Epstein-Barr Virus Corneal Endotheliitis and Uveitis in a Patient With Extranodal Natural Killer/T-Cell Lymphoma.

Purpose: To report a case of Epstein-Barr virus (EBV) corneal endotheliitis and uveitis in a patient diagnosed with extranodal natural killer/T-cell lymphoma (ENKTL).

Methods: This is a case report performed at a tertiary care center in the Republic of Korea.

Results: A 64-year-old man presented with decreased vision in his right eye that had persisted for 4 days.

Safety and efficacy of transcatheter aortic valve replacement using Sapien 3 balloon-expandable valve in type 0 bicuspid aortic valve stenosis patients.

Background: Data regarding the safety and efficacy of balloon expandable valves (BEVs) for transcatheter aortic valve replacement (TAVR) in patients with Sievers type 0 bicuspid aortic valve (BAV) stenosis remain limited.

Aims: This study aims to evaluate the clinical outcomes of BEVs implantation in patients with Sievers type 0 BAV.

Methods: We conducted a multicenter, retrospective study across 28 centers in China between October 2020 and March 2023.

Transcatheter aortic valve implantation in pure aortic regurgitation: one-year outcomes of the AURORA trial.

Background: Transcatheter aortic valve implantation (TAVI) in pure aortic regurgitation (AR) remains challenging because of inadequate anchoring forces. Traditional approaches, which rely solely on virtual annulus oversizing, have demonstrated limited success. We propose a novel anatomical classification system and dual-anchoring theory to optimise the TAVI strategy in patients with pure AR.

Effects of matrix metalloproteinase inhibition in cultured human Tenon's capsule fibroblasts.

Background: This study aimed to compare the characteristics of anterior and posterior human Tenon's capsule fibroblasts and determine the effect of matrix metalloproteinase (MMP) inhibition on cultured human Tenon's capsule fibroblasts.

Methods: Tissues obtained from the anterior and posterior Tenon's capsules were partially incised, cultured, and subjected to microarray analysis. Electrophoresis was performed on the cells treated with Ilomastat (MMP-9 inhibitor), and collagen 1, 3, and 6.

Global burden of low back pain attributable to smoking in 204 countries and territories in 1990-2021.

Background: Smoking has a major influence on the development and worsening of low back pain (LBP). However, the effect of smoking on the burden of LBP has not been thoroughly examined at the global, regional, and national levels. This study aims to analyze the trends in smoking-related LBP from 1990 to 2021.

Cooperative Photoenzymatic Catalysis for Enantioselective Fluoroalkylation/Cyclization Cascade.

Due to the invaluable properties of organofluorine compounds, incorporating a fluorinated unit has become necessary in pharmaceuticals, agrochemicals, and materials. However, achieving asymmetric fluorination such as trifluoromethylation through chemo- or biocatalysis has been a synthetic challenge. Here, we introduce a unique cooperative photoenzymatic catalysis for the enantioselective fluoroalkylation/cyclization cascade.

Cellular Landscape of Synovial Chondromatosis Synovium Revealed by Single-Cell RNA Sequencing.

Synovial chondromatosis (SC) is a rare joint disorder characterized by cartilaginous loose bodies, yet its cellular underpinnings remain incompletely understood. To define the cellular landscape in SC, single-cell RNA sequencing was performed on synovial tissue obtained from both healthy individuals and SC patients. Analysis of this comprehensive dataset revealed significant alterations in the cellular composition and unique transcriptional profiles of key synovial cell populations within SC synovium.

Decoding 4-vinylanisole biosynthesis and pivotal enzymes in locusts.

Aggregation pheromone, 4-vinylanisole (4VA), is specifically released by gregarious migratory locusts, and is crucial in forming locust swarms that cause destructive plagues. Control of locust plagues relies heavily on the extensive application of chemical pesticides, which has led to severe environmental and health issues. As pheromones are primary mediators of insect communication and behaviour, exploring their biosynthesis can provide important cues to develop innovative behavioural regulators, potentially reducing the reliance on chemical pesticides.

A Biomimetic Copper Silicate-MOF Hybrid for Highly Stable Zn Metal Anode.

To promote the electrochemical performance of aqueous zinc-ion batteries, various artificial interlayers are developed to mitigate dendrite growth and HO-induced side reactions of Zn anode. Metal-organic framework (MOF) interlayers show much potential in solving these problems, yet their practical usage is inhibited by their inferior structural stability during cycles. Herein, inspired by the biological mechanism and symbiotic architecture of drosera rotundifolia, this challenge is tackled by constructing a hierarchical hollow CuSiO-MOF hybrid through in situ MOF conversion.

Comparison of Cu Strengthened by Ionic Bonded Particles and Cu Strengthened by Metallic Bonded Particles.

Cu matrix composites, because of their high mechanical strength, are often used as conductors in high-performance electrical applications. These composites are manufactured through thermomechanical processing, which introduces a high density of particles that act as obstacles to dislocation motion. Increasing the density of these particles enhances the mechanical strength of the conductors, which we tested under static loading.

Trends and mechanisms of Alzheimer's disease and hearing impairment: A 20-year perspective.

Alzheimer's disease (AD) and hearing loss (HL) are major age-related public health challenges with emerging evidence suggesting their interconnection. This study aimed to investigate global research trends, shared molecular mechanisms, and clinical implications of AD and HL. A total of 349 articles published between 2004 and 2024 were retrieved from the Web of Science Core Collection and analyzed using VOSviewer and CiteSpace.

Trends and driving factors of age-related hearing loss and severity over 30 years: a cross-sectional study.

Background: Age-related hearing loss (AHL) is a modifiable risk factor for chronic disability and cognitive decline in adults over 60 years globally. Despite its preventable nature, long-term trends (1992-2021) in AHL burden and its demographic, socioeconomic, occupational noise exposures, and geographic drivers remain underexplored, limiting targeted intervention strategies.

Methods: This observational study analyzed age-standardized prevalence and years lived with disability (YLDs) for AHL among adults aged ≥60 years using the Global Burden of Disease Study 2021 (1992-2021).

Case Report: Linezolid-associated toxic optic neuropathy in patients with pulmonary tuberculosis: case series and mini review.

Linezolid is a useful second-line medication for the treatment of tuberculosis that is resistant to multiple drugs. However, long-term therapy can cause side effects, such as optic neuropathy. We describe three cases of progressive painless bilateral visual loss in patients taking long-term linezolid therapy for multidrug-resistant and extensively drug-resistant tuberculosis.

Mapping the lung-brain axis: Causal relationships between brain network connectivity and respiratory disorders.

Background: The mechanistic relationship between respiratory disorders and brain function remains poorly understood, despite growing evidence of cognitive and neurological manifestations in respiratory diseases. We aim to identify whether specific brain network connectivity patterns causally influence respiratory disease susceptibility, while respiratory conditions might reciprocally affect brain network architecture.

Methods: We performed bidirectional Mendelian randomization (MR) analyses using genome-wide association studies (GWAS) of brain network connectivity from UK Biobank resting-state functional MRI (rs-fMRI) data (N = 31,453) and GWAS data from ten major respiratory conditions: chronic obstructive pulmonary disease (COPD), asthma, idiopathic pulmonary fibrosis (IPF), sleep apnea syndrome (SAS), lung squamous carcinoma (LUSC), lung adenocarcinoma (LUAD), small cell lung carcinoma (SCLC), hospitalized COVID-19, very severe COVID-19, and bronchiectasis.

Multi-enzymatic biomimetic cerium-based MOFs mediated precision chemodynamic synergistic antibacteria and tissue repair for MRSA-infected wounds.

Antibiotic-resistant pathogens represent a significant global public health challenge, particularly in refractory infections associated with biofilms. Urgent development of innovative, safe, and therapeutically adaptive strategies to combat these resistant biofilms is essential. We present a novel biomimetic antibacterial system inspired by the multifunctional enzymatic properties of cerium-based metal-organic frameworks.

Unraveling Spinal Cord Injury Nutrition: Effects of Diet on the Host and Microbiome.

Spinal cord injury (SCI) leads to severe neurological dysfunction with significant nutritional alterations. These alterations are closely associated with gut dysbiosis and neurogenic gut dysfunction after SCI, creating complex interactions that further exacerbate metabolic disturbances and impede neurological recovery. In the context of SCI, diet not only fulfills basic nutritional needs but also serves as an important therapeutic tool to modulate these interactions.

SurvGraph: A hybrid-graph attention network for survival prediction using whole slide pathological images in gastric cancer.

Whole slide pathological images have shown significant potential for patient prognostication. Graph representation learning provides a robust framework for in-depth analysis of whole-slide images to construct predictive models. In this study, we introduce SurvGraph, an innovative graph-based deep learning network designed for gastric cancer survival prediction using whole slide pathological images.

Disrupting cross-adaptation in high-risk MRSA: Sanguinarine as a multi-effective stress sensitizer for environmental and food safety.

Methicillin-resistant Staphylococcus aureus (MRSA) represents a significant public health concern owing to its formidable antibiotic resistance and robust capacity for biofilm formation. The cross-adaptation mechanism enables MRSA to develop tolerance to environmental stressors such as antibiotics, acid, heat and osmotic pressure, leading to the persistence infections and environmental contamination. The cross-adaptation mechanism enables MRSA to develop tolerance to environmental stressors, such as antibiotics, acid, heat and osmotic pressure, leading to the persistence infections and environmental contamination.

Air classification efficiency evaluation of landfilled municipal solid waste using experiments and a probabilistic method.

The air classification efficiency of landfilled Municipal Solid Waste (MSW) is critical for resource recovery but remains challenged by the heterogeneity and non-spherical morphology of waste. In this study, a probabilistic framework that integrates spheroid modeling with the Monte Carlo procedure to predict and optimize the separation efficiency was developed, and the results were compared using orthogonal experiments. The morphological distributions (elongation, flatness, and size) of 381 landfill samples and the density distributions of 184 landfill samples were statistically characterized.

Search for Solar Boosted Dark Matter Particles at the PandaX-4T Experiment.

We present a novel constraint on light dark matter utilizing 1.54 metric ton/year of data acquired from the PandaX-4T dual-phase xenon time projection chamber. This constraint is derived through detecting electronic recoil signals resulting from the interaction with solar-enhanced dark matter flux.

Correlations of resilience with coping styles and quality of life in patients with malignancies.

Background: Resilience is an individual's ability and psychological rebound capacity to adapt well after experiencing adversity, trauma, Patients with strong resilience can face illnesses actively.

Aim: To determine the association of resilience with coping styles and quality of life in patients with malignancies.

Methods: This study included patients with malignant tumors who were hospitalized at Fuyang Hospital Affiliated to Anhui Medical University from March 2022 to March 2024.

Estimating soil cadmium concentration using multi-source UAV imagery and machine learning techniques.

Urbanization and industrialization have led to widespread soil heavy metals contamination, posing significant risks to ecosystems and human health. Conventional methods for mapping heavy metal distribution, which rely on soil sampling followed by chemical analysis, are costly and time-consuming. This study proposes a novel approach for estimating soil cadmium (Cd) concentrations by integrating multi-source data captured by Unmanned Aerial Vehicle (UAV), including multispectral images, Digital Elevation Model (DEM), and high-resolution RGB aerial imagery, with machine learning algorithms.

Engineered injection and extraction combined with in situ oxidation remediation at an industrial site and evaluation of contaminant plume dynamics.

Complex organic compounds derived from industrial production have caused serious pollution of groundwater and soil, persisting for prolonged periods within the seepage zone and aquifers. Engineered injection and extraction (EIE) combined with in situ remediation technology is widely used at industrial contaminated sites. However, detailed investigations and dynamic assessments of changes in the characteristic pollutants plume and quantification of restoration are still lacking.

Pan-cancer analysis and validation show GTF2E2's diagnostic, prognostic, and immunological roles in regulating ferroptosis in endometrial cancer.

Background: Transcription initiation factor IIE subunit beta (GTF2E2) is a crucial component of the RNA polymerase II transcription initiation complex. There is a lack of more detailed research on the biological function of GTF2E2 in pan-cancer.

Methods: We conducted a comprehensive pan-cancer analysis using data from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) project.