Osmotic Energy Directly Driving Flexible All-Solid-State 2D Nanofluidic Pressure Sensors.

Current utilization of osmotic energy often involves multiple complex processes, including collection, storage, and conversion, which limits its applicability in portable electronic devices. Inspired by the biosensing system of human skin, a novel iontronic pressure sensor is developed, directly driven by osmotic energy. By leveraging the tunable nanofluidic effects of 2D materials, ion selective migration driven by osmotic energy is controlled through mechanical modulating of interlayer spacing, thereby converting external pressure into encodable electrical signals.

Inhibiting JNK and PI3K-Akt signaling pathways altered spontaneous network bursts and developmental trajectories of neuronal networks.

Spontaneous network bursts (NBs) are critical for neuronal circuit development, influencing synaptogenesis and functional organization. While JNK and PI3K-Akt signaling pathways are known to regulate synaptic plasticity, their specific roles in governing NBs dynamics and functional network organization remain poorly understood. This study investigates the roles of JNK and PI3K-Akt signaling in regulating spontaneous NBs dynamics and network organization in cultured neuronal networks.

Causal relationship between immune cells and venous thromboembolism: a bidirectional two-sample Mendelian randomization study.

Background: Venous thromboembolism (VTE), which includes Pulmonary embolism (PE) and Deep vein thrombosis (DVT), is a complex vascular disorder with poorly understood pathological mechanisms. Emerging research highlights the potential involvement of immune cells in the pathogenesis of VTE, although their causal relationship remains unproven.

Methods: To systematically assess the causal relationships between 731 immune phenotypic traits and VTE, PE, and DVT, this study employed a bidirectional, two-sample Mendelian randomization (MR) approach.

Comprehensive analysis of complete Chloroplast genome sequence of Cardiospermum halicacabum L. (Sapindaceae).

Cardiospermum halicacabum L., a notable species of the genus Cardiospermum, is well-known for its culinary and medicinal properties. Nonetheless, a detailed description of the C.

A visual monitoring DNA-free multi-gene editing system excised via LoxP::FRT/FLP in poplar.

The CRISPR-Cas9 system has emerged as a potent molecular scalpel for precise genome editing, and profoundly revolutionized plant genetics and breeding, facilitating the development of innovative and improved plant varieties. Typically, the CRISPR-Cas9 gene-editing construct is delivered into target organisms via Agrobacterium tumefaciens-mediated transformation or biolistic methods. However, the incorporation of the CRISPR-Cas9 machinery increases the risk of off-target effects, causing unintended genomic alterations.

Study on the Secondary Cathodic Deposition Modification and Properties of Anodic Oxidation Coating on 6061 Aluminum Alloy.

This paper proposes a method for preparing a ceramic-metal composite coating by using different concentrations of HPO as an etching solution to etch the hard anodized aluminum oxide coating and modify it by cathode deposition of Ni. This method successfully solves the problem of low hardness and poor wear resistance of the hard anodized aluminum coating. The bonding effect between the hard anodized aluminum coating and the Ni layer after etching with different concentrations of HPO was systematically studied, and friction, corrosion and coating bonding tests were carried out.

Passive compliance or active innovation: The diffusion of public sport policies in China.

As an important tool for governing, regulating, and safeguarding national sports, sports policy not only centralizes and expresses the state's vision for sports but also advances the development of the sports economy, and distributes the benefits of social sports. Accordingly, we collect policy samples from 31 provinces of China. Adopting the central-local relationship perspective, we use the grey correlation analysis method to explore the intrinsic relationship between the factors influencing the diffusion of public sports policies and the degree of policy text reproduction by provincial governments.

Predictive Modeling of Endograft Limb Occlusion after Endovascular Aneurysm Repair: A Propensity Score Matching Analysis.

Background: Endovascular aneurysm repair (EVAR) is widely used to treat abdominal aortic aneurysm (AAA). However, it carries the risk of complications that often require further interventions. Endograft limb occlusion (ELO), though relatively rare, significantly affects patient outcomes.

Synergistic Effect of Polyurethane on Pore-Sealing and Lubrication of Microarc Oxidation Coating.

Microarc oxidation (MAO) is a widely used surface treatment technology. However, its processing inevitably leads to the presence of micropores, microcracks, and other defects in the MAO coating. These defects lead to suboptimal tribological performance and diminished corrosion resistance of the MAO coating.

Breathomics for diagnosing tuberculosis in diabetes mellitus patients.

Introduction: Individuals with diabetes mellitus (DM) are at an increased risk of (Mtb) infection and progressing from latent tuberculosis (TB) infection to active tuberculosis disease. TB in the DM population is more likely to go undiagnosed due to smear-negative results.

Methods: Exhaled breath samples were collected and analyzed using high-pressure photon ionization time-of-flight mass spectrometry.

Variations in Quinolinic Acid Levels in Tuberculosis Patients with Diabetes Comorbidity: A Pilot Prospective Cohort Study.

Objective: We aimed to investigate dysregulated metabolic pathways and identify diagnostic and therapeutic targets in patients with tuberculosis-diabetes (TB-DM).

Methods: In our prospective cohort study, plasma samples were collected from healthy individuals, diabetic (DM) patients, untreated TB-only (TB-0)/TB-DM patients (TB-DM-0), and cured TB (TB-6)/TB-DM patients (TB-DM-6) to measure the levels of amino acids, fatty acids, and other metabolites in plasma using high-throughput targeted quantification methods.

Results: Significantly different biological processes and biomarkers were identified in DM, TB-DM-0, and TB-DM-6 patients.

Engineered Cellular Vesicles Displaying Glycosylated Nanobodies for Cancer Immunotherapy.

Immune checkpoint blockade targeting the CD47/SIRPα axis represents an alluring avenue for cancer immunotherapy. However, the compromised efficacy and safety concerns in vivo of conventional anti-CD47 antibodies impede their wide clinical applications. Here we introduced a single type of high-mannose glycans into the nanobody against CD47 (HM-nCD47) and subsequently displayed HM-nCD47 on cellular vesicles (CVs) for enhanced cancer immunotherapy.

Myriocin enhances the clearance of by macrophages through the activation of PLIN2.

Myriocin is an inhibitor of synthesis of sphingolipids and ceramides. In this research, we showed myriocin could significantly reduce Mtb burden and histopathological inflammation in mice. However, the underlying mechanism remains unclear.

Effect of Treatment with Microarc Oxidation Technology on Tribological Properties of Nonvalve Metal Low-Carbon Steel.

Steel is one of the most widely used alloys because of its excellent properties such as high toughness, good workability, and low cost. However, steel has weak wear resistance, which limits its range of applications and service life. We have used the microarc oxidation (MAO) technique to form an AlO ceramic coating on the surface of nonvalve metal low-carbon steel, which is used to enhance the wear resistance of low-carbon steel.

Tribological properties of MAO ceramic coatings with annulus array texture on disposable surgical gloves.

In recent research, the expansion in the use of Mg alloys for biomedical applications has been approached by modifying their surfaces in conjunction with micro-arc oxidation (MAO) techniques which enhance their abrasion and corrosion resistance. In this study, combining laser texturing and MAO techniques to produce the dense ceramic coatings with microstructures. On the surface of the AZ31 Mg alloy, a micro-raised annulus array texture has been designed in order to increase the surface friction under liquid lubrication and to improve the operator's grip when holding the tool.

Association between lactate metabolism‑related molecules and venous thromboembolism: A study based on bioinformatics and an model.

Venous thromboembolism (VTE) is characterized by a high recurrence rate and adverse consequences, including high mortality. Damage to vascular endothelial cells (VECs) serves a key role in VTE and lactate (LA) metabolism is associated with VEC damage. However, the pathogenesis of VTE and the role of lactate metabolism-related molecules (LMRMs) remain unclear.

Effects and regulatory pathway of proopinmelanocortin on feeding habit domestication in mandarin fish.

Proopiomelanocortin (POMC) is a hormone precursor, and has been reported to participate in domestication. However, its effects on feeding habit domestication in fish are poorly understood. Mandarin fish (Siniperca chuatsi) feeds solely on live prey fish since first-feeding.

Random Traffic Flow Simulation of Heavy Vehicles Based on R-Vine Copula Model and Improved Latin Hypercube Sampling Method.

The rationality of heavy vehicle models is crucial to the structural safety assessment of bridges. To establish a realistic heavy vehicle traffic flow model, this study proposes a heavy vehicle random traffic flow simulation method that fully considers the vehicle weight correlation based on the measured weigh-in-motion data. First, a probability model of the key parameters in the actual traffic flow is established.

Small Molecule-Activated -GlcNAcase for Spatiotemporal Removal of -GlcNAc in Live Cells.

The nutrient sensor O-linked -acetylglucosamine (-GlcNAc) is a post-translational modification found on thousands of nucleocytoplasmic proteins. -GlcNAc levels in cells dynamically respond to environmental cues in a temporal and spatial manner, leading to altered signal transduction and functional effects. The spatiotemporal regulation of -GlcNAc levels would accelerate functional interrogation of -GlcNAc and manipulation of cell behaviors for desired outcomes.

Kruppel-like Factors 3 Regulates Migration and Invasion of Gastric Cancer Cells Through NF-κB Pathway.

Context: The poorly understood regulatory mechanisms impede gastric cancer therapy. Kruppel-like factors (KLFs) are associated with the development of various tumors, The studies on the role of the KLF transcription factor 13 (KLF13) in gastric cancer progression haven't been studied.

Objective: The current study aimed to investigate the role of KLF13 in the migration and invasion of gastric cancer and the regulatory mechanism of KLF13 in gastric cancer progression.

Anterior cervical discectomy and fusion with zero-profile versus stand-alone cages for two-level cervical spondylosis: A retrospective cohort study.

Objective: To assess the mid-long-term clinical and radiological outcomes of zero-profile (ZP) compared with stand-alone (ST) cages for two-level anterior cervical discectomy and fusion (ACDF).

Methods: We included 77 patients (39 women and 38 men) who underwent two-level ACDF between May 5, 2016, and May 5, 2020, and who were followed up for at least 1 year. The subjects were divided into the ST ( = 38) and ZP ( = 39) group.

Preparation and performance study of a reactive polyurethane hot-melt adhesive/CS-FeO magnetic nanocomposite film/fabric.

Magnetic nanoparticles are attracting significant attention for their wide application as biomaterials and magnetic storage materials. As an environmentally friendly adhesive, reactive polyurethane hot-melt adhesive (PUR) is a biocompatible polymer with a wide range of applications. In this paper, chitosan (CS)-surface-modified magnetic FeO nanoparticles were synthesized by the sol-gel method.

Preparation and characterization of polyethylene glycol/chitosan composite water-based wound healing lubricant.

The proportion of pregnant women giving birth through cesarean section is increasing annually worldwide. However, post-cesarean section scar diverticulum is a common condition that occurs and requires better surgical strategies than the methods currently used. We hypothesized that using biological lubricant topically on the incision area during C-section could be an option to minimize the scar.

Cytocompatibility of pH-sensitive, chitosan-coated FeO nanoparticles in gynecological cells.

Nanoparticles that contact human cells without damaging basic human tissues are becoming more widely used in medicine. Efficient delivery to the intracellular target cell or compartment through the cell membrane must be achieved with minimal cytotoxicity to healthy cells. FeO nanoparticles have been widely used in biomedical research for their magnetic, non-toxic, and biocompatible properties.