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Background: The buccal mucosa is a frequent site of precancerous lesions, and surgical excision often leaves a mucosal defect. owing to the inherent limited length of the buccal fat pad, its efficacy in covering mucosal defects is confined. In cases where the defect is anterior in the cheek, reliance solely on buccal fat pad is insufficient for complete coverage of the affected area. The currently used reconstructive approach for cheek mucosal defects, biological membrane coverage, is associated with a risk of severe mouth opening restriction due to scar contracture, adversely affecting the patient's quality of life. This study introduces a novel technique combining a cheek mucosal flap with the buccal fat pad to address anterior cheek defects. The aim of this study is to evaluate the efficacy of a combined cheek mucosal flap and buccal fat pad technique for reconstructing anterior cheek mucosal defects.
Methods: A retrospective analysis of five patients who underwent this surgical procedure at Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University was conducted. The technique involved creating a cheek mucosal flap and advancing the buccal fat pad to cover the defect. Postoperative outcomes, including mouth opening and scar formation, were assessed.
Results: All patients achieved satisfactory healing with mouth openings exceeding 3.0 cm. No significant complications were observed, and the surgical sites were fully mucosalized within three months.
Conclusion: The combined cheek mucosal flap and buccal fat pad technique is a viable solution for reconstructing anterior cheek defects, offering improved functional and aesthetic outcomes with minimal complications. This surgical methodology boasts considerable practicality and potential for widespread dissemination.
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http://dx.doi.org/10.1016/j.jormas.2025.102380 | DOI Listing |
BMC Oral Health
September 2025
Department of Craniomaxillofacial Plastic and Cosmetic Center, Hospital of Stomatology, Jilin University, No.1500 Qinghua Road, Changchun, Jilin, 130021, China.
Background: It has been reported that CD4 + helper T cells, such as Th1, Th2, Th17 and Treg, play crucial roles in the immunological balance especially when the immune system is invaded by the tumor. Oral squamous cell carcinoma undergoes a process from normal epithelium to dysplasia. However, the dynamic equilibrium of Th1/Th2 and Th17/Treg remained unclear during the process of epithelial malignant transformation.
View Article and Find Full Text PDFCureus
July 2025
Internal Medicine, AdventHealth Orlando, Orlando, USA.
Evans syndrome is a rare condition that can be seen among patients with pre-existing rheumatological disorders such as lupus, rheumatoid arthritis, or adult-onset Still's disease. There is an association between positive anti-phospholipid antibodies and the development of Evans syndrome, but the underlying pathophysiology remains unknown. To our knowledge, this is one of the few case reports to date that describes the development of Evans syndrome triggered by parvovirus B19 in patients with pre-existing positive antiphospholipid antibodies.
View Article and Find Full Text PDFJ Oral Pathol Med
August 2025
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Background: Aphthous stomatitis (AS) is a common idiopathic condition that affects approximately 5% to 25% of the general population. AS is characterized by recurrent painful aphthous ulcers on non-keratinized oral mucous membranes. Lifestyle modifications and topical treatments are often used to manage symptoms, but no definitive cure exists.
View Article and Find Full Text PDFCureus
June 2025
Department of Oral Surgery, Hôpital Pitié Salpêtrière, Paris, FRA.
Odontogenic cutaneous fistula is a rare condition that is frequently misdiagnosed. This article presents a case of an odontogenic cutaneous fistula following mandibular wisdom tooth removal. An 18-year-old woman with no underlying medical conditions presented to the oral and maxillofacial surgery department with swelling of the left cheek and a facial skin fistula.
View Article and Find Full Text PDFCureus
June 2025
Dermatology, Government Medical College & Hospital, Chandigarh, Chandigarh, IND.
Xeroderma pigmentosum (XP) is a rare autosomal recessive genodermatosis characterized by a defect in the nucleotide excision repair pathway of DNA. This condition leads to extreme photosensitivity, pigmentary changes, premature aging, and increased risk of UV-induced skin and mucous membrane neoplasms. We report a case of squamous cell carcinoma in a 55-year-old female with XP.
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