Efficacy of Dupilumab in Patients with Chronic Rhinosinusitis with Nasal Polyps and Eosinophilic Otitis Media: A Six-Month Observational Study.

Chronic rhinosinusitis with nasal polyps (CRSwNP) and eosinophilic otitis media (EOM) are frequently co-existing eosinophilic disorders related to type 2 inflammation, which significantly impair the quality of life of patients. Dupilumab, a monoclonal antibody targeting the IL-4 receptor alpha and anti-IL-13, has demonstrated a promising profile of efficacy and safety in the treatment of CRSwNP; however, evidence on its role in concomitant EOM and CRSwNP remains limited in the literature. This study aims to evaluate the clinical efficacy of dupilumab in patients with concomitant CRSwNP and EOM over a six-month observational period.

Chair-Time During Polishing with Different Burs and Drills After Cement Customized Brackets Bonding: An In Vitro Comparative Study.

Digital planning and evolution of technology is allowing dentistry to be more efficient in time than before. In orthodontics the main purpose is to obtain fewer patient visits and to reduce the bonding time. For that, indirect bonding planned with CAD-CAM softwares is used to obtain a shorter treatment period, in general, and less chair-time.

ChatGPT and Microsoft Copilot for Cochlear Implant Side Selection: A Preliminary Study.

: Artificial Intelligence (AI) is increasingly being applied in otolaryngology, including cochlear implants (CIs). This study evaluates the accuracy and completeness of ChatGPT-4 and Microsoft Copilot in determining the appropriate implantation side based on audiological and radiological data, as well as the presence of tinnitus. : Data from 22 CI patients (11 males, 11 females; 12 right-sided, 10 left-sided implants) were used to query both AI models.

Formwork Technique with Mesh in Elevations of Sinus Floors with Large Perforations of the Schneider Membrane: A Case Pilot.

: Currently, maxillary sinus floor elevation is one of the most common procedures used in implantology practice. Despite its predictability, the technique is not without complications, such as graft material dispersion in the sinus cavity, wound dehiscence, hematoma, fenestrations, oroantral fistulas, epistaxis, acute sinusitis, and Schneider membrane perforations. The treatment of the latter can be complex, and depending on its extent, surgery deferral may be necessary, leading to increased patient morbidity.

Parotid Epithelial-Myoepithelial Carcinoma, Lymph Node Metastasis After 9 Years: A Case Report.

: Epithelial-myoepithelial carcinoma (EMC) is a rare, low-grade malignant tumor of the salivary glands. It is characterized by a low malignancy potential, as indicated by its low rate of lymph node involvement and distant metastasis, and has a local recurrence rate of approximately 50%. Due to the rarity of EMC and the limited data available in the literature, there are no established treatment or follow-up guidelines.

Salivary and tissue CD44 expression in laryngeal cancer.

The most common malignant tumor of head and neck cancer is laryngeal carcinoma, often diagnosed at advanced stages, underscoring the need for reliable diagnostic and prognostic biomarkers. This study investigates the correlation between CD44 expression in tumor tissues and its soluble fraction (CD44sol) in saliva, evaluating their potential as diagnostic and prognostic markers. The study was conducted on 74 patients with laryngeal carcinoma.

Evaluation of Computer-Aided Navigation and Augmented Reality for Bicortical Mini-Implant Placement in Maxillary Expansion: An In Vitro Study.

The objective of the present study was to evaluate and compare the accuracy of the computer-aided static navigation technique (NAV), augmented reality (AR) and freehand placement technique (FHT) for the bicortical orthodontic self-drilling mini-implants for maxillary skeletal expansion (MSE) appliances placed in palate. : A total of 120 bicortical orthodontic self-drilling mini-implants were placed in the palate of ten 3D printed anatomically based polyurethane models of a completely edentulous upper maxilla. The orthodontic mini-implants were randomly assigned to the following placement techniques: (A) computer-aided static navigation technique ( = 40) (NAV), (B) augmented reality device ( = 40) (AR) and (C) conventional freehand technique ( = 40) (FHT).

ChatGPT in the Management of Chronic Rhinosinusitis with Nasal Polyps: Promising Support or Digital Illusion? Insights from a Multicenter Observational Study.

Chronic rhinosinusitis with nasal polyps is a chronic inflammatory disease with a significant impact on quality of life and is frequently associated, from a pathogenetic perspective, with type 2 inflammation. The introduction of biologic therapies has marked a turning point in the management of severe forms of the disease, offering a valuable treatment option. However, selecting the most suitable biologic agent for a specific patient remains a clinical challenge.

In Vitro Assessment of Tooth Reduction in Incisors, Canines, and Bicuspids Using Horizontal (Chamfer) and Vertical (BOPT and BOPTm) Finishing Lines.

Introduction: The selection of the finishing line for dental abutment preparation is influenced by various factors such as the restorative material, esthetic demands, procedural simplicity, and the clinician's experience. However, fundamental principles of tooth preparation, including the preservation of tooth structure, retention form, abutment strength, and margin integrity, are paramount in ensuring predictable and successful prosthodontic outcomes.

Objective: This study aims to evaluate the extent of tooth reduction in upper central incisors, canines, and premolars when three abutment preparation techniques-horizontal (chamfer) and vertical (biologically oriented preparation technique (BOPT) and modified BOPT (BOPTm))-are applied.

The Global Burden of Maxillofacial Trauma in Critical Care: A Narrative Review of Epidemiology, Prevention, Economics, and Outcomes.

: Maxillofacial trauma represents a significant global health challenge with substantial physical, psychological, and socioeconomic consequences. This narrative review analyzed 112 articles published between 2000 and 2024 examining epidemiology, prevention, economics, and outcomes of maxillofacial trauma in critical care settings. : Road traffic accidents remain the primary cause globally, followed by interpersonal violence and occupational injuries.

Options for Regenerative Treatment with Bone Grafts in Children with Anterior Lip/Palate Cleft-A Review.

Anterior lip/palate cleft is a congenital deformity affecting the upper lip and palate, posing significant challenges in both aesthetic and functional aspects for children. Effective management of this condition is crucial for improving quality of life and ensuring normal development. This review aims to highlight the regenerative treatment options available for children with anterior lip/palate cleft, focusing on the use of bone grafts and other advanced dental procedures.

A rare case of a mammary analog secretory carcinoma of the right submandibular gland.

Salivary gland cancer is one of the most common malignant neoplasms of head and neck. Not only is it rare but its clinical course is also very heterogeneous. A 64-year-old woman was diagnosed with submandibular gland carcinoma.

Association Between Alzheimer's Disease and Periodontal Inflammatory Parameters: A Systematic Review.

Background: The purpose of this systematic review was to analyze the current evidence of the potential correlation between periodontitis inflammatory parameters and Alzheimer's Disease (AD).

Material And Methods: A systematic review was conducted in accordance with the PRISMA guidelines. Electronic literature searches in PubMed, Medline, EBSCO, Scopus (ELSEVIER), Cochrane Library (Wiley) and Grey Library were conducted to analyze relevant references.

Effectiveness and Safety of Antibiotic Therapy Combined with NSAIDs or SAIDs in Osteomyelitis of the Oral and Maxillofacial Region: A Systematic Review.

Osteomyelitis is a progressive bone infection requiring a combination of antimicrobial and anti-inflammatory therapies. While antibiotics remain the cornerstone of treatment, the role of NSAIDs and steroidal anti-inflammatory drugs (SAIDs) in modulating inflammation and improving clinical outcomes warrants further investigation. This systematic review evaluates the effectiveness and safety of combined antibiotic and NSAID/SAID therapy in osteomyelitis, aligning treatment strategies with disease stage and pathogenesis.

Patients' satisfaction and efficacy of modern conventional hearing aids: A comprehensive analysis of the self-reported user experiences in adult people.

Objective: Hearing loss is a widespread condition that impacts the quality of life, affecting communication, social interactions, and cognitive functions. This study aimed to evaluate the subjective benefit and satisfaction of using hearing aids among patients since the adoption rate of hearing aids remains low.

Methods: The study retrospectively analysed data from 133 patients with hearing aids, using the Abbreviated Profile of Hearing Aid Benefit (APHAB) and the Satisfaction with Amplification in Daily Life (SADL) questionnaires.

Mepolizumab in chronic rhinosinusitis with nasal polyps: Real life data in a multicentric Sicilian experience.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a type 2 pattern of inflammation. Mepolizumab was approved for the treatment of CRSwNP in 2021. However, there is a lack of real-life studies.

Exploring the Hearing Improvement and Parental Stress in Children with Hearing Loss Using Hearing Aids or Cochlear Implants.

This study aims to describe the stress levels experienced by parents of children with hearing loss who use conventional hearing aids or cochlear implants, and to assess the correlation between parental stress and the auditory skills acquired by the children. The study was conducted at the Policlinic "Gaetano Martino" in Messina, evaluating data from 42 pairs of parents of children using hearing aids or cochlear implants. Parents completed the LittlEARS Auditory Questionnaire (LEAQ) and the Parental Stress Scale (PSS) 18 months after the initial device (hearing aid or cochlear implant) had been activated.

Investigation of Deficits in Auditory Emotional Content Recognition by Adult Cochlear Implant Users through the Study of Electroencephalographic Gamma and Alpha Asymmetry and Alexithymia Assessment.

Background/objectives: Given the importance of emotion recognition for communication purposes, and the impairment for such skill in CI users despite impressive language performances, the aim of the present study was to investigate the neural correlates of emotion recognition skills, apart from language, in adult unilateral CI (UCI) users during a music in noise (happy/sad) recognition task. Furthermore, asymmetry was investigated through electroencephalographic (EEG) rhythm, given the traditional concept of hemispheric lateralization for emotional processing, and the intrinsic asymmetry due to the clinical UCI condition.

Methods: Twenty adult UCI users and eight normal hearing (NH) controls were recruited.

Immediate versus conventional loading in short and ultra-short implants: a protocol design.

Background: After tooth extraction, inevitable resorption of the postextraction socket occurs. Placing an immediate implant does not fully preserve the bone integrity of the socket. Preservation techniques cannot avoid alveolar resorption.

Characterization of Cochlear Implant Artifact and Removal Based on Multi-Channel Wiener Filter in Unilateral Child Patients.

Cochlear implants (CI) allow deaf patients to improve language perception and improving their emotional valence assessment. Electroencephalographic (EEG) measures were employed so far to improve CI programming reliability and to evaluate listening effort in auditory tasks, which are particularly useful in conditions when subjective evaluations are scarcely appliable or reliable. Unfortunately, the presence of CI on the scalp introduces an electrical artifact coupled to EEG signals that masks physiological features recorded by electrodes close to the site of implant.

Open-fitting hearing aids: a comparative analysis between open behind-the-ear and open completely-in-the-canal instant-fit devices.

Purpose: Our study aims to assess the open-fitting capabilities and vent properties of traditional open-fitting behind-the-ear (open BTE) hearing aids to instant-fit open-fitting completely-in-the-canal (open CIC) systems.

Methods: The study analysed data from 40 patients grouped in two groups based on the used hearing aids. Free field pure tone and speech audiometry were performed to obtain the free-field pure tone average and free-field word recognition score (WRS).

The Use of Statins as an Adjunctive Periodontal Disease Treatment: Systematic Review and Meta-Analysis.

Background: the purpose of this systematic review was to assess the clinical and radiographic effect of subgingival-administered statins as an adjunct periodontal treatment in patients with periodontitis.

Methods: Electronic literature searches in Medline/PubMed and the Cochrane Library were conducted to identify all relevant articles. Eligibility was based on inclusion criteria which included Randomized Controlled Trials (RCTs) published after 2010, where the periodontal variables were assessed before and after periodontal treatment in combination with a statin administration.

Effectiveness and safety profile of mepolizumab in chronic rhinosinusitis with nasal polyps: Real life data in a tertiary care.

Background: Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by a type 2 pattern of inflammation. Mepolizumab was approved for the treatment of CRSwNP in 2021, it may be useful to evaluate its safety profile in a real-world setting.

Aim: This work aimed to prospectively highlight the effectiveness and safety profile of Mepolizumab in patients with CRSwNP enrolled in the Otorhinolaryngology Unit of the University Hospital of Messina.

The Morphology of Nasal Polyps in Different Age Groups: Histopathological Features.

Background: Nasal polyps (NPs) represent the end-stage manifestation of chronic rhinosinusitis (CRS), a relatively common pathological condition encountered in all ages of life.

Methodology: The aim of our study was to evaluate the histological features and inflammatory cellular components of NPs in a retrospective cohort (143 cases) of pediatric, adult and elderly populations in order to discuss the possible morphological age-related differences statistically documented.

Results: In the pediatric group, the inflammatory infiltrate presented many eosinophils mixed with lymphocytes, while in the adult population, lymphocytes and plasma cells were mainly evident, frequently with a perivascular distribution or with the formation of subepithelial lymphoid nodules.

Functional outcomes for speech-in-noise intelligibility of NAL-NL2 and DSL v.5 prescriptive fitting rules in hearing aid users.

Purpose: The primary aim of this research study is to assess whether differences exist in the application of the NAL-NL2 and DSL v.5 prescription formulas in terms of speech-in-noise intelligibility.

Methods: Data from 43 patients, were retrospectively evaluated and analyzed.