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Article Abstract
Medical catheters often fail due to bacterial infections during clinical use. An antibacterial coating offers an effective material solution to this issue. Herein, we prepared a polyelectrolyte hydrogel coating with tunable antibiotic loading. The crosslinked poly(2-acrylamido-2-methylpropanesulfonic acid sodium salt) (pAN) hydrogel coating was prepared by initiator pre-entrapment and UV initiation. The sulfonate groups in pAN enable efficient hydrophobic rifampicin (RIF) loading electrostatic interactions with the antibiotic's positively charged groups. RIF loading could reach 119.3 ± 10.8 μg cm at pH 2.0 and remain tunable (the range >100 μg cm) across a pH range of 2.0-9.5 due to pH-dependent charge modulation. Additionally, the sulfonated polyelectrolyte simultaneously offered excellent hydrophilic lubricity with a coefficient of friction <0.03 and anticoagulant properties. Such a multifunctional hydrogel coating with antibacterial, lubricating, and anticoagulant properties provides a promising approach to reducing catheter-associated infections, equipping medical polymer-based catheters with better practical performance.
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