Tripartite influence and social comparison theories for explaining eating disorder psychopathology in Chinese boys and girls: A longitudinal network perspective.

The present study used longitudinal network analysis to investigate the applicability of the tripartite influence model (TIM) and social comparison theories in explaining eating disorder (ED) psychopathology among Chinese adolescents. A total of 1428 Chinese adolescents (607 boys, 821 girls) participated in a four-wave longitudinal study over 18 months. Separate within-person contemporaneous and temporal networks were estimated for boys and girls, both demonstrating adequate network stability.

Disrupting tumor homeostasis with an autoamplificatory nanoinducer to augment pyroptosis for efficient immunotherapy.

Abnormal tumor homeostasis is crucial in maintaining tumor cell survival and growth. Thus, developing effective antitumor strategies that can simultaneously disrupt multiple intracellular homeostatic mechanisms may be more effective and less laborious. Herein, an autoamplificatory nanoinducer (CLRN) composed of photosensitizer Ce6, glucose metabolism inhibitor lonidamine and methyltransferase inhibitor RG108 is designed and constructed to enhance pyroptosis and upregulate immunosurveillance by disrupting intracellular redox and metabolic homeostasis.

The potential risk of microplastics accumulation in farmland soils and vegetables from the development of rural tourism.

Development of rural tourism, such as in the Erhai Lake region of China's Yunnan Province, can lead to significant increases in farmers' incomes. However, the large amounts of plastic waste generated by tourism activities may increase microplastics (MPs) concentrations in surrounding farmland soils and pose a risk to human health. Here, we investigated the abundance and characteristics of MPs in farmland soils and vegetables in the Erhai Lake region.

Amplification of cGAS-STING pathway with "single-molecule multitarget" nanoparticles for chemo-immunotherapy of ovarian cancer.

With a low autoimmune risk and dedicated induction of type Ⅰ interferon production in immunotherapy, "STING therapy" holds broad prospects in the treatment of aggressive and metastatic cancers such as ovarian cancer (OC). Inducing pyroptosis constitutes a promising approach for activating the anti-tumor immune response. Nevertheless, compared to combination therapies, "single-molecule multitarget" drugs possess the merits of a lower interaction risk, more predictable pharmacokinetics and a lower cost of clinical trials.

Pairwise encounters boost bacterial motion by transient velocity spikes.

For swimming bacteria near surfaces, pairwise encounters inevitably occur and impact their social behavior. However, we know little about how the encounter events influence bacterial dynamics due to the limitations in tracking interplaying bacteria in 3D. Herein, we elucidated the motions of encountering E.

Brief antibiotic use drives human gut bacteria towards low-cost resistance.

Understanding the relationship between antibiotic use and the evolution of antimicrobial resistance is vital for effective antibiotic stewardship. Yet, animal models and in vitro experiments poorly replicate real-world conditions. To explain how resistance evolves in vivo, we exposed 60 human participants to ciprofloxacin and used longitudinal stool samples and a new computational method to assemble the genomes of 5,665 populations of commensal bacterial species within participants.

Case report: Whole exome sequencing identifies a novel variant in the gene in a male with developmental delay.

Lesch-Nyhan syndrome (LNS, OMIM #300322) is a rare X-linked genetic disorder caused by variants in the gene, which codes for the Hypoxanthine-guanine phosphoribosyltransferase (HGPRT). gene variants disrupt normal purine metabolism, leading to the involvement of multiple organ systems, primarily characterized by hyperuricemia, dystonia, and neurological abnormalities, which makes LNS clinically heterogeneous and diagnostically challenging. Here, we report a rare case of a 27-year-old Chinese male exhibiting severe lower limb motor disorders, hyperuricemia, and intellectual development delay.

Development and validation of a graph convolutional network (GCN)-based automatic superimposition method for maxillary digital dental models (MDMs).

Objectives: To validate the accuracy and reliability of a graph convolutional network (GCN)-based superimposition method of a maxillary digital dental model (MDM) by comparing it with manual superimposition and quantifying the clinical error from this method.

Materials And Methods: Based on a GCN, learning the features from 100 three-dimensional digital occlusal models under supervision of the palatal stable structure labels that were manually annotated by senior specialists, the palatal stable structure was automatically segmented. The average Hausdorff distance was calculated to assess the difference between automatic and manual segmentations.

Feasibility using a compact fiber optic Sagnac interferometer for non-contact soft tissue surface mechanical wave speed detection.

The Sagnac interferometer offers distinct advantages in vibrational wave detection. In this study, an air-coupled transducer and a compact fiber-optic Sagnac interferometer were developed for non-contact elasticity characterization in biological tissues. Given the challenge of limited light collection by a compact fiber optic Sagnac interferometer in biological tissues, this study aims to explore the potential of using a compact Sagnac interferometer to measure vibrational waves in biological tissues.

Displacement measurement with CCD Moiré method considering the relative rotation of gratings.

Utilizing the periodic pixel configuration of the CCD/CMOS imaging sensor as the reference grating and the image of the real grating formed by the lens as the specimen grating, the CCD Moiré method directly outputs amplified Moiré fringes, facilitating high-resolution, full-field deformation measurement. Due to the amplification effect of CCD Moiré, even minor relative rotations of the two gratings can significantly affect Moiré imaging and introduce measurable errors. This paper mainly addresses the imaging and measurement challenges of in-plane rotation in the CCD Moiré method.

A Integrated Molecule Based on Ferritin Nanoplatforms for Inducing Tumor Ferroptosis with the Synergistic Photo/Chemodynamic Treatment.

Ferroptosis combined with photodynamic therapy (PDT) has emerged as a powerful approach to induce cancer cell death by producing and accumulating lethal reactive oxygen species (ROS) in the tumor microenvironment (TME). Despite its efficacy and safety, challenges persist in delivering multiple drugs to the tumor site for enhanced antitumor efficacy and improved tissue targeting. Hence, we designed a method of inducing ferroptosis through laser-mediated and human homologation-specific efficient activation, which is also a ferroptosis therapy with higher safety through ROS-mediated.

Metagenomic Insights into the Enhancement of Bioavailable Nitrogen in Continuous Cropping Soil Through the Application of Traditional Chinese Medicine Residue Following Fumigation.

Chemical fumigation can effectively inhibit the occurrence of soil-borne diseases; however, this approach can negatively affect the structure of the soil microbial community. The combination of soil fumigant and organic fertilizer application thus represents a widely adopted strategy in agricultural practice. Traditional Chinese medicine residue (TCMR) is a high-quality organic fertilizer; however, the impact of post-fumigation TCMR application on keystone taxa and their functional traits remains uncertain.

Mitigating saturation effects in rice nitrogen estimation using Dualex measurements and machine learning.

Nitrogen is essential for rice growth and yield formation, but traditional methods for assessing nitrogen status are often labor-intensive and unreliable at high nitrogen levels due to saturation effects. This study evaluates the effectiveness of flavonoid content (Flav) and the Nitrogen Balance Index (NBI), measured using a Dualex sensor and combined with machine learning models, for precise nitrogen status estimation in rice. Field experiments involving 15 rice varieties under varying nitrogen application levels collected Dualex measurements of chlorophyll (Chl), Flav, and NBI from the top five leaves at key growth stages.

Enhancing Nitrogen Nutrition Index estimation in rice using multi-leaf SPAD values and machine learning approaches.

Accurate nitrogen diagnosis is essential for optimizing rice yield and sustainability. This study investigates the potential of using multi-leaf SPAD measurements combined with machine learning models to improve nitrogen nutrition diagnostics in rice. Conducted across five locations with 15 rice cultivars, SPAD values from the first to fifth fully expanded leaves were collected at key growth stages.

Lignin-based hyper-cross-linked resin as an adsorbent for aniline from aqueous solution.

Lignin serves as an ideal substrate for the synthesis of chemically functionalized hyper-cross-linked resins due to the structural composition of its aromatic rings, aliphatic side chains, and multiple active functional groups. These resins have shown to be highly effective in the adsorption of aromatic compounds. In this study, hyper-cross-linked polymer (HCPs-3), synthesized using 1,3,5-triphenyl and lignin, demonstrated a significant adsorption capacity for aniline, with a maximum adsorption capacity (q) of 189.

Ultra-Fast Degradation of Mustard Gas Simulant by Titanium Dioxide-Phosphomolybdic Acid Sub-1 nm Nanobelts.

The development of novel catalysts for the rapid detoxification of sulfur mustard holds paramount importance in the field of military defense. In this work, titanium dioxide-phosphomolybdic acid sub-1 nm nanobelts (TiO/PMA SNBs) are employed as effective catalysts for the ultra-fast degradation of mustard gas simulants (2-chloroethyl ethyl sulfide, CEES) with 100% selectivity and a half-life (t, time required for 50% conversion) as short as 12 s, which is the fastest time to the best of the knowledge. Even in dark conditions, this material can still achieve over 90% conversion within 5 min.

Negative emotional eating patterns in Chinese adolescents: A replication and longitudinal extension with latent profile and transition analyses.

This study, which is a longitudinal extension of previous cross-sectional studies in Chinese and American college students and general adults (Dixit, He, Whited, Ellis, & Zickgraf, 2023; He, Chen, Wu, Niu, & Fan, 2020; Xu et al., 2024), used latent profile and latent transition analyses to investigate negative emotional eating patterns and the stability of these patterns in 1462 Chinese adolescents (41% boys, aged 11-17 years) at baseline and 18 months later. We also explored baseline demographic predictors of negative emotional eating patterns and the associations between these patterns and outcome variables measured 18 months later.

A Longitudinal Network Analysis of Emotion Regulation, Interpersonal Problems, and Eating Disorder Psychopathology in Chinese Adolescents.

Objective: The present longitudinal study examined sex-specific, symptom-level relationships among emotion regulation (ER), interpersonal problems (IP), and eating disorder (ED) psychopathology in a large sample of Chinese adolescents.

Method: Data were from a project with four waves of data collection (N = 1540; 710 boys and 830 girls) at 6-month intervals over 18 months. Questionnaires assessed ED psychopathology, ER, and IP at each wave of data collection.

Network analysis of three-dimensional hard-soft tissue relationships in the lower 1/3 of the face: skeletal Class I-normodivergent malocclusion versus Class II-hyperdivergent malocclusion.

Background: The determining effect of facial hard tissues on soft tissue morphology in orthodontic patients has yet to be explained. The aim of this study was to clarify the hard-soft tissue relationships of the lower 1/3 of the face in skeletal Class II-hyperdivergent patients compared with those in Class I-normodivergent patients using network analysis.

Methods: Fifty-two adult patients (42 females, 10 males; age, 26.

A Bimetallic Electro-Sensitizer Improves ROS Therapy by Relieving Autophagy-Induced ROS Tolerance and Immune Suppression.

Reactive oxygen species (ROS)-dependent monotherapy usually demonstrates poor therapeutic outcomes, due to the accompanied activation of protective autophagy in tumor cells, which results in ROS tolerance and immune suppression. In this study, a bimetallic electro-sensitizer, Pt-Ir NPs is constructed, loaded with the autophagy inhibitor chloroquine (Pt-Ir-CQ NPs), to enhance the effectiveness of electrotherapy by inhibiting autophagy and activating anti-tumor immune responses. This novel electrotherapy platform demonstrates unique advantages, particularly in the treatment of hypoxic and immunosuppressive tumors.

Carrier-Free Photodynamic Bioregulators Inhibiting Lactic Acid Efflux Combined with Immune Checkpoint Blockade for Triple-Negative Breast Cancer Immunotherapy.

Abnormal tumor metabolism creates a complex tumor immune microenvironment that plays a dominant role in the metastasis of triple-negative breast cancer (TNBC). TNBC is insensitive to immune checkpoint blockade (ICB) therapy because of insufficient cytotoxic T lymphocyte (CTL) infiltration and a hyper-lactic acid-suppressive immune microenvironment caused by abnormal glycolysis. Herein, we propose an amplified strategy based on lactic acid regulation to reprogram the immunosuppressive tumor microenvironment (ITM) and combine it with ICB therapy to achieve enhanced antitumor immunotherapy effects.