Impaired glymphatic system is associated with secondary neuronal injury in the thalamus following cerebral cortical infarction.

Focal cerebral infarction leads to abnormal amyloid-β (Aβ) deposits, which relates to secondary neuronal injury in the ipsilateral thalamus and hinders post-stroke functional recovery. However, the mechanisms underlying Aβ-pathology in the thalamus remain unclear. This study was designed to investigate the potential associations of glymphatic system with Aβ deposits and delayed neuronal damage of the ipsilateral thalamus secondary to cerebral infarction.

Thyroid Endocrine Disrupting Potential of Fluoxetine in Zebrafish Larvae.

Fluoxetine (FLX), a typical selective serotonin reuptake inhibitors, has been frequently detected in aquatic environment and wild fish. However, little is known about its effect on thyroid endocrine system. In the present study, zebrafish (Danio rerio) embryos were exposed to 1, 3, 10, and 30 μg/L of FLX for 6 days.

Behavioral impairments and disrupted mitochondrial energy metabolism induced by polypropylene microplastics in zebrafish larvae.

Polypropylene microplastics (PP-MPs) are emerging pollutant commonly detected in various environmental matrices and organisms, while their adverse effects and mechanisms are not well known. Here, zebrafish embryos were exposed to environmentally relevant concentrations of PP-MPs (0.08-50 mg/L) from 2 h post-fertilization (hpf) until 120 hpf.

Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate Enhances -Mediated Lipophagy to Remodel Lipid Metabolism in Zebrafish Liver.

An emerging environmental contaminant, bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate (TBPH), can bioaccumulate in the liver and affect hepatic lipid metabolism. However, the in-depth mechanism has yet to be comprehensively explored. In this study, we utilized transgenic zebrafish : to image the interference of TBPH on zebrafish liver development and lipid metabolism at the early development stage.

Remote cortical atrophy and language outcomes after chronic left subcortical stroke with aphasia.

Objective: Subcortical stroke can cause a variety of language deficits. However, the neural mechanisms underlying subcortical aphasia after stroke remain incompletely elucidated. We aimed to determine the effects of distant cortical structures on aphasia outcomes and examine the correlation of cortical thickness measures with connecting tracts integrity after chronic left subcortical stroke.

Diagenetic evolution of the Oligocene Huagang Formation in Xihu sag, the East China Sea Shelf Basin.

The deep and ultra deep clastic reservoir is characterized by strong reservoir heterogeneity and complicated reservoir-forming characteristics for its high degree of diagenetic stage and the complexity of diagenesis. In order to better study the diagenetic evolution of deep and ultra deep reservoir in the burial process, a fine subsection scheme of 36 diagenetic micro-stage (DS) in diageneitic process was proposed based on paleotemperature (T), vitrinite reflectance (Ro%) and proportion of smectite in illite/smectite interstratified minerals (I/S-S%). Taking the Oligocene Huagang Formation in the Xihu sag of the East China Sea Basin as an example, the diagentic stage IIA1-IIA2-IIB was identified mainly by means of formation temperature data (T), homogenization temperature of fluid inclusion (Th), vitrinite analysis and clay mineral X-ray diffraction method.