Platycodin D targets ZNF70 to inhibit NLRP3 inflammasome and STAT3 signaling pathway to ameliorate colitis.

Background: UC is a chronic inflammatory bowel disease that can be severe enough lead to bowel perforation and even colorectal cancer. The current treatments for UC have several limitations, highlighting the urgent need for the development of novel therapeutic agents. Recent research has shown that ZNF70 plays a crucial role in colitis-associated colorectal cancer.

Vertical distribution of new and weathered microplastics in the water column: Implications for developing reliable sampling methods.

Microplastics (MPs) exposure to environmental conditions results in weathering, alters their physicochemical properties, and subsequently influences their mobility in aquatic systems. This study aims to investigate the interrelated roles of MP type and weathering conditions on their terminal settling/rise velocities and subsequently distribution in the water column under turbulent flow to further inform sampling methodologies. Low density polyethylene (LDPE), polyvinyl chloride (PVC), and ground tire rubber (GTR) were subjected to accelerated photodegradation and sedimentation processes, and biofilm was grown on LDPE and GTR MPs.

Immunotherapy and its racial specificity for breast cancer treatment in Asia: a narrative review.

Immunotherapy, including immune checkpoint inhibitors, adoptive cell therapy, cancer vaccines, and other modalities, represents a significant advancement in cancer treatment. Breast cancer, traditionally considered less amenable to immunotherapy, has demonstrated responsiveness to immunotherapy when combined with conventional treatment options. These integrative strategies enhance the effectiveness of immunotherapy, bringing hope to patients.

Neuroplasticity and functional reorganization of language in patients with arteriovenous malformations: insights from neuroimaging and clinical interventions.

Patients with arteriovenous malformations (AVMs) located in the functional area of speech often exhibit language dysfunction, and neuroplasticity allows the brain of some patients to regain speech through functional reorganization. Exploring the mechanism of AVMs-induced reorganization of language function is important for understanding neuroplasticity and improving clinical intervention strategies. This review systematically searched and analyzed the research literature in related fields in recent years, covering data from neuroimaging, functional magnetic resonance imaging (fMRI), and clinical case studies.

Combining machine learning with external validation to explore necroptosis and immune response in moyamoya disease.

Moyamoya disease (MMD) is a rare chronic vascular disease leads to cognitive impairment and stroke with its etiology unknown. The relationship between necroptosis or necroinflammation and MMD pathogenesis was poorly understood. Differentially expressed necroinflammation and necroptosis related genes (DE-NiNRGs) were selected based on the public gene expression data from Gene Expression Omnibus (GEO) and validated by our self-test data of MMD patients and control group.

Feature sequence-based genome mining uncovers the hidden diversity of bacterial siderophore pathways.

Microbial secondary metabolites are a rich source for pharmaceutical discoveries and play crucial ecological functions. While tools exist to identify secondary metabolite clusters in genomes, precise sequence-to-function mapping remains challenging because neither function nor substrate specificity of biosynthesis enzymes can accurately be predicted. Here, we developed a knowledge-guided bioinformatic pipeline to solve these issues.

Ecological inferences on invasive carp survival using hydrodynamics and egg drift models.

Bighead carp (Hypophthalmichthys nobilis), silver carp (H. molitrix), black carp (Mylopharyngodon piceus), and grass carp (Ctenopharyngodon idella), are invasive species in North America. However, they hold significant economic importance as food sources in China.

Deciphering Depressor Anguli Oris for Lower Face Rejuvenation: A Prospective Ultrasound-based Investigation.

Background: The depressor anguli oris muscle (DAO) is a pivotal treatment target when creating a harmonic jawline. However, evidence of its live morphology remains scarce.

Objectives: In this study we aimed to reevaluate the DAO with a facile ultrasound analysis and thereby guide safer and more effective botulinum toxin type A (BTX-A) injection.

The effects of wind-wave disturbances on sediment resuspension and phosphate release in Lake Chao.

As a typical shallow lake with a wind-generated flow, the resuspension state of sediment and phosphorus release under wind field disturbance plays an important role in controlling lake eutrophication in Lake Chao. In this study, we proposed a combination of experimental analysis of dynamic disturbances, wind-wave disturbance shear stress calculation, and model simulation (experimental-calculative-modeling) to quantitatively investigate the effects of wind-wave disturbances on the resuspension state of Lake Chao bottom sediment and phosphorus release and distribution. The results showed that the release rate of phosphorus from the Lake Chao bottom sediment was affected by the wind field and bottom sediment content, which varied significantly spatially and showed some difference between different seasons.

Low depression literacy exacerbates the development and progression of depressive mood in Chinese adult social media users during COVID-19: A 3-month observational online questionnaire-based study with multiple cross-sectional analyses.

Background: The main purpose of this study was to explore the relationship between depression literacy (D-Lit) and the development and progression of depressive mood.

Methods: This longitudinal study with multiple cross-sectional analyses used data from a nationwide online questionnaire administered the Wen Juan Xing survey platform. Eligible participants were 18 years or older and had subjectively experienced mild depressive moods at the time of their initial enrollment in the study.

Post-COVID-19 human memory impairment: A PRISMA-based systematic review of evidence from brain imaging studies.

Many people with coronavirus disease 2019 (COVID-19) report varying degrees of memory impairment. Neuroimaging techniques such as MRI and PET have been utilized to shed light on how COVID-19 affects brain function in humans, including memory dysfunction. In this PRISMA-based systematic review, we compared and summarized the current literature looking at the relationship between COVID-19-induced neuropathological changes by neuroimaging scans and memory symptoms experienced by patients who recovered from COVID-19.

Neuroprotective Effects of Sodium Butyrate and Monomethyl Fumarate Treatment through GPR109A Modulation and Intestinal Barrier Restoration on PD Mice.

Research has connected Parkinson's disease (PD) with impaired intestinal barrier. The activation of G-protein-coupled receptor 109A (GPR109A) protects the intestinal barrier by inhibiting the NF-κB signaling pathway. Sodium butyrate (NaB), which is a GPR109A ligand, may have anti-PD effects.

Potential roles of gut microbiota and microbial metabolites in Parkinson's disease.

Parkinson's disease (PD) is a complicated neurodegenerative disease attributed to multifactorial changes. However, its pathological mechanism remains undetermined. Accumulating evidence has revealed the emerging functions of gut microbiota and microbial metabolites, which can affect both the enteric nervous system and the central nervous system via the microbiota-gut-brain axis.

Effects of different habitats on the bacterial community composition in the water and sediments of Lake Taihu, China.

Bacterial communities are sensitive to environmental fluctuations, and a better understanding of the relationships between bacterial community distribution and complex environmental conditions is important for the remediation of lake ecosystems. In this study, bacterial communities from 7 water and 7 sediment samples in 3 different regions (east, the hydrophyte-dominated region; north, the transitional region; west, the highly polluted region) of Lake Taihu were investigated via high-throughput sequencing. The physicochemical characterization showed that there were obvious differences in the trophic statuses of the three lake regions, which were mainly due to the differences in pollutant concentration and hydrophyte coverage.

[Adsorption Behavior of Low Concentration Phosphorus from Water onto Modified Reed Biochar].

In order to remove low concentration of phosphorus in wastewater and realize resource utilization of reed, reed biochar(RB) was prepared using reed and then modified by ferric chloride, and the adsorption behavior of low concentration phosphorus was investigated. The results showed that the iron content of modified reed biochar(MRB) was 11.98 mg·g, which was 44.