Computational Analyses Identified Three Diagnostic Biomarkers Associated With Programmed Cell Death for Lung Adenocarcinoma.

The high morbidity and mortality of lung adenocarcinoma (LUAD) are partly caused by a lack of sensitive and reliable molecular markers for early diagnosis. Programmed cell death (PCD) is a crucial process involved in tumorigenesis and immune regulation, and identifying PCD-correlated genes may contribute to the precision diagnosis and targeted therapy of LUAD. LUAD samples were acquired from UCSC Xena and Gene Expression Omnibus (GEO) database.

Liquid biopsy diagnostics for non-small cell lung cancer via elucidation of tRNA signatures.

Background: Lung cancer, particularly non-small cell lung cancer (NSCLC), accounts for about 85% of all lung cancer cases and remains a major global health challenge. Traditional diagnostic methods, such as chest X-rays and low-dose CT scans, have limitations, including high false-positive rates, radiation risks, and the invasiveness of tissue biopsies. This study aims to develop a non-invasive liquid biopsy approach for early NSCLC diagnosis.

Interplay between MRI-based axon diameter and myelination estimates in macaque and human brain.

Axon diameter and myelin thickness affect the conduction velocity of action potentials in the nervous system. Imaging them non-invasively with MRI-based methods is, thus, valuable for studying brain microstructure and function. Electron microscopy studies suggest that axon diameter and myelin thickness are closely related to each other.

Detecting glioblastoma infiltration beyond conventional imaging tumour margins using MTE-NODDI.

Glioblastoma (GBM) is the most common and aggressive brain tumour with starkresistance to available therapies, leading to relapse and a median survival of<15 months. A key cause of therapy resistance is diffuse infiltration oftumour cells into brain regions surrounding the tumour, which presents a majorclinical challenge as existing imaging techniques offer limited detection of theresectable margin. Here, we use diffusion weighted imaging (DWI) and apply themultiple echo time neurite orientation dispersion and density imaging(MTE-NODDI) model as a tool to detect tumour cells in the hard-to-distinguishmargin.

A robust machine learning model based on ribosomal-subunit-derived piRNAs for diagnostic potential of nonsmall cell lung cancer across multicentre, large-scale of sequencing data.

Nonsmall cell lung cancer (NSCLC) is a lethal cancer and lacks robust biomarkers for noninvasive clinical diagnosis. Detecting NSCLC at the early stage can decrease the mortality rate and minimise harm caused by various treatments. We curated 2050 samples from public tissue and plasma datasets including both invasive and noninvasive types, then supplemented with in-house pooled plasma and exosome samples.

Unveiling nonribosomal peptide synthetases from the ergot fungus involved in the formation of diverse ergopeptines.

Ergopeptines or their derivatives are widely used for treating neurodegenerative and cerebrovascular diseases. The nonribosomal peptide synthetase-d-lysergyl peptide synthetase A (LPSA) determines ergopeptine formation but the detailed mechanism remains to be elucidated. Here, we characterized two LPSAs from Cp-1 strain through heterologous expression in feeding with d-lysergic acid.

Multi-TE Diffusion MRI Dataset for Exploring Combined Diffusion-Relaxometry Methods in Microstructure Imaging.

Multi-echo-time (MTE) diffusion MRI (dMRI) offers several advantages over conventional single TE dMRI, including disentanglement of microstructural and compositional differences, reduction of bias in microstructural properties, and addition of sub-cellular T2 measures. However, MTE methods require additional data acquisition and complex model fitting. In this work, we share a comprehensive MTE dMRI dataset acquired from three healthy subjects in ten TE sessions (each with eight TEs: 62-132 ms and repeated measures at the shortest and longest TEs).

The L-shaped association between weight-adjusted-waist index and all-cause mortality in individuals with psoriasis: results from NHANES database retrospective cohort study.

Background: While obesity is widely recognized as a robust risk factor contributing to both the onset and exacerbation of psoriasis-a chronic, immune-mediated skin disorder-the relationship between the Weight-Adjusted-Waist Index (WWI), an emerging metric for the nuanced evaluation of obesity, and mortality rates specifically within the psoriatic population is uncharted territory in current medical academic research. This study investigated the associations of WWI with all-cause mortality among American individuals with psoriasis.

Methods: Data from the National Health and Nutrition Examination Survey (2003-2004, 2005-2006, 2009-2010, 2011-2012, and 2013-2014).

Atomic Layer Deposited Silicon Anode with Nanoporous Fluorinated Surface Modulation Enabling Invertible Electrochemical Lithium Storage.

Silicon anodes lose energy density during cycling due to baneful volume expansions and unfavorable interfacial rearrangements. In this work, silicon active materials are synthesized upon carbon black (CB@Si) using alternating pulses of SiCl4 and SiH by H/Cl exchange mechanism via atomic layer deposition. The loading and thickness of the deposited silicon material can be precisely tuned by changing the deposition cycle.

Exploring the role of ferroptosis in pemphigus: identification of diagnostic markers and regulatory mechanisms.

Background: Pemphigus is an autoimmune blistering disorder characterized by the loss of cell adhesion in the epidermis. Recent studies have suggested a potential link between ferroptosis, a form of regulated cell death dependent on iron, and various diseases. However, the role of ferroptosis-related genes in pemphigus remains largely unexplored.

Atypical tinea corporis with Id reaction: A case report and successful treatment with upadacitinib.

Atypical tinea corporis, characterized by clinical manifestations that resemble other skin disorders, can lead to misdiagnosis and delayed treatment. This 67-year-old male had a seven-month history of pruritic skin lesions resembling subcorneal pustular dermatosis. Dermatological exam and fungal culture confirmed -induced atypical tinea corporis.

EDIL3 regulates pulmonary artery smooth muscle cell proliferation and migration via integrin αVβ3/ERK1/2 axis in pulmonary hypertension.

The abnormal expression of matricellular proteins involved in pulmonary vascular remodelling can accelerate the development of pulmonary hypertension (PH). Epidermal growth factor-like repeats and discoidin I-like domains 3 (EDIL3) is a matrix protein associated with the onset and progression of various diseases, yet its role in PH remains unexamined. This research aims to assess the expression of EDIL3 in PH and to investigate its underlying mechanisms in the condition.

Involvement of Ferroptosis in Bullous Pemphigoid Pathogenesis.

Background: Bullous pemphigoid (BP) primarily affects the elderly and frequently coexists with ferroptosis-related conditions, such as cardiovascular and immune-mediated diseases. However, little is known about how ferroptosis affects BP formation. Here, we investigate the role of ferroptosis in the pathogenesis of BP and its impact on disease prognosis.

Development and validity of type II sulcus vocalis in excised canine larynx.

Objectives: This study aims to develop a sulcus vocalis model in the excised canine larynx and to investigate the validity of the model.

Methods: Type II sulcus vocalis was created by continuous intradermal suture in six excised canine larynges. We investigated the validity of the model based on phonatory (aerodynamic and acoustic) measures, laryngeal videostroboscopy (LVS), and histological examination.

Development of an FDM-TDLAS Sensor for Long-Term Online Monitoring of HS and CO to Predict Water Wall Corrosion Trends.

A laser sensor system was developed to be employed in power plants and specifically engineered for high-particulate and high-temperature environments to be applicable for the online monitoring of hydrogen sulfide (HS) and carbon monoxide (CO) near the furnace water wall. The system was designed based on frequency division multiplexing (FDM) and tunable diode laser absorption spectroscopy (TDLAS). A corrosion-resistant Herriott multipass cell was designed to withstand temperatures of up to 120 °C while providing an 18 m optical path length.

Genetically engineered bacteria-based nanocomposite synergistic HIFU for tumor therapy by changing the acoustic environment of tumor tissues.

High-intensity focused ultrasound (HIFU) is a novel non-invasive technique with tremendous potential applications. However, ensuring effectiveness and safety of HIFU therapy remains a substantial challenge. Changing the acoustic environment of tumor tissues is an emerging way to solve this problem.

Predictive value of the uric acid to high-density cholesterol ratio (UHR) combined with atherogenic index of plasma (AIP) for abnormal bone mineral density in type 2 diabetes mellitus patients.

Background And Aims: Osteoporosis, characterized by systemic bone mass reduction and microstructural deterioration, is a growing clinical and economic burden. Type 2 diabetes mellitus (T2DM) has been increasingly linked to poor bone health, elevating the risk of osteoporosis and fragility fractures. The uric acid to high-density lipoprotein cholesterol ratio (UHR) and atherogenic index of plasma (AIP) have emerged as novel metabolic indicators, but their combined role in predicting abnormal bone mineral density (BMD) remains unexplored.

Corrigendum to "Robust and compact light-induced thermoelastic sensor for atmospheric methane detection based on a vacuum-sealed subminiature tuning fork" [Photoacoustics 42 (2025) 100691].

[This corrects the article DOI: 10.1016/j.pacs.

Quality and reliability of pediatric pneumonia related short videos on mainstream platforms: cross-sectional study.

Background: Pediatric pneumonia remains a major global health concern, accounting for one of the leading causes of mortality among children under five years of age. With the prevalence of COVID-19, public attention to pediatric pneumonia has significantly increased. In recent years, short video platforms such as Bilibili, TikTok, and Kwai-boasting billions of global users-have emerged as critical channels for disseminating and accessing health-related information.

Calibration-free, high-sensitivity CO2 sensor based on cavity ringdown spectroscopy for real-time seed respiration monitoring.

A real-time, calibration-free, and high-sensitively CO2 sensor based on cavity ringdown spectroscopy (CRDS) has been developed, incorporating a Fabry-Pérot (F-P) cavity with a finesse of 6500 and an STM32-controlled ringdown acquisition scheme. The sensor enables CO2 concentration measurements at the ppb level. Allan variance analysis indicates a minimum detectable sensitivity of 1.

Correction: The impact of tax burden on welfare attitudes: Micro evidence from welfare states.

[This corrects the article DOI: 10.1371/journal.pone.

Roles of TLR4 in macrophage immunity and macrophage-pulmonary vascular/lymphatic endothelial cell interactions in sepsis.

In sepsis, acute lung injury (ALI) is a severe complication and a leading cause of death, involving complex mechanisms that include cellular and molecular interactions between immune and lung parenchymal cells. In recent decades, the role of Toll-like receptor 4 (TLR4) in mediating infection-induced inflammation has been extensively studied. However, how TLR4 facilitates interactions between innate immune cells and lung parenchymal cells in sepsis remains to be fully understood.