circSCAP-encoded SCAP-129aa mediates platinum resistance in triple-negative breast cancer via the PI3K/AKT pathway.

Triple-negative breast cancer (TNBC) often acquires resistance to platinum-based chemotherapy, presenting significant challenges to therapeutic management and adversely affecting patient survival. In such refractory cases, even advanced treatment modalities often exhibit diminished efficacy. This study aims to elucidate the molecular mechanisms underlying platinum resistance.