The effects of 5-HT on vascular endothelial dysfunction in patients with panic disorder.

Panic Disorder (PD) is a prevalent psychiatric condition characterized by recurrent episodes of acute severe anxiety. These episodes frequently present with symptoms that overlap with those of cardiovascular diseases (CVD), such as elevated blood pressure and chest pain. Despite the prevalence and impact of this comorbidity, the underlying mechanisms are not well understood and remain underexplored.

Baseline tumor burden predicts the efficacy of first-line chemoimmunotherapy in patients with advanced non-small cell lung cancer: results from 2 phase 3 randomized placebo-controlled trials.

Background: Baseline tumor burden (TB), measured radiographically, has emerged as a potential biomarker for stratifying survival outcomes with immune checkpoint inhibitors (ICI) across solid tumors. However, the predictive value for ICI plus chemotherapy (chemoimmunotherapy) in NSCLC has not been confirmed with large cohorts that include a chemotherapy-only control group.

Methods: This post hoc analysis utilized data from ORIENT-11 trial, a phase III, randomized clinical trial of advanced NSCLC patients who were administered with either chemoimmunotherapy or chemotherapy alone.

Preliminary application of the Sharesource connect data collection and analysis system in the management of continuous renal replacement therapy in the intensive care unit.

Background: This study investigated the application of software-based data monitoring for quality control (QC) in continuous renal replacement therapy (CRRT) management.

Methods: This single-center pre-post intervention study, conducted in three ICUs of a tertiary hospital in Shanghai, compared outcomes before (Jan-Dec 2023) and after (Jan-Dec 2024) implementing the Sharesource Connect system. Data from 9 Prismaflex CRRT machines were collected retrospectively during 2023 and prospectively on a monthly basis during 2024.

Study on the influence and control of different processing methods on the quality characteristics of brown rice cake.

Background: To enhance the taste and flavor quality of brown rice cake, various processing methods are employed, including internal enzyme germination modification, extrusion, stabilization of rice bran, exogenous enzyme hydrolysis, and backfilling. This study aimed to compare the texture, volatile flavor substances, taste changes, and internal texture structure of brown rice cakes subjected to different modification treatments, thereby clarifying the impact of these treatments on the overall quality of the brown rice cake.

Results: Following extrusion and enzymatic hydrolysis, the characteristic viscosity and disintegration value of brown rice flour decreased, while the recovery value and gelatinization temperature increased significantly.

Sodium alginate-mediated interfacial structuring in soy protein-quercetin composite emulsions: A synergistic strategy for encapsulation and bioavailability enhancement of lipophilic bioactives.

This study explored the mechanisms by which sodium alginate (SA) improved the stability and release efficiency of lutein (Lut) encapsulated in binary complexes of soybean protein isolate (SPI) and quercetin (Que). The addition of SA increased the fluorescence intensity of the interfacial protein, resulting in increased β-turn (22.94 %) and random coil contents (27.

Disrupting the MC1R/α-MSH-pCREB-MITF Axis: Rhein-based PROTAC D16 as a Potent Melanogenesis Inhibitor.

Melanin protects skin from ultraviolet rays, but excessive or misdistributed synthesis can cause issues like melasma, freckles, or melanoma. Rhein from traditional Chinese herbs shows various bioactivities, with recent structural modifications enhancing its derivatives, but its effect on melanogenesis is unreported. The study reports synthesizing and evaluating D16, Rhein-based proteolysis targeting chimera (PROTACs) utilizing pomalidomide as an E3 ligand.

A Comprehensive Review of the Role of the Microbiota-Gut-Brain Axis via Neuroinflammation: Advances and Therapeutic Implications for Ischemic Stroke.

The human gastrointestinal tract harbors a complex and diverse microbial community. Emerging evidence has revealed bidirectional communication between the gut microbiome and the central nervous system, termed the "microbiota-gut-brain axis". This axis serves as a critical regulator of glial cell function, positioning it as an essential target for ameliorating the onset and progression of ischemic stroke.

Threshold effect study on the development of prefabricated buildings for energy conservation and emission reduction in the construction industry.

Prefabricated construction is a key strategy for achieving a low-carbon transformation in the construction sector. In the context of national policies and standards aimed at promoting an increase in the prefabrication rate, recent investigations have revealed that the environmental benefits of prefabricated construction cannot be consistently realized, and the lack of data on the development of prefabricated construction has resulted in limited related research. To address this issue, this paper tackles the issue of inadequate data on indicators pertaining to the growth of prefabricated construction by utilizing crawler technology.

The application of radiomics in the diagnosis and evaluation of cognitive impairment related to neurological diseases.

Cognitive impairment (CI) is common, with diverse underlying causes, symptoms, and imaging features. It often leads to disability and loss of independence. Early diagnosis and assessment of CI are crucial for the prognosis improvement.

Risk of new-onset and recurrent uveitis with different biologics for ankylosing spondylitis: a network meta-analysis.

Background: Uveitis is a common extra-articular manifestation of ankylosing spondylitis (AS), and a systematic analysis of the effects of biologics on new-onset and recurrent uveitis is clinically important.

Methods: We conducted a network meta-analysis (NMA) to assess the impact of anti-TNF-α (adalimumab, etanercept, golimumab, and infliximab), IL-17 inhibitors (secukinumab, bimekizumab, and ixekizumab), and JAK inhibitors (tofacitinib and upadacitinib) on new-onset and recurrent uveitis. Phase II/III double-blind randomized controlled trials and cohort studies were included.

Rainfall-driven heavy metals wet deposition in a typical small city at southern foothills of Qinling Mountains, the boundary zone of north and south China.

Atmospheric heavy metals (HMs) posed a continuing threat to humans and ecosystems, and it is therefore essential to identify their source and sink processes. Wet deposition (rainwater) is an important sink for atmospheric HMs, thereby effectively diminishing their atmospheric levels. However, previous studies of rainwater HMs mainly focused on coastal metropolitan areas, resulting in a relative lack of studies concerned inland small cities (especially those influenced by mountain topography).

Washed microbiota transplantation alleviates tyrosine kinase inhibitors associated gastrointestinal adverse effects.

Gut microbiota dysbiosis is implicated in tyrosine kinase inhibitor (TKI)-induced gastrointestinal adverse effects (GAEs), often necessitating medication adjustments or discontinuation in severe or persistent cases. This study aimed to evaluate the efficacy and safety of washed microbiota transplantation (WMT) in managing TKI-induced GAEs. This prospective study involved cancer patients presenting TKI-induced GAEs.

Long non-coding RNA SNHG7 as a key driver of colorectal cancer proliferation and metastasis by inhibiting cuproptosis.

Background: Copper-induced cell death, where copper induces cytotoxicity to kill cancer cells, exerts an unclear role in colorectal cancer. This study aimed to identify lncRNAs co-expressed with CICD-related genes and explore their effect on CRC.

Methods: Differentially expressed lncRNAs between CRC and normal samples were identified from public datasets, followed by co-expression analysis of 10 CICD-related genes.

Molecular Insight into the Recognition of DNA by the DndCDE Complex in DNA Phosphorothioation.

In a vast variety of prokaryotes such as and , the DNA degradation (Dnd) CDE protein complex (consisting of DndC, DndD, and DndE), together with the DndA/IscS protein and the DndFGH complex, function as a defense barrier to prevent the invasion of non-self-DNA. The DndCDE complex introduces phosphorothioation (PT) modifications into DNA, and the DndFGH complex specifically cleaves non-PT DNA and, thus, restricts horizontal gene transfer and phage invasion. Despite the central importance of the DndCDE complex in DNA PT modification, which catalyzes the oxygen-sulfur swap on DNA, our understanding of this key complex remains poor.

Angular dispersion-enabled dynamic metasurface for tunable reflective focusing.

Active metasurfaces have garnered significant attention due to their potential to replace conventional bulky optical systems, offering advantages in terms of reduced weight and compactness. In this study, we introduce the incident angle as a novel degree of freedom for controlling wavefront modulation in dielectric metasurfaces. By utilizing the angular dispersion of Mie resonances supported by a silicon ring disk, different reflective phases are modulated under varying incident angles.

Comparative impacts of polyethylene and biodegradable film residues on soil microbial communities and rapeseed performance under field conditions.

Introduction: Soil health is critical for sustainable agriculture and food security, however, the accumulation of agricultural mulch film residues in soil raises environmental concerns. The effects of conventional polyethylene (PE) and biodegradable (PBAT and PLA) film residues on soil health, microbial communities, and crop productivity under field conditions have not been adequately investigated.

Methods: This study simulated the accumulation of PE film residues from over 30 years of continuous mulching and evaluated PBAT and PLA film residues under field conditions, examining their effects on soil physicochemical properties, microbial communities and rapeseed performance.

Translation and psychometric evaluation of the Chinese version of The Prediction-Related Experiences Questionnaire (PRE-Q-C).

Objective: Prediction is a fundamental cognitive process that facilitates adaptive interactions with the environment. The Prediction-Related Experiences Questionnaire (PRE-Q), a 19-item measure, assesses individuals' everyday predictive abilities. This study aimed to develop and validate a Chinese version (PRE-Q-C) by translating and adapting the original scale and examining its psychometric properties in a large Chinese sample.

Enhanced extraction of negatively charged emerging contaminants by amine-modified amphiphilic materials-based solid phase microextraction fibers.

The solid phase microextraction (SPME) technique is an efficient method for emerging contaminants (ECs) detection, however, many commercial fibers are not suitable for extracting negatively charged ECs. Herein, three amine-functionalized amphiphilic materials(MAM) were synthesized via a high-speed shear dispersion emulsification technique. These materials were employed as SPME fiber coatings to enhance the selectivity for negatively charged ECs, attributed to their substantial specific surface area (679-693 m/g), high ion-exchange capacity (1.

Grape seed polyphenol water-in-oil emulsion: preparation and application in functional cookies.

Background: The study aimed to address the characteristics of grape seed polyphenols (GSPs), such as high hydrophilicity and poor stability in fats and oils, as well as the poor digestive properties of traditional cookies due to their high fat content. A GSP delivery system based on water-in-oil (W/O) emulsion technology was innovatively developed, aiming at solving the difficult problem of the limited application of GSPs in high-fat cookie systems. In this study, we explored the potential application of GSPs in functional cookie products by constructing a GSP-tea seed oil stabilized emulsion system.

Washed microbiota transplantation for ribotype 027 infection in a pregnant woman with two-year follow-up: a case report.

( ) is one of the major causes of nosocomial infections. The pregnant women, who were considered at low risk for infection (CDI), have attracted attention with increasing reports. Oral vancomycin, the only first-line treatment for the pregnant women infected with , came with the problem of increasing strains resistance that was associated with decreased efficacy.

Atrial fibrillation-related ischemic stroke and cognitive impairment: Research progress on the characteristics and pathogenesis.

Post-stroke cognitive impairment (PSCI) is a significant neurological complication, affecting up to one-third of stroke survivors. Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia, significantly increasing the risk of ischemic stroke. Increasing evidence suggests that AF plays a pivotal role in exacerbating cognitive decline in stroke patients.

Discovery and Characterization of Actinosynnelassin: An Anti- Lasso Peptide Derived from a Large Precursor Open Reading Frame.

Lasso peptides, a unique class of ribosomally synthesized and post-translationally modified peptide (RiPP), are challenging to synthesize chemically, making the discovery of new peptides and their biosynthetic pathways essential. This study reports the discovery and characterization of a novel lasso peptide, actinosynnelassin, from subsp. DSM 44131.

Single-cell combined transcriptome probes prognostic mechanisms of sialylation-related genes in cervical cancer.

Introduction: Sialylation has been linked to cervical dysplasia, while its involvement in cervical cancer is uncertain. Hence , the aim of this study was to develop a prognostic model based on sialylation-related characteristics for cervical cancer patients and investigate how sialylation-related genes are altered in cervical cancer via analyses of transcriptome and single-cell RNA sequencing (scRNA-seq) data.

Methods: The current work incorporated 4 transcriptome datasets relevant to cervical cancer (including scRNA-seq) and 110 sialylation-related genes (SRGs).

Mechanistic insights into proteasome inhibitor MG132 induced apoptosis in melanoma A375 cells.

Despite advancements in melanoma therapy, the prognosis remains unfavorable for many patients. The proteasome inhibitor MG132 has shown therapeutic potential through pathway regulation, yet its precise mechanisms in melanoma require systematic elucidation. Using A375 melanoma cells, we conducted multi-modal investigations combining cytotoxicity assessment (CCK8), migration analysis (wound healing), apoptosis quantification (flow cytometry), and proteomic profiling (western blot) to dissect MG132's molecular mechanisms.