Multi-omics profiling of metastatic colorectal cancer reveals the transcriptional network of focal adhesion and immune suppression and the role of p-RPS6.

Background: Colorectal cancer (CRC) is one of the deadliest malignancies worldwide characterized by rapid progression, high metastasis propensity. Our study aimed to identify the driving biological factors of metastatic CRC.

Methods: We obtained frozen tumor tissues of 8 metastatic CRC (mCRC) patients and 10 non-metastatic CRC (nmCRC) patients from Ruijin Hospital for proteome analysis.

The dual role of mTOR signaling in lung development and adult lung diseases.

The architecture of the mammalian lung is both intricate and distinct. The respiratory system consists of a complex network of semirigid airway tubes, stretching from the trachea to the alveoli, highly vascularized sacs responsible for gas exchange. This system demands precise regulation.

Tertiary lymphoid structures signature predicts prognosis and clinical benefits from neoadjuvant chemotherapy and PD-1 blockade in colorectal adenocarcinoma.

Background: Tertiary lymphoid structures (TLS) are emerging biomarkers for enhanced anti-tumoral immunity and treatment efficacy in colorectal cancer (CRC). This study aimed to develop a CRC-specific TLS signature and evaluate its predictive roles in survival prognosis and therapeutic responses to chemotherapy, and PD-1 blockade.

Materials And Methods: Transcriptomic data from TCGA database were analyzed to establish a TLS signature.

Bulk Bi-Sb polycrystals underpinned by high electron/phonon mean free path ratio enabling thermoelectric cooling under 77 K.

Bi-Sb alloy, as a promising thermoelectric material at cryogenic temperatures, has seen stagnant progress due to challenges in understanding the transport behaviors of energy carriers, and difficulties in synthesizing high-homogeneity, large-grain samples. In this study, an inherent electron-phonon decoupling in Bi-Sb is revealed using the first-principles calculations based on the virtual crystal approximation. The mean free path of the dominant electrons (λ ~ 10 nm) is found of two orders of magnitude larger than that of phonons (λ ~ 10nm), suggesting that a grain size greater than 10 μm would be favorable for thermoelectric transport.

Passive compliance or active innovation: The diffusion of public sport policies in China.

As an important tool for governing, regulating, and safeguarding national sports, sports policy not only centralizes and expresses the state's vision for sports but also advances the development of the sports economy, and distributes the benefits of social sports. Accordingly, we collect policy samples from 31 provinces of China. Adopting the central-local relationship perspective, we use the grey correlation analysis method to explore the intrinsic relationship between the factors influencing the diffusion of public sports policies and the degree of policy text reproduction by provincial governments.

β-elemene: A promising natural compound in lung cancer therapy.

Lung cancer, a leading cause of cancer-related mortality globally, presents complex challenges in treatment and disease management. This review explores β-elemene, a sesquiterpene from Curcuma wenyujin, emphasising its pharmacological effects and therapeutic mechanisms in lung cancer. Focusing on its roles in modulating cellular pathways, this study details β-elemene's influence on apoptosis, autophagy, ferroptosis, hypoxic responses, metabolic shifts, and cell cycle arrest, as well as its impact on the tumour microenvironment and regulatory pathways (including PI3K/AKT, STAT3, AMPK/MAPK) and non-coding RNAs.

Parthenolide ameliorates diabetic retinopathy by suppressing microglia-induced Müller cell gliosis and inflammation via the NF-κB signalling.

Diabetic retinopathy (DR) is characterized by retinal inflammation and gliosis and the interaction between Müller cells and microglia plays a crucial role in DR pathogenesis. A sesquiterpene lactones, Parthenolide (PTL), has potent anti-inflammatory effects. This study aimed to evaluate the efficacy of PTL in ameliorating DR and the underlying mechanisms.

Prourokinase vs Standard Care for Patients With Mild Ischemic Stroke: The PUMICE Randomized Clinical Trial.

Importance: Trials have not demonstrated superiority of alteplase or tenecteplase vs standard care in patients with mild stroke and have raised safety concerns. Prourokinase is an alternative fibrinolytic that may have a favorable safety profile, and the benefit-risk profile of prourokinase in mild stroke is unknown.

Objective: To investigate the efficacy and safety of prourokinase in mild ischemic stroke within 4.

Progress in Continuous Flow Synthesis of Hydrogen-Bonded Organic Framework Material Synthons.

Hydrogen-bonded organic framework (HOF) materials are typically formed by the self-assembly of small organic units (synthons) with specific functional groups through hydrogen bonding or other interactions. HOF is commonly used as an electrolyte for batteries. Well-designed HOF materials can enhance the proton exchange rate, thereby boosting battery performance.

Dupilumab, corticosteroids and their combination for the treatment of bullous pemphigoid.

Background: Conventional systemic corticosteroid therapy for bullous pemphigoid (BP) has been challenged due to severe adverse events. Dupilumab has emerged as an alternative therapeutical option of BP patients.

Objectives: To evaluate the efficacy of dupilumab monotherapy and the combination with medium/low-dose corticosteroids for BP treatment.

Assessment of anterior scleral thickness in myopes and emmetropes using anterior segment optical coherence tomography.

Purpose: To investigate the differences in anterior scleral thickness (AST) among the refractive statuses of Chinese adults aged 18-35.

Methods: This study recruited 170 Chinese participants (mean age, 24.06 ± 2.

Design of Ligand-Nonbridging Sites in Metal-Organic Frameworks for Boosting Lithium Storage Capacity.

Metal-organic frameworks (MOFs) are lagging in the use of lithium-ion batteries (LIBs), ascribing to full coordination between metal nodes and organic ligands, to a large extent. By integrating a modulator into a ligand with missing bridging functionality, this study elucidates the role of non-bridging defect sites in MOFs in tailoring lithium storage performance. A fully bridged pristine MOF (p-MOF) utilizing the meso-tetra(4-carboxylphenyl) porphyrin ligand is compared with a modified MOF containing non-bridging defects (d-MOF) introduced by a homologous ligand, tris(4-carboxyphenyl) porphyrin.

Integrated Analyses of Metabolome and RNA-seq Data Revealing Flower Color Variation in Ornamental Planchon.

Planchon is an important ornamental species in the northern hemisphere. Flower color is an important objective of breeding programs. However, information on anthocyanin synthesis in is limited.

Clinical and immunoserological characteristics of anti-p200 pemphigoid: Comparisons of patients with epitope spreading and non-epitope spreading.

Background: Anti-p200 pemphigoid is a rare autoimmune subepidermal blistering disease. Although the phenomenon of epitope spreading has been reported to be common in anti-p200 pemphigoid, the association between its clinical and immunoserological features has yet to be elucidated.

Objectives: Our aim was to compare the clinical and immunoserological characteristics of anti-p200 pemphigoid patients with and without epitope spreading.

Bee Pollen Extract Inhibits Proliferation and Migration of Hepatocellular Carcinoma HepG2 Cells via Ferroptosis-, Wnt-, and Focal Adhesion-Signaling Pathways.

Purpose: Bee pollen possesses favorable anticancer activities. As a medicinal plant source, bee pollen (SCBP) possesses potential pharmacological properties, such as reducing cisplatin-induced liver injury, but its anti-liver cancer effect is still rarely reported. This paper aims to investigate the effect and mechanism of SCBP extract (SCBPE) on hepatocellular carcinoma HepG2 cells.

Efficacy of Repetitive Transcranial Magnetic Stimulation Over the Supplementary Motor Area on Motor Function in Parkinson's Disease: A Meta-analysis.

Objective: The objective of this study was to assess the effect of repetitive transcranial magnetic stimulation on the supplementary motor area in motor function in Parkinson's disease patients.

Method: Databases searched included five databases from October 7, 2022, to January 4, 2023. The Cochrane Bias Risk Assessment Tool was used for quality assessment.

Metabolite analysis reveals flavonoids accumulation during flower development in sweet (Ericaceae).

The azalea (.) is an important ornamental woody plant with various medicinal properties due to its phytochemical compositions and components. However little information on the metabolite variation during flower development in has been provided.

Targeting the Ferroptosis and Endoplasmic Reticulum Stress Signaling Pathways by CBX7 in Myocardial Ischemia/reperfusion Injury.

Ferroptosis and endoplasmic reticulum stress (ERS) are common events in the process of myocardial ischemia/reperfusion injury (IRI). The suppression of chromobox7 (CBX7) has been reported to protect against ischemia/reperfusion injury, This research is purposed to expose the impacts and mechanism of CBX7 in myocardial IRI. CBX7 expression was detected using RT-qPCR and western blotting analysis.

Can cerebellar theta-burst stimulation improve balance function and gait in stroke patients? A randomized controlled trial.

Background: The cerebellum is a key structure involved in balance and motor control, and has become a new stimulation target in brain regulation technology. Interference theta-burst simulation (iTBS) is a novel simulation mode of repetitive transcranial magnetic simulation. However, the impact of cerebellar iTBS on balance function and gait in stroke patients is still unknown.

Vascular Endothelial Cell-Derived Exosomal Sphingosylphosphorylcholine Attenuates Myocardial Ischemia-Reperfusion Injury through NR4A2-Mediated Mitophagy.

Cardiomyocyte survival is a critical contributing process of host adaptive responses to cardiovascular diseases (CVD). Cells of the cardiovascular endothelium have recently been reported to promote cardiomyocyte survival through exosome-loading cargos. Sphingosylphosphorylcholine (SPC), an intermediate metabolite of sphingolipids, mediates protection against myocardial infarction (MI).

IgE anti-BP180 NC16A autoantibody in both serum and blister fluid samples does not correlate with disease activity of bullous pemphigoid.

The correlation between IgE anti-BP180 NC16A autoantibody and disease activity of bullous pemphigoid (BP) remains disputable. To determine the levels of IgE anti-BP180 NC16A autoantibody and its clinical significance in untreated BP patients. IgG and IgE anti-BP180 NC16A autoantibody in serum and blister fluid samples of 34 untreated BP patients was detected by enzyme-linked immunosorbent assay (ELISA), and correlation with clinical and pathological features of BP were statistically analysed.

A QTL of eggplant shapes the rhizosphere bacterial community, co-responsible for resistance to bacterial wilt.

Resistant crop cultivars can recruit beneficial rhizobacteria to resist disease. However, whether this recruitment is regulated by quantitative trait loci (QTL) is unclear. The role of QTL in recruiting specific bacteria against bacterial wilt (BW) is an important question of practical significance to disease management.

Suppressing ACQ of molecular photosensitizers by distorting the conjugated-plane for enhanced tumor photodynamic therapy.

Non-AIE-type molecular photosensitizers (PSs) suffer from the aggregation-caused-quenching (ACQ) effect in an aqueous medium due to the strong hydrophobic and π-π interactions of their conjugated planes, which significantly hinders the enhancement of tumor photodynamic therapy (PDT). So far, some ionic PSs have been reported with good water-solubility, though the ACQ effect can still be induced in a biological environment rich in ions, leading to unsatisfactory delivery and fluorescence imaging performance. Hence, designing molecular PSs with outstanding anti-ACQ properties in water is highly desirable, but it remains a tough challenge for non-AIE-type fluorophores.