Gastrointestinal involvement in very early and established systemic sclerosis: insights from the SPRING-SIR national Italian registry.

Objectives: To describe the prevalence of gastrointestinal (GI) symptoms in systemic sclerosis (SSc) and Very Early Diagnosis of SSc (VEDOSS), identify clinical and serological features associated with GI involvement, and explore a cranio-caudal pattern of symptom distribution, using data from the Italian SPRING-SIR registry.

Methods: This cross-sectional analysis included patients fulfilling 2013 ACR/EULAR SSc or VEDOSS criteria. GI involvement was defined as symptoms in at least one GI tract segment and categorized as upper and lower.

Chronotropic incompetence during exercise or pharmacological stress is associated with reduced survival in patients with chronic coronary syndromes.

Aims: Chronotropic incompetence (CI) is a biomarker of cardiac autonomic dysfunction. The aim of the study is to assess the risk stratification value of CI during exercise or pharmacological stress echocardiography in patients with chronic coronary syndromes.

Methods And Results: In a prospective, multicenter, international, observational study, we enrolled 13 445 patients with known or suspected chronic coronary syndromes who underwent stress echocardiography in 19 clinical sites from 10 countries using either exercise (n = 2594), dobutamine (n = 2440), or dipyridamole (n = 8411).

Fluoromethylcarnitine, a novel inhibitor of trimethylamine levels in trimethylaminuria and trimethylamine N-oxide related disorders.

Excessive production of trimethylamine (TMA) by the gut microbiota leads to increased concentrations of TMA or trimethylamine N-oxide (TMAO) in the bloodstream, which is associated with health risks. High levels of TMAO have been linked to cardiovascular disease, inflammation and other health problems. In addition, people affected by a genetic deficiency of the liver enzyme FMO3, which oxidises TMA to TMAO, suffer from trimethylaminuria (TMAU), a rare disorder caused by mutations in the Fmo3 gene, in which the body odour resembles that of rotting fish, leading to significant discomfort and social isolation.

Influence of Leaves Extract on Human Erythrocytes.

L. (MA) is a member of the Moraceae family, known as "white mulberry". Due to the high levels of bioactive compounds, mulberry plants can be considered a good source of nutrients and antioxidant compounds.

In Vivo Wound-Healing and Molecular Docking Studies Support the Traditional Use of Arisarum vulgare Aqueous Extract.

In Algerian traditional medicine, Arisarum vulgare O. Targ. Tozz.

Multi-biomarker assessment of essential and toxic elements accumulation in Labeo gonius from Khushab Lake (Pakistan).

The continuous increase in the concentration of heavy metals in bodies of water due to human activity poses a serious threat to the sustainability and overall health of the ecosystem. This study investigated the essential and toxic elements bioaccumulation in various tissues (gills, muscles, liver, and brain) of the Minor carp (Labeo gonius) from two sampling sites of highly polluted Khushab Lake, a tributary of River Jhelum (in the Pakistan's Punjab province), along with a less exposed reference site (Chashma Lake-less polluted site). The impacts of pollution on the health profile of the fish were assessed using multiple biomarkers for analysis.

Polycationic calixarene micellar aggregate as a novel iodophor platform for on-demand iodine release to bacteria.

Iodine is the most potent antiseptic agent used in clinical applications, but its volatility and toxicity are serious drawbacks that are stimulating the search of new strategies to achieve formulations stable at low iodine concentration. Here, we report that polycationic micellar aggregates, formed by the self-assembling of the amphiphilic choline-calix[4]arene derivative (CholCalix) in aqueous medium, are able to complex triiodide anions (I) both in solution and in solid phase. This novel iodophor enhances the stability of 0.

RETRACTED: Vaccaro et al. Differential Expression of Nitric Oxide Synthase Isoforms nNOS and iNOS in Patients with Non-Segmental Generalized Vitiligo. 2017, , 2533.

The retracts the article, "Differential Expression of Nitric Oxide Synthase Isoforms nNOS and iNOS in Patients with Non-Segmental Generalized Vitiligo" [...

Practice of oxygenation and respiratory support during fibreoptic bronchoscopy: the OxyFOB study protocol.

Introduction: Flexible bronchoscopy (FB) is widely used for diagnostic and therapeutic procedures in pulmonary medicine. However, FB can cause respiratory and haemodynamic complications, especially in patients with pre-existing lung and/or cardiovascular comorbidities. Despite the range of oxygenation and ventilatory approaches available to prevent these risks, evidence regarding their real-world application and clinical impact is limited.

Field cancerization in women without conventional risk factors: insights from a case-cohort study.

Background: Field cancerization (FC) is a well-documented phenomenon in oral squamous cell carcinoma (OSCC), typically reported in patients with known risk habits such as tobacco and alcohol use. To date, limited evidence exists regarding FC in individuals without traditional carcinogenic exposures, as well as in those associated with chronic mechanical trauma. The study aims to report a case series of FC in patients without well-known risk habits observed in the last two years.

Frequency of anticholinergic drug use in patients treated with aripiprazole once-monthly: a 2-year cohort study using European healthcare databases.

Background: Extrapyramidal symptoms (EPS) in association with the long-acting, injectable, atypical antipsychotic aripiprazole once monthly (AOM) have been observed in clinical trials, but information on EPS requiring treatment with anticholinergic drugs in clinical practice is limited.

Objectives: The objective of this European post-authorisation safety study (PASS) was to assess the risk of EPS-related events, as defined by dispensings of anticholinergic drugs, linked to the use of AOM in routine clinical practice.

Design: This European cohort study was based on healthcare databases from Germany (German Pharmacoepidemiological Research Database GePaRD), Italy (Caserta and Palermo healthcare claims databases), and Sweden (National health registers).

Personalized or Standard Duration of Dual Antiplatelet Therapy after Percutaneous Coronary Intervention: PARTHENOPE Randomized Trial.

Background: Dual antiplatelet therapy (DAPT) is recommended for patients undergoing percutaneous coronary intervention (PCI), although its optimal duration remains uncertain.

Objectives: We performed a randomized trial comparing a personalized duration of DAPT, based on a risk score, for 3-, 6-, or 24-months with a standard duration of DAPT for 12 months after PCI.

Methods: We randomly assigned 2,107 patients undergoing PCI to receive either a personalized or a standard DAPT.

The current role of photodynamic diagnosis (PDD) in the management of non-muscle invasive bladder cancer: the Italian Society of Urology (SIU) Position Paper.

Photodynamic diagnosis (PDD) significantly enhances the detection of bladder cancer (BCa) and is able to reduce the risk of disease recurrence, although it may not affect disease progression and mortality rates. Despite its advantages, widespread adoption of PDD is limited by cost considerations and the absence of unified guidelines on its application, highlighting the need for continued evaluation of its cost-effectiveness across different healthcare settings. To date, no specific recommendations for PDD in non-muscle invasive bladder cancer (NMIBC) management have been provided by the Italian Society of Urology (Società Italiana di Urologia, SIU).

Faecal microbiota differences between an autochthonous pig breed and a commercial line.

The gut microbiota is recognized as one of the most complex microbial ecosystems in mammals. In pigs, the structure of this microbial community significantly influences their overall physiological functions, with breed also contributing to its diversity. This study explores the potential differences in the bacterial composition of the faecal microbiota between two pig breeds: the autochthonous Nero Siciliano (NS) and a commercial crossbreed (CB) (Landrace × Large White).

Minimally invasive microvascular decompression for trigeminal neuralgia: results and complication avoidance in a consecutive series of patients.

Objective: Microvascular decompression (MVD) represents a milestone for the treatment of trigeminal neuralgia (TN). Nevertheless, several complications still occur and may negatively affect the outcome. The authors recently proposed a minimally invasive technique, including endoscopic assistance in instances of intraoperative hidden corners, with which they were able to achieve good results in terms of pain relief and minimize overall complication rates.

Prediction of Activity and Selectivity Profiles of Sigma Receptor Ligands Using Machine Learning Approaches.

Sigma (σ) receptors (SRs) have emerged as important therapeutic targets due to their roles in various biological pathways. They are classified into two subtypes: S1R, primarily distributed in the central nervous system and related to neuroprotection and neurodegenerative diseases, and S2R mainly expressed in cancer cells and associated with cell proliferation and apoptosis, as well as in neurons. Although S1R and S2R exhibit structural differences in receptor architecture and assembly, they share similar binding site features and ligand recognition mechanisms.

The first complete mitochondrial genome of Zu cristatus (Bonelli, 1819) sheds new light on its phylogenetic position and molecular evolution.

Background: Fishes are key components of the megafauna of the deep sea, and evolutionary adaptations to deep-sea life appear to have occurred independently in at least 22 fish orders. In this context, the analysis of even more fish genomes and mitogenomes has fundamental importance, providing a valuable resource for understanding the molecular mechanisms underlying evolutionary adaptation, especially to extreme environments such as the deep sea. Here, we report the first complete mitochondrial genome of Zu cristatus (Bonelli, 1819), providing essential information on its structure and phylogeny.

Understanding food addiction in obesity: a genetic perspective.

Background: Food addiction (FA) has gained more scientific attention but needs deeper understanding. Data indicates that the central melanocortin (MC) system through the MC4 receptor (MC4R) and its polymorphisms play a crucial role in the regulation of eating behaviour and in the motivation for the rewarding properties of food potentially leading to obesity. This may also contribute to the emergence of altered reward-related behaviors such as FA.

Predictive Factors and Clinical Markers of Recurrent Wheezing and Asthma After RSV Infection.

Respiratory syncytial virus (RSV) is a major cause of acute lower respiratory infections (ALRIs) in young children, especially bronchiolitis, with significant global health and economic impact. Increasing evidence links early-life RSV infection to long-term respiratory complications, notably recurrent wheezing and asthma. This narrative review examines these associations, emphasizing predictive factors and emerging biomarkers for risk stratification.

Evaluation of Depth of Anesthesia Sleep Quality in Swine Undergoing Hernia Repair: Effects of Romifidine/Ketamine-Diazepam Protocols with and Without Tramadol and the Potential Role of Serotonin as a Biomarker.

Sedation and anesthesia are essential for ensuring animal welfare during surgical procedures such as hernia repair in swine. However, the number of sedative and anesthetic agents officially approved for livestock use remained limited. This study evaluated the sedative efficacy and serotonergic effects of a romifidine/ketamine/diazepam protocol, with and without the addition of tramadol, in swine undergoing umbilical hernia repair.