Computer-Assisted Screening of Active Compounds in Traditional Chinese Medicine Targeting SNX10 as a Promising Treatment for Inflammatory Bowel Diseases.

Inflammatory bowel diseases (IBD) are chronic and recurrent gastrointestinal disorders affecting millions worldwide, imposing significant social and economic burdens. Safe and effective medications for IBD prevention and treatment are urgently needed. SNX10 has emerged as a potential therapeutic target, while traditional Chinese medicine (TCM) active compounds offer unique advantages in drug development due to their inherent safety and therapeutic properties.

Attention Performance and Altered Amplitude of Low-frequency Fluctuations in the Attention Network of Patients with MCI: A Resting-state Functional MRI Study.

Background: This study aimed to explore attention alteration in mild cognitive impairment (MCI) patients and their association with abnormalities of autonomic brain activity within the attention network to reveal the neuroimaging basis behind these changes.

Methods: A total of 25 MCI patients and 31 normal controls (NCs) were recruited for the study. The Test of Attention Performance (TAP) version 2.

Ganoderic Acid Ameliorates Ulcerative Colitis by Improving Intestinal Barrier Function via Gut Microbiota Modulation.

Ulcerative colitis (UC) is a chronic and recurrent gastrointestinal disease that affects millions of humans worldwide and imposes a huge social and economic burden. It is necessary to find safe and efficient drugs for preventing and treating UC. The aim of this study was to determine whether ganoderic acid (GA), the main bioactive components of Ganoderma lucidum, has preventive and therapeutic effect on UC in a dextran sulfate sodium (DSS)-induced UC mouse model.

A novel and high-performance tumor inhibitor of La, N co-doped carbon dots for U251 and LN229 cells.

To address the medical challenges posed by glioblastoma, a novel and high-performance tumor inhibitor (La@FA-CDs) composed of folic acid and lanthanum nitrate hexahydrate, was successfully synthesized and demonstrated effectiveness in inhibiting the growth of U251 and LN299 cells. The microstructure of La@FA-CDs was extensively analyzed by FTIR, UV-Vis, XPS, TEM, AFM NMR, and nanoparticle size analyzer. The optical and electrical properties of La@FA-CDs were characterized using a fluorescence spectrometer and a zeta potential analyzer.

Thiol-ene Click Chemistry Synthesis of L-Cysteine-Grafted Graphene Oxide As a New Corrosion Inhibitor for Q235 Steel in Acidic Environment.

l-cysteine, as an eco-friendly and nontoxic corrosion inhibitor, was directly covalently linked to the carbon/carbon double bonds of the GO flakes by a thiol-ene click reaction to avoid decreasing the number of hydrophilic oxygen-containing polar functionalities. The corrosion inhibition performances of Cys-GO toward Q235 steel (QS) in diluted hydrochloric acid were studied by electrochemical methods. The corrosion was a charge transfer-controlled process, and Cys-GO manifested as a mixed-type corrosion inhibitor.

Gut microbiota in cancer: insights on microbial metabolites and therapeutic strategies.

In recent years, the role of gut microbiota in cancer treatment has attracted substantial attention. It is now well established that gut microbiota and its metabolites significantly contribute to the incidence, treatment, and prognosis of various cancers. This review provides a comprehensive review on the pivotal role of gut microbiota and their metabolites in cancer initiation and progression.

Aquaporins in Digestive System.

In this chapter, we mainly discuss the expression and function of aquaporins (AQPs) expressed in digestive system. AQPs are highly conserved transmembrane protein responsible for water transport across cell membranes. AQPs in gastrointestinal tract include four members of aquaporin subfamily: AQP1, AQP4, AQP5, and AQP8, and three members of aquaglyceroporin subfamily: AQP3, AQP7, and AQP10.

The comparative efficacy and safety of 9 traditional Chinese medicines combined with standard quadruple therapy for associated gastritis: a systematic review and network meta-analysis.

Background: There are 9 traditional Chinese medicines (TCMs) combined with standard quadruple (SQ) available for the treatment of (Hp)-associated gastritis, but their relative efficacy and best options in clinical decision making are unknown due to a lack of high-quality head-to-head randomized controlled trials (RCTs). This study aimed to explore which formulas are the most effective and/or safest for Hp-associated gastritis.

Methods: We performed a search of electronic databases including PubMed, Web of Science, Cochrane Library, Embase, Chinese databases and South Korean database from inception to March 2022 to identify all relevant RCTs on the comparison between TCM combined with SQ and SQ for Hp-associated gastritis.

Family with sequence similarity 153 member B as a potential prognostic biomarker of gastric cancer.

Gastric cancer (GC) is one of the most common digestive tumors in Northwest China. Previous sequencing analysis revealed that family with sequence similarity 153 member B (FAM153B) might be the primary driver gene of GC. In this study, we aim to explore the potential roles of FAM153B in GC.

Oridonin Delays Aging Through the AKT Signaling Pathway.

Aging is a major risk factor for chronic diseases and disability in humans. Nowadays, no effective anti-aging treatment is available clinically. In this study, oridonin was selected based on the drug screening strategy similar to Connectivity MAP (CMAP) but upon transcriptomes of 102 traditional Chinese medicines treated cell lines.

The Association of Trefoil Factors with Gastric Cancer and Premalignant Lesions: A Cross-Sectional Population-Based Cohort Study.

Background: A lack of research on the association of trefoil factors (TFF) with gastric cancer and premalignant lesions (PML) in the general population is an important obstacle to the application of TFFs for gastric cancer screening. We aimed to analyze the association of TFFs with gastric cancer and PMLs in a general population.

Methods: We evaluated 3,986 adults residing in Wuwei, China.

Prevalence and risk factors of Helicobacter pylori infection in Wuwei, a high-risk area for gastric cancer in northwest China: An all-ages population-based cross-sectional study.

Objective: This study aimed to determine the prevalence and risk factors of Helicobacter pylori infection across all age groups in Wuwei City, a high-risk area for gastric cancer in Northwest China.

Methods: We conducted this study from 2016 to 2017 in an urban and a rural community in Wuwei City. Stool antigen tests targeted individuals aged 0 to 3 years old, and C-urea breath tests targeted individuals aged above 3 years.

Prevalence and associated risk factors of Helicobacter pylori infection in the Wuwei cohort of north-western China.

Objectives: To evaluate the prevalence of Helicobacter pylori infection and risk factors and to serotype the strains in Wuwei, located in north-western China, which has a high incidence of gastric cancer.

Methods: Helicobacter pylori infection was analysed in 21 291 adults by C-urea breath test, and H. pylori antibody were detected in 9183 serum samples by latex immunoturbidimetric method.

A high-efficiency corrosion inhibitor of N-doped citric acid-based carbon dots for mild steel in hydrochloric acid environment.

Novel N-doped carbon dots (CDs) were obtained through pyrolysis of ammonium citrate at 180 °C for 1, 2 and 3 h, and their corrosion inhibition effect on Q235 steel in 1 M HCl solution were evaluated through electrochemical impedance spectroscopy (EIS), potentiodynamic polarization (Tafel), scanning vibrating electrode technique (SVET) analysis. The changes of corrosion current density and impedance modulus of Q235 steel in inhibitor solutions showed that the as-prepared carbon dots presented a valid protective effect on steel in 1 M HCl solution. Meanwhile, the inhibition efficiency of three carbon dots exceeded 90% at 200 mg/L and the highest inhibitive efficiency was found for the carbon dots prepared at the reaction time of 2 h.

A comprehensive evaluation of clinical efficacy and safety of celecoxib in combination with chemotherapy in metastatic or postoperative recurrent gastric cancer patients: A preliminary, three-center, clinical trial study.

Aim: To evaluate the efficacy and safety of celecoxib combined with chemotherapy in the treatment of metastatic or postoperative recurrent gastric cancer.

Methods: This preliminary, three-center, clinical trial study was conducted between September 2010 and December 2016. In the experimental group (n = 100), patients were treated with celecoxib combined with chemotherapy, and chemotherapy alone was used in the control group.

Improvement of anticorrosion ability of epoxy matrix in simulate marine environment by filled with superhydrophobic POSS-GO nanosheets.

Super-hydrophobicity polyhedral oligomeric silsesquioxane-modified graphene oxide (POSS-GO) was synthesized by one-step reaction between graphene oxide (GO) and aminopropylisobutyl polyhedral oligomeric silsesquioxane (POSS-NH). Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) spectra indicated that the POSS were successfully connected to the edge and surface of GO nanosheets. Scanning probe microscope (SPM) and transmission electron microscope (TEM) images demonstrated that the POSS-GO with a thickness of 1.

Effect of interlayer design on friction and wear behaviors of CrAlSiN coating under high load in seawater.

In this paper, CrAlSiN coatings with different interlayer designs (without interlayer, Cr interlayer, CrN interlayer and Cr/CrN interlayer) were successfully obtained on 316L stainless steel and single crystal silicon by multi-arc ion plating technique. Coating microstructure, mechanical, anticorrosion and tribological behaviors in artificial seawater were systematically investigated by XRD, SEM, XPS, TEM, nanoindentation, electrochemical workstation and frictional tester system. Results showed that the CrAlSiN layer presented a typical nanocrystalline/amorphous structure, which consisted of CrN, AlN and SiN phases.

Molecular mechanisms of lncRNA SMARCC2/miR-551b-3p/TMPRSS4 axis in gastric cancer.

Decreased expression of miR-551b-3p has been identified in gastric cancer tissues but its biological role and underlying mechanism in this malignancy is poorly understood. In this study, we show that the expression of miR-551b-3p negatively correlates with the depth of tumour invasion and lymphatic metastasis, but it positively correlates with tumour differentiation and the patient survival. MiR-551b-3p negatively affects the proliferation, mobility and invasiveness of gastric cancer cells.

COX-2 regulates Snail expression in gastric cancer via the Notch1 signaling pathway.

The conversion of arachidonic acid into prostaglandins by cyclooxygenase (COX)-2 contributes to the biological properties of malignant tumours. During the initiation and development of various tumours, the Notch family plays a key role. However, the association between COX‑2 and the Notch family in gastric cancer (GC) remains unclear.