[Therapeutic mechanism of Compound Xuanju Capsule on erectile dysfunction].

Objective: To investigate the pharmacological mechanism of Compound Xuanju Capsule in the treatment of erectile dysfunction (ED) by using network pharmacology and molecular docking technology.

Methods: The active ingredients and targets of Compound Xuanju Capsule were screened using Traditional Chinese Medicine Systematic Pharmacology Database and Analysis Platform (TCMSP). TTD, OMIM, DrugBank and GeneCards databases were used to obtain genes related to ED, and the union of the results was taken as the disease genes of ED.

Exploring the Risk Factors of Rosacea Exacerbation Associated with COVID-19 Infection or Vaccination: A Cross-sectional Study.

COVID-19 can affect the skin, with rosacea flare-ups reported after infection or vaccination. This study compared rosacea patients with and without post-COVID-19 exacerbation to identify contributing factors. A customized electronic questionnaire was administered to rosacea patients, gathering COVID-19 infection/vaccination status, demographics, and rosacea features.

A Hybrid Nanogenerator Based on Rotational-Swinging Mechanism for Energy Harvesting and Environmental Monitoring in Intelligent Agriculture.

With the rapid growth of the Internet of Things, intelligent agriculture is becoming increasingly important. Traditional agricultural monitoring methods, which rely on fossil fuels and complex wiring, hinder progress. This work introduces a hybrid nanogenerator based on a rotational-swinging mechanism (RSM-HNG) that combines triboelectric nanogenerators (TENGs) and electromagnetic generators (EMGs) for efficient wind energy harvesting and smart agriculture monitoring.

Sulfonium lipid nanoparticles for intranasal mRNA delivery to lung epithelial and immune cells.

Lung epithelial and immune cells play an important role in respiratory health, serving as the first line of defense. Targeting these cells presents significant therapeutic opportunities, particularly for mRNA-based medicine. However, efficient mRNA delivery to lung cells remains challenging due to mucosal barriers, enzymatic degradation, and complex tissue architecture.

Global, regional, and national burden and trends of bladder cancer in individuals Aged 55 Years and older From 1990 to 2021: Findings from the Global Burden of Disease Study 2021.

Background: Bladder cancer (BC), a prevalent genitourinary malignancy, poses a substantial threat to public health, particularly among middle-aged and elderly populations. Given the increasing life expectancy, understanding the BC burden in these demographic groups is imperative.

Methods: Based on the GBD 2021 dataset encompassing 371 diseases and injuries with 88 risk factors globally, this study analyzed bladder cancer data from 204 countries and territories (1990-2021) for populations aged ≥55 years, with core metrics including incidence, deaths, and disability-adjusted life years (DALYs).

Lung-targeting lipid nanoparticle-mediated sparstolonin B delivery improves acute lung injury.

Acute respiratory distress syndrome (ARDS), a severe manifestation of acute lung injury (ALI), is characterized by high morbidity and mortality, with limited therapeutic options. Sparstolonin B (SsnB), a selective antagonist of Toll-like receptors (TLR)-2 and TLR-4 with significant anti-inflammatory activity, has been studied in various diseases. However, its potential for targeted delivery to lung tissues in the treatment of ARDS/ALI remains an underexplored area warranting further investigation.

Combining quantitative lipidomics with meat quality traits to identify key lipids involved in intramuscular fat deposition in geese.

This study utilized the O2PLS model to successfully integrate multidimensional data from meat quality traits and quantitative lipidomics, identifying key lipids involved in lipid deposition in goose meat. Meat quality analysis showed higher intramuscular fat content in goose meat during the sexual maturity phase. Lipidomics techniques were subsequently applied to elucidate differences in breast muscle lipid profiles between the growth phase and sexual maturity phase.

Design and synthesis of ROCK2-selective inhibitors bearing 6-indazolamino-2-pyrrolidinylpyridine for the treatment of breast cancer metastasis.

Rho-associated coiled-coil kinase (ROCK) serves as a critical driver of cellular metastasis, demonstrating therapeutic potential against breast cancer cell metastasis. To further enhance the ROCK2 inhibitory activity of belumosudil (ROCK2 IC = 0.153 μM), a novel series of 6-indazolamino-2-pyrrolidylpyridine derivatives were designed and synthesized.

Integrating lipidomics and machine learning to characterize lipid profile differences among goose breeds.

This study combined lipidomics technology with machine learning models to identify differences in intermuscular fat (IMF) between goose breeds and to screen for key lipid molecules. Here, we compared the meat quality characteristics and IMF lipid profiles of two goose breeds. The results showed that the meat quality traits of Yangzhou goose (YG) and Zhedong white goose (ZG) exhibited significant breed-specific differences, particularly in muscle color and physical properties.

Rational Design of 6-Amino-2-Piperazinylpyridine-Based ROCK2 Inhibitors With Anti-Breast Cancer Metastatic Efficiency.

Rho-associated coiled coil kinase (ROCK) plays a pivotal role in regulating actin cytoskeleton remodeling and cellular motility, establishing it as a promising therapeutic target for metastatic breast cancer. Guided by the lead compound belumosudil, a novel series of ROCK2 inhibitors based on a 6-amino-2-piperazine pyridine scaffold was designed and synthesized. The Kinase-Glo assay identified compound 14r as the most potent analog, showing an IC value of 82.

Childhood trauma and adulthood adverse experiences and risk of new-onset depression across the lifespan.

Background: Exposure to childhood trauma or adverse adulthood experiences (AAEs) may increase depression risk. However, the relationships between these factors and age of depression onset remain unclear.

Aims: We aimed to investigate the associations of childhood trauma and AAEs with depression risk across life stages, and their joint effects on lifetime depression risk.

LGALS3BP/90K suppresses porcine reproductive and respiratory syndrome virus replication by enhancing GP3 degradation and stimulating innate immunity.

Porcine reproductive and respiratory syndrome virus (PRRSV) seriously affects the world pig industry, and existing vaccines are not enough to protect against PRRSV efficiently. Identifying host factors that inhibit PRRSV infection may provide potential targets for antiviral therapies. Galectin 3 binding protein (LGALS3BP), also referred to as 90K, is a multifunctional protein that plays significant roles in viral infections, but its role in PRRSV infection is not clearly defined.

Distribution and potential involvement of PTEN in the innate immune response during viral infections in Cherry Valley ducks.

Introduction: Phosphatase and tensin homolog (PTEN) is a well-established tumor suppressor gene that antagonizes the PI3K/AKT signaling pathway and plays a critical role in regulating both innate and adaptive immune responses. However, its function in avian species, particularly in ducks, remains largely unexplored.

Methods: In this study, the full-length cDNA of duck PTEN (PTEN) was cloned from the spleen of healthy Cherry Valley ducks.

Strength and Push Gait Asymmetry in Skeleton Athletes.

The aim of this study was to explore how lower limb strength and push gait asymmetry affected performance of skeleton athletes. Isokinetic strength of the bilateral lower limb was measured in sixteen skeleton athletes. Kinematic and kinetic data were also collected during pushing.

Unraveling Laser-Induced peripheral Pain: Proteomic profiling and electrophysiological Dynamics in mice.

With the rapid development of their technology, lasers are now widely used in science and industry over a range of fields. Unfortunately, accidents involving lasers also occur, in which there is a risk of skin damage and pain. At present, there are few studies on laser-induced pain, and the mechanism of peripheral pain following irradiation remains unclear.

Childhood maltreatment and depression: mediating role of lifestyle factors, personality traits, adult traumas, and social connections among middle-aged and elderly participants.

Background: Accumulating evidence has supported the associations between childhood maltreatment and increased risk of depression; however, the underlying mechanisms remain largely unclear. We aimed to explore the potential role of lifestyle factors, personality traits, adult traumas, and social connections in the association between childhood maltreatment and depression.

Methods: We used a nationwide cohort data from the UK Biobank, involving half a million participants aged 37-73 years, recruited across 22 centers in the UK between 2006 and 2010.

Carbon Balance of China-Made Wood Products Assessed Using a Trade-Linked Approach.

Harvested wood products (HWPs) contribute to forestry carbon removal and, therefore, to climate change mitigation. However, the complex international trade of raw wood materials and HWPs and the associated biogenic carbon conversion along the global supply chain are not properly accounted for in the existing HWP carbon accounting schemes, precluding effective climate policy design. To address the gap, we developed a generalizable Trade-Linked Approach to account for trade and the associated carbon stocks and emissions.

Shared genetic architecture between leukocyte telomere length and Alzheimer's disease.

Background: Epidemiological and clinical studies have reported an association between leukocyte telomere length (LTL) and Alzheimer's disease (AD). However, genetic association between the two phenotypes remains largely unknown. We aimed to elucidate the potential shared genetic architecture between LTL and AD.

M-site transition metal activation in MoTiCT MXene for enhanced lithium storage with superior rate performance.

MoTiCT (DM) MXene is a promising energy storage material with rich M-site transition metal components and adjustable structural properties. However, its practical lithium storage capacity remains limited, particularly at high current densities. This study presents a feasible activation strategy for DM MXene, where chemically inert M-X bonds were effectively activated through electrophoretic deposition and annealing treatment, enabling in-situ construction of amorphous transition metal compounds without compromising the layered structure of DM MXene.

Accelerometer-Measured Physical Activity and Neuroimaging-Driven Brain Age.

A neuroimaging-derived biomarker termed the brain age is considered to capture the degree and diversity in the aging process of the brain, serving as a robust indicator of overall brain health. The impact of different levels of physical activity (PA) intensities on brain age is still not fully understood. This study aimed to investigate the associations between accelerometer-measured PA and brain age.

Multiplex one-step RT-qPCR assays for simultaneous detection of BRV, BCoV, K99 and .

Introduction: Bovine rotavirus (BRV), bovine coronavirus (BCoV), K99 ( K99), and () are the most common pathogens involved in calf production. These pathogens can cause calf diarrhea, leading to significant economic losses in the cattle farming industry. These four pathogens have similar clinical symptoms, making them difficult to distinguish.

Integrating Stock-Flow Modeling and Energy System Optimization to Explore Decarbonization Pathways for China's Cement Industry.

In the global effort to mitigate climate change, the cement sector remains highly emission-intensive and hard-to-decarbonize. Previous research has highlighted material efficiency strategies─including more intensive use, lifetime extension, material-efficient design, and end-of-life processes, as demand-side options for reducing emissions. However, unintended effects and supply side responses, such as shifts in technological portfolios and investment trends, remain underexplored.

Acid-resistant bismuth-doped antimony for effective Sr adsorption in nitric acid solutions.

Sr, a radioactive fission product in high-level liquid waste (HLLW), poses long-term environmental risks due to potential waterborne dispersion. A bismuth-doped SbO material (BiSb-0.1) was synthesized in this work to effectively remove strontium from simulated high-level liquid waste (HLLW).

Unequal impacts of global urban-rural settlement construction on cropland and production over the past three decades.

The world has experienced a rapid expansion of human settlements in both urban and rural areas in recent decades, yet the unequal impacts of this construction on global food security remain unclear. In this study, we delineated the global-scale expansion of urban-rural settlements at a fine resolution from 1985 to 2020 and quantified their uneven impacts on food security, focusing on the relationships between settlement types, cropland categories, and disparities in crop production. Our results showed that despite dramatic urbanization, rural settlements still constituted the majority of human settlement areas in 2020.

A cross-tissue transcriptome-wide association study reveals novel susceptibility genes for erectile dysfunction.

Background: Erectile dysfunction (ED) is a common condition affecting millions of men worldwide. While genome-wide association studies (GWAS) have identified genetic loci associated with ED risk, the potential causative genes and their biological mechanisms leading to ED remain largely unexplored.

Objectives: This study aimed to conduct a comprehensive cross-tissue transcriptome-wide association study (TWAS) to identify susceptibility genes associated with ED risk.