Bioelectrochemistry increases the risk of resistance genes proliferation and transfer with sulfamethoxazole pressure decreasing in constructed wetlands: An overlooked double-edged effect.

Microbial electrochemical system-enhanced constructed wetland (MES-CW) attracts more attention for antibiotic-contaminated wastewater treatment, but the effect of bioelectrochemistry on resistance genes is still unclear with the removal of antibiotic. In this study, the antibiotic resistance genes (ARGs) dynamics, driving factors and transmission mechanism in effluent and substrate samples were investigated under decreasing sulfamethoxazole (SMX) pressure. Bioelectrochemistry was suitable for reducing the risk of ARGs proliferation and transmission at concentration of 0.

Histopathological analysis of nauplii under different forms of mercury stress.

Inorganic mercury (Hg) and methylmercury (MeHg) have emerged as global pollutants owing to their long-term environmental stability and bioaccumulation. These heavy metals enter aquatic systems via industrial emissions, coal combustion, and natural processes, posing a serious threat to ecosystems and human health. This study assesses the impact of Hg and MeHg on the growth and development of brine shrimp () nauplii by analyzing the histopathological effects on their tissues.

Nicotinamide Solid Cosolvent Enhanced Two-Electron Zinc Peroxide Chemistry for Stable Neutral Zinc-Air Batteries.

Zinc-air batteries (ZABs) are promising energy storage systems due to their high energy density and sustainability. Neutral electrolytes effectively address the CO sensitivity and zinc corrosion issues in alkaline systems but face challenges such as hydrogen evolution reactions (HER) and sluggish oxygen reduction and evolution reactions (ORR/OER) dynamics. Herein, we introduce nicotinamide (NAM), a solid cosolvent with high donor number (DN) and acceptor number (AN) in neutral electrolyte.

Cross-lagged analysis of physical fitness and cognitive control in Chinese early adolescents.

This study aims to explore the relationship between physical fitness levels and cognitive control in Chinese early adolescents, focusing on longitudinal analysis to understand how these variables interact over time. Additionally, the study investigates the moderating effect of gender on this relationship. The study included 160 junior high students (aged 12-14) with gender-balanced participation (64 boys, 79 girls retained after attrition).

Spin-polarized d-orbital filling in cobalt catalysts boosts solution-mediated Li-O batteries.

The sluggish reaction kinetics in current Li-O batteries (LOBs) hinder the efficient nucleation and decomposition of insulating LiO on catalyst surfaces. Therefore, developing effective strategies to regulate LiO growth and elucidating the catalytic mechanism are essential for unlocking the full potential of LOB technology. Herein, a spin-polarized Co-based catalyst exhibits a significant reversible magnetization change (9.

An artificial-enzyme-equipped immunoregulator blocks platelet-mediated breast cancer hematogenous metastasis.

Platelet activation and adhesion on the surface of circulating tumor cells (CTCs) assist them in surviving within the vasculature and acquiring enhanced migratory potential. Simultaneously, protected by surrounding/covering "micro-thrombi," CTCs evade immune surveillance in circulation, thereby promoting hematogenous tumor metastasis. Based on this, we designed a self-assembling nanoenzyme drug GSNO@B (NO donor-modified GOx self-assembled with the hydrophobic drug BMS-202) against platelet-mediated tumor metastasis.

Effect of SGLT2 inhibitors on liver fat content: A meta-analysis.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major metabolic disorder linked to increased morbidity and mortality. Sodium-glucose co-transporter-2 (SGLT2) inhibitors, commonly used to manage type 2 diabetes (T2DM), have shown potential in reducing liver fat content (LFC). However, the magnitude and consistency of this effect remain uncertain.

Children's physical fitness and cognitive control in China: the moderating role of family support for physical activity.

Objective: This study aimed to explore the relationship between physical fitness and cognitive control in Chinese children, with a focus on gender differences and the moderating role of family support for physical activity (FSFPA).

Method: This study employed a cross-sectional design to assess 148 children aged 12-14 years from Guangzhou. Physical fitness was evaluated using the National Student Physical Fitness Standard, family support for physical activity (FSFPA) was measured with the validated Family Support for Physical Activity Scale, and cognitive control was assessed using the Stroop color-word task, Go/No-Go task, and task-cue paradigm.

Generation Dynamics of Broadband Extreme Ultraviolet Vortex Beams.

Light beams carrying orbital angular momentum (OAM) can be generated in the extreme ultraviolet and soft X-ray spectra by means of high harmonic generation (HHG). In HHG, phase properties of the drive laser, such as curvature, aberrations, and topological charge, are upconverted to the harmonic beams and coherently added to the inherent dipole phase. The strong nonlinearity of the HHG process, combined with the rapid phase variations corresponding to large OAM values in these vortex beams, leads to a high sensitivity to small variations in the driving field.

Comparison of Guide to Expression of Uncertainty in Measurement and Monte Carlo Method for Evaluating Gauge Factor Calibration Test Uncertainty of High-Temperature Wire Strain Gauge.

High-temperature strain gauges are widely used in the strain monitoring of the hot-end components of aero-engines. In the application of strain gauges, the calibration of the gauge factor (GF) is the most critical link. Evaluating the uncertainty of GF is of great significance to the accuracy analysis of measurement results.

Circulating Inflammatory Factors and Bidirectional Mendelian Randomization Analysis in Patients with Kawasaki Disease.

Background: Kawasaki disease (KD), also known as mucocutaneous lymph node syndrome, is a systemic immune vasculitis with an unclear etiology. It is often complicated by coronary artery disease. This study uses bidirectional Mendelian randomization (MR) to investigate the interaction between KD and circulating inflammatory factors, providing insights into their causal relationships.

Organelle-targeted BODIPY-conjugated platinum(IV) anticancer prodrugs for overcoming drug resistance.

Platinum-based chemotherapy, despite being a cornerstone of cancer treatment, faces significant challenges due to acquired drug resistance. To address this issue, we have designed three organelle-targeting platinum(IV) prodrugs conjugated with BODIPY fluorophores, enabling spatiotemporal control through green light irradiation. These BODIPY-Pt(IV) conjugates exhibit excellent stability in PBS buffer, demonstrating resilience under physiological conditions.

A room temperature rechargeable Li-LiNO battery with high capacity.

Lithium-ion batteries (LIBs) have become advanced energy storage technologies; however, specific capacity remains limited by the active materials in cathodes. Here, we report Li-LiNO batteries (LNBs) where LiNO in electrolyte serves as both active materials and ion conductor at room temperature. LNBs operate on a highly reversible redox between NO and NO, which results in an impressive areal capacity of 19 mAh cm at a plateau voltage of 1.

Characterizing post-compression of mJ-level ultrafast pulses via loose focusing in a gas cell.

The ability to generate high-intensity ultrashort laser pulses is a key driver for advancing the strong-field physics and its applications. Post-compression methods aim to increase the peak intensity of amplified laser pulses via spectral broadening through self-phase modulation (SPM), followed by temporal pulse compression. However, other unavoidable nonlinear self-action effects, which typically occur parallel to SPM, can lead to phase distortions and beam quality degradation.

Fast spectroscopic imaging using extreme ultraviolet interferometry.

Extreme ultraviolet pulses as generated by high harmonic generation (HHG) are a powerful tool for both time-resolved spectroscopy and coherent diffractive imaging. However, the integration of spectroscopy and microscopy to harness the unique broadband spectra provided by HHG is hardly explored due to the challenge to decouple spectroscopic and microscopic information. Here, we present an interferometric approach to this problem that combines Fourier transform spectroscopy (FTS) with Fourier transform holography (FTH).

Recent Progress of Three-Dimensional Graphene-Based Composites for Photocatalysis.

Converting solar energy into fuels/chemicals through photochemical approaches holds significant promise for addressing global energy demands. Currently, semiconductor photocatalysis combined with redox techniques has been intensively researched in pollutant degradation and secondary energy generation owing to its dual advantages of oxidizability and reducibility; however, challenges remain, particularly with improving conversion efficiency. Since graphene's initial introduction in 2004, three-dimensional (3D) graphene-based photocatalysts have garnered considerable attention due to their exceptional properties, such as their large specific surface area, abundant pore structure, diverse surface chemistry, adjustable band gap, and high electrical conductivity.

A Supramolecular Deep Eutectic Electrolyte Enhancing Interfacial Stability and Solution Phase Discharge in Li-O Batteries.

Li-O batteries (LOBs) have gained widespread recognition for their exceptional energy densities. However, a major challenge faced by LOBs is the lack of appropriate electrolytes that can effectively balance reactant transport, interfacial compatibility, and non-volatility. To address this issue, a novel supramolecular deep eutectic electrolyte (DEE) has been developed, based on synergistic interaction between Li-bonds and H-bonds through a combination of lithium salt (LiTFSI), acetamide (Ace) and boric acid (BA).

A Bimetallic Electro-Sensitizer Improves ROS Therapy by Relieving Autophagy-Induced ROS Tolerance and Immune Suppression.

Reactive oxygen species (ROS)-dependent monotherapy usually demonstrates poor therapeutic outcomes, due to the accompanied activation of protective autophagy in tumor cells, which results in ROS tolerance and immune suppression. In this study, a bimetallic electro-sensitizer, Pt-Ir NPs is constructed, loaded with the autophagy inhibitor chloroquine (Pt-Ir-CQ NPs), to enhance the effectiveness of electrotherapy by inhibiting autophagy and activating anti-tumor immune responses. This novel electrotherapy platform demonstrates unique advantages, particularly in the treatment of hypoxic and immunosuppressive tumors.

The correlation between serum angiopoietin-2 levels and acute kidney injury (AKI): a meta-analysis.

Introduction: The correlation between serum angiopoietin-2 levels and acute kidney injury (AKI) is a topic of significant clinical interest. This meta-analysis aims to provide a comprehensive evaluation of this relationship.

Content: A systematic search was conducted in PubMed, Embase, Web of Science, and Cochrane databases up to October 11, 2023.

Electrically activated polymetallic nanocrystals for long-term tumor suppression via oxygen-independent ROS generation and electro-immunotherapy.

The low oxidation level and immunosuppressive microenvironment within hypoxic tumor tissue are critical factors contributing to the inefficacy of various anti-tumor strategies. Herein, we have designed a novel intravenous injection nanoplatform to conduct electro-immunotherapy, based on phospholipid-modified PtPd nanocrystals loaded with the immunoregulator IPI549 (LP@Pt-Pd@IPI549 nanoparticles, LPPI). LPPI responds to reactive oxygen species (ROS), triggering a cascade of therapeutic effects that overcome hypoxia-related resistance and effectively eradicate hypoxic tumors.

Regulating Sulfur Redox Kinetics by Coupling Photocatalysis for High-Performance Photo-Assisted Lithium-Sulfur Batteries.

Challenges such as shuttle effect have hindered the commercialization of lithium-sulfur batteries (LSBs), despite their potential as high-energy-density storage devices. To address these issues, we explore the integration of solar energy into LSBs, creating a photo-assisted lithium-sulfur battery (PA-LSB). The PA-LSB provides a novel and sustainable solution by coupling the photocatalytic effect to accelerate sulfur redox reactions.

Super-Ionic Conductor Soft Filler Promotes Li Transport in Integrated Cathode-Electrolyte for Solid-State Battery at Room Temperature.

Composite polymer solid electrolytes (CPEs), possessing good rigid flexible, are expected to be used in solid-state lithium-metal batteries. The integration of fillers into polymer matrices emerges as a dominant strategy to improve Li transport and form a Li-conducting electrode-electrolyte interface. However, challenges arise as traditional fillers: 1) inorganic fillers, characterized by high interfacial energy, induce agglomeration; 2) organic fillers, with elevated crystallinity, impede intrinsic ionic conductivity, both severely hindering Li migration.

Amphipathic Phenylalanine-Induced Nucleophilic-Hydrophobic Interface Toward Highly Reversible Zn Anode.

Aqueous Zn-ion batteries (AZIBs), recognized for their high security, reliability, and cost efficiency, have garnered considerable attention. However, the prevalent issues of dendrite growth and parasitic reactions at the Zn electrode interface significantly impede their practical application. In this study, we introduced a ubiquitous biomolecule of phenylalanine (Phe) into the electrolyte as a multifunctional additive to improve the reversibility of the Zn anode.

Sanmiao wan alleviates inflammation and exhibits hypouricemic effect in an acute gouty arthritis rat model.

Ethnopharmacological Relevance: Sanmiao wan (SMW), a classical traditional Chinese medicine (TCM) formula, has been employed to treat gouty diseases in clinic as early as Yuan dynasty. It shows remarkably therapeutic effects in acute gouty arthritis (GA). However, the potential mechanisms of SMW are still not fully revealed.