Impact of Larvae on Nile Tilapia (): A Morpho-Histopathological Perspective.

(Joyeux and Baer, 1935) larvae, a member of the Gryporhynchidae family (Cestoda: ), are commonly found in a variety of African fish species, including Nile tilapia (, Linnaeus, 1758). Nonetheless, little is known regarding their existence in native Egyptian fish species. Two hundred were examined in the current investigation, using standard parasitological techniques to detect the presence of these larvae in different fish organs.

Endocrine Adverse Events Induced by Cancer Treatments: The Role of F-Fluorodeoxyglucose Positron Emission Tomography.

Immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs) have revolutionized cancer therapy, substantially improving survival across a broad range of malignancies. However, these agents are associated with a unique profile of endocrine immune-related adverse events (irAEs), including thyroiditis, hypophysitis, adrenalitis, and pancreatitis, which differ significantly from the toxicities seen with conventional chemotherapy. These complications often arise unpredictably during treatment and may result in irreversible hormone deficiencies requiring lifelong replacement, underscoring the importance of early detection.

Prejudice, Proxemic Space, and Social Odor: The Representation of the 'Outsider' Through an Evolutionary Metaverse Psychology Perspective.

Prejudices, particularly those related to social biases, are shaped by various cognitive and sensory mechanisms. This study investigates the interaction between olfactory perception and propensity and implicit or explicit prejudices through three experimental protocols in a metaverse condition. Experiment 1 examines the impact of five different odors on proxemic behavior when interacting with individuals from stigmatized social groups.

Redox Homeostasis in Red Blood Cells: From Molecular Mechanisms to Antioxidant Strategies.

Red blood cells (RBCs) are uniquely vulnerable to oxidative stress due to their role in O transport and their high content of heme iron and polyunsaturated fatty acids (PUFAs). Despite lacking nuclei and organelles, RBC homeostasis relies on a finely tuned redox system to preserve membrane integrity, cytoskeletal organization, and metabolic function. Impairment of this delicate balance results in a series of oxidative events that ultimately leads to the premature clearance of RBCs from the bloodstream.

Correction: Timing matters! Academic assessment changes throughout the day.

[This corrects the article DOI: 10.3389/fpsyg.2025.

Loss of ANK3 Function Causes a Recessive Neurodevelopmental Disorder with Cerebellar Ataxia.

Background: ANK3 encodes ankyrin-G, a key scaffolding protein essential for neuronal function. While both monoallelic and biallelic ANK3 variants have been linked to neurodevelopmental disorders (NDDs), existing evidence for their pathogenicity and clinical correlation remains limited and heterogeneous.

Objective: To delineate the clinical features associated with biallelic ANK3 predicted loss-of-function (pLOF) variants.

Hypercontractile phenotype in hypertrophic cardiomyopathy indicates unfavorable hemodynamics, coronary flow and prognosis.

Aims: Our aim was to assess the clinical and prognostic significance of the left ventricular (LV) hypercontractile phenotype (HP) in hypertrophic cardiomyopathy (HCM), which until now remains unclear.

Methods And Results: We enrolled 1533 HCM patients (age 51 ± 15 years, 965 males, 63%) with ejection fraction (EF) ≥ 50%, referred for rest transthoracic echocardiography (TTE) in 27 laboratories from 13 countries. Two-dimensional volumetric TTE assessment included LV outflow tract gradient (LVOTG), LV EF, and LV force (systolic blood pressure + LVOTG/ESV, mmHg/mL).

A survey of current management practices for delayed maculopapular exanthemas during antibiotic treatment among primary care pediatricians.

Background: Several guidelines recommended how to manage delayed maculopapular exanthemas during antibiotic treatment. The aim of the present survey was to assess knowledge gaps of primary care pediatricians in managing children with delayed maculopapular exanthemas during a course of antibiotics.

Methods: We conducted an online survey among primary care pediatricians in Italy, focusing on the management of children with maculopapular exanthemas occurring during antibiotic administration.

Exploring the relationship between temperament traits, psychological symptoms, and functional disability assessed with the WHODAS 2.0 in persons with multiple sclerosis.

Background: The relationship between psychological comorbidity and functional impairment in multiple sclerosis (MS) remains to be thoroughly investigated. This study examined the associations between temperament traits, psychological comorbidities, and disability as measured by the World Health Organization Disability Assessment Schedule (WHODAS) 2.0 in persons with Relapsing-Remitting Multiple Sclerosis (RRMS).

Investigational agents for pancreatic neuroendocrine tumors: what clinical progress have we seen in the last 5 years?

Introduction: Pancreatic neuroendocrine tumors (pNETs), a group of endocrine tumors that arise in the pancreas from the hormonal cells of the islets of Langerhans, are among the most common gastroenteropancreatic neuroendocrine tumors. The incidence of pNETs has increased in recent years to about 1.5 per 100,000 population and prognosis correlates with histologic grade.

Towards Post-Genomic Oncology: Embracing Cancer Complexity via Artificial Intelligence, Multi-Targeted Therapeutics, Drug Repurposing, and Innovative Study Designs.

Recent advances in precision oncology have led to significant breakthroughs through the targeting of defined oncogenic drivers. However, the clinical efficacy of single-target therapies is increasingly constrained by the intrinsic complexity and adaptability of cancer. Solid tumors frequently arise from multifactorial oncogenic processes and adapt via diverse resistance mechanisms, ultimately limiting the durability of monotherapies.

In vivo assessment on effects of zinc-doped cadmium sulphide nanoparticles synthesized using Hypsizygus ulmarius mushroom extract on toxicity of paclobutrazol in Zebrafish (Danio rerio) early-life stages.

Paclobutrazol (PBZ), a fungicide widely used as growth regulator in plants, is often detected in surface waters, posing potential risks to aquatic life. While its toxicity in adult fish is known, effects on early-life stages remain underexplored. The study evaluated the effect of PBZ on zebrafish (Danio rerio) embryos/larvae and the potential protective role of zinc-doped cadmium sulphide nanoparticles (Zn-CdS NPs) synthesized using Hypsizygus ulmarius mushroom extract.

Tuning Nanofibrous Sensor Performance in Selective Detection of B-VOCs by MIP-NP Loading.

In this study, we investigate the effect of varying the loading of molecularly imprinted polymer nanoparticles (MIP-NPs) on the morphology and sensing performance of electrospun nanofibres for the selective detection of linalool, a representative plant-emitted monoterpene. The proposed strategy combines two synergistic technologies: molecular imprinting, to introduce chemical selectivity, and electrospinning, to generate high-surface-area nanofibrous sensing layers with tuneable architecture. Linalool-imprinted MIP-NPs were synthesized via precipitation polymerization using methacrylic acid (MAA) and ethylene glycol dimethacrylate (EGDMA), yielding spherical particles with an average diameter of ~135 nm.

The Nursing Student Licensure Examination: A Scoping Review.

: In an increasingly globalized context marked by growing professional mobility, establishing shared standards for assessing nursing competencies is essential. The licensure examination represents a critical gateway between academic preparation and professional practice. However, significant ambiguity remains regarding what competencies are assessed and how this assessment is conducted internationally.

What Are the Game Changers in Total Knee Arthroplasty? A Narrative Review.

: Total knee arthroplasty (TKA) has evolved significantly, yet achieving consistently optimal outcomes remains challenging across diverse patient populations. This comprehensive narrative review identifies evidence-based "game changers" that genuinely transform TKA success while distinguishing them from interventions lacking clinical superiority. The analysis organizes findings across three perioperative phases: preoperative optimization, intraoperative techniques, and postoperative management.

The Mediating Role of Dispositional Optimism and Perfectionism on the Relationship Between Perceived Parental Psychological Control and Support and Adolescents' Well-Being.

Adolescents' psychological well-being results from the interaction between individual traits, such as optimism and perfectionism, and contextual factors. According to the Self-Determination Theory (SDT), the living environment can promote well-being by fulfilling basic psychological needs. Perceived parental support or control may influence the satisfaction of these needs and the development of dispositional traits, with significant consequences on well-being.

ChatGPT and Microsoft Copilot for Cochlear Implant Side Selection: A Preliminary Study.

: Artificial Intelligence (AI) is increasingly being applied in otolaryngology, including cochlear implants (CIs). This study evaluates the accuracy and completeness of ChatGPT-4 and Microsoft Copilot in determining the appropriate implantation side based on audiological and radiological data, as well as the presence of tinnitus. : Data from 22 CI patients (11 males, 11 females; 12 right-sided, 10 left-sided implants) were used to query both AI models.

Septic Shock in Hematological Malignancies: Role of Artificial Intelligence in Predicting Outcomes.

Septic shock is a life-threatening complication of sepsis, particularly in patients with hematologic diseases who are highly susceptible to it due to profound immune dysregulation. Recent advances in artificial intelligence offer promising tools for improving septic shock diagnosis, prognosis, and treatment in this vulnerable population. In detail, these innovative models analyzing electronic health records, immune function, and real-time physiological data have demonstrated superior performance compared to traditional scoring systems such as Sequential Organ Failure Assessment.

Adverse cardiovascular events in coronary Plaques not undeRgoing pErcutaneous coronary intervention evaluateD with optIcal Coherence Tomography. The PREDICT-AI risk model.

Introduction: Most acute coronary syndromes (ACS) originate from coronary plaques that are angiographically mild and not flow limiting. These lesions, often characterised by thin-cap fibroatheroma, large lipid cores and macrophage infiltration, are termed 'vulnerable plaques' and are associated with a heightened risk of future major adverse cardiovascular events (MACE). However, current imaging modalities lack robust predictive power, and treatment strategies for such plaques remain controversial.

Problem difficulty and expertise modulate planning performance in a virtual embodied task.

Expertise in cognitively and motorically demanding tasks, such as indoor climbing and bouldering, is often associated with enhanced planning abilities, yet the specific relationship between cognitive and motor planning in such tasks remains underexplored. This study investigates how expertise influences route planning in bouldering, with a focus on the impact of problem difficulty. We asked expert and novice climbers to virtually solve easy and hard bouldering problems on a familiar indoor climbing wall, using a custom app that allowed them to plan and select sequences of hand movements.

Update on pediatric inflammatory bowel diseases epidemiology during SARS-CoV-2 outbreak:data from the Italian society of pediatric gastroenterology, epatology and nutrition registry.

Unlabelled: The SARS-CoV-2 pandemic significantly affected clinical practice worldwide. In Italy, hospital access was limited to urgent cases in 2020. The primary aim was to assess the impact of SARS-CoV-2 on pIBD in Italy during 2020 compared to 2019 and to 2021.

Platelet inhibition strategies in rescue stenting after failed thrombectomy: a large retrospective multicenter registry.

Background: Rescue stenting (RS) is a bailout strategy for failed thrombectomy. Optimal platelet inhibition strategy after RS remains unclear.

Objectives: We aimed to describe and compare different platelet inhibition strategies during/after RS.

Proteomic profiling identifies a stromal TGF-β1/podoplanin axis as a driver of colorectal cancer progression.

Background: The tumor microenvironment (TME) plays a pivotal role in the development and progression of colorectal cancer (CRC), yet the complex crosstalk among its components remains incompletely understood. Cancer-associated fibroblasts (CAFs) and tumor-associated macrophages (TAMs) have emerged as key regulators of CRC progression, but their specific contributions, particularly given their heterogeneity, are not fully elucidated. This study identifies podoplanin (PDPN), a transmembrane glycoprotein enriched in CAFs, as highly expressed in the CRC TME, in particular surrounding the tumor, and associated with macrophage infiltration and cancer progression.