catheter surface is a promising strategy; however, it usually faces the challenge of weak interfacial adhesion, thus leading to coating delamination or fracture and failure. Here, a waterborne polyurethane (WPU)-triggered surface bonding strategy was presented to construct hydrogel coatings, which involved two key steps: (i) coating a sticky WPU layer on the catheter surface and (ii) dip-coating the WPU-coated catheter with a monomer solution consisting of quaternary ammonium chitosan (QCS), sulfobetaine methacrylate (SBMA), -vinylpyrrolidone (NVP), and zinc sulfate heptahydrate (ZnSO·7HO) for growing the hydrogel layer by ultraviolet initiation.

Chloroplast-targeting gold nanoclusters promoting leafy and fruit vegetables yields through improving photosynthesis.

Low solar energy utilization and reactive oxygen species (ROS) accumulation limit the growth of photosynthetic plants, including leafy and fruit vegetables. Herein, we developed chloroplast-targeted peptide-modified bovine serum albumin-gold nanoclusters (TBSA-Au NCs) for improving vegetable yields. The incorporation of chloroplast-targeted peptide could effectively improve the binding ability of Au NCs whether by foliar spraying or root fertilization.

Atomically dispersed cerium on copper tailors interfacial water structure for efficient CO-to-acetate electroreduction.

Electrosynthesis of acetate from carbon monoxide (CO) powered by renewable electricity offers one promising avenue to obtain valuable carbon-based products but undergoes unsatisfied selectivity because of the competing hydrogen evolution reaction. We report here a cerium single atoms (Ce-SAs) modified crystalline-amorphous dual-phase copper (Cu) catalyst, in which Ce SAs reduce the electron density of the dual-phase Cu, lowering the proportion of interfacial K ion hydrated water (K·HO) and thereby decreasing the H coverage on the catalyst surface. Meanwhile, the electron transfer from dual-phase Cu to Ce SAs yields Cu species, which boost the formation of active atop-adsorbed CO (CO), improving CO-CO coupling kinetics.

Genetic Variation in Ornamental and Growth Traits in Hybrid Populations of var. .

var. is an important genetic resource for the origin of Asiatic hybrid lilies and a vital edible lily resource in China. To develop new lily germplasm combining ornamental and edible values, this study conducted five hybrid combinations between var.

Tumor‑stroma ratio as a clinical prognostic factor in colorectal carcinoma: A meta‑analysis of 7,934 patients.

The tumor-stroma ratio (TSR) has been regarded as an important factor associated with tumor metastasis, based on the 'seed and soil' theory, which may have guiding significance for the selection of chemotherapy regimens. Therefore, a high TSR may be a new risk factor for tumor recurrence in patients with stage II colorectal cancer (CRC). The present study aimed to evaluate the prognostic value of TSR in CRC, especially for the computer-calculated TSR.

Advanced High-Entropy Halide Solid Electrolytes Enabling High-Voltage, Long-Cycling All-Solid-State Batteries.

Stable solid electrolytes are essential for advancing the safety and energy density of lithium batteries, especially in high-voltage applications. In this study, we designed an innovative high-entropy chloride solid electrolyte (HE-5, LiInScZrHfTaCl), using multielement doping to optimize both ionic conductivity and high-voltage stability. The high-entropy disordered lattice structure facilitates lithium-ion mobility, achieving an ionic conductivity of 4.

An Efficient HS-Tolerant Hydrogen Oxidation Electrocatalyst Enabled by a Lewis Acid Modifier for Fuel Cells.

Industrial hydrogen fuel typically comprises about 5 ppm of hydrogen sulfide (HS), incurring irreversible poisoning of platinum on carbon (Pt/C) catalyst in fuel cells. For realistic use, HS should be removed to below 4 ppb; this process, however, is challenging and costly. We describe an exceptional HS-tolerant yet high-performing hydrogen oxidation reaction (HOR) catalyst prepared by chemical grafting of chromic oxide (CrO) onto a molybdenum-nickel (MoNi) alloy.

Regulating Chemical Bonds in Halide Frameworks for Lithium Superionic Conductors.

Developing solid-state electrolytes (SSEs) is a critical task for advancing all-solid-state batteries (ASSBs) that promise a high energy density and improved safety. The dominant strategy in engineering advanced SSEs has been substitutional doping, where foreign atoms are introduced into the atomic lattice of a host material to enhance ionic conduction. This enhancement is typically attributed to optimized charge carriers' concentration or lattice structure alterations.

Okra juice used for rapid wound healing through its bioadhesive and antioxidant capabilities.

Rapid wound healing is of great importance as it plays a crucial role in the body's response to injury or trauma. Biological adhesives are generally easy to apply, allowing for quick and efficient wound closure. In this study, we develop a natural biological adhesive derived from okra juice through a simple and environmentally friendly producing process.

Integrating traditional machine learning with qPCR validation to identify solid drug targets in pancreatic cancer: a 5-gene signature study.

Background: Pancreatic cancer remains one of the deadliest malignancies, largely due to its late diagnosis and lack of effective therapeutic targets.

Materials And Methods: Using traditional machine learning methods, including random-effects meta-analysis and forward-search optimization, we developed a robust signature validated across 14 publicly available datasets, achieving a summary AUC of 0.99 in training datasets and 0.

WWC proteins-mediated compensatory mechanism restricts schwannomatosis driven by loss of function.

NF2-related schwannomatosis, previously known as neurofibromatosis type 2, is a genetic disorder characterized by nerve tumors due to gene mutations. Mice with deletion develop schwannomas slowly with low penetrance, hence inconvenient for preclinical studies. Here, we show that NF2, by recruiting E3 ubiquitin ligases β-TrCP1/2, promotes WWC1-3 ubiquitination and degradation.

Highly Tension-Strained Copper Concentrates Diluted Cations for Selective Proton-Exchange Membrane CO Electrolysis.

Electrolysis of carbon dioxide (CO) in acid offers a promising route to overcome CO loss in alkaline and neutral electrolytes, but requires concentrated alkali cations (typical ≥3 M) to mitigate the trade-off between low pH and high hydrogen evolution reaction (HER) rate, causing salt precipitation. Here we report a strategy to resolve this problem by introducing tensile strain in a copper (Cu) catalyst, which can selectively reduce CO to valuable multicarbon products, particularly ethylene, in a pH 1 electrolyte with 1 M potassium ions. We find that the tension-strained Cu creates an electron-rich surface that concentrates diluted potassium ions, contributing to CO activation and HER suppression.

Mechanism of sodium nitroprusside regulating ginseng quality.

The roots of Panax ginseng C. A. Meyer (ginseng) are one of the traditional medicinal herbs in Asian countries and is known as the "king of all herbs".

Metabolomics-based analysis of nitric oxide regulation of ginseng herb quality.

Background: Ginsenosides, the primary active ingredients in Panax ginseng, are secondary metabolites. However, their content varies significantly across batches due to differences in environmental conditions and production methods. Ecological stress can increase the levels of reactive oxygen species (ROS) in plants, and ROS can enhance secondary metabolism.