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Anterior lip/palate cleft is a congenital deformity affecting the upper lip and palate, posing significant challenges in both aesthetic and functional aspects for children. Effective management of this condition is crucial for improving quality of life and ensuring normal development. This review aims to highlight the regenerative treatment options available for children with anterior lip/palate cleft, focusing on the use of bone grafts and other advanced dental procedures. A review of the current literature and clinical practices was conducted to identify and evaluate the most effective treatment options. Emphasis was placed on regenerative techniques, particularly the use of bone grafts. Advancements in regenerative dentistry offer promising outcomes for children with anterior lip/palate cleft. Bone grafts, combined with innovative techniques such as growth factors, stem cell therapy, and distraction osteogenesis, provide effective solutions for restoring function and aesthetics. A multidisciplinary approach is essential to ensure comprehensive care and optimal results for these patients.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12109887 | PMC |
http://dx.doi.org/10.3390/children12050559 | DOI Listing |
Knee Surg Sports Traumatol Arthrosc
September 2025
UPMC Sports Surgery Clinic, Santry Demesne, Dublin, Ireland.
Purpose: Bone-patellar tendon-bone (BPTB) and Hamstring (HT) autografts are commonly used for anterior cruciate ligament reconstruction (ACLR). Concerns exist regarding postoperative anterior knee pain (AKP) and kneeling discomfort with BPTB grafts. However, many studies solely report the presence/absence of anterior knee pain, without assessing its clinical significance in terms of functional limitation or impact on quality of life.
View Article and Find Full Text PDFGut Liver
September 2025
Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Background/aims: Despite medical advances in recent decades, the mortality rate of advanced liver cirrhosis remains high. Although liver transplantation remains the most effective treatment, candidate selection is limited by donor availability and alcohol abstinence requirements. Bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation has shown promise for the treatment of advanced cirrhosis.
View Article and Find Full Text PDFInt Endod J
September 2025
Department of Biochemistry, School of Dentistry, IHBR, Kyungpook National University, Daegu, South Korea.
Aim: Prickle planar cell polarity (PCP) protein 2 (Prickle2) encodes a homologue of Drosophila prickle and is involved in the non-canonical Wnt/PCP signalling pathway. However, its exact role in dentinogenesis remains unclear. Dentinogenesis, a key process in tooth morphogenesis, involves the patterned arrangement of odontoblasts and the formation of dentine matrix along the pulp cavity.
View Article and Find Full Text PDFBest Pract Res Clin Haematol
September 2025
Department of Personalized Medicine and Rare Diseases, Medfuture Institute for Biomedical Research - Department of Hematology, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Hematology, Ion Chiricuta Cancer Center, Cluj Napoca, Romania. Electronic address:
Plasma cell myeloma (multiple myeloma) is a blood cancer characterized by the clonal proliferation of plasma cells in the bone marrow. Treatment strategies evolve year by year, new drugs getting Food and Drug Administration (FDA)-approved each year. Chimeric antigen receptor (CAR) therapies are an advanced form of immunotherapy that engineer T cells to recognize and destroy cancer cells.
View Article and Find Full Text PDFBest Pract Res Clin Haematol
September 2025
Department of Personalized Medicine and Rare Diseases, Medfuture Institute for Biomedical Research - Department of Hematology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Hematology, Ion Chiricuta Cancer Center, Cluj Napoca, Romania. Electronic address: c
Lymphomas are a group of malignant proliferations of B, T or NK-lymphoid cells at different stages of maturation. While they primarily occur in lymph nodes or lymphatic tissues, they can also involve bone marrow, blood, or other organs. Despite advances in treatment, many patients experience relapse, or develop refractory disease, prompting the development of new therapies.
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