Washed microbiota transplantation alleviates tyrosine kinase inhibitors associated gastrointestinal adverse effects.

Gut microbiota dysbiosis is implicated in tyrosine kinase inhibitor (TKI)-induced gastrointestinal adverse effects (GAEs), often necessitating medication adjustments or discontinuation in severe or persistent cases. This study aimed to evaluate the efficacy and safety of washed microbiota transplantation (WMT) in managing TKI-induced GAEs. This prospective study involved cancer patients presenting TKI-induced GAEs.

Bolus Use in Postmastectomy Radiation Therapy for Breast Cancer: A Systematic Literature Review.

IntroductionTissue-equivalent boluses are used to increase the skin surface dose in patients with breast cancer undergoing postmastectomy radiotherapy. Boluses made from various materials have been developed and applied in clinical practice. However, there is currently no international standardization for their use.

The dosimetric value and safety evaluation of 3D printed bolus in adjuvant intensity-modulated radiotherapy after radical mastectomy for breast cancer: a prospective cohort study.

Purpose: Breast cancer patients may use a bolus to increase the dose to skin in radiotherapy after radical mastectomy. The 3D printed bolus (3DPB) specifically customized based on individual conditions offers better conformity. This study aims to provide clinical insights by evaluating the dosimetric benefits and safety of 3DPB in radiotherapy following radical mastectomy for breast cancer.

The application of organoids in investigating immune evasion in the microenvironment of gastric cancer and screening novel drug candidates.

Gastric cancer (GC) is a prevalent digestive system tumor, the fifth most diagnosed cancer worldwide, and a leading cause of cancer deaths. GC is distinguished by its pronounced heterogeneity and a dynamically evolving tumor microenvironment (TME). The lack of accurate disease models complicates the understanding of its mechanisms and impedes the discovery of novel drugs.

Research Progress and Prospect of Perovskite and Anti-Perovskite Solid Electrolytes for Sodium Solid-State Batteries.

Sodium solid-state batteries (SSSBs) are poised to revolutionize energy storage by capitalizing on sodium's exceptional crustal abundance (2.36% vs 0.0017% for lithium) and cost-effectiveness, addressing critical sustainability challenges of lithium-dependent technologies.

Investigation of Cryptosporidium spp. and Enterocytozoon bieneusi in free-ranged livestock on the southeastern Qinghai-Xizang Plateau, China.

Background: Cryptosporidium spp. and Enterocytozoon bieneusi are zoonotic pathogens with global distribution, infecting humans and various livestock. For yaks, Tibetan sheep and horses, the traditional grazing models still hold a main position.

Brain structure and function differences across varying levels of endurance training: a cross-sectional study.

Background: Although previous studies have shown that athletes engaged in endurance sports exhibit unique characteristics of brain plasticity, there has been no systematic investigation into the structural and functional brain characteristics of endurance athletes with varying training levels.

Methods: Utilizing the "expert-novice paradigm" design, we employed functional magnetic resonance imaging (fMRI) to obtain images of brain structure and functional activity. We compared differences in gray matter volume (GMV), fractional amplitude of low-frequency fluctuations (fALFF), and degree centrality (DC) among high-level endurance athletes, moderate-level endurance athletes, and non-athlete controls.

Colonic transendoscopic enteral tubing is revolutionizing intestinal therapeutics, diagnosis, and microbiome research.

The intestine, as a crucial organ of the human body, has remained enigmatic despite the remarkable advancements in modern medical technology. Over the past decades, the invention of endoscopic technology has made the noninvasive intervention of the intestine a reality, expanding diagnostic and therapeutic options for diseases. However, due to the single-treatment feature of endoscopic procedures, continuous or repeated medication administration, sampling, and decompression drainage within the intestine have yet to be fulfilled.

Wastewater-based intestinal protozoa monitoring in Shanghai, China.

Intestinal protozoa spp., , and have been implicated in serious waterborne outbreaks worldwide. Wastewater-based epidemiology (WBE) is a promising approach for evaluating the disease prevalence in a catchment population in that it monitors the contamination level of the intestinal pathogens in wastewater.

Rational Molecular Design of Phenanthroimidazole-Based Fluorescent Materials toward High-Efficiency Deep-Blue OLEDs by Molecular Isomer Engineering.

Organic light-emitting diodes (OLEDs) have been extensively investigated in full-color displays and energy-saving lighting owing to their unique advantages. However, deep-blue OLEDs based on nondoped emitting layers with a satisfactory external quantum efficiency (EQE) are still rare for applications. In this work, six hot exciton materials, PPIM-12F, PPIM-22F, PPIM-13F, PPIM-23F, PPIM-1CN, and PPIM-2CN, are designed and synthesized via an isomer engineering design strategy and their photophysical properties and OLED performance are systematically investigated.

Brown rats () as potential reservoirs of in Heilongjiang Province, China: high prevalence, genetic heterogeneity, and potential risk for zoonotic transmission.

Introduction: , an obligatory intracellular fungus, is prevalent among animals and humans. Due to their close interaction with humans and their extensive regional distribution, brown rats () are important pathogen reservoirs. To assess the zoonotic transmission potential of , a molecular investigation was conducted on 817 from four cities in Heilongjiang Province, China.

Prognostic predictive value of Ki-67 in stage I-II triple-negative breast cancer.

Our research aimed to determine an optimal cutoff value and investigate the prognostic predictive function of Ki-67. We retrospectively enrolled 1146 patients diagnosed with stage I-II triple-negative breast cancer. Disease-free and overall survival were analyzed using the Kaplan-Meier method and the Cox regression model.

Occurrence and genetic characterization of Enterocytozoon bieneusi in pet dogs in Yunnan Province, China.

Enterocytozoon bieneusi is the most common microsporidian species in humans and can affect over 200 animal species. Considering possible increasing risk of human E. bieneusi infection due to close contact with pet dogs and identification of zoonotic E.

Treatments and Prognosis of the Breast Ductal Carcinoma In Situ.

Introduction: With progress in treatments, breast ductal carcinoma in situ (DCIS) outcomes have substantially improved. However, as various treatment methods are used in different countries and institutions, consensus on the optimal treatment method is lacking. This study aimed to analyze the prognostic factors and provide a reference for optimizing the clinical treatment of DCIS.

Investigation of Hexagonal Mesoporous Silica-Supported Composites for Trace Moisture Adsorption.

Moisture control is an important part of effective maintenance program for gas-insulated switchgear (GIS). Herein, hexagonal mesoporous silica (HMS) materials were synthesized by adopting dodecylamine as a structure directing agent, which was then employed as a host for supporting polyethylenimine (PEI) without further calcinations or extraction treatment. The physicochemical properties of the silica support and composites were characterized, and the moisture adsorption capacity of these composites was determined.

Investigation by MD simulation of the key residues related to substrate-binding and heme-release in human ferrochelatase.

Molecular dynamics (MD) simulations of three models based on the crystal structure of the E343K variant of human ferrochelatase were performed in this study. The "open" and "closed" conformations of the enzyme obtained by simulations are in agreement with the corresponding crystal structures. The snapshots and the structure analysis indicate that alterations of the hydrogen bonds and the positions of E347 and E351 lead to a conformational change in the π-helix.

Is it possible for Fe2+ to approach protoporphyrin IX from the side of Tyr-13 in Bacillus subtilis ferrochelatase? An answer from QM/MM study.

We previously reported the insertion process of the ferrous ion into the protoporphyrin IX from the side of the residue His-183 (J. Inorg. Biochem.

QM/MM study of the insertion of metal ion into protoporphyrin IX by ferrochelatase.

Ferrochelatase catalyzes the metallation of protoporphyrin IX in the terminal step of heme biosynthesis. Mutations in the ferrochelatase gene can lead to the disease erythropoietic porphyria. The catalyzing mechanism of ferrochelatase is still not fully understood.