Effects of Dietary Tannic Acid and Tea Polyphenol Supplementation on Rumen Fermentation, Methane Emissions, Milk Protein Synthesis and Microbiota in Cows.

To develop sustainable strategies for mitigating ruminal methanogenesis and improving nitrogen efficiency in dairy systems, this study investigated how low-dose tannic acid (T), tea polyphenols (TP), and their combination (T+TP; 50:50) modulate rumen microbiota and function. A sample of Holstein cows were given four dietary treatments: (1) control (basal diet); (2) T (basal diet + 0.4% DM tannic acid); (3) TP (basal diet + 0.

Effects of Rumen-Protected Chromium-Nicotinic Acid on Lactation Performance, Nutrient Digestion, Ruminal Fermentation, Serum Biochemical Parameters, and Antioxidant in Lactating Water Buffaloes.

This study evaluated the effects of rumen-protected chromium-nicotinic acid (RPCNA) supplementation on lactation performance, nutrient digestion, ruminal fermentation, serum biochemical parameters and antioxidant in lactating water buffaloes under conditions of a critical thermal comfort index (TCI). Healthy lactating water buffaloes (milk yield = 5.96 ± 0.

BioGraphFusion: graph knowledge embedding for biological completion and reasoning.

Motivation: Biomedical knowledge graphs (KGs) are crucial for drug discovery and disease understanding, yet their completion and reasoning are challenging. Knowledge embedding (KE) methods capture global semantics but struggle with dynamic structural integration, while graph neural networks (GNNs) excel locally but often lack semantic understanding. Even ensemble approaches, including those leveraging language models, often fail to achieve a deep, adaptive, and synergistic co-evolution between semantic comprehension and structural learning.

High resolution two photon fluorescence probe monitoring ClO based on anion exchange for the synergistic ROS and ferroptosis activated by thermal energy.

Ferroptosis, closely correlated with hypochlorite (ClO), is an emerging form of iron-dependent cell death. Exploring the ClO content in living cells will help to further reveal the biological function of ferroptosis. In this work, we have developed a two-photon excited fluorescent probe (CMI-ClO) which can detect the ClO changes during ferroptosis.

Thermally Activated Delayed Fluorescence of Organic-Inorganic Hybrid Menshutkin-Type Cu-Sb Halides.

Organic-inorganic hybrid metal halides have attracted much attention due to their excellent optoelectronic properties. The heterometallic structure is expected to achieve more complex luminescence centers, thereby improving the tunability of the fluorescent materials. This paper reports the synthesis of crystals [Cu(2,2'-bpy)(PPh)][CuCl(PPh)SbOCl] (, 2,2'-bpy = 2,2'-bipyridine, PPh = triphenylphosphine) and (Mim)[SbOCl] (, Mim = 1-methylimidazole).

Daily hassle effects on daily cigarette and/or e-cigarette use: the moderating effect of daily uplifts.

Background: Daily hassles, as minor stressful events, are common in life. However, they have received less attention in previous studies on relationships between stressful events and nicotine product use. Meanwhile, daily uplifts have also been investigated less in research on nicotine use.

Epidemic risks of measles and rubella in China: a systematic review and meta-analysis.

Background: Seroprevalence studies across various countries can contribute to achieving the elimination target for measles and rubella. However, in the Mainland of China, the concept of herd immunity remains unclear due to the lack of a nationwide serosurvey.

Methods: This systematic review and meta-analysis was conducted by retrieving literature reporting the seroprevalence of measles and rubella published between 2012 and 2023.

The established of a machine learning model for predicting the efficacy of adjuvant interferon alpha1b in patients with advanced melanoma.

Background: Interferon-alpha1b (IFN-α1b) has shown remarkable therapeutic potential as adjuvant therapy for melanoma. This study aimed to develop five machine learning models to evaluate the efficacy of postoperative IFN-α1b in patients with advanced melanoma.

Methods: We retrospectively analyzed 113 patients with the American Joint Committee on Cancer (AJCC) stage III-IV melanoma who received postoperative IFN-α1b therapy between July 2009 and February 2024.

Dorsolateral prefrontal cortex to ipsilateral primary motor cortex intercortical interactions during inhibitory control enhance response inhibition in open-skill athletes.

Numerous studies have reported that long-term sports training can affect inhibitory control and induce brain functional alterations. However, the influence of environmental dynamics in sports training on inter-cortical connectivity has not been well studied. In the current study, we used twin-coil transcranial magnetic stimulation to investigate the functional connectivity between dorsolateral prefrontal cortex (DLPFC) and ipsilateral primary motor cortex (M1) during proactive and reactive inhibition in participants with sports skills in dynamic environment (open-skill experts), stable environment (closed-skill experts), and no sports skills (controls).

Single-Atom Ce-N-C Nanozyme Ameliorates Type 2 Diabetes Mellitus by Improving Glucose Metabolism Disorders and Reducing Oxidative Stress.

Type 2 diabetes mellitus (T2DM) as a chronic metabolic disease has become a global public health problem. Insulin resistance (IR) is the main pathogenesis of T2DM. Oxidative stress refers to an imbalance between free radical production and the antioxidant system, causing insulin resistance and contributing to the development of T2DM via several molecular mechanisms.

White light emission in 0D halide perovskite [(CH)S]SnCl·HO crystals through variation of doping ns ions.

With the rapid development of white LEDs, the research of new and efficient white light emitting materials has attracted increasing attention. Zero dimensional (0D) organic-inorganic hybrid metal halide perovskites with superior luminescent property are promising candidates for LED application, due to their abundant and tailorable structure. Herein, [(CH)S]SnCl·HO is synthesized as a host for dopant ions Bi and Sb.

A Promising Plant-Based Eugenol-Loaded Nano Delivery System (EUG@CMC-PGMA-CS) for Enhanced Antibacterial and Insect Repellent Behavior.

Pathogens and pests pose significant threats to global crop productivity and plant immunity, necessitating urgent measures from researchers to prevent pathogen contamination and pest damage to crops. A natural plant-based antibacterial agent, eugenol (EUG), has demonstrated excellent antimicrobial and insect repellent capabilities, but the characteristics of volatilization and poor dissolution limit the practical application. The nanoization of pesticide formulations holds promise in the development of highly effective pesticides for antibacterial and insecticidal purposes.

Single-Atom Ce-N-C-(OH) Nanozyme-Catalyzed Cascade Reaction to Alleviate Hyperglycemia.

The enzyme-mimicking catalytic activity of single-atom nanozymes has been widely used in tumor treatment. However, research on alleviating metabolic diseases, such as hyperglycemia, has not been reported. Herein, we found that the single-atom Ce-N-C-(OH) (SACe-N-C-(OH)) nanozyme promoted glucose absorption in lysosomes, resulting in increased reactive oxygen species production in HepG2 cells.

Exploring the links between celebrity worship, body dissatisfaction, and disordered eating among young adult celebrity worshippers in China.

Considerable evidence exists on the associations of celebrity worship with body dissatisfaction and disordered eating. However, relevant findings are confined to Western contexts and thinness-oriented body dissatisfaction and disordered eating. Consequently, the relationships of celebrity worship with muscularity-oriented body dissatisfaction and disordered eating are largely underexplored, especially in non-Western countries.

Expedient delivery of quinolinone drugs a traceless -nitroso enabled oxidative Heck/amidation cascade.

The exploration of green C-H oxidation for the rapid construction of functional molecules, remains a permanent goal in synthetic chemistry. Herein, a traceless -nitroso enabled oxidative Heck and amidation cascade was realized, leading to quinolinones that feature green oxidation and great functional group tolerance. The expedient construction of quinolinone containing pharmaceuticals including Flucarbril, Clostamide and Aripiprazole was achieved in a concise and environmentally friendly manner.

Proteomic and metabolomic analyses reveal the novel targets of spermine for alleviating diabetic cardiomyopathy in type II diabetic mice.

Diabetic cardiomyopathy (DCM) is one of the most serious complications of diabetes. Recent cardiology studies suggest that spermine has a cardioprotective effect. Here, we used proteomic and metabolomic analyses to reveal the underlying research targets in a type II diabetic (T2D) mouse model treated with spermine.

Extraction Optimization, Structural Characterization, and Anti-Hepatoma Activity of Acidic Polysaccharides From D. Don.

The Chinese medicinal herb D. Don has antitumour effects and is used to treat liver cancer in the clinic. polysaccharide (SBP), one of the main active components extracted from D.

Clinical Epidemiology of Sporotrichosis in Jilin Province, China (1990-2019): A Series of 4969 Cases.

Introduction: This study was aimed to examine the clinical and epidemiological characteristics of sporotrichosis in China and specifically Jilin Province, which is one of the areas with the highest incidence worldwide, and to provide data support for the global prevalence of sporotrichosis.

Methods: A total of 4969 cases of sporotrichosis diagnosed at the Second Hospital of Jilin University from January 1, 1990 to December 31, 2019 were collected.

Results: In Jilin Province, the male-to-female ratio was 1:2, the average age at onset was 48 ± 1 years, and the average disease duration was 4.

Itraconazole therapy for infant hemangioma: Two case reports.

Background: Infantile hemangiomas (IHs) are the most common childhood benign tumors, showing distinctive progression characteristics and outcomes. Due to the high demand for aesthetics among parents of IH babies, early intervention is critical in some cases. β-Adrenergic blockers and corticosteroids are first-line medications for IHs, while itraconazole, an antifungal medicine, has shown positive results in recent years.

Multi-Dopant Engineering in Perovskite CsSnCl: White Light Emitter and Spatially Luminescent Heterostructure.

Bi/Te co-doped CsSnCl with dual emission spectrum (i.e., 450 and 575 nm) was achieved by a modified solution method, which can overcome the phase separation in the previous method for CsSnCl crystal growth.

Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer's disease through reducing neuroinflammation and modulating intestinal microbiota.

Hydrogen exhibits the potential to treat Alzheimer's disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic (3×Tg) Alzheimer's disease mice were treated with hydrogen-rich water for 7 months.