Genetic Etiology of Epilepsy: A Retrospective Study From a Single-Center Cohort.

Next generation sequencing (NGS) technology has made significant progress in the genetic diagnosis and treatment of epilepsy. However, genetic studies on epilepsy with different etiologies remain relatively limited. In this study, whole-genome or whole-exome sequencing was performed on 158 unrelated patients with epilepsy of various etiologies, and the identified variants were analyzed for their association with 1356 seizure-related genes in the database.

Autophagy-related genes in mesial temporal lobe epilepsy: an integrated bioinformatics analysis.

Background: Autophagy plays essential roles in the development and pathogenesis of mesial temporal lobe epilepsy (mTLE). In this research, we aim to identify and validate the autophagy-related genes associated with mTLE through bioinformatics analysis and experimental validations.

Methods: We obtained the dataset GSE143272 and high-throughput sequencing results of mTLE from public databases.

Epigenetic Mechanisms in the Pathophysiology and Progression of Epilepsy: A Comprehensive Review of Experimental and Clinical Studies.

Epilepsy is a prevalent neurological disorder that presents with a diverse range of clinical manifestations and etiologies influenced by both genetic and environmental factors. However, traditional genetic mechanisms alone are insufficient to fully elucidate the pathogenesis of epilepsy, highlighting the increasing importance of epigenetics in epilepsy research. Several studies have demonstrated that epigenetic mechanism play a pivotal role in the development and progression of epilepsy.

Scalp ripple rates for rapid epilepsy differentiation and seizure activity assessment: Applicability and influential factors.

Objective: We aim to determine whether automatically detected ripple rate (ADRR) of 10-min scalp electroencephalography (EEG) during slow-wave sleep can be a useful tool for rapid epilepsy differentiation and seizure activity assessment, and we analyze the clinical factors that may affect the scalp ripple rates.

Methods: We retrospectively included 336 patients who underwent long-term video-EEG with a sampling rate ≥1000 Hz, and three groups were established based on their final clinical diagnosis (non-epilepsy; non-active epilepsy [epilepsy being seizure-free for at least 1 year]; and active epilepsy [epilepsy with one or more seizures in the past year]). ADRRs between groups were compared and diagnostic thresholds set according to the maximum of Youden index with the receiver-operating characteristic curve.

Molecular and clinical characteristics of -related diseases.

Objective: With detailed studies of -related diseases, the phenotypic spectrum of has greatly expanded. This study aimed to potentially identify the mechanisms by which caused neurological dysfunction by analyzing the clinical features and phenotypes of -related diseases, and exploring the distribution patterns of mutations in the subregions of the protein, thus providing new and effective therapeutic approaches.

Methods: Databases of PubMed, Online Mendelian Inheritance in Man, and Human Gene Mutation Database, Wanfang Data, and Embase were searched for case reports of -related diseases.

Identification of Ion Channel-Related Genes and miRNA-mRNA Networks in Mesial Temporal Lobe Epilepsy.

It aimed to construct the miRNA-mRNA regulatory network related to ion channel genes in mesial temporal lobe epilepsy (mTLE), and further identify the vital node in the network. Firstly, we identified ion channel-related differentially expressed genes (DEGs) in mTLE using the IUPHAR/BPS Guide to Pharmacology (GTP) database, neXtProt database, GeneCards database, and the high-throughput sequencing dataset. Then the STRING online database was used to construct a protein-protein interaction (PPI) network of DEGs, and the hub module in the PPI network was identified using the cytoHubba plug-in of Cytoscape software.

The Impact of Specialized Knowledge Search on Enterprise Innovation.

Against the backdrop of the fierce competition in the market nowadays, a closed innovation model based on internal knowledge is no longer sufficient to support enterprises in search of high-performance innovation. Instead, corporations are desperately required to search for resources of external knowledge to meet their innovation goals. Existing studies on open innovation in corporate management failed to fully elaborate on the mechanism of how the external knowledge search could impose an impact on sustaining innovation and disruptive innovation.

Transient ischemic attack presenting as recurrent migratory numbness by seconds: a rare case confirmed by transcranial Doppler micro-emboli monitoring.

Background: Transient ischemic attack (TIA) is a brief episode of cerebral ischemia. However, if a symptom is not presented as drop attack or hemiplegia, and alarming to the patient and the physician, how short of a symptom duration would raise the concern of a physician for TIA? It will be more complicated if the location of the neurological deficit is vagrant. This report highlights a rare TIA case which presented a very short duration of migratory patchy distribution numbness.

Risk of seizure recurrence from antiepileptic drug withdrawal among seizure-free patients for more than two years.

Objective: The aim of this study was to determine the outcome of antiepileptic drug (AED) withdrawal in patients who were seizure-free for more than two years.

Methods: Patients with epilepsy who were seizure-free for at least two years and decided to stop AED therapy gradually were followed up every two months for seizure relapse. The inclusion criteria were as follows: (1) diagnosis of epilepsy, defined as the following conditions: ① at least two unprovoked (or reflex) seizures occurring >24 h apart; ② one unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after two unprovoked seizures, occurring over the next 10 years; ③ diagnosis of an epilepsy syndrome; (2) patients remained seizure-free for at least 24 consecutive months during AED therapy; and (3) patients expressed a desire to discontinue AED therapy gradually and agreed to return for regular follow-ups.

Research on the Effects of Entrepreneurial Education and Entrepreneurial Self-Efficacy on College Students' Entrepreneurial Intention.

Entrepreneurship is one of the important engines of economic development. Under the influence of policy encouragement and economic situation, college students have become the emerging entrepreneurial subjects. Studying the factors influencing their willingness to innovate is conducive to improving the entrepreneurial status and performance.