Repairing composite mandibular defects with the chimeric deep circumflex iliac artery perforator flap.

Mandibular defects caused by congenital anomalies, oncologic resections, trauma, or infections impair essential functions such as mastication, speech, and facial aesthetics, necessitating reconstruction to restore both biomechanical integrity and quality of life. While fibula osteocutaneous flaps remain the gold standard for complex defects due to their versatility, the deep circumflex iliac artery (DCIA) bone flap-historically limited by inconsistent vascular anatomy and technical harvesting challenges-provides anatomical advantages but lacks reliable soft tissue utility. The chimeric DCIA perforator flap (DCIAPF) addresses these limitations by utilizing terminal DCIA skin perforators to create thin, well-vascularized skin paddles independent of muscular branches, thereby reducing bulk and donor-site morbidity.

Psychological stress-activated NR3C1/NUPR1 axis promotes ovarian tumor metastasis.

Ovarian tumor (OT) is the most lethal form of gynecologic malignancy, with minimal improvements in patient outcomes over the past several decades. Metastasis is the leading cause of ovarian cancer-related deaths, yet the underlying mechanisms remain poorly understood. Psychological stress is known to activate the glucocorticoid receptor (NR3C1), a factor associated with poor prognosis in OT patients.

The short-term effects of spiral stabilization on human posture correction.

Background: Changes in human posture directly impact the structures of various body parts, often leading to musculoskeletal disorders. While identifying suitable treatments for pain associated with long-term postural abnormalities is important, preventing such conditions is demonstrably a superior solution. Spiral stabilization, known for its practical application, has proven effective in treating low back pain.

Chaihu Shugan San formula alleviates psychological stress-induced ovarian cancer susceptibility by inhibiting ubiquitin degradation of TLR2 in macrophages.

Background: Psychological stress is increasingly recognized for its potential to expedite tumor growth and enhance cancer susceptibility, yet the specific mechanisms at play remain largely unclear. Traditional Chinese Medicine (TCM) formulation, Chaihu Shugan San formula (CHSGS), known for its efficacy in alleviating liver Qi stagnation syndrome, has exhibited therapeutic benefits in cancer management. Macrophages are key immune cells in the tumor microenvironment, and their phagocytic and clearance functions for tumor cells play a crucial role in the occurrence and progression of tumors.

Responses of the contents and stoichiometry of soil carbon, nitrogen, and phosphorus to elevated atmospheric CO concentration and warming in paddy field.

To study the effects of elevated atmospheric CO concentration and warming on the contents and stoichio-metry of soil organic carbon (SOC), total nitrogen (TN), total phosphorus (TP) in paddy field is of great significance for understanding the functions of paddy ecosystem under climate change. Based on the T-FACE platform, we conducted an experiment with four treatments: ambient conditions (CK); elevated atmospheric CO concentration up to 600 μmol·mol; warming of canopy air by 2 ℃ over ambient; elevated atmospheric CO concentration up to 600 μmol·mol combined with warming of canopy air by 2 ℃ over ambient. The contents of SOC, TN, TP, soil organic carbon composition, soil bulk density (BD), soil water content (SWC) and particle size composition were measured.

[Aluminum absorption capacity of different cultivars of seedlings under aluminum stress and the physiological and biochemical mechanisms].

exhibits strong tolerance to acid and aluminum stress. Many cultivars can absorb Al from soils, resulting in variations of their flower color from red to blue. This characteristic presents a potential avenue for the ecological remediation of aluminum-rich acidic soils.

Development of a clinical prediction model for postoperative complications following tubularized incised plate urethroplasty: a multicenter study.

Purpose: This multicenter study aimed to identify risk factors for postoperative complications following tubularized incised plate urethroplasty (TIP) in hypospadias patients and develop a clinical prediction model.

Methods: Retrospective data from 17 tertiary centers (2018-2021) were analyzed.

Inclusion Criteria: primary TIP surgery with complete anatomical and follow-up data.

Anterior Attachments of the Medial Patellofemoral Ligament: Morphological Characteristics.

Background: The medial patellofemoral ligament (MPFL) is the most important passive restraint of the medial patella and provides approximately 53% to 80% of medial soft-tissue restraints, although its relationship to the parapatellar structures is still not completely understood.

Methods: Twenty-six formalin-fixed knees (13 for P45 plastination, 10 for dissection, and 3 for histology) were obtained from cadavers donated to the Department of Anatomy at Dalian Medical University. The mean age of the donors was 78.

The role of HIF-1α in hypoxic metabolic reprogramming in osteoarthritis.

The joint dysfunction caused by osteoarthritis (OA) is increasingly becoming a major challenge in global healthcare, and there is currently no effective strategy to prevent the progression of OA. Therefore, better elucidating the relevant mechanisms of OA occurrence and development will provide theoretical basis for formulating new prevention and control strategies. Due to long-term exposure of cartilage tissue to the hypoxic microenvironment of joints, metabolic reprogramming changes occur.

Analysis of recurrence factors after radical mandibular resection for ameloblastoma.

Background: To analyze causes of recurrence following radical mandibular resection of ameloblastoma, and to propose surgical variation.

Methods: We conducted a retrospective analysis of patients treated for ameloblastoma from 2012 to 2024, specifically those who underwent radical mandibular resection followed by reconstruction with autologous bone flaps, focusing on cases of recurrence.

Results: Six patients were included in the study, all with primary tumors located in the mandible.

Comparing the pregnancy outcomes of Re‑ICSI and ICSI embryos in fresh ET and FET cycles.

Early rescue intracytoplasmic sperm injection (Re-ICSI) can prevent total fertilization failure (TFF) during conventional fertilization (IVF). However, the implantation rate of Re-ICSI embryos is lower than that of direct ICSI during fresh embryo transfer (ET). The aim of the present study was to investigate the effect of frozen ET (FET) after Re-ICSI.

Complications and Peri-operative Characteristics of Flaps for Reconstruction of Defects after Ablation of Squamous Cell Carcinoma of the Floor of the Mouth.

Objective: To determine the appropriate method to use to repair defects after ablation of squamous cell carcinoma (SCC) of the floor of the mouth (FOM).

Methods: A retrospective review of 119 patients who underwent surgical resections of SCC of the FOM and flap reconstructions was conducted. A Student t test was used to examine the statistical differences in operative time, length of hospital stay and complications among groups with different reconstructions.

An anatomical study of the suboccipital cavernous sinus and its relationship with the myodural bridge complex.

The suboccipital cavernous sinus (SCS) and the myodural bridge complex (MDBC) are both located in the suboccipital region. The SCS is regarded as a route for venous intracranial outflow and is often encountered during surgery. The MDBC consists of the suboccipital muscles, nuchal ligament, and myodural bridge and could be a power source for cerebrospinal fluid circulation.

REGγ promotes mantle cell lymphoma cell apoptosis by downregulating NF-κB signaling.

Background: Mantle cell lymphoma (MCL) is an aggressive B-cell non-Hodgkin lymphoma (NHL). REGγ is important for tumor occurrence and development, but understanding of the specific role of REGγ in MCL is lacking. We aimed to identify REGγ effects on the proliferation and apoptosis of MCL cells and clarify the underlying mechanisms.

A multicenter study on surgical procedure selection and risk factor analysis of postoperative complications after TIP and Duckett hypospadias repair.

Background: Hypospadias is a common congenital malformation in pediatric urology with surgery being the only curative treatment. Although there are hundreds of surgical methods for hypospadias, no single method can treat all types, and there are still high rates of postoperative complications. We performed this study to investigate surgical procedure selection and perform risk factor analysis of postoperative complications in hypospadias repair.

Genetic analysis of recurrent parthenogenesis: A case report and literature review.

The present study reported a case of bilateral salpingectomy for an ectopic pregnancy with recurrent parthenogenesis over two fertilization (IVF) cycles. The first IVF cycle resulted in short-time fertilization. Two cleaved embryos were present after removing the cumulus cells.

The relationship between compensatory hyperplasia of the myodural bridge complex and reduced compliance of the various structures within the cranio-cervical junction.

The myodural bridge complex (MDBC) is described as a functional anatomic structure that involves the dense connective tissue fibers, muscles, and ligaments in the suboccipital region. It has recently been proposed that the MDBC can influence cerebrospinal fluid (CSF) circulation. In the present study, bleomycin (BLM), a type of antibiotic that is poisonous to cells, was injected into the posterior atlanto-occipital interspace (PAOiS) of rats to induce fibrous hyperplasia of structures in PAOiS.

Frozen blastocysts: Assessing the importance of day 5/day 6 blastocysts or blastocyst quality.

The aim of the present study was to analyze the high-quality blastocyst (HB) rate in all embryo frozen cycles and investigate the pregnancy outcomes for day 5/day 6 (D5/D6) blastocysts with respect to the blastocyst quality in programmed single vitrified-warmed blastocyst transfer (SVBT). We performed a retrospective study comparing D5/D6 HBs in fertilization/intracytoplasmic sperm injection (IVF/ICSI) for all blastocyst frozen cycles. Patients were <35 years at the oocyte collection in their first fresh cycle without fresh transfer.

Alpha-Fetoprotein Ratio Predicts Alpha-Fetoprotein Positive Hepatocellular Cancer Patient Prognosis after Hepatectomy.

Background: This study was conducted to investigate the effect of alpha-fetoprotein (AFP) ratio on the prognosis of AFP-positive hepatocellular carcinoma (HCC) patients after hepatectomy.

Methods: We retrospectively included 879 HCC patients with AFP-positive who underwent hepatectomy from February 2012 to October 2017 and randomly divided into training cohort and validation cohort. AFP ratio was equal to the AFP level within one week before hepatectomy to AFP level within 20-40 days after surgery.

A Prospective Phase II Study of Simultaneous Modulated Accelerated Radiotherapy Concurrently With CDDP/S1 for Esophageal Squamous Cell Carcinoma in the Elderly.

Background: To explore the efficacy and toxicity of simultaneous modulated accelerated radiotherapy (SMART) concurrently with cisplatin (CDDP) and S1 (tegafur/gimeracil/oteracil) in elderly patients with esophageal squamous cell carcinoma (ESCC).

Methods: This single-arm, phase II study enrolled pathologically confirmed, stage II-IVa ESCC of 70-80 years old and Eastern Cooperative Oncology Group performance status (ECOG PS) 0-2. Patients received SMART (64 Gy to gross tumor volume and 48 Gy to clinical target volume in 30 fractions) with concurrent CDDP (day 1 of each week) and S1 (days 1-14, 22-35).

Identification of SOX6 and SOX12 as Prognostic Biomarkers for Clear Cell Renal Cell Carcinoma: A Retrospective Study Based on TCGA Database.

Background: The SOX gene family has been proven to display regulatory effects on numerous diseases, particularly in the malignant progression of neoplasms. However, the molecular functions and action mechanisms of SOX genes have not been clearly elucidated in clear cell renal cell carcinoma (ccRCC). We aimed to explore the expression status, prognostic values, clinical significances, and regulatory actions of SOX genes in ccRCC.