Primary thyroid lymphoma complicated with papillary thyroid carcinoma characterized by recurrent neck pain and fever.

Introduction: The coexistence of primary thyroid lymphoma (PTL) and papillary thyroid carcinoma (PTC) is extremely rare, especially in young populations. Therefore, it is extremely important to understand and master the clinical manifestations, diagnosis, treatment, and prognosis of these diseases.

Methods: This article reports a case of a 29-year-old female patient with recurrent right neck swelling and pain with fever and progressive enlargement of the thyroid gland.

Individualized survival prediction and risk stratification using machine learning for patients with malignant struma ovarii: a population-based study with external validation.

Background: Malignant struma ovarii (MSO) is a rare thyroid-type cancer originating in ovarian teratoma. Prognosis of MSO is less studied without unanimous staging or stratification system. This study aimed to developed and validated a machine learning (ML)-based model to predict overall survival (OS) for patients with MSO and to risk-stratify them.

Robotic versus open level III-IV inferior vena cava thrombectomy: A multicenter, retrospective, propensity-matched analysis.

Background: The safety and efficacy of robotic inferior vena cava thrombectomy (IVCTE) for level III-IV thrombus with a comparison to open IVCTE is still unclear. This study aimed to compare robotic vs open IVCTE for renal tumors with level III-IV tumor thrombus.

Materials And Methods: We performed a retrospective analysis of patients who underwent R-IVCTE or O-IVCTE in four academic tertiary centers between 2015 and 2023.

Identifying Hemodynamic Predictors of Aortic Growth After Thoracic Endovascular Aortic Repair for Type B Aortic Dissection.

Objective: To explore independent predictors of aortic growth in patients with type B aortic dissection (TBAD) after thoracic endovascular aortic repair (TEVAR), utilizing computational fluid dynamics (CFD) simulation.

Materials And Methods: Patients who underwent TEVAR for TBAD in a single center between April 2014 and April 2023 were evaluated retrospectively. Rapid enlargement (defined as ≥5 mm/year) or aortic rupture were used to categorize patients into aortic growth and nongrowth groups.

Chemigenetic Encoding of Fluorescent Dyes Enables High-Fidelity and Wash-Free Imaging of Proteins in Live Cells.

Fluorescent dyes are indispensable chemical tools for protein labeling, yet their utility in live-cell imaging remains constrained by background fluorescence from off-target interactions. A chemigenetic strategy is presented that integrates synthetic dye chemistry with genetically encoded fluorescence to achieve high-fidelity, wash-free imaging of target proteins. By leveraging Förster resonance energy transfer (FRET) between fluorescent proteins (FPs) and Halo-tag dyes, a system is engineered where fluorescence emission depends on FPs donor excitation, ensuring only dyes bound to target protein are fluorescent, while nonspecifically bound dyes remain dark, enhancing the signal-to-noise ratio (SNR).

Enhancing the photostability of red fluorescent proteins through FRET with Si-rhodamine for dynamic super-resolution fluorescence imaging.

Red fluorescent proteins (RFPs) are extensively utilized in biological imaging. However, their susceptibility to photobleaching restricts their effectiveness in super-resolution imaging where high photostability is crucial. In this study, we substantially improved the photostability of RFPs by incorporating a hybrid Förster resonance energy transfer (FRET) pair, utilizing RFPs as the energy donor and a photostable fluorophore, tetramethyl-Si-rhodamine (TMSiR), as the acceptor.

Clinical Outcomes and Safety Profile of Neoadjuvant PD-1 Inhibitors Combined With VEGFR-TKI Versus VEGFR-TKI in Nonmetastatic Renal Cell Carcinoma.

Objective: The effectiveness of combining immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs) in neoadjuvant therapy for renal cell carcinoma (RCC) remains unclear. This study aim to compare the efficacy and safety of neoadjuvant ICI plus TKI combination therapy versus TKI monotherapy in locally RCC patients.

Methods: This study included 185 cases of locally RCC disease(TanyNanyM0) receiving neoadjuvant therapy from 29 centers across China from January 2019 to Feburary 2024.

Experimental and modeling investigation of long-term leachability of nickel in re-molded cement-stabilized sediments.

The environmental impact of recycling waste sediments as construction materials has raised significant concerns, particularly regarding the long-term leachability of heavy metals. This study investigates the leaching behavior of nickel (Ni) in cement-stabilized sediments through tank leaching tests and modeling approaches. Considering the practical construction scenario, the effects of curing age and ambient pH on Ni release were examined, including the impact of crushing and re-molding processes.

Surface engineering of NIR-II luminescent gold nanoclusters for brain glioma-targeted imaging.

Ultrasmall gold nanoclusters (AuNCs) with photoluminescence in the second near-infrared region (NIR-II) have emerged as promising probes for biomedical applications. However, it remains a challenge to utilize NIR-II-emitting AuNCs for imaging brain glioblastoma (GBM), which is highly lethal and hard to diagnose in time. Herein, we have presented systematic investigations on the brain delivery and GBM targeting efficacies of NIR-II-emitting AuNCs protected by different ligands.

MLKL triggers NLRP3 activation in sodium arsenite-induced myocardial necroinflammation.

Prolonged exposure to arsenic elevates the risk of developing a range of cardiovascular disorders. However, the mechanisms underlying myocardial damage from arsenic exposure remain elusive. Our earlier research suggest that drinking arsenic-contaminated water can lead to substantial inflammatory and necrotic injury in the myocardium of rats.

Exploring the roles of ncRNAs in prostate cancer via the PI3K/AKT/mTOR signaling pathway.

Although various treatment options are available for prostate cancer (PCa), including androgen deprivation therapy (ADT) and chemotherapy, these approaches have not achieved the desired results clinically, especially in the treatment of advanced chemotherapy-resistant PCa. The PI3K/AKT/mTOR (PAM) signaling pathway is a classical pathway that is aberrantly activated in cancer cells and promotes the tumorigenesis, metastasis, resistance to castration therapy, chemoresistance, and recurrence of PCa. Noncoding RNAs (ncRNAs) are a class of RNAs that do not encode proteins.

Extraction and characterization of natural cellulosic fiber from the bark of the Wikstroemia monnula plant as potential reinforcement in composites.

The aim of this paper is to study the possibility of using of Wikstroemia monnula (W. monnula) fibers as reinforcement in composites. The fibers are extracted from the stem bark of W.

Enhancing Analysis of Extracellular Vesicles by Microfluidics.

Extracellular vesicles (EVs) play crucial roles in intercellular communication and hold great promise as biomarkers for noninvasive disease diagnosis. Intensive research efforts have been devoted to discovering the EV subpopulations responsible for specific functions or with enhanced effectiveness as disease markers, through extensive EV purification and content analysis. However, their high heterogeneity in size and cargo composition poses significant challenges for reaching such goals.

Improved Photovoltaic Performance of PEDOT:PSS/C-Si Hybrid Solar Cells with an Inverted Structure.

In this study, n-type crystalline silicon and organic conjugated polymer PEDOT:PSS were combined to prepare backside Si/PEDOT:PSS hybrid heterojunction solar cells by a low-temperature solution method. This provides a novel approach to reduce the production cost of crystalline Si solar cells and improve device efficiency. To address the issue that the contact performance of PEDOT:PSS film deteriorates due to the pyramidal structure of the Si surface, the contact performance of PEDOT:PSS and Si interface was optimized by using high-speed dual spin-coating technology, and the power conversion efficiencies (PCE) reached 15.

A Phase 2 Study of Tislelizumab as Neoadjuvant Treatment of Cisplatin-Ineligible High-Risk Upper Tract Urothelial Carcinoma.

Purpose: We investigated the efficacy and safety of tislelizumab as neoadjuvant therapy in patients with cisplatin-ineligible high-risk upper tract urothelial carcinoma (UTUC).

Materials And Methods: In this single-arm phase 2 trial (NCT04672330), 20 patients with high-risk UTUC were enrolled. Eligibility criteria included high-risk UTUC (defined as high-grade UTUC confirmed by endoscopic biopsy or urinary cytology, radiographic evidence of invasion [cT2-T4N0-2M0], and/or hydronephrosis), an Eastern Cooperative Oncology Group performance status of 0 to 2, no previous systemic therapy, and cisplatin ineligibility.

The optimal training intervention for improving the change of direction performance of adolescent team-sport athletes: a systematic review and network meta-analysis.

Background: Due to the influence of growth, adolescent team-sport athletes have the need to improve their change of direction (COD) performance and reduce the risk of anterior cruciate ligament (ACL) injuries during COD. However, the optimal intervention for improving COD performance has not yet been determined.

Objective: To quantitatively assess the effects of diverse training interventions on COD performance.

Naphthalimide-derived fluorogenic SNAP probe for real-time monitoring of protein degradation.

We developed the fluorogenic SNAP probe BGAN-8C to monitor protein degradation. It exhibited a 6-fold fluorescence enhancement upon binding with SNAP-tag. After the SNAP protein is degraded, the fluorescence of the released probe is quenched due to aggregation.

Long-Term Outcomes of PETTICOAT Technique-Assisted Thoracic Endovascular Aortic Repair for the Treatment of Acute and Subacute Complicated Type B Aortic Dissection.

Objective: To evaluate the long-term outcomes of the provisional extension to induce complete attachment technique (PETTICOAT) for the treatment of acute and subacute complicated type B aortic dissection (TBAD).

Methods: We retrospectively collected and analyzed the clinical data of patients with acute and subacute TBAD who were treated using the PETTICOAT technique at our center between March 2014 and March 2023. The primary endpoint was all-cause mortality; secondary endpoints were a composite of complications, such as entry flow, stent-graft-induced new entry (SINE), and re-intervention.

Rare case of spontaneous duodeno-colic fistula.

A 48-year-old woman presented to the outpatient clinic with a 4-month history of alternating diarrhea and constipation with bloating. Physical examination revealed a body mass index of 22.89 kg/m², normal development, and no tenderness or rebound tenderness in the abdomen.