Novel Self-Powered Biosensor Based on Highly Efficient Cosignal Accelerator and Multiple Signal Amplification Strategies toward Ultrasensitive miRNA-141 Assay.

A highly sensitive self-powered biosensor is designed based on gold-platinum nanorods (AuPt NRs) and the cascade reaction of catalytic hairpin assembly (CHA) and hybrid chain reaction (HCR) toward the miRNA-141 assay. As a cosignal accelerator, AuPt NRs enhance electrical conductivity between glucose oxidase (GOD) and a carbon paper (CP) electrode, thereby assisting in output signal enhancement. The cascade reaction of CHA-HCR is employed to efficiently amplify the detection signal and improve the sensitivity of the self-powered biosensor.

An "on-off-on" self-powered biosensor based on enzyme-free amplification for detection of three biomarkers.

Background: MicroRNAs (miRNAs), a type of small non-coding RNA sequences, are very important biomarkers and are involved in various physiological processes, such as cell proliferation, growth, differentiation, and apoptosis. Many reports have shown that miRNAs are closely associated with a variety of diseases, including neurodegenerative diseases and cancer. Currently, researchers have developed various methods for miRNAs detection, such as fluorescence, surface-enhanced Raman scattering, electrochemiluminescence, and electrochemical sensing.

Trametinib treatment for early-stage extracranial arteriovenous malformations: A multicenter, prospective, single-arm pilot study.

Background: Extracranial arteriovenous malformations (eAVMs) are progressive vascular anomalies for which conventional therapies are rarely curative. Few standard therapies have been developed for early-stage eAVMs. In particular, the efficacy and safety of trametinib for treating early-stage childhood eAVM are unclear.

Multifunctional AuAgPt Nanoframes for a Stimuli-Responsive Electrochemiluminescence Aptasensor.

A multifunctional electrochemiluminescence (ECL) coreaction accelerator, AuAgPt nanoframes (NFs), is described for use in an ECL aptasensor for highly sensitive aflatoxin B1 (AFB1) detection. As a signal quencher, the broad UV-vis absorption spectrum of AuAgPt nanosheets (NSs) overlaps the ECL emission spectrum of g-CN@Au, triggering an ECL resonance energy transfer (ECL-RET). By the adjustment of the dosage of hydrogen peroxide (HO), the AuAgPt NSs are transformed into AuAgPt NFs because HO etches Ag in AuAgPt NSs into Ag, which disrupts the RET process.

Simulation study of low-level disturbances affecting near surface inversion events in Urumqi.

With accelerated urbanization, temperature inversion phenomena are becoming more prominent in urban atmospheric environments, playing a very important role in air quality and public health. Despite the widespread literature on the formation and longevity of inversions, little is understood about the measures to mitigate them. Filling this knowledge gap, this work examines the impact of low-level artificial perturbations on near-surface inversions through the use of numerical modeling.

Ilizarov-assisted periosteal distraction for refractory arteriovenous malformation ulcers: first clinical report in Asia.

Refractory ulcers caused by high-flow arteriovenous malformations (AVMs) pose significant therapeutic challenges due to persistent tissue ischemia and shear stress-induced graft failure. Traditional embolization or flap reconstruction strategies often yield suboptimal outcomes, particularly in weight-bearing regions. We present a 28-year-old female with a non-healing dorsal foot AVM ulcer despite multiple embolizations and radical toe amputations.

Fully Wearable Devices for Real-Time Health Monitoring and Multimodal Sensing in Nanomedicine Using Multiplexed Green Biofuels.

Fully wearable devices are crucial for real-time health monitoring, but existing devices often lack stable power, on-site signal processing, and multimodal sensing. To overcome these limitations, we introduce the first self-powered and fully wearable sensor (MESFW) based on multiplexed green biofuels. The MESFW integrates a microfluidic module, sensing module, laser-induced graphene (LIG) electrodes, and customized electronics, enabling highly sensitive detection of glucose and alcohol in noninvasive biofluids (sweat, breath, saliva, tears) while monitoring daily activities (temperature, pressure, touch).

Syndromic capillary malformation with leg length discrepancy: Parkes-Weber syndrome treated by embolization, chemotherapy and Ilizarov technique.

Capillary malformations (CMs) are congenital low-flow vascular anomalies caused by dilated capillaries. Leg length discrepancy (LLD) is the condition characterized by unequal lower limb lengths, leading to functional and postural challenges. Capillary malformation with leg length discrepancy (CM-LLD) formally reveals syndrome such as Klippel-Trenaunay syndrome and Diffuse Capillary Malformation Overgrowth.

Bio-based sodium alginate/ammonium polyphosphate aerogel-coated rigid polyurethane foam: A sustainable approach for enhanced flame retardancy.

In order to overcome the fire risk of rigid polyurethane foam, this work aims to construct APP/SA/TEOS aerogel fire-proof coating on the surface of RPUF by vacuum freeze-drying, and the effect of the coating on the flame retardancy, thermal insulation and char formation properties of RPUF were systematically investigated. The results of thermogravimetry analysis (TG) shows that the APP/SA/TEOS aerogel coating endows the RPUF with better thermal stability, and the residual char at 700 °C is 198 % higher than that of the pure sample. Meanwhile, the LOI value was greatly improved to 60 vol%.

Plants Distinguish Different Photoperiods to Independently Regulate Post-Flowering Vegetative Growth and Reproductive Growth.

The post-flowering stage is critical for plant yield and seed quality. This can be influenced by the photoperiod; however, the underlying mechanisms are not clear. was selected as the experimental material to test this phenomenon.

adapts to desert environments through seed polymorphism during diaspore germination and seedling establishment.

Introduction: Seed polymorphism, defined as the production of two or more types of diaspores with distinct morphology and ecological function within a species, represents a bet-hedging strategy that enables plants to cope with unpredictable spatiotemporal environmental variability. Previous studies have mainly focused on annual plants; therefore, little is known about in perennial species, particularly in desert constructive plants.

Methods: This study investigated seed polymorphism in , a foundational desert shrub critical for maintaining the stability of fragile arid ecosystems.

The untold story of CD82: Exploring its non-canonical roles in cancer.

CD82, traditionally recognized as a metastasis suppressor within the tetraspanin family, has emerged as a key player in diverse cancer-related processes beyond its canonical functions. This review highlights recent research on the non-canonical roles of CD82 in cancer progression, with a particular focus on its regulation of immune cell interactions, its impact on tumor microenvironment modulation, and its potential as both a therapeutic target and a biomarker. By examining the novel functions of CD82 in immune modulation and its influence on key signaling pathways, we propose that CD82 offers promising avenues for therapeutic interventions in cancer.

Pd@Au Nanoframe Hydrogels for Closed-Loop Wound Therapy.

In this work, a multifunctional Pd@Au nanoframe hydrogel was designed to detect uric acid (UA) for in situ monitoring of wound infection and enhance wound healing by a chemo-photothermal strategy. In acidic conditions, the Pd@Au nanoframe hydrogels show high peroxidase-like activity by catalyzing HO to produce reactive oxygen species (ROS) to damage RNAs of bacteria and enhance antibacterial activity. Under Near-infrared (NIR) laser irradiation, the Pd@Au nanoframe hydrogels exhibit photothermal conversion performance; i.

Single-cell and spatial transcriptomic analyses reveal transcriptional cell lineage heterogeneity in extracranial arteriovenous malformation.

Background: Extracranial arteriovenous malformations (eAVMs) are rare congenital vascular anomalies consisting of abnormal artery-vein bypass with no intervening capillary network, and can lead to disability and death. The critical genetic determination factors and key transcriptional pathways of the eAVMs genesis process are still unclear.

Objective: To generate an overview of the molecular information within eAVMs at the single-cell level.

Hydrophobic Pedicularis Kansuensis/graphene aerogel with solar thermal effect enables efficient removal of sulfadiazine and oil from water.

The contamination of water resources by organic pollutants is a significant factor contributing to the scarcity of water resources. Furthermore, the various forms and quantities of organic pollutants present a considerable challenge to their management and remediation. Antibiotics and oil are two typical organic pollutants in water, which have a serious impact on the environment and biological health.

Machine Learning Assisted-Intelligent Lactic Acid Monitoring in Sweat Supported by a Perspiration-Driven Self-Powered Sensor.

Lactic acid has aroused increasing attention due to its close association with serious diseases. A real-time, dynamic, and intelligent detection method is vital for sensitive detection of lactic acid. Here, a machine learning (ML)-assisted perspiration-driven self-powered sensor (PDS sensor) is fabricated using Ni-ZIF-8@lactate oxidase and pyruvate oxidase (Ni-ZIF-8@LOx&POx)/laser-induced graphene (LIG), bilirubin oxidase (BOD)/LIG, and a microchannel for highly sensitive and real-time monitoring of lactic acid in sweat.

Microfluidics for Nanomedicine Delivery.

Nanomedicine is revolutionizing precision medicine, providing targeted, personalized treatment options. Lipid-based nanomedicines offer distinct benefits including high potency, targeted delivery, extended retention in the body, reduced toxicity, and lower required doses. These characteristics make lipid-based nanoparticles ideal for drug delivery in areas such as gene therapy, cancer treatment, and mRNA vaccines.

On-demand controlled bidirectional DNAzyme path for ultra-sensitive heavy metal ion detection.

A bidirectional self-powered biosensor is constructed for the quasi-simultaneous detection of Pb and Hg based on MoS@CuS heterostructures as an accelerator and hybridization chain reaction (HCR) as a signal amplification strategy. MoS@CuS heterostructures significantly facilitate electron transfer between glucose and bioelectrodes, thereby greatly improving the detection signal of self-powered biosensors. This novel biosensor employs the unique sequences of DNAzymes to isolate Pb and Hg by the cleavage effect and thymine (T)-Hg-thymine (T) structures, respectively.

Novel Ternary System for Electrochemiluminescence Biosensor and Application toward Pb Assay.

This study constructed an electrochemiluminescence (ECL) biosensor for ultrasensitive detection of Pb in a ternary system by employing DNAzyme. The ternary system is composed of a potassium-neutralized perylene derivative (KPTC) as the ECL emitter, KSO as the coreactant, and neodymium metal-organic frameworks (Nd-MOFs) as the coreaction accelerators. Nd-MOFs immobilize DNAzymes and enhance the luminescence intensity of the KPTC/KSO system.

Nitrogen-doped MoS QDs as fluorescent probes for sensitive detection of curcumin and cell imaging.

Background: Curcumin has been used in traditional medicine because of its pharmacological activity, including antioxidant, antibacterial, anticancer, and anticarcinogenic properties. Therefore, sensitive and selective monitoring of curcumin is highly demand for practical application.

Results: In this study, we describe the construction of a fluorescence method for curcumin assay based on nitrogen-doped MoS quantum dots (N-MoS QDs).

A Triple Signal Amplification Strategy for Accurate and Ultrasensitive miRNA-21 Detection.

A triple signal amplification strategy was integrated with a built-in double electrode and external energy storage device to fabricate a novel self-powered biosensor for ultrasensitive detection of miRNA-21. Specifically, DNA tetrahedra and haripin2-glucose oxidase are modified on the surface of the biocathode and bioanode by catalytic hairpin assembly (CHA) to achieve dual signal amplification. Moreover, triple signal amplification is realized by including an external capacitor.

Novel Self-Powered Biosensor Based on Au Nanoparticles @ Pd Nanorings and Catalytic Hairpin Assembly for Ultrasensitive miRNA-21 Assay.

An ultrasensitive self-powered biosensor is constructed for miRNA-21 detection based on Au nanoparticles @ Pd nanorings (Au NPs@Pd NRs) and catalytic hairpin assembly (CHA). The Au NPs@Pd NRs possess excellent electrical conductivity to improve the electron transfer rate and show good elimination of byproduct HO to assist glucose oxidase (GOD) to catalyze glucose; CHA is used as an amplification strategy to effectively enhance the sensitivity of the biosensor. To further amplify the output signal, a capacitor is integrated into the self-powered biosensor.