FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2.

Introduction: Fatty acid synthase (FASN) is a key regulator of lipid metabolism, but its role in colorectal cancer (CRC) stemness and ferroptosis remains unclear.

Methods: FASN expression in CRC was analyzed using TCGA data and validated in CRC cell lines (CACO-2, HCT116, SW480) and normal HIEC-6 cells via qRT-PCR and Western blot. HCT116 cells (highest FASN expression) were used for experiments.

Dual-Probe Strategy-Enabled Multiplex Photoelectrochemical Sensor for Highly Sensitive Screening of Diabetes and Related Complications.

Photoelectrochemical (PEC) biosensing has emerged as a vital tool in disease surveillance and therapeutic monitoring. However, most current PEC platforms are constrained to single biomarker detection, limiting their utility in comprehensive disease management. In this study, we report the development of a dual-target PEC biosensor by integrating silane molecules and β-cyclodextrin (β-CD) with carbon nitride materials, specifically designed for monitoring diabetes and its associated complication, uremia.

The epigenetic landscape of tumor-associated macrophages: orchestrating immune evasion in the tumor microenvironment.

Tumor-associated macrophages (TAMs), the predominant immune cell population within the tumor immune microenvironment (TIME), play a vital role in promoting immune evasion and driving tumor progression. Beyond their well-established roles in reprogramming oncogenic signaling and silencing tumor suppressors, emerging evidence highlights that epigenetic modifications also critically shape the immunogenic landscape of tumors by modulating the phenotype and function of infiltrating immune cells. The TIME imposes persistent metabolic and inflammatory stressors-such as hypoxia, nutrient deprivation, and lactate accumulation-that profoundly influence the epigenetic and transcriptional states of TAMs, promoting their phenotypic plasticity and skewing them toward immunosuppressive, pro-tumoral phenotypes.

Fluorination of Fe, Sn, N atoms doped carbon enables the balance of activity and stability for oxygen reduction.

The development of highly active and durable carbon-based electrocatalysts for the oxygen reduction reaction (ORR) is of critical importance. In this study, a heteroatom-doped carbon catalyst (FeSn-NFC) was synthesized through the chelation of Fe and dopamine hydrochloride, followed by Sn/F co-doping and carbonization. The resulting FeSn-NFC catalyst exhibits an ultrahigh specific surface area of 2387.

Causal relationship between white matter structural connectivity and epilepsy.

White matter structural connectivity has recently been linked to epilepsy pathogenesis, yet its causal role remains unclear. This study used Mendelian randomization (MR) to investigate the causal relationship between white matter structural connectivity and epilepsy. GWAS summary statistics for white matter structural connectivity were sourced from the UK Biobank, while epilepsy data were obtained from FinnGen R10 and the International League Against Epilepsy (ILAE).

Effects of Micro-Topography on Soil Nutrients and Plant Diversity of Artificial Shrub Forest in the Mu Us Sandy Land.

In ecological restoration of arid/semi-arid sandy lands, micro-topographic variations and artificial shrub arrangement synergistically drive vegetation recovery and soil quality improvement. As a typical fragile ecosystem in northern China, the Mu Us Sandy Land has long suffered wind erosion, desertification, soil infertility, and vegetation degradation, demanding precise vegetation configuration for ecological rehabilitation. This study analyzed soil nutrients, plant diversity, and their correlations under various micro-topographic conditions across different types of artificial shrub plantations in the Mu Us Sandy Land.

Near-infrared organic nanoparticles (6BQ NPs) enhance the random flaps survival by modulating the HSP90/HIF-1α axis through mild photothermal therapy.

Random flaps are primarily employed in clinical practice for wound repair; however, the ischemic necrosis following surgery remains a significant challenge. To address this issue, we developed high-performance near-infrared (NIR) photothermal agent, 6BQ, to enhance random flaps survival through mild photothermal therapy (MPTT). In this study, we assessed the effects of 6BQ NPs on cell viability, proliferation, migration, and angiogenesis of human umbilical vein endothelial cells (HUVECs) using MPTT in vitro.

Structural chemistry of antimony(III) oxalates with lone pairs: polyhedral distortion [SbOF], π-conjugation [CO], and birefringence tuning.

The development of novel advanced ultraviolet (UV) birefringent materials has remained a significant research focus, owing to their requirement for considerable optical anisotropy to enable effective light polarization modulation in laser technologies and scientific applications. In this work, we report the structural chemistry and optical properties of three antimony(III) oxalate crystals: NHSb(CO)F·HO (1), [C(NH)]Sb(CO)F·2HO (2) and (NH)Sb(CO)F·2HO (3); they have been synthesized an aqueous solution evaporation method. Their crystal structures feature distinct architectures driven by Sb lone pair effects: one-dimensional [Sb(CO)F] chains and zero-dimensional [Sb(CO)F] and [Sb(CO)F] clusters.

Ligand-Mediated Activity of Cu Clusters Boosts Electrocatalytic Nitrate Reduction.

Surface ligands play a crucial role in modifying catalytic environments and enhancing performance through various mechanisms. However, the multivariate synergistic mechanisms, dynamic evolution patterns, and universal design principles of ligand effects remain to be thoroughly investigated. Metal clusters, with their atomically precise structures, serve as ideal models for studying ligand regulation mechanisms.

The role of plasma glucose in association of food-specific serum immunoglobulin G reactivity with metabolic dysfunction-associated fatty liver disease: a real-world cross-sectional study.

Background: As the immune response product to food antigens, food-specific serum immunoglobulin G reactivity (FSsIgGR) has been reported the clinical relevance to metabolic disorders, but its connections to metabolic dysfunction-associated fatty liver disease (MAFLD) remain underexplored, particularly within Chinese populations. Understanding this association could facilitate personal diet modification for MAFLD treatment. We investigated the association between FSsIgGR and MAFLD and the mediating roles of plasma glucose markers, specifically fasting blood glucose (FPG) and hemoglobin A1c (HbA1c).

Cost-effectiveness of pentavalent meningococcal (MenABCWY) vaccination among adolescents in the United States.

Background: Invasive meningococcal disease (IMD) is a severe, acute illness associated with considerable mortality and long-term morbidity. In the United States, meningococcal serogroup A, C, W, and Y (MenACWY) vaccines and serogroup B (MenB) vaccines are used to prevent IMD among adolescents. GlaxoSmithKline has developed a new pentavalent (MenABCWY) vaccine, covering all five serogroups: A, B, C, W, and Y, with licensure in spring 2025.

Piezo1-Mediated Ferroptosis Delays Wound Healing in Aging Mice by Regulating the Transcriptional Activity of SLC7A11 through Activating Transcription Factor 3.

Ferroptosis plays a role in wound healing during the maturation of senescent endothelial cells. This study explores the modulation of ferroptosis in senescent human umbilical vein endothelial cells (HUVECs) and wound-healing processes by Piezo1 activation at the molecular, cellular, and tissue levels. Elevated Piezo1 expression was observed in HUVECs treated with the senescence inducer doxorubicin (Doxo) and the ferroptosis inducer erastin and in aged wound tissue.

In situ regulating the accessibility and structure of Fe-based catalytic sites to break trade-off between the activity and stability for oxygen reduction.

How to synchronously boost the activity and stability of Fe/N-doped carbons (Fe-N-Ce-N-C) for oxygen reduction reaction (ORR) becomes important to promote their commercial applications. Here we synthesize a Fe-N-Ce-N-C catalyst by secondary sintering and removing endogenous CeO nanoparticles to in situ regulate the accessibility and structure of N and O atoms coordinated Fe sites (FeNO). Theoretical studies indicate that the electron density distribution surrounding the Fe atom in FeNO sites exhibits significant differences compared to that in FeN, inducing a downward shift of the Fe d-band center.

Impact of fermentation on the processing and digestion characteristics of honeysuckle polyphenols by .

The technology and digestive characteristics of honeysuckle beverages fermented by were researched, the digestive characteristics were evaluated by simulating the gastrointestinal digestive system . The optimum conditions were as follows: fermentation temperature, 35°C; fermentation time, 19 h; and inoculation amount, 3%. Fermented honeysuckle beverages had greater antioxidant and -glucosidase inhibition capacities than unfermented beverages after digestion.

Engineered Exosome-Loaded Silk Fibroin Composite Hydrogels Promote Tissue Repair in Spinal Cord Injury Via Immune Checkpoint Blockade.

Spinal cord injury (SCI) is a severe central nervous system disorder characterized by a high rate of disability and limited axonal regeneration. Excessive post-injury inflammation often leads to further neuronal damage. Immune checkpoint (IC) genes, which regulate immune cell activity, play a critical role in modulating post-injury inflammation and thus influence neural repair and functional recovery.

Morphological Traits and Water-Nutrient Utilization Efficiency of Fine Roots Under Different Stubble Heights in Arsenic Sandstone Area, Inner Mongolia.

(family Elaeagnaceae) is a deciduous shrub that has become a uniquely advantageous species in the arsenic sandstone area of Inner Mongolia due to its well-developed root system and strong tillering ability. This study, by taking 10-year-old in the arsenic sandstone area as the research object and analyzing the morphological traits of their fine roots and their coordination within soil under different stubble heights (0, 10, 15, and 20 cm) and non-stubble treatment, aims to select the optimal stubble height that is most conducive to the rejuvenation of and thus improve the decline in the productivity of in this region. The results reveal significant differences in fine root and soil properties under different stubble heights ( < 0.

The Chinese adverse prognosis of very preterm infants (CARE-Preterm) cohort: study design and baseline characteristics for a prospective multicenter cohort study.

Background: As the increasing survival of preterm infants bearing lower gestational age (GA) and birth weight (BW), new challenges have emerged regarding their management and prognosis. In low- and middle-income countries, there is notable absence of prospective multicenter cohorts to accurately reflect their real treatment capacity for these preterm infants. This cohort study aims to fill this gap by investigating the impact of perinatal management on the prognosis of preterm infants in Northern China.

The role of semaphorin 3A in the pathogenesis and progression of Alzheimer's disease and other aging-related diseases: A comprehensive review.

Aging serves as a pivotal factor in the etiology of numerous diseases, such as Alzheimer's disease (AD), Parkinson's disease, diabetes, osteoarthritis, atherosclerosis and aging-related macular degeneration. Notably, these diseases often interact with AD through various pathways, facilitating the onset or progression of one another. Semaphorin 3 A (Sema3A), a protein that is essential for axonal guidance during neural development, has recently been identified as a novel regulator in the pathogenesis and progression of multiple aging-related diseases.

Predictive modeling of obstructive sleep apnea using pharyngeal magnetic resonance imaging radiomics and clinical data.

Study Objectives: This study aims to assess the predictive performance of models combining pharyngeal magnetic resonance imaging radiomics and clinical data for distinguishing severe and nonsevere obstructive sleep apnea.

Methods: A total of 106 patients were included in the study, with 48 patients having an apnea-hypopnea index < 30 events/h and 58 patients having an apnea-hypopnea index ≥ 30 events/h. Radiomics features were extracted from magnetic resonance imaging images.

Natural, safety immunomodulatory derivatives of lactobacillus biofilms promote diabetic wound healing by metabolically regulating macrophage phenotype and alleviating local inflammation.

Introduction: Long-term inflammatory microenvironment further impairs the healing process of diabetic wounds. Many studies have shown that Lactobacillus can regulate immune function and promote injured tissue repair. However, the immunomodulatory function and safety of Lactobacillus biofilm (LB) on wounds need further investigation.

Study on the spatial and temporal differences and influencing factors of out-of-pocket payments as a share of total health expenditure in China.

Background: Globally, Out-of-pocket (OOP) payments as a share of Total Health Expenditure (THE) has always been a focus of attention in the field of health economics, which affects the economic burden of medical treatment for residents. At present, countries around the world have widely used spatial econometric models to conduct in-depth discussions and analyses of their own OOP, exploring the spatial distribution characteristics and influencing factors of OOP in different regions. However, in China, research in this area is relatively scarce, and few studies have been conducted from a macro perspective and space-time dimension.

Carbon paper anodes decorated with TiO nanowires and Au nanoparticles for facilitating bacterial extracellular electron transfer.

Au nanoparticles-composite TiO nanowires (NWs) modified carbon paper (CP) anode was synthesized via the hydrothermal method. Field emission scanning electron microscopy (FESEM) images demonstrate that the modified nanocomposite electrode features a rough and bumpy surface structure. The electrochemical activities of TiO-Au/CP and the control electrodes (TiO-NWs/CP, Au/CP, CP) for microbial fuel cell (MFC) are investigated by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS).

Erythromycin repurposing for hepatocellular carcinoma treatment: Targeting CD24 to enhance anti-tumor immunity.

Hepatocellular carcinoma (HCC) is a malignant tumor, making up about 90% of all primary liver cancers and ranking as a top cause of cancer mortality globally. With the severe side effects of conventional radiotherapy and chemotherapy, there's an ongoing quest for less toxic treatment options. CD24, a highly glycosylated membrane surface protein, plays a role in cancer cell adhesion and metastasis.

Causal relationship between gut microbiota, lipids, and neuropsychiatric disorders: A Mendelian randomization mediation study.

Background: Numerous studies have shown an interconnection between the gut microbiota and the brain via the "gut-brain" axis. However, the causal relationships between gut microbiota, lipids, and neuropsychiatric disorders remain unclear. This study aimed to analyze potential associations among gut microbiota, lipids, and neuropsychiatric disorders-including AD, PD, ALS, MS, SCZ, MDD, and BD-using summary data from large-scale GWAS.

Association of proteomics with lymph node metastasis in early gastric cancer patients.

Surgical decision making for early gastric cancer (EGC) is heavily influenced by its metastasis into the lymph nodes. Currently, the clinicopathological features of EGC cannot be used to accurately distinguish between EGC patients with and without lymph node metastasis. Our retrospective case-matching study included a total of 132 samples from 66 pairs of EGC patients with or without lymph node metastasis and conducted proteomic assays.