Overexpression of Ent-Kaurene Synthase Genes Enhances Gibberellic Acid Biosynthesis and Improves Salt Tolerance in (Wall.) Lindl.

: (Wall.) Lindl. () was widely used in traditional Chinese medicine and also as a health food in China.

A Natural Major Module Confers the Trade-Off between Phenotypic Mean and Plasticity of Grain Chalkiness in Rice.

A critical challenge in crop breeding is the trade-off between improving the mean of an important trait and maintaining its phenotypic plasticity. Grain chalkiness is a key cereal grain-quality trait highly susceptible to environments. However, the genetic and molecular mechanisms controlling the trade-off between phenotypic mean and plasticity of grain chalkiness remain unknown.

From Adhesions to Conception: A Case Study on Platelet-Rich Plasma's Role in Gynecologic Recovery.

Intrauterine adhesions (IUA) are a common gynecologic disorder usually caused by infection, surgery, or trauma. Its pathogenesis is complex and involves multiple factors such as cytokines, inflammatory responses, and tissue fibrosis. In recent years, diagnostic and therapeutic options for uterine adhesions have evolved, encompassing both traditional surgical methods and emerging biologic therapies.

An Efficient FoG-M3 Method for Self-Adaptive Labeling and Predicting Freezing of Gait.

Freezing of gait (FoG) is a common motor impairment that occurs as Parkinson's disease patients enter the moderate stage or higher, leading to a high risk of falls. Although previous methods have accurately identified FoG, significant challenges remain in predicting it. These challenges include difficulties in labeling Pre-FoG due to its personalization, sudden onset, and variability; the imbalance between the amount of FoG and normal gait data; and inadequate feature representation by the model.

Research progress of adoptive tumor infiltrating lymphocyte therapy for cervical cancer.

Cervical cancer ranks as the fourth leading cause of cancer-related mortality among women globally, posing a significant threat to women's health. Immunotherapy has emerged as the fourth line of treatment for cervical cancer, following surgery, chemotherapy, and radiotherapy. It is particularly effective for recurrent and/or metastatic cervical cancer, yielding favorable clinical outcomes.

Discovery of Novel Piperazinone-Fused Hydroxypyridinones Inhibiting Herpes Simplex Virus Gene Transcription and Viral Replication.

Herpes simplex virus poses a significant public health burden, necessitating the development of alternative therapeutic strategies to combat infection while addressing the growing challenge of drug resistance observed with conventional nucleoside antivirals. Herein, we conducted a mixture-based library screening of an in-house small molecule library, leading to the identification of a novel piperazinone-fused hydroxypyridinone scaffold . Structure-activity relationship studies initiated from hit culminated in the development of lead , which exhibited a significant enhancement in the inhibitory activity against luc-HSV-1.

Virome Analysis Deciphers the First Virus Occurrence in Melothria scabra, Revealing Two Potyviruses, Including a Highly Divergent Zucchini Yellow Mmosaic Virus Isolate.

Melothria scabra, an annual vine plant belonging to the family Cucurbitaceae, is usually found as a weed in agricultural ecosystems, making it a potential reservoir for crop viruses. Nonetheless, no plant virus has been documented to infect M. scabra to date.

A natural gene on-off system confers field thermotolerance for grain quality and yield in rice.

Rising global temperatures threaten crop grain quality and yield; however, how temperature regulates grain quality and how to achieve synergistic thermotolerance for both quality and yield remain unknown. Here, we identified a rice major locus, QT12, which negatively controls grain-quality field thermotolerance by disrupting endosperm storage substance homeostasis through over-activating unfolded protein response (UPR). Natural variations in QT12 and an NF-Y complex form a natural gene on-off system to modulate QT12 expression and thermotolerance.

Complete Mitochondrial Genome of Two Species (Lepidoideae: : ): Characterization, Comparative Analyses, and Phylogenetic Implications.

: The subfamily represents a taxonomically critical group within , characterized by its remarkable species diversity. Despite its evolutionary significance, the phylogenetic relationships among tribal and subtribal lineages remain poorly resolved. Although mitochondrial genomes have become crucial molecular markers in Lepidoptera phylogenetics, their potential remains underutilized in the systematics of .

Highly electroconductive and mechanically strong TiCT/cellulose nanofiber composite paper with gradient structure for efficient electromagnetic interference shielding.

The remarkable electrical conductivity of TiCT endows it with significant potentiality in electromagnetic interference (EMI) shielding. However, its poor mechanical properties constrain its further application. Presently, the principal approach to improve the mechanical properties of TiCT is to introduce a large quantity of flexible polymers, which leads to a sharp decrease in conductivity and thereby impacts EMI shielding performance.

Hydrophobic TiCT/TEMPO Oxidized Cellulose Nanofibers Composite Aerogel for Efficient Oil-Water Separation.

To address the pollution issues of industrial oily wastewater and catering industry wastewater, a series of TiCT/TEMPO oxidized cellulose nanofibers composite aerogels with varying TiCT content were successfully prepared using liquid nitrogen non-directional and directional freezing methods, with TiCT and TEMPO oxidized cellulose nanofibers (TOCNF) as the main raw materials. The prepared samples were then hydrophobically modified using methyltrichlorosilane (MTCS) via chemical vapor deposition (CVD). The results showed that the directional TiCT/TOCNF composite aerogel had the most orderly SEM morphology.

BR signalling haplotypes contribute to indica-japonica differentiation for grain yield and quality in rice.

The functional difference of natural variations in conserved BR signalling genes and the genetic basis of rice indica-japonica differentiation are important yet unknown. Here, we discovered natural variations of the four key components (OsBRI1, OsBAK1, OsGSK3 and OsBZR1) in BR signalling pathway by GWAS using an indicator of indica-japonica differentiation in rice. Two major BR signalling haplotypes (BSHs), caused by co-selected variations of the four genetically unlinked genes, were identified to be highly differentiated between rice subspecies.

Extending GPU-accelerated Gaussian integrals in the TeraChem software package to f type orbitals: Implementation and applications.

The increasing availability of graphics processing units (GPUs) for scientific computing has prompted interest in accelerating quantum chemical calculations through their use. However, the complexity of integral kernels for high angular momentum basis functions often limits the utility of GPU implementations with large basis sets or for metal containing systems. In this work, we report the implementation of f function support in the GPU-accelerated TeraChem software package through the development of efficient kernels for the evaluation of Hamiltonian integrals.

The correlation between serum angiopoietin-2 levels and acute kidney injury (AKI): a meta-analysis.

Introduction: The correlation between serum angiopoietin-2 levels and acute kidney injury (AKI) is a topic of significant clinical interest. This meta-analysis aims to provide a comprehensive evaluation of this relationship.

Content: A systematic search was conducted in PubMed, Embase, Web of Science, and Cochrane databases up to October 11, 2023.

Identification and Functional Analysis of Family Genes Associated with Salt Stress in Rice.

Salinity stress has a great impact on crop growth and productivity and is one of the major factors responsible for crop yield losses. The K-homologous (KH) family proteins play vital roles in regulating plant development and responding to abiotic stress in plants. However, the systematic characterization of the family in rice is still lacking.

Characterization of the complete mitochondrial genome of an endemic species in China, (Lepidoptera: Nymphalidae: Satyrinae) and phylogenetic analysis within Satyrinae.

The mitochondrial genome (mitogenome) has been extensively used as molecular markers in determining the insect phylogenetic relationships. In order to resolve the relationships among tribes and subtribes of Satyrinae at the mitochondrial genomic level, we obtained the complete mitogenome of (Oberthür, 1890) (Lepidoptera: Nymphalidae: Satyrinae) with a size of 15,259 bp. The mitogenome consisted of 37 typical genes, including 13 protein-coding genes (PCGs), 2 ribosomal RNA genes (rRNAs), 22 transfer RNA genes (tRNAs), and an A + T-rich region.

DcERF109 regulates shoot branching by participating in strigolactone signal transduction in Dendrobium catenatum.

Shoot branching fundamentally influences plant architecture and agricultural yield. However, research on shoot branching in Dendrobium catenatum, an endangered medicinal plant in China, remains limited. In this study, we identified a transcription factor DcERF109 as a key player in shoot branching by regulating the expression of strigolactone (SL) receptors DWARF 14 (D14)/ DECREASED APICAL DOMINANCE 2 (DAD2).

Dynamic multicolor emissions of multimodal phosphors by Mn trace doping in self-activated CaGaO.

The manipulation of excitation modes and resultant emission colors in luminescent materials holds pivotal importance for encrypting information in anti-counterfeiting applications. Despite considerable achievements in multimodal and multicolor luminescent materials, existing options generally suffer from static monocolor emission under fixed external stimulation, rendering them vulnerability to replication. Achieving dynamic multimodal luminescence within a single material presents a promising yet challenging solution.

The OsCLV2s-OsCRN1 co-receptor regulates grain shape in rice.

The highly conserved CLV-WUS negative feedback pathway plays a decisive role in regulating stem cell maintenance in shoot and floral meristems in higher plants, including Arabidopsis, rice, maize, and tomato. Here, we find significant natural variations in the OsCLV2c, OsCLV2d, and OsCRN1 loci in a genome-wide association study of grain shape in rice. OsCLV2a, OsCLV2c, OsCLV2d, and OsCRN1 negatively regulate grain length-width ratio and show distinctive geographical distribution, indica-japonica differentiation, and artificial selection signatures.

Whole-Transcriptome Sequencing Reveals the Global Molecular Responses and NAC Transcription Factors Involved in Drought Stress in .

is a highly drought-tolerant herb, which usually grows on cliffs or in the branches of trees, yet the underlying molecular mechanisms for its tolerance remain poorly understood. We conducted a comprehensive study utilizing whole-transcriptome sequencing approaches to investigate the molecular response to extreme drought stress in . A large number of differentially expressed mRNAs, lncRNAs, and circRNAs have been identified, and the NAC transcription factor family was highly enriched.

Insertion of a miniature inverted-repeat transposable element into the promoter of OsTCP4 results in more tillers and a lower grain size in rice.

A class I PCF type protein, TCP4, was identified as a transcription factor associated with both grain size and tillering through a DNA pull-down-MS assay combined with a genome-wide association study. This transcription factor was found to have a significant role in the variations among the 533 rice accessions, dividing them into two main subspecies. A Tourist-like miniature inverted-repeat transposable element (MITE) was discovered in the promoter of TCP4 in japonica/geng accessions (TCP4M+), which was found to suppress the expression of TCP4 at the transcriptional level.

Graph-|⟩⟨|: A Quantum Algorithm with Reduced Quantum Circuit Depth for Electronic Structure.

The accurate determination of chemical properties is known to have a critical impact on multiple fundamental chemical problems but is deeply hindered by the steep algebraic scaling of electron correlation calculations and the exponential scaling of quantum nuclear dynamics. With the advent of new quantum computing hardware and associated developments in creating new paradigms for quantum software, this avenue has been recognized as perhaps one way to address exponentially complex challenges in quantum chemistry and molecular dynamics. In this paper, we discuss a new approach to drastically reduce the quantum circuit depth (by several orders of magnitude) and help improve the accuracy in the quantum computation of electron correlation energies for large molecular systems.

Huayuwendan decoction ameliorates inflammation via IL-17/NF-κB signaling pathway in diabetic rats.

Ethnopharmacological Relevance: Huayuwendan decoction (HYWD) is a broad used traditional Chinese medicine and therapeutic effects against type 2 diabetes mellitus (T2DM). The mechanism of HYWD on the treatment of T2DM is still unclear.

Aim Of The Study: For this reason, this study was performed to uncover the effects and mechanism of action of HYWD on T2DM.