Identification and expression characteristics of NIN-like protein (NLP) gene family in cucumber plant (Cucumis sativus L.).

Background: Nodule inception-like Protein (NLP) family genes, as transcription factors, play an important role in regulating physiological responses of plants to adapt to external nitrogen environment changes. However, there are few reports on NLP genes in cucumber.

Results: In this study, we identified members of the cucumber family, conducted a comprehensive bioinformatics analysis of them, analyzed their evolutionary relationships, and predicted their potential functions.

The Efficacy and Adverse Reactions of 755 nm Picosecond Alexandrite Laser on the treatment of Nevus of Ota at Different Endpoints: A Split-Lesion, Single-Blinded, Randomized Controlled Comparison Study.

Background: The Picosecond alexandrite laser (PSAL) is a first-line treatment for Nevus of Ota. However, low-fluence PSAL(LF-PSAL) that does not produce immediate whitening (IW) as treatment endpoint, remains unexplored.

Objective: To compare the efficacy and safety of LF-PSAL versus conventional high fluence PSAL(HF-PSAL) for treating Nevus of Ota.

[Effect and safety of electroacupuncture in the treatment of chronic prostatitis / chronic pelvic pain syndrome: A systematic review and meta-analysis of 17 randomized controlled trials].

Objective: To systematically evaluate the effect and safety of electroacupuncture in the treatment of chronic prostatitis / chronic pelvic pain syndrome (CP/CPPS).

Methods: We searched the major Chinese and English databases of CNKI, Wanfang Data, VIP, CBM, PubMed, Cochrane Library, Web of Science and Embase for randomized controlled trials (RCT) on electroacupuncture or combination therapy in the treatment of CP/CPPS published from the establishment of the databases to August 2024. The dichotomous data and continuous data were represented by risk ratio (RR) and mean difference (MD) respectively, both with 95% confidence interval (CI).

Live birth following multimodal therapy in a patient with asherman's syndrome, recurrent pregnancy loss, and polycystic ovarian syndrome: a case report and literature review.

Background: Improving the endometrial thickness (EMT) and pregnancy outcomes in cases of thin endometrium (TE) induced by severe intrauterine adhesion (IUA) is a significant clinical challenge. This report provides insight into a potential protocol for improving EMT and pregnancy outcomes in challenging cases of TE induced by IUA, especially for patients with concurrent polycystic ovary syndrome (PCOS) and experiencing recurrent spontaneous abortion (RSA).

Case Presentation: We report the case of a 29-year-old woman with severe IUA, RSA, and PCOS, who experienced three spontaneous abortions.

Screening, Identification, and Whole-Genome Sequencing of Ferulic Acid Esterase-Producing Lactic Acid Bacteria from Sheep Rumen.

Ferulic acid esterase (FAE) plays an important role in plant fiber degradation by catalyzing the hydrolysis of lignocellulosic structures. FAE-producing lactic acid bacteria (LAB), as potential probiotics, can improve ruminant digestion and gut health. In this study, two LAB strains (Q2 and Q6) with FAE activity were isolated from sheep rumen.

A DIE responsive fluorescent probe for phthalate and its application in test paper and hydrogel detection platforms.

Phthalates, classified as priority environmental contaminants, have driven intensive methodological development for environmental monitoring due to their well-documented endocrine-disrupting effects. Despite these imperatives, the design of optical probes for phthalate detection remains challenging probably due to the lack of suitable functional groups/sensing mode. Additionally, the reported probes were applied in the form of suspensions, resulting in difficulties in separation and recovery during the practical applications.

Sonodynamic Therapy Induces Pyroptosis and Recruits CAR-NK Cells to Enhance the Treatment of Oral Squamous Cell Carcinoma.

Immunotherapy strategies have demonstrated promising efficacy in treating various cancers. However, cancer cells often evade immune surveillance by reducing their immunogenicity, which limits immune cell infiltration into the tumor microenvironment. Pyroptosis, a proinflammatory form of programmed cell death, is characterized by the formation of plasma membrane pores that lead to the release of intracellular contents and stimulate a robust immune response.

A non-solvatochromic fluorescent probe for imaging of lipid droplets in live cells and tissues.

Lipid droplets (LDs) have recently attracted considerable attention owing to their crucial roles in both biological processes and disease pathogenesis. Visualization of LDs is fundamental for elucidating their roles in biological mechanisms and facilitating the early detection of diseases. Donor-acceptor (D-A) typed fluorescent probes have been extensively designed and utilized for the detection of LDs.

Sele-targeted siRNA liposome nanoparticles inhibit pathological scars formation via blocking the cross-talk between monocyte and endothelial cells: a preclinical study based on a novel mice scar model.

Background: Pathological scars (PS) are one of the most common complications in patients with trauma and burns, leading to functional impairments and aesthetic concerns. Mechanical tension at injury sites is a crucial factor in PS formation. However, the precise mechanisms remain unclear due to the lack of reliable animal models.

A Study of Sperm DNA Damage Mechanism Based on miRNA Sequencing.

To analyze the differential expression profiles of microRNAs (miRNAs) in spermatozoa of patients with sperm DNA damage and to investigate the role of miRNAs in sperm DNA damage. Male infertility patients with sperm DNA damage who attended the First Affiliated Hospital of Henan University of Chinese Medicine from October 2023 to December 2023 were selected and included in this study as a case group. Fertile healthy men who were seen at the health check-up center during the same period and diagnosed by examination were also included as a control group.

[Comprehensive therapy of traditional Chinese medicine for erectile dysfunction with damp-heat stasis: A clinical observation of 103 cases].

Objective: To assess the clinical effect and safety of comprehensive therapy of traditional Chinese medicine (TCM) in the treatment of erectile dysfunction (ED) with damp-heat stasis.

Methods: We selected 108 cases of ED with damp-heat stasis meeting the inclusion criteria and treated with tadalafil (the control group, n = 54) or tadalafil + comprehensive TCM therapy (the trial group, n = 54) in the First Affiliated Hospital of Henan University of Chinese Medicine in the same period. After 8 weeks of treatment, we recorded the patients' scores on IIEF-5, TCM syndrome, erectile quality (EQS), 9-Item Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Scale 7 (GAD-7).

D-π-A type fluorescent dyes: Effect of π-bridge units on optical and G4 DNA binding properties.

Fluorescent solvatochromic dyes that are sensitive to the nature of local microenvironmental, have been explored as probes in applications ranging from the imaging biomolecules to understanding of basic biomolecule functions. To expand the scope of fluorescent solvatochromic dyes for G-quadruplex (G4) DNA structures, and to illustrate the relationship between structure and properties, three newly designed D-π-A type fluorescent dyes were synthesized by introducing diarylimidazole to carbazole skeleton linked to benzene, furan or thiophene π-conjugated bridge and connected with pyridinium acceptor, respectively. Their structural characteristics, optical properties, and G4 DNA binding properties were discussed in detail.

Anti-ferroptosis exosomes engineered for targeting M2 microglia to improve neurological function in ischemic stroke.

Background: Stroke is a devastating disease affecting populations worldwide and is the primary cause of long-term disability. The inflammatory storm plays a crucial role in the progression of stroke. In the acute phase of ischemic stroke, there is a transient increase in anti-inflammatory M2 microglia followed by a rapid decline.

A comprehensive analysis of the KLRB1 expression and its clinical implication in testicular germ cell tumors: A review.

Testicular germ cell tumors (TGCT) are the most common testicular malignancies. KLRB1 is considered to influence the development and progression of a number of cancers. However, it is unclear how the KLRB1 gene functions in TGCT.

Development of D-π-A organic dyes for discriminating HSA from BSA and study on dye-HSA interaction.

HSA (human serum albumin), a most abundant protein in blood serum, plays a key role in maintaining human health. Abnormal HSA level is correlated with many diseases, and thus has been used as an essential biomarker for therapeutic monitoring and biomedical diagnosis. Development of small-molecule fluorescent probes allowing the selective and sensitive recognition of HSA in in vitro and in vivo is of fundamental importance in basic biological research as well as medical diagnosis.

Does erectile dysfunction predict cardiovascular risk? A cross-sectional study of clinical characteristics in patients with erectile dysfunction combined with coronary heart disease.

Background: Erectile Dysfunction (ED) is a common sexual dysfunction in men who are unable to consistently obtain and maintain sufficient penile erection to accomplish a satisfactory sexual life. ED is currently considered to be a predictor of cardiovascular disease (CVD), but few studies have observed the association between ED and clinical features of coronary heart disease (CHD). An investigation of the association between ED and clinical characteristics of CHD was carried out using a cross-sectional study design.

Data-Driven Structural Health Monitoring: Leveraging Amplitude-Aware Permutation Entropy of Time Series Model Residuals for Nonlinear Damage Diagnosis.

In structural health monitoring (SHM), most current methods and techniques are based on the assumption of linear models and linear damage. However, the damage in real engineering structures is more characterized by nonlinear behavior, including the appearance of cracks and the loosening of bolts. To solve the structural nonlinear damage diagnosis problem more effectively, this study combines the autoregressive (AR) model and amplitude-aware permutation entropy (AAPE) to propose a data-driven damage detection method.

Boosting the Hydrogen Evolution Reaction Performance of P-Doped PtTe Nanocages via Spontaneous Defects Formation.

PtTe , a member of the noble metal dichalcogenides (NMDs), has aroused great interest in exploring its behavior in the hydrogen evolution reaction (HER) due to the unique type-II topological semimetallic nature. In this work, a simple template-free hydrothermal method to obtain the phosphorus-doped (P-doped) PtTe nanocages with abundant amorphous and crystalline interface (A/C-P-PtTe ) is developed. Revealed by density functional theory calculations, the atomic Te vacancies can spontaneously form on the basal planes of PtTe by the P doping, which results in the unsaturated Pt atoms exposed as the active sites in the amorphous layer for HER.

Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis.

Ferroptosis plays a critical role in ischemic stroke, and anti-ferroptosis strategies were regarded as potentially effective measures. Based on ferroptosis-related mechanisms, this study aims to design and prepare anti-ferroptosis exosomes from adipose-derived mesenchymal stem cells (ADSC-Exo) for treating ischemic brain injury via intranasal (IN) administration. According to the bioinformatic analysis, CHAC1 was a key gene in the progress of ferroptosis in ischemic stroke.

Toward the High-Performance Lithium Primary Batteries by Chemically Modified Fluorinate Carbon with δ-MnO.

Li/CF battery is one of the most promising lithium primary batteries (LPBs) which yields the highest energy density but with poor rate capability. This Achilles'' heel hinders the large-scale applications of Li/CF batteries. This work first reports a facile chemical modification method of CF with δ-MnO .

Clinical study of comprehensive TCM therapy in the treatment of damp and hot stasis erectile dysfunction.

Background: The dilemma of male sexual dysfunction has been the focus of the whole society. Erectile dysfunction (ED) is one of the common sexual dysfunctions, and traditional Chinese medicine therapy has shown potential benefits in the treatment of ED. Comprehensive therapy of traditional Chinese medicine (CTTCM) is a comprehensive application of Chinese medicine therapy for auxiliary intervention.

Clinical study on the treatment of male infertility with Wuwei Fuzheng Yijing decoction based on microplastics: Study protocol for a randomized controlled trial.

Background: Environmental pollution and male infertility have become global public health problems. The presence of microplastics (MPs) has been detected in the human body, and it has also been demonstrated that MPs can cause damage to the reproductive system. Wuwei Fuzheng Yijing Decoction (WWFZYJ) is effective in treating male infertility.

Surface Architecture Design of LiNi Co Al O Cathode with Synergistic Organics Encapsulation to Enhance Electrochemical Stability.

Ni-rich LiNi Co Al O (NCA) material attracts extensive attention due to its high discharge specific capacity, but its distinct drawbacks of rapid capacity decline and poor cycle performance at elevated temperatures and high voltage during charge/discharge cycling restricts its widespread application. To solve these problems, a multifunctional coating layer composed of a lithium-ion-conductive lithium polyacrylate (LiPAA) inner layer and a cross-linked polymer outer layer from certain organic substances of silane-coupling agent (KH550) and polyacrylic acid (PAA) is successfully designed on the surface of NCA materials, which is favorable for eliminating residual lithium and improving lithium-ion conductivity, surface stability, and hydrophobicity of NCA materials. In addition, the amount of the coating material is also investigated.

Sodium Doping to Enhance Electrochemical Performance of Overlithiated Oxide Cathode Materials for Li-Ion Batteries via Li/Na Ion-Exchange Method.

Overlithiated oxide cathode materials show high capacity but poor cycle stability and voltage attenuation. In this work, a concentration difference driven molten salt ion exchange strategy is used to replace a small quantity of lithium ions by sodium ions. With the entry of sodium ions, the interplanar spacing is increased and the structure is stabilized.

Wireless sensing and vibration control with increased redundancy and robustness design.

Control systems with long distance sensor and actuator wiring have the problem of high system cost and increased sensor noise. Wireless sensor network (WSN)-based control systems are an alternative solution involving lower setup and maintenance costs and reduced sensor noise. However, WSN-based control systems also encounter problems such as possible data loss, irregular sampling periods (due to the uncertainty of the wireless channel), and the possibility of sensor breakdown (due to the increased complexity of the overall control system).